Abstract:
:Fluoride compounds are abundant and widely distributed in the environment at a variety of concentrations. Further, fluoride induces toxic effects in target organs such as the liver. In this study, we investigated liver histopathology, DNA damage, apoptosis, and the mRNA and protein expressions of caspase-3 and -9 in the rat livers by administering varying concentrations of fluoride (0, 50, 100, 200 mg/L ) for 120 days. The results showed fluoride-induced morphological changes and significantly increased apoptosis and DNA damage in rats exposed to fluoride, especially in response to higher doses. The immunohistochemical and qRT-PCR results indicated that caspase-3, caspase-9 protein positive expression and mRNA relative expression enhanced with increasing NaF concentration. In summary, our findings suggest that chronic exposure to fluoride causes damages to liver histopathology and leads to liver apoptosis through caspase-mediated pathways.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Song GH,Huang FB,Gao JP,Liu ML,Pang WB,Li Wb,Yan XY,Huo MJ,Yang Xdoi
10.1007/s12011-015-0265-zsubject
Has Abstractpub_date
2015-08-01 00:00:00pages
173-82issue
2eissn
0163-4984issn
1559-0720journal_volume
166pub_type
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