Abstract:
:In this study, lead acetate solution and porcine cerebral hydrolysate peptides (PCHPs) were administered to developing mice. Porcine cerebral protein pretreated by ultrasound was hydrolyzed with alcalase, and 11 peptide fragments were obtained by Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis of PCHPs. Our data showed that PCHPs significantly decreased Pb2+-induced spontaneous locomotor activity, latencies to reach the platform, and the time in target quadrant. It also decreased the accumulation of lead in the blood and brain of Pb2+-exposed developing mice. Co-administration of PCHPs and dimercaptosuccinic acid (DMSA) did not only reduce the accumulation of lead in blood but also increased the absorption of zinc and iron in Pb2+-exposed mice. Administration of PCHPs individually significantly enhanced hematopoietic parameters compared with the Pb2+-exposed group. PCHPs significantly reduced the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) but increased glutathione (GSH) content and anti-oxidant enzymes and nitric oxide synthase (NOS) activities in Pb2+-exposed brain. Our findings suggest that PCHPs have the ability to protect against Pb2+-exposed learning and memory deficits and oxidative damage.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Zou Y,Feng W,Wang W,Chen Y,Zhou Z,Li Q,Zhao T,Mao G,Wu X,Yang Ldoi
10.1007/s12011-015-0329-0subject
Has Abstractpub_date
2015-12-01 00:00:00pages
429-40issue
2eissn
0163-4984issn
1559-0720pii
10.1007/s12011-015-0329-0journal_volume
168pub_type
杂志文章abstract::An in vitro system employing collagen isolated from the sheep tendons to induce mineralization and demineralization reactions was used not only to study the effect of various concentrations of fluoride on the collagen-induced mineralization and demineralization reactions but also to compare their action with the inhib...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02340-3
更新日期:2020-08-27 00:00:00
abstract::This study aims to examine the effect of zinc supplementation on free-radical formation and antioxidant system in individuals who are actively engaged in wrestling as a sport. The study registered a total of 40 male subjects, of whom 20 were wrestlers and 20 were sedentary individuals. The subjects were equally alloca...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-009-8457-z
更新日期:2010-04-01 00:00:00
abstract::The tissue distribution of 14 elements was simultaneously determined in rats 28 d after hypophysectomy (HPY), thyroparathyroidectomy (TPTY), adrenalectomy (ADY), and castration (CTN). The elements Na, K, Ca, Mg, Fe, S, P, Rb, Sr, Mn, Cu, and Zn were investigated in whole blood, plasma, brain, liver, kidney, heart, ske...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02797096
更新日期:1988-07-01 00:00:00
abstract::Zinc has been shown to increase bone mass and promote bone cell proliferation and differentiation. We, therefore, hypothesized that zinc might be cytoprotective for bone cells during oxidative stress. The cells were divided into H(2)O(2), zinc and zinc+H(2)O(2) groups. In the present study, zinc was found to inhibit H...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-012-9387-8
更新日期:2012-09-01 00:00:00
abstract::Forty-six elements have been detected in fresh banana pulp purchased weekly in Pittsburgh, PA for the past twelve years (1968-1980). Samples were prepared by lyophilization or low temperature ashing. Analyses were performed using X-ray fluorescence spectrometry, optical emission spectrometry, atomic absorption spectro...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02789122
更新日期:1981-03-01 00:00:00
abstract::The nuclear microscope is now gaining popularity in the field of life sciences. In particular, the combination of proton-induced X-ray emission to measure the elemental concentrations of inorganic elements, Rutherford backscattering spectrometry to characterize the organic matrix, and scanning transmission ion microsc...
