Cadmium Alters the Concentration of Fatty Acids in THP-1 Macrophages.

Abstract:

:Fatty acid composition of human immune cells influences their function. The aim of this study was to evaluate the effects of known toxicant and immunomodulator, cadmium, at low concentrations on levels of selected fatty acids (FAs) in THP-1 macrophages. The differentiation of THP-1 monocytes into macrophages was achieved by administration of phorbol myristate acetate. Macrophages were incubated with various cadmium chloride (CdCl2) solutions for 48 h at final concentrations of 5 nM, 20 nM, 200 nM, and 2 μM CdCl2. Fatty acids were extracted from samples according to the Folch method. The fatty acid levels were determined using gas chromatography. The following fatty acids were analyzed: long-chain saturated fatty acids (SFAs) palmitic acid and stearic acid, very long-chain saturated fatty acid (VLSFA) arachidic acid, monounsaturated fatty acids (MUFAs) palmitoleic acid, oleic acid and vaccenic acid, and n-6 polyunsaturated fatty acids (PUFAs) linoleic acid and arachidonic acid. Treatment of macrophages with very low concentrations of cadmium (5-200 nM) resulted in significant reduction in the levels of arachidic, palmitoleic, oleic, vaccenic, and linoleic acids and significant increase in arachidonic acid levels (following exposure to 5 nM Cd), without significant reduction of palmitic and stearic acid levels. Treatment of macrophages with the highest tested cadmium concentration (2 μM) produced significant reduction in the levels of all examined FAs: SFAs, VLSFA, MUFAs, and PUFAs. In conclusion, cadmium at tested concentrations caused significant alterations in THP-1 macrophage fatty acid levels, disrupting their composition, which might dysregulate fatty acid/lipid metabolism thus affecting macrophage behavior and inflammatory state.

journal_name

Biol Trace Elem Res

authors

Olszowski T,Gutowska I,Baranowska-Bosiacka I,Łukomska A,Drozd A,Chlubek D

doi

10.1007/s12011-017-1071-6

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

29-36

issue

1

eissn

0163-4984

issn

1559-0720

pii

10.1007/s12011-017-1071-6

journal_volume

182

pub_type

杂志文章
  • Effect of Dietary Supplementation of Organic Trace Minerals at Reduced Concentrations on Performance, Bone Mineralization, and Antioxidant Variables in Broiler Chicken Reared in Two Different Seasons in a Tropical Region.

    abstract::Two experiments were conducted to study the performance, antioxidant activity, and bone mineral variables in broilers fed organic trace minerals (OTM) at lowered concentrations in the diet. In experiment 1, a total of 1500 day-old broiler male chicks were randomly distributed into six groups with 10 replicates of 25 c...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02481-5

    authors: Savaram Venkata RR,Bhukya P,Raju MVLN,Ullengala R

    更新日期:2020-11-20 00:00:00

  • Regional distribution of metallothionein and zinc in the mouse gut: comparison with metallothionien-null mice.

    abstract::Gut Zn homeostatic responses to low, replete, and excess dietary Zn (10, 150, and 400 mg Zn/kg, respectively) were compared in mice with (MT+/+) and without (MT-/-) metallothionein (MT) expression. MT concentrations decreased progressively from stomach (12.9 nmol Cd bound/g) to colon (4.6 nmol Cd bound/g). Small intes...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02778942

    authors: Tran CD,Butler RN,Philcox JC,Rofe AM,Howarth GS,Coyle P

    更新日期:1998-09-01 00:00:00

  • Effects of gestational cadmium exposure on pregnancy outcome and development in the offspring at age 4.5 years.

    abstract::The objective of the present study was to evaluate the potential effect of maternal cadmium exposure on pregnancy outcome and development in the offspring at age 4.5 years. Between November 2002 and December 2003, 109 normal pregnant women were enrolled in our cohort from Da-Ye Country, Hubei Province in Central China...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-009-8391-0

    authors: Tian LL,Zhao YC,Wang XC,Gu JL,Sun ZJ,Zhang YL,Wang JX

    更新日期:2009-12-01 00:00:00

  • Effects of iron(II) salts and iron(III) complexes on trace element status in children with iron-deficiency anemia.

    abstract::Iron-deficiency anemia (IDA) is the most common nutritional deficiency in childhood throughout the world. Although it has been shown that IRA is associated with elevated plasma copper and depleted zinc levels in children, there are conflicting results on the effect of iron supplementation on the absorption of these el...

    journal_title:Biological trace element research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1385/BTER:94:1:79

    authors: Sözmen EY,Kavakli K,Cetinkaya B,Akçay YD,Yilmaz D,Aydinok Y

    更新日期:2003-07-01 00:00:00

  • Association of headaches and the metals.

