Abstract:
:Selenium is known to be a neuroprotective agent in respect to a number of neuronal diseases and pain. The aim of this study was to evaluate the neuroprotective effect of the oral administration of selenium nanoparticles in rats with spinal cord injury (SCI). Forty adult female rats were randomly assigned to two equal groups as experimental and control. Under general inhalation anesthesia, in both groups, SCI was created, at the T9-10 level of the column. On the third day after the operation, a supplement of selenium nanoparticle was administered to the experimental group at 0.2 mg/kg per day. The histology of the site of injury, IGF-1 serum concentrations, and changes in the white blood cells were examined in both groups at different pre-surgical and post-surgical times. The results of the current study showed a significant decrease in the total white blood cells, including lymphocyte, neutrophil, and monocyte in the experimental group compared to the control group. Histological evaluation showed that the inflammatory responses reduced significantly in the experimental group compared to the control group. In conclusion, we speculate that the decrease in the number of inflammatory cells after oral administration of the selenium nanoparticles is due to the neuroprotective effects of this nanoparticle.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Javdani M,Habibi A,Shirian S,Kojouri GA,Hosseini Fdoi
10.1007/s12011-018-1371-5subject
Has Abstractpub_date
2019-01-01 00:00:00pages
202-211issue
1eissn
0163-4984issn
1559-0720pii
10.1007/s12011-018-1371-5journal_volume
187pub_type
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