Abstract：
:Preeclampsia is a syndrome of unknown etiopathogenesis. Recent studies carried out on preeclampsia have focused on the increase in free radicals in the feto-placental unit with poor perfusion. It is believed that the renin-angiotensin system (RAS) has a role in the poor perfusion of the placenta. It is uncertain whether there is a pre-existing impairment in RAS in pre-eclamptic pregnant women or not. In the present study, we measured angiotensin-converting enzyme (ACE), malonaldehyde (MDA), zinc, and copper levels in the placental tissue of 16 pre-eclamptic pregnant women and compared them with those in 20 healthy pregnant women. Whereas ACE activity and MDA were found to be high in the placentas of pre-eclamptic patients, zinc and copper levels were low and there was a negative correlation between ACE activity and zinc concentration. These findings suggest that high ACE activity might play a role in the increase in tissue hypoxia and consequent lipid peroxidation through vasoconstriction; zinc deficiency in the placental tissue might cause insufficiency of superoxide dismutase, an antioxidant enzyme. Furthermore, deficiency in placental zinc also plays a role in the biosynthesis of connective tissue, maintaining its integrity, which might have an impact on the structure of the spiral arteries.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Açikgoz S,Harma M,Harma M,Mungan G,Can M,Demirtas Sdoi
10.1385/BTER:113:1:1subject
Has Abstractpub_date
2006-10-01 00:00:00pages
1-8issue
1eissn
0163-4984issn
1559-0720pii
BTER:113:1:1journal_volume
113pub_type
杂志文章abstract：:Wistar male rats were exposed to nickel oxide (NiO) aerosols (mass median aerodynamic diameter, 1.2 μm). The average exposure concentration was controlled from low level (0.6 mg/m(3)) to high level (8.0 mg/m(3)) and total exposure time ranged from 140 to 216 h. Some rats were sacrificed just after the exposure, wherea...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02916542
更新日期：1985-02-01 00:00:00
abstract：:In this study, experimental hyperthyroidism was established and used to investigate possible alterations in the calcium (Ca), magnesium (Mg), and zinc (Zn) homeostasis by assessing their concentrations in plasma and erythrocytes. In the L-thyroxine-induced hyperthyroidism condition, the experimental animals show a sig...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02778196
更新日期：1997-05-01 00:00:00
abstract：:Concentrations of toxic elements (lead, cadmium, mercury, and arsenic) were measured in water, sediment, and four commercial fish species (Cyprinus carpio, Hypophthalmichthys molitrix, Silurus glanis, and Esox lucius) and their tissues (muscle, liver, and kidney) from Saničani Lake, Bosnia and Herzegovina. The concent...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01982-2
更新日期：2020-09-01 00:00:00
abstract：:In the present study, spectroscopic determinations of copper ions using chimeric metal-binding green fluorescent protein (His6GFP) as an active indicator have been explored. Supplementation of copper ions to the GFP solution led to a remarkable decrease of fluorescent intensity corresponding to metal concentrations. F...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-009-8476-9
更新日期：2010-06-01 00:00:00
abstract：:Nowadays, 70 % of global monogastric feeds contains an exogenous phytase. Phytase supplementation has enabled a more efficient utilisation of phytate phosphorous (P) and reduction of P pollution. Trace minerals, such as iron (Fe), zinc (Zn), copper (Cu) and manganese (Mn) are essential for maintaining health and immun...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0161-y
更新日期：2015-02-01 00:00:00
abstract：:Assessment of trace element levels in general population from the specific area is of importance for nutritional and occupational monitoring. In the current study, baseline blood levels of 12 toxic and/or essential metals and metalloids, including arsenic (As), cadmium (Cd), lead (Pb), mercury (Hg), chromium (Cr), tha...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1486-8
更新日期：2019-06-01 00:00:00
abstract：:Studies were performed on adult and fetal rats receiving either a zinc-deficient (<0.5 ppm) diet and/or ethanol (20%) throughout pregnancy. Liver zinc levels were depressed in fetuses exposed toin utero zinc deficiency, but brain zinc levels were unchanged. Ethanol had no effect on the concentration of zinc in the sev...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02795685
更新日期：1987-12-01 00:00:00
abstract：:Androgenetic alopecia (AGA) is the most common variant of male pattern baldness in which occurrence and development of multiple genetic, hormonal, and metabolic factors are involved. We aimed to estimate plasma element content (Mg, Ca, Zn, Cu, Se, Fe), vitamin status (B12, D, E, and folic acid) in patients with AGA us...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02468-2