    abstract::Lack of specific markers constitutes a problem during diagnosis of headache syndromes. Recently, some metals have gained importance as biological parameters for the diagnosis and during treatment. Low-ionized Mg and high-ionized Ca/Mg in patients with daily migrainous headaches were noted. The blood Na level was shown...

    journal_title:Biological trace element research

    pub_type: 杂志文章,评审

    doi:10.1385/BTER:90:1-3:1

    authors: Donma O,Donma MM

    更新日期:2002-01-01 00:00:00

  • Selenium reduces mobile phone (900 MHz)-induced oxidative stress, mitochondrial function, and apoptosis in breast cancer cells.

    abstract::Exposure to mobile phone-induced electromagnetic radiation (EMR) may affect biological systems by increasing free oxygen radicals, apoptosis, and mitochondrial depolarization levels although selenium may modulate the values in cancer. The present study was designed to investigate the effects of 900 MHz radiation on th...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-014-0032-6

    authors: Kahya MC,Nazıroğlu M,Çiğ B

    更新日期:2014-08-01 00:00:00

  • The susceptibility to stress-induced gastric injury of rats exposed to cadmium.

    abstract::In this experimental study, the effect of cadmium on cold and restraint stress-induced gastric lesions has been studied. Rats received 15 micrograms/mL cadmium-containing water for 30 d, and at the end of this period, they were subjected to cold and restraint stress. Cadmium accumulation in gastric mucosa was associat...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02790120

    authors: Oner G,Izgüt VN,Sentürk UK

    更新日期:1995-01-01 00:00:00

  • Effect of Selenium Nanoparticle Supplementation on Tissue Inflammation, Blood Cell Count, and IGF-1 Levels in Spinal Cord Injury-Induced Rats.

    abstract::Selenium is known to be a neuroprotective agent in respect to a number of neuronal diseases and pain. The aim of this study was to evaluate the neuroprotective effect of the oral administration of selenium nanoparticles in rats with spinal cord injury (SCI). Forty adult female rats were randomly assigned to two equal ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-018-1371-5

    authors: Javdani M,Habibi A,Shirian S,Kojouri GA,Hosseini F

    更新日期:2019-01-01 00:00:00

  • Comparison of chromosome damage induced by three zinc compounds using human leukocyte culture.

    abstract::The degree of chromosome damage induced by three compounds of zinc (zinc chloride, zinc sulfate, zinc acetate) was compared in human leucocytes in vitro. Three concentrations of each salt, 3.0 x 10(-5)M, 3.0 x 10(-4)M, and 1.5 x 10(-3)M, were added to leukocyte cultures. The cells were harvested after 48 and 72 h and ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:78:1-3:113

    authors: Santra M,Talukder G,Sharma A

    更新日期:2000-01-01 00:00:00

  • Source apportionment of trace element pollution in surface sediments using positive matrix factorization combined support vector machines: application to the Jinjiang River, China.

    abstract::In this study, a method of positive matrix factorization (PMF) combined support vector machines (SVMs) was adopted to identify possible sources and apportion contributions for trace element pollution in surface sediments from the Jinjiang River, Southeastern China. Utilizing diagnostics tools, four significant factors...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-012-9576-5

    authors: Chen H,Teng Y,Wang J,Song L,Zuo R

    更新日期:2013-03-01 00:00:00

  • Comparison of angiotensin-converting enzyme, malonaldehyde, zinc, and copper levels in preeclampsia.

    abstract::Preeclampsia is a syndrome of unknown etiopathogenesis. Recent studies carried out on preeclampsia have focused on the increase in free radicals in the feto-placental unit with poor perfusion. It is believed that the renin-angiotensin system (RAS) has a role in the poor perfusion of the placenta. It is uncertain wheth...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:113:1:1

    authors: Açikgoz S,Harma M,Harma M,Mungan G,Can M,Demirtas S

    更新日期:2006-10-01 00:00:00

  • Decreases of calcium and phosphorus in monkey cardiac walls with development and aging.

    abstract::To elucidate compositional changes of the cardiac walls with development and aging, the authors investigated changes of elements in the atrial and ventricular walls of monkeys. The left and right atrial walls, left and right ventricular walls, and interatrial and interventricular septa were resected from the subjects....

