Inflammatory Factor Alterations in the Gastrointestinal Tract of Cocks Overexposed to Arsenic Trioxide.


:Exposure of people and animals to arsenic (As) is a global public health concern because As is widely distributed and associated with numerous adverse effects. As is a poisonous metalloid and arsenic trioxide (As2O3) is a form of As. Thus far, there have been very few reports on the inflammatory factor alterations of the gastrointestinal tract in birds exposed to As2O3. To investigate the possible correlation of As2O3 with inflammatory injury induced by an arsenic-supplemented diet in birds, 72 1-day-old male Hy-line cocks were selected and randomly divided into four groups. They were fed with either a commercial diet or an arsenic-supplemented diet containing 7.5, 15, and 30 mg/kg As2O3. The experiment lasted for 90 days, and samples of gizzard, glandular stomach, duodenum, jejunum, ileum, cecum, and rectum were collected at days 30, 60, and 90 of the experiment period. The inflammation-related genes were determined, including NF-κB, iNOS, COX-2, PTGEs, and TNF-α. The connection between arsenic dosage and inflammation-related genes was assessed. The content of inducible NO synthase (iNOS) was measured by Western blot of the samples. The results showed that arsenic supplementation increased the mRNA expression levels of inflammation-related genes in the gastrointestinal tract of cocks at different time points (p < 0.05). Moreover, the expression of the tissue and organ injury-related gene iNOS was upregulated (p < 0.05). These data suggest that As induces the inflammatory response and may trigger digestive function regression of the gastrointestinal tract by affecting inflammation-related genes and iNOS in cocks. This study offers some information on the mechanism of gastrointestinal tract inflammatory injury and iNOS expression level alterations induced by arseniasis.


Biol Trace Elem Res


Xing M,Zhao P,Guo G,Guo Y,Zhang K,Tian L,He Y,Chai H,Zhang W




Has Abstract


2015-10-01 00:00:00












  • Effect of Nano-Titanium Dioxide on Blood-Testis Barrier and MAPK Signaling Pathway in Male Mice.

    abstract::Some studies have found that nano-sized titanium dioxide (nano-TiO2) has adverse effects on the male reproductive system. Blood-testis barrier (BTB), as one of the tightest blood-tissue restriction, is crucial to the male reproductive system. However, the potential effects on BTB and signaling pathway changes in testi...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Lu T,Ling C,Hu M,Meng X,Deng Y,An H,Li L,Hu Y,Wang H,Song G,Guo S

    更新日期:2020-09-29 00:00:00

  • Effect of nutritional copper deficiency on carrageenin edema in the rat. A quantitative study.

    abstract::The effects of nutritional copper deficiency on carrageenin edema in the rat were investigated with emphasis on studying the correlation between the degree of copper deficiency and the degree of edema. Carrageenin paw edema in both copper-sufficient and copper-deficient groups of rats was compared after either 20, 40,...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Kishore V,Wokocha B,Fourcade L

    更新日期:1989-01-01 00:00:00

  • Semen Uranium Concentrations in Depleted Uranium Exposed Gulf War Veterans: Correlations with Other Body Fluid Matrices.

    abstract::Environmental metal exposure, as well as dietary metals, may adversely affect semen quality even as others play an essential role in normal spermatogenesis and fertility. Measures of seminal fluid metals have therefore been of high interest in the last several decades but have shown inconsistent results in correlation...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: McDiarmid MA,Gucer P,Centeno JA,Todorov T,Squibb KS

    更新日期:2019-07-01 00:00:00

  • Selenium. Mechanistic aspects of anticarcinogenic action.

    abstract::Selenium is increasingly recognized as a versatile anticarcinogenic agent. Its protective functions cannot be solely attributed to the action of glutathione peroxidase. Instead, selenium appears to operate by several mechanisms, depending on dosage and chemical form of selenium and the nature of the carcinogenic stres...

    journal_title:Biological trace element research

    pub_type: 杂志文章,评审


    authors: Schrauzer GN

    更新日期:1992-04-01 00:00:00

  • The Effects of Selenium Supplementation on Clinical Symptoms and Gene Expression Related to Inflammation and Vascular Endothelial Growth Factor in Infertile Women Candidate for In Vitro Fertilization.

