Abstract:
:The present paper describes protective effects of supplemental selenium in mice infected with influenza virus. The effects of supplemental selenium on serum selenium levels, mortality, lung virus titers, and cytokine titers were investigated in mice inoculated intranasally with suspensions of influenza virus. Whereas the mortality of the virus-infected Se-deficient mice was 75%, along with a marked reduction in body weight, lower levels of TNF-α and IFN-γ and lower serum selenium concentrations, the mortality of mice maintained on feed containing 0.5 mg Se/kg in the form of sodium selenite was 25%.There were no significantly differences, however, in viral titer between the Se-adequate and the selenium-supplemented groups. The data indicate that selenium supplementation may provide a feasible approach to improving the immune response to viral infections, such as lethal influenza infection.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Yu L,Sun L,Nan Y,Zhu LYdoi
10.1007/s12011-010-8726-xsubject
Has Abstractpub_date
2011-06-01 00:00:00pages
254-61issue
1-3eissn
0163-4984issn
1559-0720journal_volume
141pub_type
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