Zinc sulfate in the prevention of total-body irradiation-induced early hematopoietic toxicity: a controlled study in a rat model.

Abstract:

:Exposure to ionizing total-body radiation suppresses hematopoiesis, resulting in decreased production of blood cells. Many researchers have demonstrated the critical role of zinc (Zn) in diverse physiological processes, such as growth and development, maintenance and priming of the immune system, and tissue repair. The aim of the present study was to determine the effects of zinc sulfate (40 mg/kg and 80 mg/kg) on early hematopoietic toxicity, caused by total-body irradiation (TBI) of rats with a single dose of 8 Gy. Both in the Zn 40 and in the Zn 80 groups, there were significantly increased white blood cell (WBC) count, when compared with control group. The WBC count was higher in the control group than in the TBI group. This result was statistically significant (p<0.05). Both the TBI+Zn 40 and the TBI+Zn 80 groups had a significantly protected WBC count against TBI. No difference was detected in any final measurement of thrombocyte count and hemoglobin level with direct comparison among all groups, with the exception that the hemoglobin level in the Zn 80 group compared to the control group. Whereas hemoglobin level in the control group was at a median figure of 13.98 g/dL (13.30-14.80), it was at a median figure of 14.25 g/dL (14.10-15.50) in the Zn 80 group. It would be worthwhile studying the effect of oral zinc sulfate supplements in radiation-treated cancer patients, in the hope of reducing radiation-induced toxicity.

journal_name

Biol Trace Elem Res

authors

Ertekin MV,Karslioğlu I,Erdem F,Sezen O,Gepdiremen A,Serifoğlu K

doi

10.1385/bter:100:1:063

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

63-73

issue

1

eissn

0163-4984

issn

1559-0720

pii

BTER:100:1:063

journal_volume

100

pub_type

杂志文章
  • Assessment of Plasma Zinc and Total Leukocyte Count in Calves Experimentally Infected with Mannheimia haemolytica.

    abstract::Mannheimia haemolytica is the main bacterial pathogen isolated in bovine respiratory disease (BRD), a common disease affecting calves before weaning. Previous research has shown that experimental infection with bovine herpesvirus 1, a respiratory virus, decreases plasma zinc (Zn) levels. However, changes in plasma Zn ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02145-4

    authors: Galarza EM,Lizarraga RM,Streitenberger N,Arriaga G,Abraham G,Mattioli GA,Anchordoquy JM,Fazzio LE

    更新日期:2021-01-01 00:00:00

  • Supplementation with selenium augments the functions of natural killer and lymphokine-activated killer cells.

    abstract::This study examined the effects of dietary (2.0 ppm for 8 wk) and in vitro (1 x 10(-7)M) supplementation with selenium (Se, as sodium selenite) on the activity of spleen natural killer (NK) cells and plastic-adherent lymphokine-activated killer (A-LAK) cells from C57B1/6J male mice. Dietary supplementation with Se res...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02789164

    authors: Kiremidjian-Schumacher L,Roy M,Wishe HI,Cohen MW,Stotzky G

    更新日期:1996-06-01 00:00:00

  • Effects of lanthanum chloride administration in prenatal stage on one-trial passive avoidance learning in chicks.

    abstract::Lanthanum cations (La 3+) are well known for their inhibitory actions on calcium channels. Prenatal lanthanum exposure may affect the development of embryo and alter the capacity for learning and memory in adults, and the one-trial passive avoidance learning paradigm with day-old chicks is an excellent model to study ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-008-8225-5

    authors: Che Y,Cui Y,Jiang X

    更新日期:2009-01-01 00:00:00

  • The distribution of several elements in cat urine and the relation between the content of elements and urolithiasis.

    abstract::The concentrations of elements in urine obtained from cats with urolithiasis were compared with those of healthy cats. The concentration of several elements, such as sodium (Na), phosphorus (P), sulfur (S), and potassium (K), in urine obtained from cats with urolithiasis was significantly higher than that of healthy c...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-010-8893-9

    authors: Mochizuki M,Morikawa M,Yogo T,Urano K,Ishioka K,Kishi M,Hondo R,Ueda F,Sako T,Sakurai F,Yumoto N,Tagawa M

    更新日期:2011-11-01 00:00:00

  • The effect of albumin, ceruloplasmin, and other serum constitutents on Fe(II) oxidation.

    abstract::This study has analyzed the role of several serum constituents, that have been proposed to effect the following reactionin situ: {fx1-1} {fx1-2} These reactions were monitored by measuring the rate of Fe(II) oxidation in the presence of apo-transferrin (reaction A) and Fe(III)-transferrin formation (reaction B) at 465...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02789129

    authors: Carver FJ,Farb DL,Frieden E

    更新日期:1982-03-01 00:00:00

  • Effect of dietary vanadium on the ileac T cells and contents of cytokines in broilers.