    abstract::This study was performed to determine the effects of selenium supplementation on clinical symptoms and gene expression related to inflammatory markers in infertile women with polycystic ovary syndrome (PCOS) who were candidate for in vitro fertilization (IVF). Thirty-six women candidate for IVF were recruited in this ...

    journal_title:Biological trace element research

    pub_type: 杂志文章,随机对照试验


    authors: Heidar Z,Hamzepour N,Zadeh Modarres S,Mirzamoradi M,Aghadavod E,Pourhanifeh MH,Asemi Z

    更新日期:2020-02-01 00:00:00

  • Delineation of the Residues of Bacillus anthracis Zinc Uptake Regulator Protein Directly Involved in Its Interaction with Cognate DNA.

    abstract::Zinc uptake regulator (Zur) is a negative transcriptional regulator of bacteria that belongs to the FUR superfamily of proteins and regulates zinc (Zn) homeostasis under extreme Zn conditions. The Zur protein of Bacillus anthracis (BaZur) was though characterized previously, but the residues of this transcriptional re...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Kandari D,Joshi H,Tanwar N,Munde M,Bhatnagar R

    更新日期:2020-10-14 00:00:00

  • Increased oxidative stress and altered levels of nitric oxide and peroxynitrite in Tunisian patients with chronic obstructive pulmonary disease: correlation with disease severity and airflow obstruction.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: ben Anes A,Fetoui H,Bchir S,ben Nasr H,Chahdoura H,Chabchoub E,Yacoub S,Garrouch A,Benzarti M,Tabka Z,Chahed K

    更新日期:2014-10-01 00:00:00

  • Blood selenium status in normal Punjabi population of Pakistan.

    abstract::Selenium concentrations in the blood of 112 (56 females and 56 males) normal subjects, from different regions of the Punjab (Pakistan), have been determined using the technique of inductively coupled plasma-mass spectrometry. The whole blood selenium concentrations were found to be 452 ± 12 ppb (parts per billion or n...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Alvi FM,Chaudhri MA,Watling J,Hasnain S

    更新日期:2011-10-01 00:00:00

  • Dietary boron supplementation enhances the effects of estrogen on bone mineral balance in ovariectomized rats.

    abstract::The present study investigated whether boron would enhance the action of 17beta-estradiol (E2) or parathyroid hormone (PTH) on bone mineral balance in ovariectomized (OVX) rats. Forty-three days after OVX, the rats were treated for 5 wk with vehicle, boron (5 ppm as boric acid), E2 (30 microg/kg/d, sc), PTH (60 microg...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Sheng MH,Taper LJ,Veit H,Thomas EA,Ritchey SJ,Lau KH

    更新日期:2001-07-01 00:00:00

  • Determination of trace elements in biological materials by inductively coupled plasma spectroscopy with novel chelating resins.

    abstract::Although substantial progress has been achieved in inductovely coupled plasma (ICP) spectroscopy, placing it among the principal spectroscopic tools in analytical chemistry research and applications laboratories, some limitations exist especially for the analysis of ultratrace concentration levels in biological materi...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Barnes RM

    更新日期:1984-02-01 00:00:00

  • Nutrients Other than Selenium Are Important for Promoting Children's Health in Kashin-Beck Disease Areas.

    abstract::Overall nutritional status has been proved associated with people's health. The overall nutritional status of children in Kashin-Beck disease (KBD) areas has been overlooked for decades. Therefore, it is worth investigating in the current generation to gather evidence and make suggestions for improvement. A cross-sect...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Ning Y,Wang X,Guo X,Zhang P,Qu P,Zhang F,Wang S,Lei Y,Lammi M

    更新日期:2018-06-01 00:00:00

  • Effect of some nickel compounds on red blood cell characteristics.

    abstract::The effect of certain inorganic and coordinated nickel compounds on the resistance to different destructive substances, rheological properties, and functional activity of healthy human red blood cells (RBC), was investigated. It is shown that nickel compounds affect the erythrocyte membrane lipid bilayer, as well as m...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Tkeshelashvili LK,Tsakadze KJ,Khulusauri OV

    更新日期:1989-07-01 00:00:00

  • Identification of citrate as the albumin-bound inhibitor of the ferroxidase activity of ceruloplasmin.

    abstract::The influence of several commercial albumin preparations on the ferroxidase activity of ceruloplasmin (ferroxidase I, ferrous: O2 oxidoreductase EC at pH 6.0 was determined using ferric-transferrin formation. The ability of several albumin preparations to inhibit the ferroxidase activity of ceruloplasmin dif...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Witwicki J,Chidambaram MV,Frieden E

