Serum arsenic and lipid peroxidation levels in patients with multiple sclerosis.

Abstract:

:Oxidative stress plays a crucial role in the pathogenesis of multiple sclerosis (MS). Previous studies have shown that oxidative stress is one of the main underlying mechanisms of arsenic-induced cellular damage. The aim of this study was to assess the serum levels of arsenic and its relationship with lipid peroxidation in MS patients from Tabriz, as the third polluted city of Iran. The study population included 38 MS female patients and 38 age-matched healthy controls. Serum malondialdehyde (MDA) and arsenic levels were measured using thiobarbituric acid reactive substances (TBARS) assay and electrothermal atomic absorption spectrometry, respectively. The results showed that the arsenic (P < 0.01) and MDA (P = 0.03) levels were significantly higher in patients with MS than those in control. Moreover, serum levels of arsenic and MDA were positively correlated in MS patients. The elevated levels of serum arsenic might explain the increased oxidative stress in MS patients. We suggest that high arsenic levels in serum may lead to MS development, and therefore, exposure to this metal should be limited.

journal_name

Biol Trace Elem Res

authors

Yousefi B,Ahmadi Y,Ghorbanihaghjo A,Faghfoori Z,irannejad VS

doi

10.1007/s12011-014-9956-0

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

276-9

issue

3

eissn

0163-4984

issn

1559-0720

journal_volume

158

pub_type

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