Abstract:
:We hypothesized that blood heavy metal levels such as lead, cadmium, and mercury were associated with uric acid level and hyperuricemia, and that this association remains significant after adjustment for other metals. We tested this hypothesis using the Korean National Health and Nutrition Examination Survey data. Beta coefficients and 95% confidence intervals (95% CIs) were calculated using multiple linear regression, and odds ratios (ORs) and 95% CIs were calculated using logistic regression in the cross-sectional study design. Relative to women, men had a higher geometric mean (GM) of lead (1.95 vs. 1.50 μg/dL) and mercury (3.94 vs. 2.77 μg/L), a lower GM of cadmium (0.80 vs. 1.04 μg/L), and a higher arithmetic mean (AM) of uric acid (5.84 vs. 4.40 mg/dL). Women had significant positive associations of log uric acid level with doubling of lead and mercury, and negative association with cadmium. Logistic regression analysis indicated the inverse association of serum hyperuricemia with doubling of blood metals was only significant for cadmium in women (OR = 0.641, 95% CI = 0.463 to 0.886) and the associations of serum hyperuricemia in the highest versus lowest quartiles of heavy metals were only significant for cadmium in women (OR = 0.495, 95% CI = 0.246 to 0.998). For both genders, age and estimated glomerular filtration rate (e-GFR) had negative associations with uric acid, but hypertension and triglycerides had positive associations with uric acid. In conclusion, blood lead and mercury levels were positively associated with uric acid level, but blood cadmium level was inversely associated with uric acid level and hyperuricemia in women.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Park J,Kim Ydoi
10.1007/s12011-020-02152-5subject
Has Abstractpub_date
2021-01-01 00:00:00pages
102-112issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-020-02152-5journal_volume
199pub_type
杂志文章abstract::Selenium (Se) is an essential trace element in animals and human, however, excess Se intake can result in adverse health effects. Se supplementation increased glutathione peroxidase (GSH-Px) and thioredoxin reductase (TR) expressions in Se-deficient rats. However, little information is available on the relationship be...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:89:2:165
更新日期:2002-11-01 00:00:00
abstract::Reversed-phase liquid chromatography-inductively coupled plasma mass spectrometric hyphenation was used for iodine speciation in human serum. First investigations showed that iodine species nearly quantitatively were eluted in the void volume. The result indicated that protein-linked thyroid hormones were not interact...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:78:1-3:81
更新日期:2000-01-01 00:00:00
abstract::According to undiscovered toxicity and safety of magnesium oxide nanoparticles (MgO NPs) in isolated pancreatic islet cells, this study was designed to examine the effects of its various concentrations on a time-course basis on the oxidative stress, viability, and function of isolated islets of rat's pancreas. Pancrea...
journal_title:Biological trace element research
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:95:3:247
更新日期:2003-12-01 00:00:00
abstract::Relative stability of mineral elements in tissues is necessary for health. High static magnetic fields (HiSMFs) have been widely used in biomedical research and industry. However, the bioeffect of HiSMFs on animals is still unclear. In this study, we investigated the effects of HiSMF exposure on the levels of Mg, Fe, ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02469-1
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abstract::Antioxidants can play a significant role in chronic inflammatory process. The aim of this study was to evaluate the content of selenium (Se), zinc (Zn), copper (Cu), and total antioxidant status (TAS) of patients with chronic tonsillitis (CT). The study group consisted of 84 patients with CT from 18 to 62 years old an...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
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abstract::Cadmium (Cd) exposure has been recognized to result in a wide variety of cellular responses, including oxidative stress and body weight loss. The aim of the present study was to examine the effect of lycopene supplementation on the antioxidant defense system, lipid peroxidation (LPO) level, nitric oxide (NO), tumor ne...
journal_title:Biological trace element research
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doi:10.1007/s12011-007-0027-7
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:108:1-3:169
更新日期:2005-01-01 00:00:00
abstract::To examine longitudinal and gestational effects of mineral content in human milk, we analyzed human milk from lactating mothers of premature (PRT, n = 24, < 2000 g birth weight, < 37 wk gestation) and full-term (FT, n = 19, > 2500 g, 39-41 wk gestation), living in Newfoundland, Canada. Samples were collected once a we...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784423
更新日期:1999-03-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9576-5
更新日期:2013-03-01 00:00:00
abstract::The aim of this study was to evaluate the impact of three different chromium forms--chromic chloride (CrCl3), chromium picolinate (CrPic), and a newly synthesized complex of chromium chelated with small peptides (CrSP)--on protein metabolism in vitro. In cultured skeletal muscle cells, CrSP was able to increase the ba...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8579-3
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abstract::The concentrations of 3,4-dihydroxybenzoic acid, caffeic acid, catechin, chlorogenic acid, epicatechin, gallic acid, p-coumaric acid, quercetin, rutin, ferulic acid, and the major metals in graviola (Annona muricata), atemoya (A. squamosa x A. cherimola), fruta do conde (A. squamosa), biribá (Rollinia mucosa), and the...