    更新日期:1983-04-01 00:00:00

  • The Concentration and Probabilistic Health Risk of Potentially Toxic Elements (PTEs) in Edible Mushrooms (Wild and Cultivated) Samples Collected from Different Cities of Iran.

    abstract::The present study was devoted to investigate the PTE concentrations including cadmium (Cd), chromium (Cr), copper(Cu), iron (Fe), mercury (Hg), manganese (Mn), nickel (Ni), lead (Pb), arsenic(As), and zinc (Zn) among six types of edible wild, 23 cultivated mushroom samples collected from Iran's market by the aid of an...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Karami H,Shariatifar N,Nazmara S,Moazzen M,Mahmoodi B,Mousavi Khaneghah A

    更新日期:2021-01-01 00:00:00

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Chen X,Medeiros DM,Jennings D

    更新日期:2005-07-01 00:00:00

  • Serum parathyroid hormone levels in chronic endemic fluorosis.

    abstract::Endemic waterborne fluorosis is a public health problem in Isparta, a city located in southern Turkey. Fluoride is a cumulative element that increases metabolic turnover of the bone and also affects the homeostasis of bone mineral metabolism. There are number of similarities between the effects of excess parathyroid h...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Koroglu BK,Ersoy IH,Koroglu M,Balkarli A,Ersoy S,Varol S,Tamer MN

    更新日期:2011-10-01 00:00:00

  • The influence of fluoride ions upon selected enzymes of protein metabolism in blood plasma of rabbits with hypercholesterolemia.

    abstract::Three-month studies were performed on 18 adult rabbits of New Zealand breed divided into three groups, with six animals in each: a control group on standard diet, a cholesterol group receiving 500 mg of cholesterol/100 g of feed per rabbit per 24 h (CH group), and a cholesterol + fluorine group (CH + F group) receivin...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Birkner E,Grucka-Mamczar E,Kasperczyk S,Kasperczyk A,Stawiarska-Pieta B,Zalejska-Fiolka J,Birkner B

    更新日期:2008-08-01 00:00:00

  • Amberlite IR-120 modified with 8-hydroxyquinoline as efficient adsorbent for solid-phase extraction and flame atomic absorption determination of trace amounts of some metal ions.

    abstract::In this study, a solid-phase extraction method combined with atomic absorption spectrometry for extraction, preconcentration, and determination of iron (Fe(3+)), copper (Cu(2+)), and lead (Pb(2+)) ions at trace levels in water samples has been reported. The influences of effective parameters such as flow rate, pH, elu...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Daneshfar A,Ghaedi M,Vafafard S,Shiri L,Sahrai R,Soylak M

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  • Zinc Regulates Lipid Metabolism and MMPs Expression in Lipid Disturbance Rabbits.

    abstract::Lipid disturbance induced by high-fat diet is a worldwide problem, and it can induce inflammation and oxidative stress in vivo. Zinc is considered as an antioxidant, anti-inflammatory agent. Since matrix metalloprotease 2 (MMP2) and matrix metalloprotease 9 (MMP9)'s expressions are changed under many pathological cond...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Xu C,Huang Z,Liu L,Luo C,Lu G,Li Q,Gao X

    更新日期:2015-12-01 00:00:00

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    abstract::X-ray fluorescence experiments at the Photon Factory in Japan are described. An energy-dispersive X-ray fluorescence system was combined with various excitation modes, i.e., a continuum and a monochromatic excitation, which consist of a crystal monochromator or a wide band pass monochromator. These excitation modes pr...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Gohshi Y,Iida A,Matsushita T

    更新日期:1987-04-01 00:00:00

  • Assessing Heavy Metal Burden Among Cigarette Smokers and Non-smoking Individuals in Iran: Cluster Analysis and Principal Component Analysis.

    abstract::Smoking is one of the major causes of mortality and numerous diseases, both directly and indirectly. The role of smoking as a significant risk factor is already known in several human diseases such as cardiovascular diseases, lung cancer, and chronic obstructive pulmonary disease. We aimed to compare the toxicity of h...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Shakeri MT,Nezami H,Nakhaee S,Aaseth J,Mehrpour O