journal_title:Biological trace element research
pub_type: 杂志文章,评审
doi:10.1007/BF02784192
更新日期:1999-01-01 00:00:00
abstract::Cadmium (Cd) is a kind of toxic heavy metal and it can cause damage to organs and tissues. Selenium (Se) can antagonize some metal element toxicity including Cd. The present study was designed to investigate Cd-induced damage to chicken ovary by autophagy and the protective mechanism of Se on Cd-induced damage. Admini...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1341-y
更新日期:2018-12-01 00:00:00
abstract::Zinc deficiency, which is common among Iranian populations, is believed to play a crucial role in the onset and progression of mood disorders such as depression in different stages of life. We have therefore investigated the relationship between serum/dietary zinc status and depression scores among adolescent girls li...
journal_title:Biological trace element research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12011-018-1301-6
更新日期:2018-11-01 00:00:00
abstract::Head hair concentrations of zinc, copper, manganese, alid iron from a total of 418 subjects (154 male and 264 female) aged between 6 mo and 20 yr were measured mainly with flameless atomic absorption spectrophotometry. Only zinc analysis of a part of the female samples (n = 140) were analyzed with inductively coupled ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:77:1:43
更新日期:2000-10-01 00:00:00
abstract::Descriptions of the effects of paraquat (P2+) on the peroxidation of liver microsomes are very divergent. Therefore, the presence of ferric iron in the medium and the activity of microsomal mixed-function oxidase system are two factors that we have taken into consideration to explain the discrepancies. The results sho...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02790096
更新日期:1995-01-01 00:00:00
abstract::The effects of cerium oxide nanoparticles on the proliferation, differentiation, and mineralization function of primary osteoblasts in vitro were evaluated. The results showed that the cell biological effects of cerium oxide nanoparticles varied with different diameters. The cytotoxicity of cerium oxide nanoparticles ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-013-9655-2
更新日期:2013-06-01 00:00:00
abstract::The effects of 10 wk of selenium (Se) supplementation (5 ppm) in drinking water on immune responses and resistance to a myocarditic Coxsackie virus B3 (CB3) infection were studied in female Balb/c mice. Se supplementation reduced CB3-induced mortality: at day 14 postinoculation, survival was 58% in the Se-treated grou...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02785277
更新日期:1998-07-01 00:00:00
abstract::Suppression subtractive hybridization analysis in our laboratory recently revealed that transferrin mRNA may be elevated in Sedeficient rat liver. In this work, we compared expression in rat liver of genes for transferrin, transferrin receptor, ferritin light and heavy chains, and iron-regulatory proteins 1 and 2 in S...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:74:1:55
更新日期:2000-04-01 00:00:00
abstract::In this study, a solid-phase extraction method combined with atomic absorption spectrometry for extraction, preconcentration, and determination of iron (Fe(3+)), copper (Cu(2+)), and lead (Pb(2+)) ions at trace levels in water samples has been reported. The influences of effective parameters such as flow rate, pH, elu...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-011-9171-1
更新日期:2012-02-01 00:00:00
abstract::This work is a first attempt to determine the speciation of Cr in human plasma. With the aid of in vitro and in vivo 51Cr-labeled experiments, it was possible to develop the necessary biochemical techniques for the separation of the plasma proteins. Further work will use real samples, taking care to avoid contaminatio...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02992700
更新日期:1990-07-01 00:00:00
abstract::Previous studies have shown that there is a controversial relationship between iron homeostasis and obesity. This study aims to explore the relationship of anemia and iron status with different body size phenotypes in adult Chinese population. Using information on iron status-related parameters and lifestyle data from...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-017-1213-x
更新日期:2018-09-01 00:00:00
abstract::The metabolic thermograms and heat output of mitochondria isolated from carp liver have been determined by using an LKB bioactivity monitor. The thermogram can be divided into four parts: the lag phase, active recovery phase, stationary phase, and decline phase. The thermokinetic equation was established for the activ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF02783314
更新日期:1997-10-01 00:00:00
