Abstract:
:Langerhans cell histiocytosis (LCH) is currently regarded as a myeloid neoplasm, with remarkably broad clinical spectrum, ranging from isolated skin or bone lesions to a disseminated disease that can involve nearly any organ. LCH is generally regarded as a sporadic disease that occurs predominantly in the paediatric population. The diagnosis of LCH is confirmed by immunohistochemistry (IHC) by demonstrating the presence of dendritic cell markers such as S100 protein, in addition to CD1a and langerin. Contrary to previous beliefs, recent literature reveals that the pathogenesis of LCH might involve a clonal process implicating BRAF c.1799T>A (p.Val600Glu) and other mutations [(600DLAT) B-RAF and (T599A) B-RAF, somatic MAP2K1 mutations].Through this review article, we have summarised the latest understanding of the biological and salient histological characteristics of LCH and its potential morphological mimics.
journal_name
Pathologyjournal_title
Pathologyauthors
El Demellawy D,Young JL,de Nanassy J,Chernetsova E,Nasr Adoi
10.1097/PAT.0000000000000256subject
Has Abstractpub_date
2015-06-01 00:00:00pages
294-301issue
4eissn
0031-3025issn
1465-3931journal_volume
47pub_type
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