更新日期：2020-11-05 00:00:00
abstract：:The effect of aging on the status of macrominerals and trace elements in tissues was studied using two strains (SAMP1 and SAMR1) of senescence accelerated mouse. Two-month-old, 6-mo-old, and 10-mo-old female SAMP1 and SAMR1 mice were fed a commercial diet. Iron, zinc, copper, calcium, magnesium, phosphorus, sulfur, so...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:80:1:53
更新日期：2001-04-01 00:00:00
abstract：:Since waterborne minerals appear in ionic form and are readily absorbed by the gastrointestinal tract, drinking water could be a crucial source of mineral intake. However, no comprehensive research has yet determined how trace elements in drinking water relate to body composition. We aimed to assess the relationship b...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-016-0779-z
更新日期：2017-02-01 00:00:00
abstract：:The developmental alterations in metallothionein (MT) proteins and zinc (Zn) were investigated in brains of two transgenic strains of mice. MT protein was measured by a cadmium binding assay and Zn by atomic absorption spectrophotometry. MT proteins were expressed at birth (day 1) both in MT-I overexpressing transgeni...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784039
更新日期：1998-01-01 00:00:00
abstract：:The metabolic significance of Se in plants is not well documented, though the presence of many selenoenzymes in bacteria and the essentiality of Se in higher animals is established. Since germination is an active process in plant growth and metabolism, the effect of Se was investigated in germinating Vigna radiata L, ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789188
更新日期：1995-05-01 00:00:00
abstract：:Although recent studies have shown that chromium (as the trivalent ion) is not an essential trace element, it has been demonstrated to generate beneficial effects at pharmacologically relevant doses on insulin sensitivity and cholesterol levels of rodent models of insulin insensitivity, including models of type 2 diab...
journal_title：Biological trace element research
pub_type： 杂志文章,评审
doi：10.1007/s12011-015-0231-9
更新日期：2015-07-01 00:00:00
abstract：:Preoperative diagnosis of papillary thyroid carcinoma (PTC) comprises numerous diagnostic procedures which are mostly applicable in tertiary institutions. Normal thyroid function depends on the presence of many trace elements and copper (Cu) and zinc (Zn) are some of those. The study is based on retrospective review o...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1007/s12011-014-0071-z
更新日期：2014-09-01 00:00:00
abstract：:Copper (Cu) and zinc (Zn) are involved in inflammatory process. This study was to investigate the clinical significance of Cu and Zn homeostasis alterations in acute appendicitis (AA). One hundred twenty-two AA patients and 102 healthy controls were enrolled in this study. Of which, 85 patients' appendixes were collec...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-01661-2
更新日期：2019-12-01 00:00:00
abstract：:We investigated the effect of exercise on iron metabolism in horses. Four horses were walked on a mechanical walker for 1 wk (pre-exercise). They then performed moderate exercise on a high-speed treadmill in the first week of the exercise and relative high in the second week and high in the third week. Serum iron was ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:107:1:033
更新日期：2005-10-01 00:00:00
abstract：:Selenium is a trace element that, although toxic in higher concentrations, is essential for human and animal health. In this study, we looked at microarray-based gene expression patterns from liver and gastrocnemius tissues in mice fed either a selenium-deficient diet or diets containing sodium selenite, selenomethion...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8894-8
更新日期：2011-11-01 00:00:00
abstract：:The aim of this study was to explore the effects of selenium addition on hepatic tissue ultrastructure and mitochondrial antioxidant capacity in copper-overloaded rats. Eighteen adult male Sprague-Dawley (SD) rats were randomly divided into three groups (n = 6 per group). Each group received 1 mL (intragastrically) of...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0293-8
更新日期：2015-09-01 00:00:00
abstract：:Selenium (Se) deficiency in the experimental models, Coturnix coturnix japonica and Corcyra cephalonica, resulted in impaired mitochondrial substrate oxidations and lowered thiol levels. Studies with respiratory inhibitors confirmed reduced mitochondrial electron transport enzyme activities, especially at cytochrome c...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784077
