Abstract：
:Parenteral administration of mercuric chloride (HgCl2) to rats enhanced lipid peroxidation in liver, kidney, lung, testis, and serum (but not in heart, spleen, or muscle), as measured by the thiobarbituric acid reaction for malondialdehyde (MDA) in fresh tissue homogenates and body fluids. After sc injection of HgCl2 (5 mg/kg body wt), MDA concentrations in liver and kidney became significantly increased by 9 h and reached peak values at 24 h. Dose-response studies were carried out with male albino rats of the Fisher-344 strain (body wt 170-280 g) injected with 1, 3, 5 mg Hg/kg as HgCl2 and sacrificed after 24 h. In time-response studies, animals were administered 5 mg Hg/kg as HgCl2 and sacrificed after 3, 9, 18, 24, and 48 h. Studies in the authors' laboratory have shown that (1) concentrations of MDA are increased in targets (liver, kidney, lung, and testis) of HgCl2-treated rats; (2) severity of hepatotoxicity and nephrotoxicity is generally consistent with the elevation of Hg and MDA concentrations, based upon the time-course and dose-effect relationships observed after administration of HgCl2 to rats; and (3) concentrations of MDA are reduced in target tissues after pre-treatment with antioxidants and chelators to HgCl2-treated rats. The results of this study implicate that the lipid peroxidation is one of the molecular mechanisms for cell injury in acute HgCl2 poisoning.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Huang YL,Cheng SL,Lin THdoi
10.1007/BF02789461subject
Has Abstractpub_date
1996-05-01 00:00:00pages
193-206issue
2eissn
0163-4984issn
1559-0720journal_volume
52pub_type
杂志文章abstract：:The relationship between Ni-induced hepatic lipid peroxidation (LPO) and the concentrations of Ni and trace elements was investigated in male ICR mice. The protective effects of antioxidants were also examined. Hepatic LPO and the concentrations of Ni, Fe, Cu, and Zn in the liver were enhanced after an ip injection of...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02784030
更新日期：1998-02-01 00:00:00
abstract：:The effect of parenteral zinc on tissue metallothionein (MT) was studied in normal and streptozotocin-induced diabetic rats. The accumulation of Zn-MT in liver and pancreas of normal and diabetic rats following the administration (ip) of various amounts of zinc was not different. Renal Zn-MT was higher in the diabetic...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02795531
更新日期：1986-12-01 00:00:00
abstract：:Glutathione peroxidase (GPx) is the prototypical eukaryotic selenoprotein, with the rare amino acid selenocysteine (Sec) at the enzyme active site, encoded by the UGA codon in RNA. A DNA virus, Molluscum contagiosum, has now been shown to encode a functional selenium-dependent GPx enzyme. Using modifications of conven...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02783852
更新日期：1999-11-01 00:00:00
abstract：:Yerba mate (Ilex paraguariensis), a widely consumed beverage in South America, contains various biochemically active substances, among them are several minerals. This paper reports on the results of a survey of trace elements in the yerba mate infusions. Three different commercially available trademarks of I. paraguar...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-011-9056-3
更新日期：2011-12-01 00:00:00
abstract：:Selenium and mercuric chloride (MC) interactions regarding effects on cell growth and cell death have been studied. Human K-562 cells were pretreated or simultaneously treated with either selenite (5 or 50 microM) or selenomethionine (10 or 50 microM) and with MC (35 or 50 microM). The 35-microM MC treatments resulted...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:92:2:105
更新日期：2003-05-01 00:00:00
abstract：:In the article, we report that effects of nano-anatase on the spectral characteristics and content of light-harvesting complex II (LHCII) on the thylakoid membranes of spinach were investigated. The results showed that nano-anatase treatment could increase LHCII content on the thylakoid membranes of spinach and the tr...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-007-8025-3
更新日期：2007-01-01 00:00:00
abstract：:Patients on total parenteral nutrition without Cr supplementation develop symptoms similar to those of diabetes. Zn has been implicated in diabetes because of its antioxidant properties and interaction with insulin. To study the effect of these metal ions on insulin signaling proteins, cultured mouse skeletal muscle c...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:101:1:19
更新日期：2004-10-01 00:00:00
abstract：:The objective of this study was to investigate the effects of dietary supplemental chromium (Cr) on growth performance, carcass traits, and meat quality of broilers reared under heat stress. A total of 252 1-d-old Cobb 500 commercial female broilers were randomly allotted by body weight (BW) to one of six replicate ca...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0443-z
更新日期：2016-03-01 00:00:00
abstract：:Retraction to: Biol Trace Elem Res 144(1–3):1120–1132, DOI 10.1007/s12011-011-9149-z. Article has been retracted due to duplicate publication. ...
