Abstract:
:Proliferation of isolated hepatocytes in long-term splenic implants was assessed by flash labelling with a 1 pulse of tritiated thymidine (3H TdR). Cell kinetics showed that the basal labelling index was 0.9% which was greater than normal non-regenerating liver. Twenty four hours following partial hepatectomy the labelling index was 2.0%, a significant rise. These results suggest that hepatocytes transplanted to the spleen constitute a suitable model for screening putative hepatotrophic factors, and are of relevance in establishing clinically useful models of hepatocyte transplantation.
journal_name
Pathologyjournal_title
Pathologyauthors
Gupta S,Johnstone R,Darby H,Selden C,Price Y,Hodgson HJdoi
10.3109/00313028709065131subject
Has Abstractpub_date
1987-01-01 00:00:00pages
28-30issue
1eissn
0031-3025issn
1465-3931journal_volume
19pub_type
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