Abstract：
:Gaucher disease (GD) is most frequent disorder of glycolipid storage. The glucosylceramide accumulation might lead to oxidative stress and changes in lipid profile. Regarding the main role of trace elements in hematopoiesis and oxidative stress, this study was aimed to evaluate the zinc and copper levels, three oxidative stress parameters, and lipid profile in GD. Thirty-three patients with GD along with 64 age- and sex-matched healthy controls participated in the study. The levels of zinc and copper were determined using atomic absorption/flame emission spectrophotometer. Malondialdehyde level was measured using HPLC. Total antioxidant capacity (TAC), catalase activity, and lipid profile were assessed using colorimetric methods. Data were analyzed using SPSS software version 16.0. Significant decrease in the serum levels of Zn (p < 0.001) and Cu (p < 0.001) was observed in patients with GD compared to controls. Subjects in control group showed significantly higher levels of TAC than patients with GD (p < 0.001). In contrast, plasma concentration of malondialdehyde was insignificantly higher in patients with GD than controls (p = 0.06). There was a direct correlation between TAC and hemoglobin concentration (p = 0.035; r = 0.369) in patients with GD. Furthermore, the calculated area under receiver operating characteristic curve for HDL cholesterol was equal to 0.938. The results showed that both zinc and copper levels decreased in patients with GD. Patients with GD showed decreased serum content of TAC. It was found that improving the deficiency of zinc and copper by supplementing them could be useful in management of patients with GD.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Mozafari H,Khatami S,Kiani A,Rahimi Z,Vaisi-Raygani A,Afsharnaderi A,Alaei MRdoi
10.1007/s12011-019-01709-3subject
Has Abstractpub_date
2020-01-01 00:00:00pages
130-137issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-019-01709-3journal_volume
193pub_type
杂志文章abstract：:Sediments from 14 stations in the Foshan Waterway, a river crossing the industrial district of Guangdong Province, South China, were sampled and subsequently analyzed. The 14 stations were selected for the pollution discharging features of the river, such as the hydrology, the distribution of pollution sources, and th...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9789-2
更新日期：2013-11-01 00:00:00
abstract：:Iron deficiency anemia (IDA) due to malnutrition and/or blood loss is a common condition, especially in women of reproductive age. Intense exercise can induce anemia via an inflammatory response, but whether intense exercise affects the efficacy of iron supplementation to treat IDA is unclear. Here, we show in a mouse...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02402-6
更新日期：2020-10-06 00:00:00
abstract：:Calcium fructoborate (CFB) has been reported as supporting healthy inflammatory response. In this study, we assess the effects of CFB on blood parameters and proinflammatory cytokines in healthy subjects. This was a randomized, double-blinded, placebo-controlled trial. Participants received placebo or CFB at a dose of...
journal_title：Biological trace element research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12011-014-0155-9
更新日期：2015-02-01 00:00:00
abstract：:The experiment was conducted to study the effects of different selenium (Se) sources on productive performance, serum and milk Se concentrations, and antioxidant status of sows. A total of 12 sows (Landrace×Yorkshire) with same pregnancy were randomly divided into two groups; each group was replicated six times. These...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8803-1
更新日期：2011-09-01 00:00:00
abstract：:In present study, the levels of some toxic elements in 19 different home-made cosmetic products (spray hair dye, henna, tattoo, eyeliner, eye mascara, smear, lip moisturizer, and lipstick) were analyzed by inductively coupled plasma mass spectrometric (ICP-MS) after microwave digestion. The ICP-MS results were verifie...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02357-8
更新日期：2020-09-05 00:00:00
abstract：:The present study investigated whether boron would enhance the action of 17beta-estradiol (E2) or parathyroid hormone (PTH) on bone mineral balance in ovariectomized (OVX) rats. Forty-three days after OVX, the rats were treated for 5 wk with vehicle, boron (5 ppm as boric acid), E2 (30 microg/kg/d, sc), PTH (60 microg...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:81:1:29