    abstract::The purpose of this 42-day study was to examine the effect of dietary vanadium on the ileac T cells and contents of cytokines including interleukin-2 (IL-2), interleukin-6 (IL-6), and interferon-gamma (IFN-γ) in broilers by flow cytometry and enzyme-linked immunosorbent assay. A total of 420 one-day-old avian broilers...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-011-9274-8

    authors: Wang K,Cui H,Deng Y,Peng X,Fang J,Zuo Z,Cui W

    更新日期:2012-06-01 00:00:00

  • The effect of copper on glutathione metabolism in human leukocytes.

    abstract::Leukocytes incubated with Cu(II) showed a decrease in both glutathione reductase activity and reduced glutathione content. The glucose 6-phosphate dehydrogenase activity under the same conditions was not affected. Serum albumin added to mixtures prevented the loss of enzyme activity, whileD-penicillamine andL-histidin...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02783258

    authors: Rafter GW

    更新日期:1982-06-01 00:00:00

  • Arjunolic Acid Improves the Serum Level of Vitamin B12 and Folate in the Process of the Attenuation of Arsenic Induced Uterine Oxidative Stress.

    abstract::Continuation of prolonged treatment against arsenicosis with conventional chelating therapy is a global challenge. The present study was intended to evaluate the defensive effect of arjunolic acid against arsenic-induced oxidative stress and female reproductive dysfunction. Wistar strain adult female rats were given s...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-017-1077-0

    authors: Maity M,Perveen H,Dash M,Jana S,Khatun S,Dey A,Mandal AK,Chattopadhyay S

    更新日期:2018-03-01 00:00:00

  • How Trace Element Levels of Public Drinking Water Affect Body Composition in Turkey.

    abstract::Since waterborne minerals appear in ionic form and are readily absorbed by the gastrointestinal tract, drinking water could be a crucial source of mineral intake. However, no comprehensive research has yet determined how trace elements in drinking water relate to body composition. We aimed to assess the relationship b...

    journal_title:Biological trace element research

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12011-016-0779-z

    authors: Cetin I,Nalbantcilar MT,Tosun K,Nazik A

    更新日期:2017-02-01 00:00:00

  • A mechanistic study on the toxic effect of copper oxide nanoparticles in soybean (Glycine max L.) root development and lignification of root cells.

    abstract::Copper oxide nanoparticles (CuONPs) are widely used in several products and their release into the environment can cause toxicity to major food crops. In this study, toxic responses as a result of CuONPs exposure were studied in soybean (Glycine max L.) seedlings. The plants were grown in 1/2 strength Murashige and Sk...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-014-0106-5

    authors: Nair PM,Chung IM

    更新日期:2014-12-01 00:00:00

  • Zinc Sulfate in Narrow Range as an In Vitro Anti-HSV-1 Assay.

    abstract::This report explains the employing of a combination test of traditional cell culture with a quantitative real-time PCR for assessment of the antiviral effect of zinc sulfate (ZnSO4) on herpes simplex virus (HSV)-infected Vero cells. Our evidence showed that the treatment with 0.3 mM ZnSO4 strongly inhibited the replic...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-019-01728-0

    authors: Fani M,Khodadad N,Ebrahimi S,Nahidsamiei R,Makvandi M,Teimoori A,Langari H

    更新日期:2020-02-01 00:00:00

  • Iodine and/or selenium deficiency alters tissue distribution pattern of other trace elements in rats.

    abstract::Tissue distribution of Fe, Mn, Cu, and Zn, the essential trace elements associated with oxidant and/or antioxidant processes, was examined in iodine- and/or selenium-deficient rats (ID, SeD, ISeD). Fe and Mn were the most affected minerals in all types of deficiency states. Mn levels decreased significantly in the liv...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:95:3:247

    authors: Giray B,Riondel J,Arnaud J,Ducros V,Favier A,Hincal F

    更新日期:2003-12-01 00:00:00

  • Enrichment, Distribution of Vanadium-Containing Protein in Vanadium-Enriched Sea Cucumber Apostichopus japonicus and the Ameliorative Effect on Insulin Resistance.

    abstract::Sea cucumbers are a potential source of natural organic vanadium that may improve insulin resistance. In this work, vanadium was accumulated rapidly in blood, body wall, and intestine by sea cucumber Apostichopus japonicus. Furthermore, water-soluble vanadium-containing proteins, the main form of the organic vanadium,...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0517-y

    authors: Liu Y,Zhou Q,Zhao Y,Wang Y,Wang Y,Wang J,Xu J,Xue C

    更新日期:2016-05-01 00:00:00

  • Multicountry estimation of dietary boron intake.