    更新日期:2021-01-20 00:00:00

  • Distribution of 14 elements in various rat tissues following hypophysectomy, thyroparathyroidectomy, adrenalectomy, and castration.

    abstract::The tissue distribution of 14 elements was simultaneously determined in rats 28 d after hypophysectomy (HPY), thyroparathyroidectomy (TPTY), adrenalectomy (ADY), and castration (CTN). The elements Na, K, Ca, Mg, Fe, S, P, Rb, Sr, Mn, Cu, and Zn were investigated in whole blood, plasma, brain, liver, kidney, heart, ske...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: LeBlondel G,Ducouret C,Allain P

    更新日期:1988-07-01 00:00:00

  • Gestational changes in concentrations of selenium and zinc in the porcine fetus and the effects of maternal intake of selenium.

    abstract::The effect of maternal dietary selenium (Se) and gestation on the concentrations of Se and zinc (Zn) in the porcine fetus were determined. Mature gilts were randomly assigned to treatments of either adequate (0.39 ppm Se) or low (0.05 ppm Se) dietary Se. Gilts were bred and fetuses were collected throughout gestation....

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Hostetler CE,Kincaid RL

    更新日期:2004-01-01 00:00:00

  • Zinc, copper, and zinc- or copper-dependent enzymes in human hypertension.

    abstract::Imbalance of zinc and copper status has been hypothesized in human hypertension. A case-control study was carried out to elucidate the possible relationship between zinc and copper status and essential hypertension. Thirty-one subjects affected by mild stable hypertension, pharmacologically untreated, were investigate...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Vivoli G,Bergomi M,Rovesti S,Pinotti M,Caselgrandi E

    更新日期:1995-08-01 00:00:00

  • Effect of long-term fluoride exposure on lipid peroxidation and histology of testes in first- and second-generation rats.

    abstract::This experiment was designed to investigate the histological and lipid peroxidation effects of chronic fluorosis on testes tissues of first- and second-generation rats. Sixteen virgin female Wistar rats were mated with eight males (2:1) for approximately 12 h to obtain first-generation rats. Pregnant rats were divided...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Oncü M,Kocak A,Karaoz E,Darici H,Savik E,Gultekin F

    更新日期:2007-09-01 00:00:00

  • Zinc sulfate in the prevention of total-body irradiation-induced early hematopoietic toxicity: a controlled study in a rat model.

    abstract::Exposure to ionizing total-body radiation suppresses hematopoiesis, resulting in decreased production of blood cells. Many researchers have demonstrated the critical role of zinc (Zn) in diverse physiological processes, such as growth and development, maintenance and priming of the immune system, and tissue repair. Th...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Ertekin MV,Karslioğlu I,Erdem F,Sezen O,Gepdiremen A,Serifoğlu K

    更新日期:2004-07-01 00:00:00

  • Protective effects of zinc in chlorpyrifos induced hepatotoxicity: a biochemical and trace elemental study.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Goel A,Chauhan DP,Dhawan DK

    更新日期:2000-05-01 00:00:00

  • Trivalent Chromium has no Effect on Delaying Azoxymethane-Induced Colorectal Cancer in FVB/NJ Mice.

    abstract::As Cr(III) compounds have been shown to increase insulin sensitivity and decrease plasma cholesterol and triglycerides in rodent models of diabetes and insulin resistance and as colorectal cancer risk has been associated with insulin resistance and diabetes, the effects of the Cr(III) compound Cr3 ([Cr3O(O2CCH2CH3)6(H...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: White PE,Deng G,Kuykendall MK,Tadros AM,Dyroff SL,Honan RE,Robertson PM,Vincent JB,Rasco JF

    更新日期:2015-11-01 00:00:00

  • Antioxidant trace elements in serum of draft horses with acute and chronic lower airway disease.

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    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Youssef MA,El-Khodery SA,Ibrahim HM

    更新日期:2012-12-01 00:00:00

  • Environmental impact of the gold mining industry in Ghana.

    abstract::X-ray Fluorescence (XRF) Analysis and Atomic Absorption Spectrophotometry (AAS) have been used in assessing heavy metal pollution from some gold mines in Ghana. The presence and levels of heavy metals in gold ore, gold tailings, inland waters, and river sediments have been determined. Using these techniques, the heavy...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Bamford SA,Osae E,Aboh I,Biney CA,Antwi LA

    更新日期:1990-07-01 00:00:00