更新日期：2001-07-01 00:00:00
abstract：:Manganese (Mn) pollution is an important environmental problem because of the potential toxicity to human and animal health. However, the effects of Mn on energy metabolism and autophagy are not clear. Consequently, we examined the effects of excessive and chronic exposure to Mn on liver function, oxidative stress, re...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01960-8
更新日期：2020-09-01 00:00:00
abstract：:Imbalance of zinc and copper status has been hypothesized in human hypertension. A case-control study was carried out to elucidate the possible relationship between zinc and copper status and essential hypertension. Thirty-one subjects affected by mild stable hypertension, pharmacologically untreated, were investigate...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02788959
更新日期：1995-08-01 00:00:00
abstract：:Our previous studies showed that serum calcium level may have influence in the blood pressure to older male subjects, but the relationship between serum calcium level and blood lipids is unclear. The aim of this study was to evaluate the relationship between total serum calcium level and blood lipids. In our study, to...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9895-9
更新日期：2014-03-01 00:00:00
abstract：:The objective of this study was to determine the effects of supplemental chromium as chromium picolinate (CrPic) on productive performance, chromium (Cr) concentration, serum parameters, and colostrum composition in sows. Thirty Yorkshire sows were bred with semen from a pool of Landrace boars. The sows were equally g...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9699-3
更新日期：2013-07-01 00:00:00
abstract：:A study was conducted to determine the effect of dietary selenium (Se) concentration and source for broiler chickens on performance, nutrient digestibility, plasma Se, glutathione peroxidase (GPx) activity, and thiobarbituric acid reactive substances (TBARS). A total of 700 1-day-old broiler chicks were assigned to 7 ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01801-8
更新日期：2020-04-01 00:00:00
abstract：:Sponge granuloma formation was compared in copper-deficient and copper-sufficient rats following feeding of respective diets for 20, 40, or 60 d. Body weight, total blood hemoglobin, and activities of ceruloplasmin and Cu, Zn-superoxide dismutase in plasma were monitored to ascertain copper deficiency. Mean granuloma ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02990272
更新日期：1990-05-01 00:00:00
abstract：:The synthesis, characterization, anti-hyperglycemic activity, oxidative DNA damage capacity, and acute toxicity of chromium(III) malate complex [Cr2(LMA)3] were described. [Cr2(LMA)3] was synthesized in a single-step reaction by chelating chromium(III) with L-malic acid in aqueous solution. Based on elemental analysis...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8916-6
更新日期：2011-11-01 00:00:00
abstract：:Concentrations of toxic elements (lead, cadmium, mercury, and arsenic) were measured in water, sediment, and four commercial fish species (Cyprinus carpio, Hypophthalmichthys molitrix, Silurus glanis, and Esox lucius) and their tissues (muscle, liver, and kidney) from Saničani Lake, Bosnia and Herzegovina. The concent...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01982-2
更新日期：2020-09-01 00:00:00
abstract：:The aim of this study was to evaluate the impact of three different chromium forms--chromic chloride (CrCl3), chromium picolinate (CrPic), and a newly synthesized complex of chromium chelated with small peptides (CrSP)--on protein metabolism in vitro. In cultured skeletal muscle cells, CrSP was able to increase the ba...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8579-3
更新日期：2010-11-01 00:00:00
abstract：:Continuation of prolonged treatment against arsenicosis with conventional chelating therapy is a global challenge. The present study was intended to evaluate the defensive effect of arjunolic acid against arsenic-induced oxidative stress and female reproductive dysfunction. Wistar strain adult female rats were given s...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1077-0
更新日期：2018-03-01 00:00:00
abstract：UNLABELLED:There is conflicting evidence regarding the relationship between magnesium deficiency and metabolic syndrome, and a systematic assessment of the literature has not been performed. Our objective was to clarify the association between magnesium levels and metabolic syndrome by performing a meta-analysis. Based...