journal_title：Biological trace element research
pub_type： 撤回出版物
doi：10.1007/s12011-012-9550-2
更新日期：2013-01-01 00:00:00
abstract：:The study was undertaken to investigate the influence of alpha-tocopherol on zinc, copper, iron, calcium, magnesium, and potassium concentrations in serum of rats with bleomycin-induced pulmonary fibrosis. Fourteen Wistar albino rats were randomly divided into two groups of seven animals each. The first group was trea...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:114:1:175
更新日期：2006-01-01 00:00:00
abstract：:To investigate the protective effect of garlic powder on cadmium-induced toxicity sea bass liver, juvenile fishes where maintained under three food diets (diet 1: normal without garlic supply, diet 2: 2% garlic powder; diet 3: 6% garlic powder). After 30 days of specific diets, each group was injected with 500 μg kg-1...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-017-1146-4
更新日期：2018-06-01 00:00:00
abstract：:Selenium selenate was administered to streptozotocin-induced diabetic rats to assess its effects on the detrusor muscle. Thirty-two rats were divided into four groups of eight subjects each. The study animals were made diabetic by means of a single intravenous injection of streptozotocin (STZ). The responsiveness of t...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:93:1-3:171
更新日期：2003-07-01 00:00:00
abstract：:Breast milk is considered the best source of nutrition for all infants. However, exposure of newborns to toxic metals is of special interest due to their potential harmful effects. Thus, the primary aims of this study were to determine the concentration of toxic heavy metals including lead, mercury, cadmium, and bariu...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1355-5
更新日期：2019-01-01 00:00:00
abstract：:The present study was designed to investigate the effect of mercuric chloride administration on copper, zinc, and iron concentrations in the liver, kidney, lung, heart, spleen, and muscle of rats. The results showed that after dose and time exposure to mercuric chloride, the concentration of mercury in the six tissues...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/BF02910676
更新日期：1997-07-01 00:00:00
abstract：:During pregnancy, the demand for daily iodine increases by 50-70% which occurs to reach around 250 μg/day. Limited information is available on the association of high-risk pregnancy (HRP) with urinary iodine concentration (UIC) and variables such as socioeconomic factors. To analyze iodine nutritional status and socio...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02028-8
更新日期：2020-10-01 00:00:00
abstract：:It has been defined that deficiency of trace elements plays an important role in the progression of asthma. However, the relationship between blood zinc (Zn), selenium (Se), and magnesium (Mg) and pulmonary functions in children remains to be clarified. A cross-sectional study was conducted in Wuxi, China, and a total...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-019-02019-4
更新日期：2020-10-01 00:00:00
abstract：:The abnormal metabolism of metal ions plays an important role in health and disease conditions; hence, the studies about them have received much interest. The objective of this study was to evaluate the association between trace and toxic elements zinc (Zn), cadmium (Cd), selenium (Se), and mercury (Hg) in biological ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-0048-y
更新日期：2014-08-01 00:00:00
abstract：:Plasma and erythrocyte lipid peroxidation levels of 20 patients with histopathologically confirmed testis cancer and 20 healthy control individuals were studied between November 1995 and June 1997. The group with testis cancer had a mean age of 24.8+/-8.2 yr and the control group's mean age was 28.3+/-6.9 yr. Stage di...
