Effect of Selenium Nanoparticle Supplementation on Tissue Inflammation, Blood Cell Count, and IGF-1 Levels in Spinal Cord Injury-Induced Rats.


:Selenium is known to be a neuroprotective agent in respect to a number of neuronal diseases and pain. The aim of this study was to evaluate the neuroprotective effect of the oral administration of selenium nanoparticles in rats with spinal cord injury (SCI). Forty adult female rats were randomly assigned to two equal groups as experimental and control. Under general inhalation anesthesia, in both groups, SCI was created, at the T9-10 level of the column. On the third day after the operation, a supplement of selenium nanoparticle was administered to the experimental group at 0.2 mg/kg per day. The histology of the site of injury, IGF-1 serum concentrations, and changes in the white blood cells were examined in both groups at different pre-surgical and post-surgical times. The results of the current study showed a significant decrease in the total white blood cells, including lymphocyte, neutrophil, and monocyte in the experimental group compared to the control group. Histological evaluation showed that the inflammatory responses reduced significantly in the experimental group compared to the control group. In conclusion, we speculate that the decrease in the number of inflammatory cells after oral administration of the selenium nanoparticles is due to the neuroprotective effects of this nanoparticle.


Biol Trace Elem Res


Javdani M,Habibi A,Shirian S,Kojouri GA,Hosseini F




Has Abstract


2019-01-01 00:00:00














  • Effects of traces of rare earth elements on the protozoan Blepherisma and on mice.

    abstract::The growth of the protozoan Blepherisma is stimulated by Lanthanum (La) at concentrations as low as 0.32 ppm. In mice Yttrium (Y) and Ytterbium (Yb) are absorbed, accumulated, and metabolized. Both rare earth elements (RE) exhibit a high affinity for teeth and bones, accumulation occurs and metabolism is slow. In the ...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Zhang WD,Li FQ,Zhang XY,Chen Y

    更新日期:1988-09-01 00:00:00

  • Comparison of metal concentrations in bones of long-living mammals.

    abstract::The aim of this study was to compare zinc, copper, lead, cadmium, and mercury concentrations in the bones of long-living mammals-humans (Homo sapiens) and Canidae (dogs Canis familiaris and foxes Vulpes vulpes) from northwestern Poland and to determine the usefulness of Canidae as bioindicators of environmental exposu...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Lanocha N,Kalisinska E,Kosik-Bogacka DI,Budis H,Sokolowski S,Bohatyrewicz A

    更新日期:2013-05-01 00:00:00

  • Feasibility of breast cancer screening by PIXE analysis of hair.

    abstract::To reveal the role of key elements present in the hair of breast cancer patients on cancer development, the levels of a number of elements in scalp hair samples of 82 people including healthy individuals, people suffering from benign breast disease, and breast cancer patients were measured by PIXE analysis. Pellets of...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Gholizadeh N,Kabiri Z,Kakuee O,Saleh-Kotahi M,Changizi V,Fathollahi V,Oliaiy P,Omranipour R

    更新日期:2013-06-01 00:00:00

  • Protective effect of selenomethionine on aflatoxin B1-induced oxidative stress in MDCK cells.

    abstract::AFB1 is a mycotoxin which exerts their cytotoxicity through increasing oxidative damage in target organ. Kidney is one of target organs vulnerable to damage caused by AFB1. In this study, Madin-Darby canine kidney (MDCK) cells were used to evaluate the AFB1-induced cell damage by the MTT assay. The results revealed th...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Parveen F,Nizamani ZA,Gan F,Chen X,Shi X,Kumbhar S,Zeb A,Huang K

    更新日期:2014-03-01 00:00:00

  • Synthesis and bioactive studies of complex 8-hydroxyquinolinato-bis-(salicylato) yttrium (III).

    abstract::This paper reports the synthesis of a new bioactive complex, 8-hydroxyquinolinato-bis-(salicylato) yttrium (III) (HSAY), whose composition and structure were characterized by elemental analysis, IR spectra, thermogravimetric analysis, and X-ray diffraction. The power-time curves of the compounds HSAY, C(7)H(6)O(3), C(...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Li X,Li QG,Zhang H,Hu JL,Yao FH,Yang DJ,Xiao SX,Ye LJ,Huang Y,Guo DC

    更新日期:2012-06-01 00:00:00

  • Evaluation of hypoglycemic activity of inorganic constituents in Nelumbo nucifera seeds on streptozotocin-induced diabetes in rats.

