Supplementation with selenium augments the functions of natural killer and lymphokine-activated killer cells.

Abstract:

:This study examined the effects of dietary (2.0 ppm for 8 wk) and in vitro (1 x 10(-7)M) supplementation with selenium (Se, as sodium selenite) on the activity of spleen natural killer (NK) cells and plastic-adherent lymphokine-activated killer (A-LAK) cells from C57B1/6J male mice. Dietary supplementation with Se resulted in a significant increase in the lytic activity of activated NK cells, and cells from these highly lytic effector cell populations expressed significantly higher numbers of intermediate affinity interleukin-2 receptors (II-2R)/cell. In the presence of high concentrations of II-2 and 1 x 10(-7)M Se, resting populations of spleen NK cells developed into A-LAK cells that had a significantly enhanced ability to proliferate, as indicated by the significantly higher amounts of nuclear 3H-thymidine incorporation, and a significantly augmented cytolytic activity against both NK-sensitive and NK-resistant target cells. Se appears to enhance the lytic activity of activated NK cells and to augment the proliferation, expansion, and lytic activity of A-LAK cells in the presence of high concentrations of II-2 through its ability to enhance the expression of intermediate affinity II-2R on these cells.

journal_name

Biol Trace Elem Res

authors

Kiremidjian-Schumacher L,Roy M,Wishe HI,Cohen MW,Stotzky G

doi

10.1007/BF02789164

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

227-39

issue

3

eissn

0163-4984

issn

1559-0720

journal_volume

52

pub_type

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