abstract::Assessing the ability of a selenium (Se) sample to induce cellular glutathione peroxidase (GPx) activity in Se-deficient animals is the most commonly used method to determine Se bioavailability. Our goal is to establish a Se-deficient cell culture model with differential incorporation of Se chemical forms into GPx, wh...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8097-8
更新日期:2008-07-01 00:00:00
abstract::Infant complementary foods are readily available in the UK markets and nowadays, weaning mothers prefer feeding their babies with these products due to modern lifestyles. However, there is a dearth of research with respect to the health risk assessment of trace essential and potentially toxic elements in these product...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02285-7
更新日期:2020-07-16 00:00:00
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journal_title:Biological trace element research
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journal_title:Biological trace element research
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abstract::Polaprezinc (zinc L-carnosine complex) is a tablet commonly prescribed for gastric ulcers in Japan. Recently, we reported the effects of polaprezinc on pressure ulcer healing at 4-week follow-up. We aimed to further evaluate the efficacy and safety of polaprezinc in 8-week treatment for chronic pressure ulcers. Patien...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
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更新日期:2014-06-01 00:00:00
abstract::The effects of cobaltous chloride in inducing chromosomal aberrations were observed on laboratory bred mice in vivo after single oral administration of different fractions (1/10, 1/20, 1/40) of the lethal toxic dose of the salt. Bone marrow cells were flushed out and processed for chromosome studies following colchici...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF03032691
更新日期:1991-05-01 00:00:00
abstract::Arsenic poisoning in aquatic ecosystem is a global concern that obstructs the productivity of agricultural lands (paddy fields) by targeting the growth of cyanobacteria. The cyanobacteria also tolerate and accumulate elevated concentration of arsenic (As) inside the cell and excrete out from cells in less toxic forms ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-020-02289-3
更新日期:2020-08-06 00:00:00
abstract::Lanthanum cations (La 3+) are well known for their inhibitory actions on calcium channels. Prenatal lanthanum exposure may affect the development of embryo and alter the capacity for learning and memory in adults, and the one-trial passive avoidance learning paradigm with day-old chicks is an excellent model to study ...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-008-8225-5
更新日期:2009-01-01 00:00:00
abstract::Selenium is an important nutrient for humans and livestock. Soil selenium concentration in the world is highly variable; deficiency and toxicity occur in populations living short distance apart. Knowledge of Se concentrations in humans and the environments, especially because the range for toxicity and deficiency is n...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/s12011-018-1489-5
更新日期:2019-06-01 00:00:00
abstract::The purpose of current study was to determine the step at which dietary selenium (Se) regulates the transcriptional expression of the gene for Se-glutathione peroxidase (Se-GPx) in rat brain and transplanted glioma tissue. Wistar rats were fed a Se-free diet or the same diet supplemented with 0.5, 2.0, and 4.0 mg Se/k...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/bter:73:1:67
更新日期:2000-01-01 00:00:00
abstract::The aim of this study was to investigate the effects of the Toxoplasma gondii infection on the total content of the essential elements Zn and Mg levels. Plasma zinc and magnesium concentrations were measured in 158 patients whose anti-T gondii IgG antibodies were positive. Scores were obtained for the patients and the...
journal_title:Biological trace element research
pub_type: 临床试验,杂志文章
doi:10.1385/BTER:92:1:11
更新日期:2003-04-01 00:00:00
abstract::This study was undertaken to evaluate a systematic analysis of mineral and trace elements of individual functionally determined parts of adult temporal bone. Marked differences were observed in basic structural elements (Ca, P, Mg, and Zn) among different bone regions. The more so, molar Ca/P ratio was significantly d...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1007/BF03032672
更新日期:1991-04-01 00:00:00
abstract::An external-sample liquid scintillation (LS) counting for the gamma emitter 75Se has been developed. An expressly designed well-type LS vial and a 2,5-diphenyoxazole-1,4-bis(5-phenyl-2-oxazoyl)-benzene-xylene solution containing 35% tertrabutylzinn allow 75Se to be counted in a standard LS counter with counting effici...
journal_title:Biological trace element research
pub_type: 杂志文章
doi:10.1385/BTER:77:3:287
更新日期:2000-12-01 00:00:00