    abstract::The seeds of Nelumbo nucifera (Lotus) have been used in the traditional system of medicine for various ailments including diabetes. The present study was aimed at analyzing the levels of biologically important trace elements in the lotus seeds by atomic absorption spectroscopy and evaluating the hypoglycemic propertie...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Mani SS,Subramanian IP,Pillai SS,Muthusamy K

    更新日期:2010-12-01 00:00:00

  • Oxidative Damage Induced by Nano-titanium Dioxide in Rats and Mice: a Systematic Review and Meta-analysis.

    abstract::Nano-titanium dioxide is a kind of widely used nanomaterial that exhibits various adverse outcomes. However, the role of oxidative stress in this regard remains controversial. This study aimed to evaluate whether oxidative stress is one of the toxicity mechanisms induced by nano-titanium dioxide in rats and mice model...

    journal_title:Biological trace element research

    pub_type: 杂志文章,meta分析


    authors: An H,Ling C,Xu M,Hu M,Wang H,Liu J,Song G,Liu J

    更新日期:2020-03-01 00:00:00

  • Effect of Selenium from Selenium-Enriched Kale Sprout Versus Other Selenium Sources on Productivity and Selenium Concentrations in Egg and Tissue of Laying Hens.

    abstract::A 6-week trial was conducted to compare the effect of selenium (Se) from hydroponically produced Se-enriched kale sprout (HPSeKS), sodium selenite (SS), and Se-enriched yeast (SeY) in laying hens. A total of 144 40-week-old hens were randomly divided into four groups, according to a completely randomized design. Each ...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Chantiratikul A,Chinrasri O,Chantiratikul P

    更新日期:2018-03-01 00:00:00

  • NAA methodology for the certification of eight trace elements in a plankton reference material.

    abstract::Neutron activation analysis (NAA) methodology was applied for the certification of eight trace elements (As, Co, Cr, Cu, Hg, Mn, Se, and Zn) in a plankton reference material (CRM 414) prepared by the BCR of the Commission of the European Communities. Average concentrations (micrograms/g dry wt) and standard deviations...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Grimanis AP,Vassilaki-Grimani M

    更新日期:1994-10-01 00:00:00

  • Pro-inflammatory Cytokines Are Involved in Fluoride-Induced Cytotoxic Potential in HeLa Cells.

    abstract::This study was designed to investigate the pro-inflammatory cytokines and their involvement in the cytotoxic potential of fluoride (F) in HeLa cells. HeLa cells were cultured with varying F concentrations (1-50 mg/L) for 48 h, and treatment effects were analyzed. The viability of HeLa cells was determined with a color...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Wang HW,Zhou BH,Cao JW,Zhao J,Zhao WP,Tan PP

    更新日期:2017-01-01 00:00:00

  • The Effect of Selenium on CYP450 Isoform Activity and Expression in Pigs.

    abstract::Selenium is an essential nutrient in diets; however, the effects of selenium on enzyme metabolic activation are not currently clear. Cytochromes P450 (CYP450) are major phase I metabolic enzymes involved in the biotransformation of xenobiotics and endogenous compounds to form electrophilic reactive metabolites. To inv...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Jiang Z,Gu L,Liang X,Cao B,Zhang J,Guo X

    更新日期:2020-08-01 00:00:00

  • Selenium and mercury in native and introduced fish species of patagonian lakes, Argentina.

    abstract::A survey of mercury (Hg) and selenium (Se) contents was performed in fish collected from lakes located in two National Parks of the northern patagonian Andean range. Two native species, catfish (Diplomystes viedmensis) and creole perch (Percichthys trucha), and three introduced species, brown trout (Salmo trutta), rai...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Arribére MA,Ribeiro Guevara S,Bubach DF,Arcagni M,Vigliano PH

    更新日期:2008-04-01 00:00:00

  • Influence of short-term silicon application on endogenous physiohormonal levels of Oryza sativa L. under wounding stress.

    abstract::The current study was conducted in order to investigate the short-term effects (6, 12, and 24 h) of silicon (Si) on the endogenous hormonal composition of rice (Oryza sativa L. cv. Dongjin-beyo), with and without wounding stress. Si applied in different concentrations (0.5, 1.0, and 2.0 mM) significantly promoted shoo...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Kim YH,Khan AL,Hamayun M,Kang SM,Beom YJ,Lee IJ

    更新日期:2011-12-01 00:00:00

  • Combined effects of muscular dystrophy, ecological stress, and selenium on blood antioxidant status in broiler chickens.

