Abstract：
:Exposure of people and animals to arsenic (As) is a global public health concern because As is widely distributed and associated with numerous adverse effects. As is a poisonous metalloid and arsenic trioxide (As2O3) is a form of As. Thus far, there have been very few reports on the inflammatory factor alterations of the gastrointestinal tract in birds exposed to As2O3. To investigate the possible correlation of As2O3 with inflammatory injury induced by an arsenic-supplemented diet in birds, 72 1-day-old male Hy-line cocks were selected and randomly divided into four groups. They were fed with either a commercial diet or an arsenic-supplemented diet containing 7.5, 15, and 30 mg/kg As2O3. The experiment lasted for 90 days, and samples of gizzard, glandular stomach, duodenum, jejunum, ileum, cecum, and rectum were collected at days 30, 60, and 90 of the experiment period. The inflammation-related genes were determined, including NF-κB, iNOS, COX-2, PTGEs, and TNF-α. The connection between arsenic dosage and inflammation-related genes was assessed. The content of inducible NO synthase (iNOS) was measured by Western blot of the samples. The results showed that arsenic supplementation increased the mRNA expression levels of inflammation-related genes in the gastrointestinal tract of cocks at different time points (p < 0.05). Moreover, the expression of the tissue and organ injury-related gene iNOS was upregulated (p < 0.05). These data suggest that As induces the inflammatory response and may trigger digestive function regression of the gastrointestinal tract by affecting inflammation-related genes and iNOS in cocks. This study offers some information on the mechanism of gastrointestinal tract inflammatory injury and iNOS expression level alterations induced by arseniasis.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Xing M,Zhao P,Guo G,Guo Y,Zhang K,Tian L,He Y,Chai H,Zhang Wdoi
10.1007/s12011-015-0305-8subject
Has Abstractpub_date
2015-10-01 00:00:00pages
288-99issue
2eissn
0163-4984issn
1559-0720journal_volume
167pub_type
杂志文章abstract：:The aim of this study was to investigate the influence of Se deficiency on the transcription of inflammatory factors and selenoprotein genes in the kidneys of broiler chicks. One hundred fifty 1-day-old broiler chicks were randomly assigned to two groups fed with either a low-Se diet (L group, 0.033 mg/kg Se) or an ad...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0512-3
更新日期：2016-05-01 00:00:00
abstract：:Aflatoxin B1 (AFB1) is a mycotoxin that causes cytotoxicity through oxidative damage to its target organs. The liver is the first target of AFB1 damage. The aim of this study was to evaluate the protective effect of selenium on AFB1-induced hepatic mitochondrial damage in ducklings using molecular biological and histo...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0189-z
更新日期：2015-02-01 00:00:00
abstract：:The effect of parenteral zinc on tissue metallothionein (MT) was studied in normal and streptozotocin-induced diabetic rats. The accumulation of Zn-MT in liver and pancreas of normal and diabetic rats following the administration (ip) of various amounts of zinc was not different. Renal Zn-MT was higher in the diabetic...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02795531
更新日期：1986-12-01 00:00:00
abstract：:Antioxidants can play a significant role in chronic inflammatory process. The aim of this study was to evaluate the content of selenium (Se), zinc (Zn), copper (Cu), and total antioxidant status (TAS) of patients with chronic tonsillitis (CT). The study group consisted of 84 patients with CT from 18 to 62 years old an...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-016-0634-2
更新日期：2016-09-01 00:00:00
abstract：:The intervention effect of fucoxanthin, which is reportedly a powerful antioxidant, on cadmium-induced thyroid damage in mice was evaluated. Animals (N = 120) were divided into control group (given pure water, N = 20) and CdCl2-exposed group (given CdCl2 orally at a dose of 30 mg/kg body weight (bw)/day for 30 days, N...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02291-9
更新日期：2020-07-21 00:00:00
abstract：:The aim of this work was to explore the effects of a low- and high-zinc diet and vitamin Aon the distribution of fatty acids in chylomicrons. Mongolian Gerbils were fed a basal diet (for 3 wk) containing 8 or 38 mg zinc/kg of feed (low-zinc group [termed LZ group] and saturated zinc group [termed SZ group], respective...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:112:2:145
更新日期：2006-08-01 00:00:00
abstract：:The purpose of current study was to determine the step at which dietary selenium (Se) regulates the transcriptional expression of the gene for Se-glutathione peroxidase (Se-GPx) in rat brain and transplanted glioma tissue. Wistar rats were fed a Se-free diet or the same diet supplemented with 0.5, 2.0, and 4.0 mg Se/k...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/bter:73:1:67
