Protection from H1N1 influenza virus infections in mice by supplementation with selenium: a comparison with selenium-deficient mice.

Abstract:

:The present paper describes protective effects of supplemental selenium in mice infected with influenza virus. The effects of supplemental selenium on serum selenium levels, mortality, lung virus titers, and cytokine titers were investigated in mice inoculated intranasally with suspensions of influenza virus. Whereas the mortality of the virus-infected Se-deficient mice was 75%, along with a marked reduction in body weight, lower levels of TNF-α and IFN-γ and lower serum selenium concentrations, the mortality of mice maintained on feed containing 0.5 mg Se/kg in the form of sodium selenite was 25%.There were no significantly differences, however, in viral titer between the Se-adequate and the selenium-supplemented groups. The data indicate that selenium supplementation may provide a feasible approach to improving the immune response to viral infections, such as lethal influenza infection.

journal_name

Biol Trace Elem Res

authors

Yu L,Sun L,Nan Y,Zhu LY

doi

10.1007/s12011-010-8726-x

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

254-61

issue

1-3

eissn

0163-4984

issn

1559-0720

journal_volume

141

pub_type

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