    abstract::The results obtained in this study demonstrated that experimentally induced alimentary muscular dystrophy (MD) in Cobb 500 broiler chickens resulted in increased plasma concentrations of malondialdehyde (MDA), deviations in activities of erythrocyte antioxidant enzymes Cu,Zn-SOD (decrease), and CAT (increase) as well ...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Georgieva NV,Stoyanchev K,Bozakova N,Jotova I

    更新日期:2011-09-01 00:00:00

  • Protective effects of selenium on aflatoxin B1-induced mitochondrial permeability transition, DNA damage, and histological alterations in duckling liver.

    abstract::Aflatoxin B1 (AFB1) is a mycotoxin that causes cytotoxicity through oxidative damage to its target organs. The liver is the first target of AFB1 damage. The aim of this study was to evaluate the protective effect of selenium on AFB1-induced hepatic mitochondrial damage in ducklings using molecular biological and histo...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Shi D,Liao S,Guo S,Li H,Yang M,Tang Z

    更新日期:2015-02-01 00:00:00

  • Iodine and/or selenium deficiency alters tissue distribution pattern of other trace elements in rats.

    abstract::Tissue distribution of Fe, Mn, Cu, and Zn, the essential trace elements associated with oxidant and/or antioxidant processes, was examined in iodine- and/or selenium-deficient rats (ID, SeD, ISeD). Fe and Mn were the most affected minerals in all types of deficiency states. Mn levels decreased significantly in the liv...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Giray B,Riondel J,Arnaud J,Ducros V,Favier A,Hincal F

    更新日期:2003-12-01 00:00:00

  • Correlation of manganese with thyroid function in females having hypo- and hyperthyroid disorders.

    abstract::The aim of present study was to compare the level of manganese (Mn) with thyroid functions, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxin (FT4) of females having hyper- (HPRT) and hypothyroid (HPOT) disorder. For comparative study, females of the same age group (16-30 years) having ...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Memon NS,Kazi TG,Afridi HI,Baig JA,Sahito OM,Baloch S,Waris M

    更新日期:2015-10-01 00:00:00

  • An estimation of the manganese requirement for broilers from 1 to 21 days of age.

    abstract::A dose-response experiment was conducted to find the sensitive and consistent biomarker for the estimation of dietary manganese (Mn) requirement and establish the optimal Mn level for broilers fed a practical corn-soybean meal diet from 1 to 21 days of age post-hatching. A total of 480 1-day-old Arbor Acres male chick...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Li S,Lin Y,Lu L,Xi L,Wang Z,Hao S,Zhang L,Li K,Luo X

    更新日期:2011-11-01 00:00:00

  • Lipid peroxidation in rats administrated with mercuric chloride.

    abstract::Parenteral administration of mercuric chloride (HgCl2) to rats enhanced lipid peroxidation in liver, kidney, lung, testis, and serum (but not in heart, spleen, or muscle), as measured by the thiobarbituric acid reaction for malondialdehyde (MDA) in fresh tissue homogenates and body fluids. After sc injection of HgCl2 ...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Huang YL,Cheng SL,Lin TH

    更新日期:1996-05-01 00:00:00

  • Coordinated regulation by iron of the synthesis of two transformation-sensitive membrane proteins in NRK cells.

    abstract::Studies were designed to characterize the plasma membrane polypeptide composition of normal rat kidney (NRK) and virus-transformed NRK cells as a function of time following iron deprivation. Using this approach we found that rapid depletion of iron from the cells increases the amounts of two membrane-associated glycop...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Fernandez-Pol JA

    更新日期:1979-06-01 00:00:00

  • An application of INAA and PIXE on the analysis of nutritional and toxicological elements in samples of drinkable water.

    abstract::Multielemental detection using Instrumental Neutron Activation Analysis (INAA) and Proton-Induced X-Ray Emission (PIXE) of drinkable water of Florence (Italy) is described. The concentrations of 52 elements were measured. No chemical treatment was performed on the samples, before or after irradiation. On the basis of ...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Blasi P,Capannesi G,Cecchi A,Lucarelli F,Sedda FA

    更新日期:1990-07-01 00:00:00

  • Human health risks derived from dietary exposure to toxic metals in Catalonia, Spain: temporal trend.

    abstract::The present study was aimed at estimating the current (2012) dietary intake of arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb) by the population of Catalonia, Spain. The temporal trends with respect to previous surveys, performed in 2000, 2005, and 2008, were also determined. For that purpose, metal concentrat...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Perelló G,Llobet JM,Gómez-Catalán J,Castell V,Centrich F,Nadal M,Domingo JL