更新日期：2000-01-01 00:00:00
abstract：:Arsenic is one of the most important environmental pollutants especially in drinking water. The S100B protein is presented as a sensitive biomarker for assessment of the blood-brain barrier integrity previously. The objective of this study was to determine the impact of chronic arsenic exposure in drinking water and s...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1463-2
更新日期：2019-05-01 00:00:00
abstract：:Calcium, magnesium, and zinc balances were determined in eleven young adult college females (mean age, 24.9±2.35) during a 39-d metabolic study when the subjects were fed an adequate calorie and protein diet based on habitually consumed foods. Analysis showed that the dietary contribution of calcium, magnesium, and zi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917454
更新日期：1985-11-01 00:00:00
abstract：:This study was performed to investigate calcium (Ca), inorganic phosphorus (P), potassium (K), magnesium (Mg), and chlorine (Cl) levels in blood serum at d 60, 100, and 150 of gestation and at d 45 after parturition and to find out the significance of differences for macromineral levels during these stages of single o...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:107:3:247
更新日期：2005-12-01 00:00:00
abstract：:The experiment was conducted to investigate the protective effects of different sources of maternal selenium (Se) on oxidative stressed chick embryo. A total of 270 Lingnan Yellow broiler breeders were randomly allocated into three treatments with five replicates for 18 birds each. Breeders were fed with basal diet (B...
journal_title：Biological trace element research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12011-015-0541-y
更新日期：2016-07-01 00:00:00
abstract：:Urine is a clinical specimen often used in medical diagnostics for monitoring of elements concentrations and kidneys function. We determined the contents of magnesium (Mg), calcium (Ca), zinc (Zn), copper (Cu), iron (Fe), lead (Pb), and cadmium (Cd) in 74 samples of 24-h urine (from 46 women and 28 men). The measureme...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8745-7
更新日期：2011-07-01 00:00:00
abstract：:The aim of the present study was to examine the effects of exogenous selenium (Se) supplementation on the tolerance of pepper (Capsicum annuum L.) cv. Suryamukhi Cluster plants to cadmium (Cd) phytotoxicity at the reproductive stage. The pepper plants were supplied with Cd (0, 0.25 or 0.50 mM) and Se (0, 3 or 7 μM), i...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0028-2
更新日期：2014-07-01 00:00:00
abstract：:Soaking of a rat diet, high in both plant phytate and phytase, progressively degraded the phytate content with time of soaking. This dephytinization in turn enhanced the digestion of feed organic matter in the animals, and it significantly improved the absorption and retention of minerals and trace elements as observe...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783810
更新日期：1993-10-01 00:00:00
abstract：:This study aimed to determine the effect of excessive fluoride (F) on the morphological characteristics of the small intestine and the contents of serum cytokines in rats. A total of 48 3-week-old healthy female Sprague-Dawley rats were randomly divided into four groups (n = 12). The control group was given deionized ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1503-y
更新日期：2019-06-01 00:00:00
abstract：:Breast milk is considered the best source of nutrition for all infants. However, exposure of newborns to toxic metals is of special interest due to their potential harmful effects. Thus, the primary aims of this study were to determine the concentration of toxic heavy metals including lead, mercury, cadmium, and bariu...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1355-5
更新日期：2019-01-01 00:00:00
abstract：:The objective of this paper is to investigate the correlation between serum macro-element and trace element contents and bone mineral density (BMD) as well as the occurrence of osteoporosis. After the epidemiological investigation of 290 postmenopausal women from ages 45 to 65 in the Xi'an urban area, their blood was ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8363-4
更新日期：2009-12-01 00:00:00
abstract：:AFB1 is a mycotoxin which exerts their cytotoxicity through increasing oxidative damage in target organ. Kidney is one of target organs vulnerable to damage caused by AFB1. In this study, Madin-Darby canine kidney (MDCK) cells were used to evaluate the AFB1-induced cell damage by the MTT assay. The results revealed th...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9887-9
更新日期：2014-03-01 00:00:00