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:110:3:233

    authors: Tohno S,Tohno Y,Azuma C,Moriwake Y,Satoh H,Minami T,Mahakkanukrauh P,Ohishi T,Hayashi M

    更新日期:2006-06-01 00:00:00

  • Evaluation of Trace Element Contamination and Health Risks of Medicinal Herbs Collected from Unpolluted and Polluted Areas in Sichuan Province, China.

    abstract::Trace element contamination in Chinese herbal medicines has been recognized as a potential health concern for consumers. To assess the health risk to the herb-consuming population, nine trace elements (Cu, Cd, Cr, Mo, Ni, Pb, Sr, Zn, and As) were investigated based on their concentrations in three common medicinal pla...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02539-4

    authors: Gao J,Zhang D,Uwiringiyimana E,Proshad R,Ugurlu A

    更新日期:2021-01-03 00:00:00

  • Iodine Deficiency as Assessed by Neonatal TSH in a Sample of Mother-and-Newborn Pairs in Jiangsu Province, China.

    abstract::China has eliminated iodine deficiency disorders since 2011 via the implementation of universal salt iodisation. Following this, a new revised salt iodisation policy was introduced to reduce iodine content in table salt. Since maternal iodine deficiency can lead to cognitive impairment and cretinism in infants, the ai...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02135-6

    authors: Zhou H,Lu Y,Pan B,Zhao Q,Ma ZF

    更新日期:2021-01-01 00:00:00

  • Effect of exercise-induced hyperthermia on serum iron concentration.

    abstract::Serum iron levels have been shown to decline both with fever and with strenuous exercise, leading to the supposition that the decrease might be the result of a rise in core body temperature. To evaluate this hypothesis, the serum iron response to an exercise-induced 1.5 degrees C rise in core body temperature was meas...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:108:1-3:061

    authors: Buono MJ,Barrack MT,Bouton-Sander F,Bradley P,Cottonaro KA

    更新日期:2005-01-01 00:00:00

  • Accumulation and distribution of samarium-153 in rat brain after intraperitoneal injection.

    abstract::It is well known that rare earth elements (REEs) have come into extensive use in a number of fields. As a result, REEs are becoming closely related to human's daily life. However, until now, the distributions of REEs in the brain are not yet very clear. In this study, Sprague-Dawley male rats were intraperitoneally in...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:104:1:033

    authors: Xiao H,Zhang Z,Li F,Feng L,Li Z,Yang J,Chai Z

    更新日期:2005-04-01 00:00:00

  • The Mechanism of Trivalent Inorganic Arsenic on HIF-1α: a Systematic Review and Meta-analysis.

    abstract::The purpose of our study was to investigate the role of hypoxia-inducible factor-1α (HIF-1α) in arsenic-induced carcinogenesis. We included 39 articles for meta-analysis. The results showed that low-dose exposure to arsenic (≤ 10 μmol/L) could promote the expression of phosphatidylinositol 3-kinase (PI3K) and phosphor...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02087-x

    authors: Liu J,Niu Q,Hu Y,Ran S,Li S

    更新日期:2020-12-01 00:00:00

  • Comparative in situ study of the intestinal absorption of aluminum, manganese, nickel, and lead in rats.

    abstract::This comparative study of the intestinal absorption of four toxic metals (aluminum, manganese, nickel, and lead) carried out in rats using the in situ intestinal perfusion technique was able to measure the partition of each metal between the intestine (intestinal retention), the blood circulation, and target tissues a...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:99:1-3:157

    authors: Arnich N,Cunat L,Lanhers MC,Burnel D

    更新日期:2004-07-01 00:00:00

  • Protective effects of zinc in chlorpyrifos induced hepatotoxicity: a biochemical and trace elemental study.

    abstract::The toxicological literature is replete with studies attempting to explain the mechanism of action of organophosphorus (OP) insecticides to their anticholinesterase activities, but not much is known about the metabolism and detoxification of these compounds. The goal of this study was to ascertain the toxic effects of...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1385/BTER:74:2:171

    authors: Goel A,Chauhan DP,Dhawan DK

    更新日期:2000-05-01 00:00:00

  • Selenium Overcomes Doxorubicin Resistance in Their Nano-platforms Against Breast and Colon Cancers.

    abstract::Colon cancer in men and breast cancer in women are regarded as major health burdens, accounting for majority of cancer diagnoses globally. Doxorubicin (DOX) resistance in breast and colon cancers represents the main reason of unsuccessful therapy. The rationale of this study is to explore whether selenium nanoparticle...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-019-01730-6

    authors: Abd-Rabou AA,Ahmed HH,Shalby AB

    更新日期:2020-02-01 00:00:00

  • Presence of Toxic Heavy Metals in Platelet-Rich Fibrin: a Pilot Study.

    abstract::Platelet-rich fibrin (PRF) is widely used blood-derived biomaterial which is directly applied to the surgical wounds. Depending on its autologous origin, PRF is thought as a safe material. However, it is not known to what extent the blood-derived toxins can be found in the PRF by considering the systemic exposure rate...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-019-01695-6

    authors: Yaprak E,Yolcubal İ

    更新日期:2019-10-01 00:00:00

  • Cadmium, selenium, and tellurium chelators in Aspergillus terreus.