    更新日期:2014-12-01 00:00:00

  • Iodine Deficiency as Assessed by Neonatal TSH in a Sample of Mother-and-Newborn Pairs in Jiangsu Province, China.

    abstract::China has eliminated iodine deficiency disorders since 2011 via the implementation of universal salt iodisation. Following this, a new revised salt iodisation policy was introduced to reduce iodine content in table salt. Since maternal iodine deficiency can lead to cognitive impairment and cretinism in infants, the ai...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Zhou H,Lu Y,Pan B,Zhao Q,Ma ZF

    更新日期:2021-01-01 00:00:00

  • N-acetylcysteine attenuates copper overload-induced oxidative injury in brain of rat.

    abstract::Copper is an integral part of many important enzymes involved in a number of vital biological processes. Even though it is essential to life, at elevated tissue concentrations, copper can become toxic to cells. Recent studies have reported oxidative damage due to copper in various tissues. Considering the vulnerabilit...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Ozcelik D,Uzun H,Nazıroglu M

    更新日期:2012-06-01 00:00:00

  • Determining human dietary requirements for boron.

    abstract::A dietary requirement is defined as the lowest continuing intake of a nutrient that for a specified indicator of adequacy, will maintain a defined level of nutriture in an individual. An essential dietary component is one that the body cannot synthesize in sufficient quantities to maintain health. Recommended dietary ...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Sutherland B,Strong P,King JC

    更新日期:1998-01-01 00:00:00

  • Manganese supplementation reduces the blood cholesterol levels in Ca-deficient ovariectomized rats.

    abstract::Manganese (Mn) is an essential element for normal development and bodily functions in humans. In the present study, we examined whether Mn supplementation can alter the serum lipid parameters and liver function in Ca-deficient ovariectomized (OVX) rats. Sixty female Sprague-Dawley rats (6 weeks) were divided into five...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Bae YJ,Choi MK,Kim MH

    更新日期:2011-06-01 00:00:00

  • Zinc nutritional status in adolescents with Down syndrome.

    abstract::Studies have evidenced that zinc metabolism is altered in presence of Down syndrome, and zinc seems to have a relationship with the metabolic alterations usually present in this syndrome. In this work, the Zn-related nutritional status of adolescents with Down syndrome was evaluated by means of biochemical parameters ...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Marques RC,de Sousa AF,do Monte SJ,Oliveira FE,do Nascimento Nogueira N,Marreiro DN

    更新日期:2007-01-01 00:00:00

  • Effects of Injectable Trace Minerals (ITMs) on Th1/Th2 Cytokine Balance of Newborn Calves with Tropical Theileriosis.

    abstract::Injectable trace minerals (ITMs) could provide a potential alternative way of trace mineral delivery for sick animals. Therefore, evaluation of ameliorative potentials of ITMs (copper, manganese, selenium, and zinc) on the circulating Th1/Th2 cytokine misbalance in Theileria annulata-infected calves was aimed. Forty-t...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Ram PK,Singh SK,Srivastava A,Kumar G,Jaiswal AK,Yadav B,Garg SK

    更新日期:2020-06-22 00:00:00

  • A study of factors that may influence the determination of copper, iron, and zinc in human milk during sampling and in sample individuals.

    abstract::The aim of this study was to establish the possible effects of the sampling protocol (between-breast, within-feed, and diurnal differences) and the mother's personal factors (age, parity, iron supplementation, smoking habits, and lactation period) on the copper, iron, and zinc contents in human milk. One hundred thirt...

    journal_title:Biological trace element research

    pub_type: 临床试验,杂志文章


    authors: Silvestre MD,Lagarda MJ,Farré R,Martínez-Costa C,Brines J,Molina A,Clemente G

    更新日期:2000-09-01 00:00:00

  • Interactive Effects of Copper Sources and a High Level of Phytase in Phosphorus-Deficient Diets on Growth Performance, Nutrient Digestibility, Tissue Mineral Concentrations, and Plasma Parameters in Nursery Pigs.

    abstract::The present study investigated the interactive effects of copper sources and a high level of phytase on growth performance, nutrient digestibility, tissue mineral concentrations, and plasma parameters in nursery pigs. Weaning piglets (N = 192; 6.06 ± 0.99 kg), blocked by body weight, were randomly allotted to 1 of 4 d...

    journal_title:Biological trace element research

    pub_type: 杂志文章


    authors: Ren P,Chen J,Hancock D,Vazquez-Añón M

    更新日期:2021-01-11 00:00:00