    abstract::Dietary Reference Intakes are not yet established for boron (B), a naturally occurring trace element in the human diet. Estimated dietary B intakes provide useful information for planning and assessing diets in healthy populations. The countries selected for this study represent a wide variety of dietary patterns and ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02783128

    authors: Rainey C,Nyquist L

    更新日期:1998-01-01 00:00:00

  • Effect of exercise-induced hyperthermia on serum iron concentration.

    abstract::Serum iron levels have been shown to decline both with fever and with strenuous exercise, leading to the supposition that the decrease might be the result of a rise in core body temperature. To evaluate this hypothesis, the serum iron response to an exercise-induced 1.5 degrees C rise in core body temperature was meas...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:108:1-3:061

    authors: Buono MJ,Barrack MT,Bouton-Sander F,Bradley P,Cottonaro KA

    更新日期:2005-01-01 00:00:00

  • Human health risks derived from dietary exposure to toxic metals in Catalonia, Spain: temporal trend.

    abstract::The present study was aimed at estimating the current (2012) dietary intake of arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb) by the population of Catalonia, Spain. The temporal trends with respect to previous surveys, performed in 2000, 2005, and 2008, were also determined. For that purpose, metal concentrat...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-014-0138-x

    authors: Perelló G,Llobet JM,Gómez-Catalán J,Castell V,Centrich F,Nadal M,Domingo JL

    更新日期:2014-12-01 00:00:00

  • Are Heavy Metal Exposure and Trace Element Levels Related to Metabolic and Endocrine Problems in Polycystic Ovary Syndrome?

    abstract::This study aimed to determine the relationship between the metabolic and endocrinological pathologies in polycystic ovary syndrome (PCOS) and the levels of arsenic, chromium, cadmium, lead, mercury, antimony, zinc, and copper to evaluate the relationship of these toxic metals with inflammatory/oxidative parameters. Th...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02220-w

    authors: Kirmizi DA,Baser E,Turksoy VA,Kara M,Yalvac ES,Gocmen AY

    更新日期:2020-11-01 00:00:00

  • Developmental effects of boric acid in rats related to maternal blood boron concentrations.

    abstract::Timed-mated Sprague-Dawley rats (60/group) were exposed to boric acid (BA) from gestational days (gd) 0 to 20. BA added to the diet (0, 0.025, 0.050, 0.075, 0.1, or 0.2%) yielded boron (B) intakes of <0.35 (control), 3, 6, 10, 13, or 25 mg B/kg body wt/d. Approximately one-half of the dams/group were terminated on gd ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02783148

    authors: Price CJ,Strong PL,Murray FJ,Goldberg MM

    更新日期:1998-01-01 00:00:00

  • Heme and Non-heme Iron on Growth Performances, Blood Parameters, Tissue Mineral Concentration, and Intestinal Morphology of Weanling Pigs.

    abstract::This experiment was conducted to evaluate the effects of heme and non-heme iron sources on growth performances, blood parameters, tissue mineral concentration, and intestinal morphology in weanling pigs. At 25 days of age, 32 newly weaned piglets (Duroc × Landrace × Yorkshire; 8.66 ± 0.59 kg) were allocated to one of ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-018-1385-z

    authors: Zhuo Z,Yu X,Li S,Fang S,Feng J

    更新日期:2019-02-01 00:00:00

  • Trace Elements in the Large Population-Based HUNT3 Survey.

    abstract::The Nord-Trøndelag Health Study (The HUNT Study) is a large health survey population study in the county of Trøndelag, Norway. The survey has been repeated four times in about 10-year intervals. In the HUNT3 survey (2006-2008), we collected 28,000 samples for trace element analysis. Blood samples from 758 healthy pers...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02376-5

    authors: Syversen T,Evje L,Wolf S,Flaten TP,Lierhagen S,Simic A

    更新日期:2020-09-08 00:00:00

  • Zinc Regulates Lipid Metabolism and MMPs Expression in Lipid Disturbance Rabbits.

    abstract::Lipid disturbance induced by high-fat diet is a worldwide problem, and it can induce inflammation and oxidative stress in vivo. Zinc is considered as an antioxidant, anti-inflammatory agent. Since matrix metalloprotease 2 (MMP2) and matrix metalloprotease 9 (MMP9)'s expressions are changed under many pathological cond...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0367-7

    authors: Xu C,Huang Z,Liu L,Luo C,Lu G,Li Q,Gao X

    更新日期:2015-12-01 00:00:00

  • Preliminary study on the relationship between osteoporosis and trace elements with rat models.

    abstract::Thirty rats were divided randomly into five groups and fed with different feeds. They were killed after 2 mo. Right thighs of these rats were taken as samples. Bone mineral densities of these samples were measured by the double-energy x-ray bone mineral densitometer, and trace elements contents of the samples were ana...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02784252

    authors: Nie H,Qin L,Tian W,Ni B,Bao A,Wang P

    更新日期:1999-01-01 00:00:00

  • Dietary boron supplementation enhanced the action of estrogen, but not that of parathyroid hormone, to improve trabecular bone quality in ovariectomized rats.

