Transplanted isolated hepatocytes: effect of partial hepatectomy on proliferation of long-term syngeneic implants in rat spleen.

Abstract:

:Proliferation of isolated hepatocytes in long-term splenic implants was assessed by flash labelling with a 1 pulse of tritiated thymidine (3H TdR). Cell kinetics showed that the basal labelling index was 0.9% which was greater than normal non-regenerating liver. Twenty four hours following partial hepatectomy the labelling index was 2.0%, a significant rise. These results suggest that hepatocytes transplanted to the spleen constitute a suitable model for screening putative hepatotrophic factors, and are of relevance in establishing clinically useful models of hepatocyte transplantation.

journal_name

Pathology

journal_title

Pathology

authors

Gupta S,Johnstone R,Darby H,Selden C,Price Y,Hodgson HJ

doi

10.3109/00313028709065131

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

28-30

issue

1

eissn

0031-3025

issn

1465-3931

journal_volume

19

pub_type

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