journal_title：Biological trace element research
pub_type： 杂志文章,meta分析
doi：10.1007/s12011-015-0446-9
更新日期：2016-03-01 00:00:00
abstract：:The aim of this study was to explore the effects of selenium addition on hepatic tissue ultrastructure and mitochondrial antioxidant capacity in copper-overloaded rats. Eighteen adult male Sprague-Dawley (SD) rats were randomly divided into three groups (n = 6 per group). Each group received 1 mL (intragastrically) of...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0293-8
更新日期：2015-09-01 00:00:00
abstract：:Lipid peroxy radicals (ROO.) were detected by electron spin resonance (ESR) at low temperature after formation by addition of H2O2 into a suspension of mice lymphocytes. If lymphocytes were treated with selenomethionine (Se-Met) prior to addition of H2O2, ROO. formation was inhibited in a fashion that was dependent on...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783233
更新日期：1997-01-01 00:00:00
abstract：:Forty-six elements have been detected in fresh banana pulp purchased weekly in Pittsburgh, PA for the past twelve years (1968-1980). Samples were prepared by lyophilization or low temperature ashing. Analyses were performed using X-ray fluorescence spectrometry, optical emission spectrometry, atomic absorption spectro...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789122
更新日期：1981-03-01 00:00:00
abstract：:The effects of rare earth elements (REEs) not only on cell growth and flavonoid accumulation of Tetrastigma hemsleyanum suspension cells but also on the isoenzyme patterns and activities of related enzymes were studied in this paper. There were no significant differences in enhancement of flavonoid accumulation in T. ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9600-4
更新日期：2013-04-01 00:00:00
abstract：:The onset of Alzheimer's disease has been shown to affect trace element concentrations in the brain when compared to "normal" subjects in ex vivo samples. The techniques used to determine trace element concentrations were proton-induced X-ray emission and instrumental neutron activation analysis. With these methods, s...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784242
更新日期：1999-01-01 00:00:00
abstract：:Both selenium and green tea have been reported to exhibit antigenotoxic and cancer chemopreventive properties. We compared the antimutagenic activities of regular green tea and selenium-enriched green tea obtained from Hubei Province, China, toward the heterocyclic amine, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) i...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:86:2:177
更新日期：2002-05-01 00:00:00
abstract：:Iron bioavailability seems to be regulated by vitamin A (VA) but the molecular events involved in this mechanism are not well understood. It is also known that retinoids mediate most of their function via interaction with retinoid receptors, which act as ligand-activated transcription factors controlling the expressio...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9397-6
更新日期：2012-10-01 00:00:00
abstract：:In this study, a new method was developed for the pre-concentration of trace mercury from seafood samples prior to analysis by spectrophotometry. The method is based on the complexation between 2-hydrazinobenzothiazole (2-HBT)-modified copolymer(s) and Hg(II) in the presence of an ionic surfactant, cetyltrimethylammon...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1614-5
更新日期：2019-09-01 00:00:00
abstract：:It has been defined that deficiency of trace elements plays an important role in the progression of asthma. However, the relationship between blood zinc (Zn), selenium (Se), and magnesium (Mg) and pulmonary functions in children remains to be clarified. A cross-sectional study was conducted in Wuxi, China, and a total...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-02019-4
更新日期：2020-10-01 00:00:00
abstract：:This work is a first attempt to determine the speciation of Cr in human plasma. With the aid of in vitro and in vivo 51Cr-labeled experiments, it was possible to develop the necessary biochemical techniques for the separation of the plasma proteins. Further work will use real samples, taking care to avoid contaminatio...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02992700
更新日期：1990-07-01 00:00:00
abstract：:A series of microcalorimetric experiments were performed to investigate the effect of La(3+) on the formation of the competent state of Escherichia coli HB101 by using a LKB-2277 BioActivity Monitor at 37 C. The thermogenic curves in the absence and in the presence of La(3+) were obtained. Based on these curves, we ca...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:91:3:267
更新日期：2003-03-01 00:00:00
abstract：:In brain, excess zinc alters the metabolism of amyloid precursor protein, leading to β-amyloid protein deposition, one of the hallmarks of Alzheimer's disease (AD) pathology. Recently, it has been reported that zinc accelerates in vitro tau fibrillization, another hallmark of AD. In the current study, we examined the ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9411-z
更新日期：2012-11-01 00:00:00
abstract：:Inducing the differentiation of stem cells from human exfoliated deciduous teeth (SHEDs) proceeds with low efficiency, which greatly limits clinical applications. Divalent metal elements play an important role in osteoinductivity for bone remodeling because they can simulate bone formation and decrease bone resorption...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1256-7
更新日期：2018-10-01 00:00:00