    abstract::This study investigated whether boron would enhance the ability of 17beta-estradiol (E2) or parathyroid hormone (PTH) to improve bone quality in ovariectomized OVX rats. Adult OVX rats were treated for 5 wk with vehicle, boron (5 ppm as boric acid), E2 (30 microg/kg/d, sc), PTH (60 microg/kg/d, sc), or a combination o...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/bter:82:1-3:109

    authors: Sheng MH,Taper LJ,Veit H,Qian H,Ritchey SJ,Lau KH

    更新日期:2001-07-01 00:00:00

  • Comparative binding study of aluminum and chromium to human transferrin. Effect of iron.

    abstract::The characteristics of aluminum and chromium binding to apo-transferrin (apo-tf) have been investigated and compared. Both metal ions were taken up by human transferrin forming complexes with the maximum absorbances at 405 nm for chromium-transferrin (cr-tf) and 240 nm for aluminum-transferrin (Al-tf). In the presence...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02784585

    authors: Moshtaghie AA,Ani M,Bazrafshan MR

    更新日期:1992-01-01 00:00:00

  • Effect of Chromium Supplementation on Performance, Carcass Characteristics, Blood Biochemistry, and Immune Response of Unstressed Broiler Chickens: a Dose-Response Meta-Analysis.

    abstract::Studies investigating the effects of Chromium (Cr) supplementation on unstressed broiler chickens have reported an inconsistent association between Cr supplementation and broiler chickens' responses. We conducted a dose-response meta-analysis of previous studies to assess the dose-response associations between Cr supp...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-021-02589-2

    authors: Piray AH,Foroutanifar S

    更新日期:2021-01-17 00:00:00

  • Interaction of Lead with Calcium, Iron, and Zinc in the Biological Samples of Malnourished Children.

    abstract::Interaction between toxic and essential elements is of particular interest, because the deficiency of essential element can dramatically increase the absorption rate of toxic metals inside the body. This study was conducted to evaluate the possible correlation of lead (Pb) with calcium (Ca), iron (Fe), and zinc (Zn) i...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-017-1141-9

    authors: Talpur S,Afridi HI,Kazi TG,Talpur FN

    更新日期:2018-06-01 00:00:00

  • Analytical Assessment of Bio- and Toxic Elements Distribution in Pu-erh and Fruit Teas in View of Chemometric Approach.

    abstract::This study concerns application of flame atomic absorption spectrometry (FAAS) in assessment of macro- and microelement and toxic metal levels (Mg, Ca, K, Na, Mn, Cu, Fe, Zn, Cr, Ni, Co, Cd and Pb) in dark (Pu-erh) and fruit tea leaves and their infusions. Phosphorus was also determined in the form of phosphomolybdate...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-016-0669-4

    authors: Brzezicha-Cirocka J,Grembecka M,Szefer P

    更新日期:2016-11-01 00:00:00

  • One-step bulk preparation of calcium carbonate nanotubes and its application in anticancer drug delivery.

    abstract::Bulk fabrication of ordered hollow structural particles (HSPs) with large surface area and high biocompatibility simultaneously is critical for the practical application of HSPs in biosensing and drug delivery. In this article, we describe a smart approach for batch synthesis of calcium carbonate nanotubes (CCNTs) bas...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-012-9325-9

    authors: Tang J,Sun DM,Qian WY,Zhu RR,Sun XY,Wang WR,Li K,Wang SL

    更新日期:2012-06-01 00:00:00

  • Evaluation of molybdenum status of cows: the use of blood plasma and milk as indicators under semi-arid environmental conditions in Punjab, Pakistan.

    abstract::The present investigation was carried out to determine the molybdenum (Mo) status of blood plasma and milk of lactating cows at the Livestock Experimental Station, Khizer abad, Sargodha, Pakistan. Blood and milk from the lactating cows were sampled periodically after every month during winter so as to examine the effe...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-010-8874-z

    authors: Khan ZI,Ahmad K,Ashraf M,Raza N

    更新日期:2011-10-01 00:00:00

  • Cerium Oxide Nanoparticles Attenuate Oxidative Stress and Inflammation in the Liver of Diethylnitrosamine-Treated Mice.

    abstract::The catalytic activity of cerium oxide nanoparticles (CeO2NPs) is responsible for its application as an antitumor agent. This activity may be due to its ability to switch between III and IV oxidation states thereby conferring pro- and antioxidant properties. This study was designed to assess the hepatoprotective poten...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-019-01696-5

    authors: Adebayo OA,Akinloye O,Adaramoye OA

    更新日期:2020-01-01 00:00:00