Abstract：
:The purpose of this study was to assess insoluble salts containing gadolinium (Gd(3+)) for effects on human dermal fibroblasts. Responses to insoluble Gd(3+) salts were compared to responses seen with Gd(3+) solubilized with organic chelators, as in the Gd(3+)-based contrast agents (GBCAs) used for magnetic resonance imaging. Insoluble particles of either Gd(3+) phosphate or Gd(3+) carbonate rapidly attached to the fibroblast cell surface and stimulated proliferation. Growth was observed at Gd(3+) concentrations between 12.5 and 125 μM, with toxicity at higher concentrations. Such a narrow window did not characterize GBCA stimulation. Proliferation induced by insoluble Gd(3+) salts was inhibited in the presence of antagonists of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways (similar to chelated Gd(3+)) but was not blocked by an antibody to the platelet-derived growth factor receptor (different from chelated Gd(3+)). Finally, high concentrations of the insoluble Gd(3+) salts failed to prevent fibroblast lysis under low-Ca(2+) conditions, while similar concentrations of chelated Gd(3+) were effective. In conclusion, while insoluble Gd(3+) salts are capable of stimulating fibroblast proliferation, one should be cautious in assuming that GBCA dechelation must occur in vivo to produce the profibrotic changes seen in association with GBCA exposure in the subset of renal failure patients that develop nephrogenic systemic fibrosis.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Bleavins K,Perone P,Naik M,Rehman M,Aslam MN,Dame MK,Meshinchi S,Bhagavathula N,Varani Jdoi
10.1007/s12011-011-9176-9subject
Has Abstractpub_date
2012-02-01 00:00:00pages
257-67issue
2eissn
0163-4984issn
1559-0720journal_volume
145pub_type
杂志文章abstract：:Fluoride (F) concentration in blood serum of healthy dromedary camel population was measured, and its relationship with age and sex was determined. In male animals, the level varied from 0.017 to 0.296 ppm, with mean (± S.E.) value of 0.163 ± 0.013 ppm. In females, the level varied from 0.036 to 0.372 ppm with mean va...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02534-9
更新日期：2021-01-06 00:00:00
abstract：:Biological half-lives of bromine in 15 different organs and tissues of the rat, in addition to the whole-body half-life, were determined by measuring the radioactive concentration of 82Br-bromide in samples of tissues collected at the time intervals of 12-396 h from animals that continuously (up to 17 d) received 82Br...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:76:1:57
更新日期：2000-07-01 00:00:00
abstract：:Consumption of edible plants satisfies a significant part of human body needs in macro- and micronutrients while biologically active substances contain strong antioxidant properties and reduce the risk of a number of diseases. Balanced nutrition and design of personalized diets and treatment rely on the data on the co...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02345-y
更新日期：2020-08-19 00:00:00
abstract：:This experiment was conducted to evaluate the effects of zinc (ZnSO4.H2O) and vitamin A (retinol) supplementation on performance, carcass characteristics, and serum concentrations of glucose, cholesterol, total protein, and malondialdehyde (MDA) as an indicator of lipid peroxidation in broiler chickens (Ross) reared a...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1385/BTER:94:3:225
更新日期：2003-09-01 00:00:00
abstract：:The present study investigated the interactive effects of copper sources and a high level of phytase on growth performance, nutrient digestibility, tissue mineral concentrations, and plasma parameters in nursery pigs. Weaning piglets (N = 192; 6.06 ± 0.99 kg), blocked by body weight, were randomly allotted to 1 of 4 d...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-021-02580-x
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abstract：:This study was designed to measure the effect of iron supplementation on antioxidant status in iron-deficient anemia, including the time for hemoglobin normalization and at the time of filling of iron body stores. The extent of plasma lipid peroxidation was evaluated by measuring the levels of malondialdehyde and glut...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:96:1-3:117
更新日期：2003-01-01 00:00:00
abstract：:The objective was to evaluate metal ion accumulation in hair of patients undergoing orthodontic treatment with fixed appliances in time. The patients (N = 47) participated in a questionnaire survey. Hair sampling was performed at the beginning and in the 4th, 8th, and 12th month of the treatment. The content of metals...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-014-0152-z
更新日期：2015-02-01 00:00:00
abstract：:Hypomagnesemia is associated with the development of neuropathy and abnormal platelet activity, both of which are risk factors for diabetic foot ulcer (DFU). This study was carried out to evaluate the effects of magnesium administration on wound healing and metabolic status in subjects with DFU. This randomized, doubl...