journal_title:Biological trace element research
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doi:10.1007/s12011-019-02005-w
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abstract::Sugar-borates (SBs) are mono- or di-sugar-borate esters (SBEs) comprised of one or two monosaccharide molecules linked to a boron (B) atom. SBEs occur naturally in commonly consumed herbs, vegetables, fruits, seeds, and nuts and, other than greatly varying levels of B found in local drinking water, are the primary nat...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/s12011-018-1550-4
更新日期:2019-03-01 00:00:00
abstract::The zinc content in the hair of 654 children living in various rural and industrial areas in southern Poland was assayed by means of the atomic absorption spectrometry, following the dry digestion procedure. The hair of girls exhibited statistically significant higher level of Zn than the boys' hair, although in the s...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790111
更新日期:1995-01-01 00:00:00
abstract::Studies have evidenced that zinc metabolism is altered in presence of Down syndrome, and zinc seems to have a relationship with the metabolic alterations usually present in this syndrome. In this work, the Zn-related nutritional status of adolescents with Down syndrome was evaluated by means of biochemical parameters ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-007-0061-5
更新日期:2007-01-01 00:00:00
abstract::Fluoride and lead are two common pollutants in the environment. Previous investigations have found that high fluoride exposure can increase the lead burden. In this experiment, in order to study on the molecular mechanisms of central neural system injury induced by the above two elements, differently expressed protein...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-014-0117-2
更新日期:2014-12-01 00:00:00
abstract::This study aimed to determine the effect of excessive fluoride (F) on the morphological characteristics of the small intestine and the contents of serum cytokines in rats. A total of 48 3-week-old healthy female Sprague-Dawley rats were randomly divided into four groups (n = 12). The control group was given deionized ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1503-y
更新日期:2019-06-01 00:00:00
abstract::The objective of this paper is to investigate the correlation between serum macro-element and trace element contents and bone mineral density (BMD) as well as the occurrence of osteoporosis. After the epidemiological investigation of 290 postmenopausal women from ages 45 to 65 in the Xi'an urban area, their blood was ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8363-4
更新日期:2009-12-01 00:00:00
abstract::It has been defined that deficiency of trace elements plays an important role in the progression of asthma. However, the relationship between blood zinc (Zn), selenium (Se), and magnesium (Mg) and pulmonary functions in children remains to be clarified. A cross-sectional study was conducted in Wuxi, China, and a total...
journal_title:Biological trace element research
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journal_title:Biological trace element research
pub_type: 杂志文章,meta分析,评审
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abstract::The study was undertaken to investigate the influence of alpha-tocopherol on zinc, copper, iron, calcium, magnesium, and potassium concentrations in serum of rats with bleomycin-induced pulmonary fibrosis. Fourteen Wistar albino rats were randomly divided into two groups of seven animals each. The first group was trea...
journal_title:Biological trace element research
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更新日期:2006-01-01 00:00:00
abstract::The solubility of both free and low molecular weight ligand complexed calcium, magnesium, and zinc in skimmed human and bovine milks over intestinal luminal pH ranges (approximately 3-7) was measured using ultrafiltration techniques. Some of the experimental difficulties associated with the separation of labile metal ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02925450
更新日期:1989-01-01 00:00:00
abstract::Previous studies revealed that Se was an important regulatory factor for glutathione peroxidase (GPx) genes. However, the relationship between Se concentrations and mRNA expression levels of GPxs were unclear in goats, especially the goats living in natural Se-enriched area. Thus, the aim of this study was to determin...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9830-5
更新日期:2013-12-01 00:00:00
abstract::China has eliminated iodine deficiency disorders since 2011 via the implementation of universal salt iodisation. Following this, a new revised salt iodisation policy was introduced to reduce iodine content in table salt. Since maternal iodine deficiency can lead to cognitive impairment and cretinism in infants, the ai...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02135-6
更新日期:2021-01-01 00:00:00
abstract::Neonatal uptake of mercury (Hg) from milk was examined in a pregnant sheep model, where radioactive mercury (Hg203)/silver tooth fillings (amalgam) were newly placed. A crossover experimental design was used in which lactating ewes nursed foster lambs. In a parallel study, the relationship between dental history and b...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785388
更新日期:1997-02-01 00:00:00
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journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1069-0
更新日期:2018-03-01 00:00:00
abstract::Evidence shows an association between markers of iron metabolism and glucose metabolism in type 2 diabetes mellitus. Acute pancreatitis is the largest contributor to diabetes of the exocrine pancreas. However, the pathogenesis of new-onset pre-diabetes or diabetes after pancreatitis remains unclear. This study aimed t...
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pub_type: 临床试验,杂志文章
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abstract::Recent studies have identified a new existence of a genetically programmed and regulated cell death characterized by necrotic cell death morphology, termed necroptosis. Lead (Pb) is a ubiquitously distributed environmental pollutant that is highly toxic to animals and human beings. However, no detailed report has been...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02094-y
更新日期:2020-12-01 00:00:00
abstract::The present study was designed to investigate the effects of montmorillonite (MMT) on dietary Cd-induced oxidative damage in liver and kidney of carp (Carassius auratus). One hundred eighty carp were randomly divided into four groups and fed with a basal diet, a basal diet supplemented with 0.5% MMT, Cd-comtaminated b...
journal_title:Biological trace element research
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
abstract::Abnormal placentation is the likely cause of the slow fetal growth and the high levels of circulating lipid peroxides found in severe pre-eclampsia. These peroxides are probably responsible for the high thromboxane:prostacyclin ratio found in this disease and may participate in the endothelial cell damage which is its...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02784164
更新日期:1996-10-01 00:00:00