Abstract:
:Oxidative stress plays a crucial role in the pathogenesis of multiple sclerosis (MS). Previous studies have shown that oxidative stress is one of the main underlying mechanisms of arsenic-induced cellular damage. The aim of this study was to assess the serum levels of arsenic and its relationship with lipid peroxidation in MS patients from Tabriz, as the third polluted city of Iran. The study population included 38 MS female patients and 38 age-matched healthy controls. Serum malondialdehyde (MDA) and arsenic levels were measured using thiobarbituric acid reactive substances (TBARS) assay and electrothermal atomic absorption spectrometry, respectively. The results showed that the arsenic (P < 0.01) and MDA (P = 0.03) levels were significantly higher in patients with MS than those in control. Moreover, serum levels of arsenic and MDA were positively correlated in MS patients. The elevated levels of serum arsenic might explain the increased oxidative stress in MS patients. We suggest that high arsenic levels in serum may lead to MS development, and therefore, exposure to this metal should be limited.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Yousefi B,Ahmadi Y,Ghorbanihaghjo A,Faghfoori Z,irannejad VSdoi
10.1007/s12011-014-9956-0subject
Has Abstractpub_date
2014-06-01 00:00:00pages
276-9issue
3eissn
0163-4984issn
1559-0720journal_volume
158pub_type
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