journal_title：Biological trace element research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12011-017-1056-5
更新日期：2018-02-01 00:00:00
abstract：:Zinc, copper, and selenium statuses were reported to be linked to the development of chronic diseases, especially coronary heart disease (CHD). Metabolic syndrome, a known CHD risk factor, was found to be highly prevalent in Lebanon. Nevertheless, no data are available on the statuses of plasma zinc, copper, and selen...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-008-8112-0
更新日期：2008-07-01 00:00:00
abstract：:The consumption of vegetables grown on soils polluted by trace elements can cause a serious threat for animal and human health and disturb the functioning of the ecosystem. The aim of this work is to determine the concentrations of As, Cd, Co, Cr, Cu, Ni, Pb, Mn, and Zn in soils and different vegetables from market ga...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01849-6
更新日期：2020-05-01 00:00:00
abstract：:Iron and copper are essential microminerals that are intimately related. The present study was performed to determine the effect of iron-deficiency anemia (IDA) and treatment with iron on laboratory indicators of copper status. Hemoglobin, mean corpuscular volume erythrocyte Zn protoporphyrin, serum ferritin, serum co...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:112:3:213
更新日期：2006-09-01 00:00:00
abstract：:The effects of zinc chloride (ZnCl2), disodium zinc ethylenediamine tetraacetate (Zn-EDTA), and zinc gluconate (Zn-GLU) on the antioxidant enzyme activities and levels of interleukins (ILs) in psoriasis-induced mice were studied. One hundred twenty female mice were randomly divided into six groups with 20 mice in each...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-013-9799-0
更新日期：2013-12-01 00:00:00
abstract：:Descriptions of the effects of paraquat (P2+) on the peroxidation of liver microsomes are very divergent. Therefore, the presence of ferric iron in the medium and the activity of microsomal mixed-function oxidase system are two factors that we have taken into consideration to explain the discrepancies. The results sho...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02790096
更新日期：1995-01-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0144-z
更新日期：2014-12-01 00:00:00
abstract：:We hypothesized that blood heavy metal levels such as lead, cadmium, and mercury were associated with uric acid level and hyperuricemia, and that this association remains significant after adjustment for other metals. We tested this hypothesis using the Korean National Health and Nutrition Examination Survey data. Bet...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02152-5
更新日期：2021-01-01 00:00:00
abstract：:The kidney has been regarded as a critical organ of toxicity induced by acute exposure to hexavalent chromium [Cr(VI)] compounds. Reactive intermediates and free radicals generated during reduction process might be responsible for Cr(VI) toxicity. In this study, the effects of pretreatment or posttreatment of taurine ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:102:1-3:209
更新日期：2004-01-01 00:00:00
abstract：:Both thermal and epithermal neutron activation analyses have been employed to determine chromium and nickel in lung tissue and arsenic in urine. Based on accuracy, precision, and detection limits, these techniques have been successfully used to analyze lung tissue from a deceased welder, who died, from cancer, and to ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02796646
更新日期：1987-08-01 00:00:00
abstract：:Magnesium is the second most abundant intracellular cation and is a fundamental cofactor in a multitude of cellular enzymatic reactions. Magnesium deficiency causes diverse clinical features predominantly due to cardio- and neurotoxicity. We describe a case of severe hypomagnesaemia associated with intermittent downbe...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8757-3
更新日期：2011-08-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1227-4
更新日期：2018-09-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02820017
更新日期：1998-04-01 00:00:00
abstract：:Exposure of people and animals to arsenic (As) is a global public health concern because As is widely distributed and associated with numerous adverse effects. As is a poisonous metalloid and arsenic trioxide (As2O3) is a form of As. Thus far, there have been very few reports on the inflammatory factor alterations of ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0305-8
更新日期：2015-10-01 00:00:00
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journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:86:1:55
更新日期：2002-04-01 00:00:00
abstract：:The present paper describes protective effects of supplemental selenium in mice infected with influenza virus. The effects of supplemental selenium on serum selenium levels, mortality, lung virus titers, and cytokine titers were investigated in mice inoculated intranasally with suspensions of influenza virus. Whereas ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8726-x
更新日期：2011-06-01 00:00:00
abstract：:Kashin-Beck disease (KBD) is an endemic, degenerative osteoarthropathy, and particularly seen in China. A deficiency of selenium and iodine is implicated as the main etiological factor for KBD. This meta-analysis aimed to evaluate the differences in the selenium and iodine levels between patients with KBD and healthy ...
journal_title：Biological trace element research
pub_type： 杂志文章,meta分析
doi：10.1007/s12011-015-0463-8
更新日期：2016-03-01 00:00:00
abstract：:The metabolic thermograms and heat output of mitochondria isolated from carp liver have been determined by using an LKB bioactivity monitor. The thermogram can be divided into four parts: the lag phase, active recovery phase, stationary phase, and decline phase. The thermokinetic equation was established for the activ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783314
更新日期：1997-10-01 00:00:00
abstract：UNLABELLED:Limited data are available indicating the effects of chromium administration on endocrine profiles, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS). This study was done to assess the effects of chromium administration on endocrine profiles, biomarkers of inf...
journal_title：Biological trace element research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12011-015-0570-6
更新日期：2016-07-01 00:00:00
abstract：:Cadmium (Cd) pollution and acid rain are the main environmental issues, and they often occur in the same agricultural region. Nevertheless, up to now, little information on the combined pollution of Cd(2+) and acid rain action on crops were presented. Here, we investigated the combined effect of Cd(2+) and acid rain o...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9053-6
更新日期：2011-12-01 00:00:00
abstract：:The effects of selenium were investigated on three human colon cancer cell lines: Caco 2, HRT 18, and HT 29. At low concentrations (10-100 nM), selenium stimulated cell growth in serum-free medium. Thus, selenium is an essential trace element for cell proliferation. At higher concentrations, selenium inhibited cell gr...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02919096
更新日期：1989-04-01 00:00:00
abstract：:Nonenzymatic glycation of long-lived proteins has been implicated in several complications related to age and diabetes. Dicarbonyl compounds such as methylglyoxal (MGO) have been identified as the predominant source for the formation of advanced glycation end-products (AGEs) in various tissues. We investigated the eff...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8915-7
更新日期：2011-11-01 00:00:00
abstract：:The objective of this study was to examine relations between basal metabolic rate (BMR) and cadmium (Cd) accumulation in the liver, kidneys, and duodenum in mice. The 5-month-old mice selected for high (H) and low (L) BMR were exposed for 8 weeks to 0, 10, and 100 μg Cd/mL of drinking water. The H-BMR mice showed sign...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9061-6
更新日期：2011-12-01 00:00:00
