Effects of aluminum chloride on normal and uremic adult male rats. Tissue distribution, brain choline acetyltransferase activity, and some biological variables.

Abstract:

:Normal and uremic adult male rats were given a daily ip injection of 20 mg Al (Al chloride)/kg for 14 d. The results indicate that Al induces a significant decrease in food ingestion, weight gain, and total protein concentration in the plasma. Compared with control animals, very high increases in Al levels were found in plasma and hepatic homogenates (about 36 and 19 times, respectively). In the brain homogenates, the Al increases were lower (about 23%). The brain cholineacetyltransferase activity was reduced: 10.6 and 14.9% in normal and uremic rats, respectively. The nephrectomy and the food restriction did not affect the total protein concentrations in plasma and the cerebral cholineacetyltransferase activity. Both were only found to be reduced in the rats treated by Al chloride.

journal_name

Biol Trace Elem Res

authors

Cherroret G,Desor D,Hutin MF,Burnel D,Capolaghi B,Lehr PR

doi

10.1007/BF02785319

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

43-53

issue

1

eissn

0163-4984

issn

1559-0720

journal_volume

54

pub_type

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