    abstract::Aspergillus terreus was cultivated on Harrold's medium supplemented with 0.1% (w/v) cadmium chloride as well as on sulfur free medium amended with 0.1% (w/v) sodium selenite and potassium tellurite separately. The cell free extract of the fungus for each treatment was fractionated on a column packed with Sephadex G 75...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02990464

    authors: Abbass IM,Razak AA

    更新日期:1991-03-01 00:00:00

  • Microcalorimetric study of the toxic effect of selenium on the mitochondrial metabolism of Cyprinus carpio liver.

    abstract::The metabolic thermograms and heat output of mitochondria isolated from carp liver have been determined by using an LKB bioactivity monitor. The thermogram can be divided into four parts: the lag phase, active recovery phase, stationary phase, and decline phase. The thermokinetic equation was established for the activ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02783314

    authors: Chen C,Liu Y,Zhou J,Xu H,Qu S

    更新日期:1997-10-01 00:00:00

  • Effect of Trace Minerals and B Vitamins on the Proliferation/Cytotoxicity and Mineralization of a Gilthead Seabream Bone-Derived Cell Line.

    abstract::Trace minerals and vitamins are known modulators of bone metabolism, and dietary optimization of these components may improve skeletal development and reduce the occurrence of skeleton deformities in farmed fish. As for larval stages, mineral and water-soluble vitamin nutrition requirements are lacking in research eff...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-019-01939-5

    authors: Viegas MN,Laizé V,Salgado MA,Aguiar C,Dias J

    更新日期:2020-08-01 00:00:00

  • Bioenvironmental Trace Elements in Warm Climatic Plant, Pigeon Pea (Cajanus cajan).

    abstract::Bioenvironmental trace elements play a vital role in plant, animal, and man metabolism. This study aims to determine trace element concentration in different parts (pods, pericarp, seeds, cotyledon, and taste) of the warm climate plant pigeon pea (Cajanus cajan L. Millsp.). The pigeon pea pods were collected from the ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02256-y

    authors: Rashed MN

    更新日期:2020-06-20 00:00:00

  • Carnosine and Histidine Supplementation Blunt Lead-Induced Reproductive Toxicity through Antioxidative and Mitochondria-Dependent Mechanisms.

    abstract::Lead (Pb)-induced reproductive toxicity is a well-characterized adverse effect associated with this heavy metal. It has been found that Pb exposure is associated with altered spermatogenesis, increased testicular degeneration, and pathological sperm alterations. On the other hand, it has been reported that Pb-induced ...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-018-1358-2

    authors: Ommati MM,Jamshidzadeh A,Heidari R,Sun Z,Zamiri MJ,Khodaei F,Mousapour S,Ahmadi F,Javanmard N,Shirazi Yeganeh B

    更新日期:2019-01-01 00:00:00

  • Associations of Blood Heavy Metals with Uric Acid in the Korean General Population: Analysis of Data from the 2016-2017 Korean National Health and Nutrition Examination Survey.

    abstract::We hypothesized that blood heavy metal levels such as lead, cadmium, and mercury were associated with uric acid level and hyperuricemia, and that this association remains significant after adjustment for other metals. We tested this hypothesis using the Korean National Health and Nutrition Examination Survey data. Bet...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-020-02152-5

    authors: Park J,Kim Y

    更新日期:2021-01-01 00:00:00

  • Evidence for dietary essentiality of lithium in the rat.

    abstract::The purpose of this study was to determine the dietary essentiality of lithium (Li) in rats. In three experiments, two types of diets were fed during growth, reproduction, and lactation. In the first experiment, dams were maintained on a corn-based diet containing 2 ng or 500 ng (controls) Li/g through five successive...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02783685

    authors: Pickett EE,O'Dell BL

    更新日期:1992-09-01 00:00:00

  • The use of PIXE in experimental studies of the physiology of human skin epidermis.

    abstract::In order to understand the normal and pathological physiologies of the epidermal cells, the simultaneous determination of several elements in the different cellular strata is of crucial importance. In recent years the electron microprobe (EMP) has become an established technique in this field. Its high spatial resolut...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/BF02796687

    authors: Malmqvist KG,Forslind B,Themner K,Hyltén G,Grundin T,Roomans GM

    更新日期:1987-04-01 00:00:00

  • Effects of selenium-chitosan on blood selenium concentration, antioxidation status, and cellular and humoral immunity in mice.

    abstract::One hundred and eighty Kunming mice were allotted to three groups in a randomized complete block design, including two treatments and one control. Mice in group 1 were fed a basal diet as control, while mice in groups 2 and 3 were fed the basal diet supplemented with 0.2 mg/kg selenium as sodium selenite (SS) or selen...

    journal_title:Biological trace element research

    pub_type: 杂志文章

    doi:10.1007/s12011-015-0243-5

    authors: Qin S,Huang B,Ma J,Wang X,Zhang J,Li L,Chen F

    更新日期:2015-06-01 00:00:00