Abstract:
:Normal and uremic adult male rats were given a daily ip injection of 20 mg Al (Al chloride)/kg for 14 d. The results indicate that Al induces a significant decrease in food ingestion, weight gain, and total protein concentration in the plasma. Compared with control animals, very high increases in Al levels were found in plasma and hepatic homogenates (about 36 and 19 times, respectively). In the brain homogenates, the Al increases were lower (about 23%). The brain cholineacetyltransferase activity was reduced: 10.6 and 14.9% in normal and uremic rats, respectively. The nephrectomy and the food restriction did not affect the total protein concentrations in plasma and the cerebral cholineacetyltransferase activity. Both were only found to be reduced in the rats treated by Al chloride.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Cherroret G,Desor D,Hutin MF,Burnel D,Capolaghi B,Lehr PRdoi
10.1007/BF02785319subject
Has Abstractpub_date
1996-07-01 00:00:00pages
43-53issue
1eissn
0163-4984issn
1559-0720journal_volume
54pub_type
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