更新日期：1996-03-01 00:00:00
abstract：:The purpose of this study was to assess insoluble salts containing gadolinium (Gd(3+)) for effects on human dermal fibroblasts. Responses to insoluble Gd(3+) salts were compared to responses seen with Gd(3+) solubilized with organic chelators, as in the Gd(3+)-based contrast agents (GBCAs) used for magnetic resonance ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9176-9
更新日期：2012-02-01 00:00:00
abstract：:The efficacy of selenate and other divalent anions to stimulate the efflux of radiolabeled sulfate from lactating rat mammary tissue slices has been examined. Both selenate and sulfate markedly increased the fractional release of sulfate via a system that is temperature-sensitive and sensitive to the anion-exchange in...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02917205
更新日期：1990-03-01 00:00:00
abstract：:The present study was undertaken to investigate the utility of cystatin C (CysC) as an early biomarker of cadmium (Cd)-induced renal injury. The study was carried out on 50 adult male individuals divided into five groups of 10 individuals as follows: control, welders, smoker welders, diabetic welders, and smoker diabe...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9939-1
更新日期：2014-06-01 00:00:00
abstract：:The objective of this study was to determine the effect of systemic MgSO4 infusion on subendocardial and subepicardial perfusion. Seventeen spontaneously breathing piglets were examined. Myocardial perfusion was measured using radiolabeled microspheres at baseline, 30 and 60 min after either MgSO4 (80 mg/kg) or saline...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784442
更新日期：1997-12-01 00:00:00
abstract：:The liver of Hooded Seal (Cystophora cristata) consists of six lobes of unequal sizes. Extensive sampling by means of cutout samples covering the depth horizon 2-30 mm below liver surface indicates that the liver may be considered homogeneous as to concentrations of zinc, cadmium, mercury, and selenium (residuals of o...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02789141
更新日期：1990-01-01 00:00:00
abstract：:The forms of Se in the Se-dependent enzyme formate dehydrogenase is known to be selenocysteine, but the way this amino acid enters the polypeptide chain has not been established. Through the use of a cysteine-requiring mutant ofEscherichia coli K-12 that could also grow in the presence of glutathione, we were able to ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02795520
更新日期：1986-12-01 00:00:00
abstract：:The biological function of selenium (Se) is mainly elicited through Se-containing proteins. Selenoprotein W (SelW), one member of the selenoprotein family, is essential for the normal function of the skeletal muscle system. To investigate the possible relationship of Se in the process of differentiation in chicken myo...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9520-8
更新日期：2012-12-01 00:00:00
abstract：:The purpose of this study was to evaluate the effects of cadmium-induced peroxidative damage to rat liver, heart, and spleen. Sprague-Dawley rats were injected subcutaneously with a single dose of 25, 125, 500, or 1250 microg Cd/kg and evaluated 6, 12, 24, or 72 h later. Liver, heart, and spleen were analyzed for lipi...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:78:1-3:219
更新日期：2000-01-01 00:00:00
abstract：:This comparative study of the intestinal absorption of four toxic metals (aluminum, manganese, nickel, and lead) carried out in rats using the in situ intestinal perfusion technique was able to measure the partition of each metal between the intestine (intestinal retention), the blood circulation, and target tissues a...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:99:1-3:157
更新日期：2004-07-01 00:00:00
abstract：:Rare earth elements (REEs) have been widely used to increase accumulation of biomass and secondary metabolites in medicinal plants in China. However, very few studies have investigated how REEs mediate secondary metabolism synthesis in medicinal plants. Lanthanum (La), an important REE, is known to improve the accumul...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-012-9379-8
更新日期：2012-09-01 00:00:00
abstract：:Experiments were conducted to determine whether the increased glutathione S-transferase (GSH-T) activity associated with selenium (Se) deficiency is necessarily related to losses in the activity of Se-dependent glutathione peroxidase (SeGSHpx) in chicks. Nutritional Se status was altered in two ways: by treatment with...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783792
更新日期：1993-05-01 00:00:00