journal_title：Biological trace element research
pub_type： 临床试验,杂志文章
doi：10.1385/BTER:73:2:181
更新日期：2000-02-01 00:00:00
abstract：:Manganese (Mn) is essential for several species and daily requirements are commonly met by an adequate diet. Mn overload may cause motor and psychiatric disturbances and may arise from an impaired or not fully developed excretion system, transporter malfunction and/or exposure to excessive levels of Mn. Therefore, dec...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-018-1531-7
更新日期：2019-03-01 00:00:00
abstract：:Lipid disturbance induced by high-fat diet is a worldwide problem, and it can induce inflammation and oxidative stress in vivo. Zinc is considered as an antioxidant, anti-inflammatory agent. Since matrix metalloprotease 2 (MMP2) and matrix metalloprotease 9 (MMP9)'s expressions are changed under many pathological cond...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0367-7
更新日期：2015-12-01 00:00:00
abstract：:Trace elemental content was analysed in edible tissues of Mytilus galloprovincialis collected in five different sampling areas near the mouth of river Tagus estuary in Lisbon. The concentrations of essential elements (S, K, Ca, Fe, Cu, Zn, As, Br and Sr) were determined by energy-dispersive X-ray fluorescence (EDXRF) ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9974-y
更新日期：2014-06-01 00:00:00
abstract：:Selenium concentrations in the blood of 112 (56 females and 56 males) normal subjects, from different regions of the Punjab (Pakistan), have been determined using the technique of inductively coupled plasma-mass spectrometry. The whole blood selenium concentrations were found to be 452 ± 12 ppb (parts per billion or n...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8867-y
更新日期：2011-10-01 00:00:00
abstract：:The present study was undertaken to investigate the utility of cystatin C (CysC) as an early biomarker of cadmium (Cd)-induced renal injury. The study was carried out on 50 adult male individuals divided into five groups of 10 individuals as follows: control, welders, smoker welders, diabetic welders, and smoker diabe...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-014-9939-1
更新日期：2014-06-01 00:00:00
abstract：:The present paper describes protective effects of supplemental selenium in mice infected with influenza virus. The effects of supplemental selenium on serum selenium levels, mortality, lung virus titers, and cytokine titers were investigated in mice inoculated intranasally with suspensions of influenza virus. Whereas ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-010-8726-x
更新日期：2011-06-01 00:00:00
abstract：:Exposure of people and animals to arsenic (As) is a global public health concern because As is widely distributed and associated with numerous adverse effects. As is a poisonous metalloid and arsenic trioxide (As2O3) is a form of As. Thus far, there have been very few reports on the inflammatory factor alterations of ...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-015-0305-8
更新日期：2015-10-01 00:00:00
abstract：:The protective effects of caffeic acid on angiotensin-converting enzyme (ACE) and purinergic enzyme activities, as well as gluconeogenesis was investigated in iron-induced cardiotoxicity. Cardiotoxicity was induced in heart tissues harvested from healthy male SD rats by 0.1 mM FeSO4. Treatment was carried out by co-in...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02227-3
更新日期：2021-03-01 00:00:00
abstract：:It is well known that rare earth elements (REEs) have come into extensive use in a number of fields. As a result, REEs are becoming closely related to human's daily life. However, until now, the distributions of REEs in the brain are not yet very clear. In this study, Sprague-Dawley male rats were intraperitoneally in...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:104:1:033
更新日期：2005-04-01 00:00:00
abstract：:The aim of this study was to analyze the effect of high dietary Fe on liver antioxidant status in mice fed a corn-oil-enriched diet. Male Balb/c mice were fed for 3 wk with a standard diet enriched with 5% by weight of corn oil with adequate Fe (FCO diet) or supplemented with 1% carbonyl Fe (FCOFe diet). The control g...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1385/BTER:113:2:177
更新日期：2006-11-01 00:00:00
abstract：:The purpose of our study was to investigate the role of hypoxia-inducible factor-1α (HIF-1α) in arsenic-induced carcinogenesis. We included 39 articles for meta-analysis. The results showed that low-dose exposure to arsenic (≤ 10 μmol/L) could promote the expression of phosphatidylinositol 3-kinase (PI3K) and phosphor...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02087-x
更新日期：2020-12-01 00:00:00
abstract：:Two experiments were conducted to study the performance, antioxidant activity, and bone mineral variables in broilers fed organic trace minerals (OTM) at lowered concentrations in the diet. In experiment 1, a total of 1500 day-old broiler male chicks were randomly distributed into six groups with 10 replicates of 25 c...
journal_title：Biological trace element research
pub_type： 杂志文章
doi：10.1007/s12011-020-02481-5
更新日期：2020-11-20 00:00:00