abstract：:We investigated the possible correlation between the leptin concentration and the Zn/Cu ratio in the plasma of women with thyroid disorder. Forty women with hypothyroidism (n = 20) or hypothyroidism (n = 20) and 20 euthyroid controls were recruited. The results showed that the women with thyroid disorder (hypothyroidi...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1385/BTER:75:1-3:99
更新日期：2000-07-01 00:00:00
abstract：:Metabolic alterations and inflammation are regarded as hallmarks of cancer. Glycolytic flux and intermediate accumulation lead to the production of building blocks and NADPH which is important in protecting the cell from oxidative damage. Inflammation causes the release of mediators responsible for regulating molecula...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02363-w
更新日期：2020-09-03 00:00:00
abstract：:Atomic absorption spectrometry was used in a quantitative study of zinc, magnesium, and manganese on 71 postmortal human aortas. Samples were obtained from accident victims 35-65 years of age. Fibrous plaques had higher levels of all three elements when compared to normal aortic tissue. The difference was significant ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02916613
更新日期：1989-12-01 00:00:00
abstract：:Retraction to: Biol Trace Elem Res 144(1–3):1120–1132, DOI 10.1007/s12011-011-9149-z. Article has been retracted due to duplicate publication. ...
journal_title：Biological trace element research
pub_type： 撤回出版物
doi：10.1007/s12011-012-9550-2
更新日期：2013-01-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease of multifactorial origin. Studies have shown that trace elements such as zinc and copper may help maintain optimum function of the immune system and metabolism, while toxic metals such as lead may increase systemic autoimmunity. The curren...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-018-1592-7
更新日期：2019-09-01 00:00:00
abstract：:The phosphorus NMR profile of normal and vanadium-treated chick muscle was obtained in vivo. The data show that the differentiation of breast and thigh muscles in terms of pH, lipid related metabolites, and bioenergetic parameters can be readily followed. Although the vanadium-treated chicks showed substantial retarda...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02990427
更新日期：1991-11-01 00:00:00
abstract：:Selenium (Se) deficiency in the experimental models, Coturnix coturnix japonica and Corcyra cephalonica, resulted in impaired mitochondrial substrate oxidations and lowered thiol levels. Studies with respiratory inhibitors confirmed reduced mitochondrial electron transport enzyme activities, especially at cytochrome c...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784077
更新日期：1996-03-01 00:00:00
abstract：:Assessment of trace element levels in general population from the specific area is of importance for nutritional and occupational monitoring. In the current study, baseline blood levels of 12 toxic and/or essential metals and metalloids, including arsenic (As), cadmium (Cd), lead (Pb), mercury (Hg), chromium (Cr), tha...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1486-8
更新日期：2019-06-01 00:00:00
abstract：:The purpose of this 42-day study was to investigate the effects of dietary excess vanadium on spleen growth and lesions by determining morphological changes and cell cycle of spleen. Four hundred twenty 1-day-old avian broilers were divided into six groups and fed on a corn-soybean basal diet as control diet or the sa...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8938-0
更新日期：2011-11-01 00:00:00
abstract：:Given the conflicting results about the positive effects of magnesium and L-carnitine and as there is no report concerning concurrent supplementation of magnesium and L-carnitine on migraine prophylaxis, the effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation on migraine indicators ...
journal_title：Biological trace element research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12011-012-9487-5
更新日期：2012-12-01 00:00:00
abstract：:The effect ofin utero zinc deficiency on fetal development in rats is reviewed. Attention is paid to the primary biochemical lesion associated with zinc-related teratogenesis and special consideration is given to the central nervous system. Evidence is presented that the thymidine kinase salvage pathway, used for the ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02916569
更新日期：1985-03-01 00:00:00
abstract：:Three kinds of plant leaves, Chinese white aspen, arborvitae, and pine needles, have been sampled from the Yanshan Oil refinery complex, the Capital Iron and Steel Factory, and Badachu, a control area in Beijing, as biomonitors for air-pollution studies. Each sample was divided into two parts, washed, and unwashed. Th...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784212
更新日期：1999-01-01 00:00:00
