Langerhans cell histiocytosis: a comprehensive review.

Abstract:

:Langerhans cell histiocytosis (LCH) is currently regarded as a myeloid neoplasm, with remarkably broad clinical spectrum, ranging from isolated skin or bone lesions to a disseminated disease that can involve nearly any organ. LCH is generally regarded as a sporadic disease that occurs predominantly in the paediatric population. The diagnosis of LCH is confirmed by immunohistochemistry (IHC) by demonstrating the presence of dendritic cell markers such as S100 protein, in addition to CD1a and langerin. Contrary to previous beliefs, recent literature reveals that the pathogenesis of LCH might involve a clonal process implicating BRAF c.1799T>A (p.Val600Glu) and other mutations [(600DLAT) B-RAF and (T599A) B-RAF, somatic MAP2K1 mutations].Through this review article, we have summarised the latest understanding of the biological and salient histological characteristics of LCH and its potential morphological mimics.

journal_name

Pathology

journal_title

Pathology

authors

El Demellawy D,Young JL,de Nanassy J,Chernetsova E,Nasr A

doi

10.1097/PAT.0000000000000256

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

294-301

issue

4

eissn

0031-3025

issn

1465-3931

journal_volume

47

pub_type

杂志文章,评审
  • Prostatic stromal proliferations: a review.

    abstract::Prostatic stromal proliferations account for the majority of benign tumour-like lesions in the prostate. The most common is nodular hyperplasia, seen in a majority of elderly men. Diagnostic difficulty is encountered with some variants, including stromal hyperplasia with atypia, characterised by degenerative changes o...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.pathol.2020.09.017

    authors: Bostwick DG,Egevad L

    更新日期:2021-01-01 00:00:00

  • Lithium-induced lung toxicity in rats: the effect of caffeic acid phenethyl ester (CAPE).

    abstract:AIMS:We aimed to evaluate the effects of caffeic acid phenethyl ester (CAPE) on lithium (Li)-induced lung toxicity. METHODS:Twenty-two adult male Wistar albino rats weighing between 280 and 300 g were used. The rats were randomly divided into three groups: control, Li and Li+CAPE groups. Li and CAPE were co-administer...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020500464904

    authors: Sahin O,Sulak O,Yavuz Y,Uz E,Eren I,Ramazan Yilmaz H,Malas MA,Altuntas I,Songur A

    更新日期:2006-02-01 00:00:00

  • Incorporation of microwave tissue processing into a routine pathology laboratory: impact on turnaround times and laboratory work patterns.

    abstract:AIMS:To examine the impact of microwave (MW) tissue processing on turnaround times (TATs) in a routine diagnostic laboratory. METHODS:A retrospective review of TATs for tissue processing (specimen receipt to completion of H&E-stained section) and pathologists' report generation (receipt of stained section to validatio...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020410001721564

    authors: Leong AS,Price D

    更新日期:2004-08-01 00:00:00

  • Reversed polarity of the glandular epithelial cells in micropapillary carcinoma of the large intestine and the EMA/MUC1 immunostain.

    abstract::Micropapillary carcinoma of the colon and rectum is associated with an adverse prognosis. This tumour type displays reverse polarity of the tumour cells and is stated to be characterised by an inside-out epithelial membrane antigen (EMA)/MUC1 staining. Nine cases of primary colorectal carcinoma and one omental metasta...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1097/PAT.0000000000000144

    authors: Cserni G

    更新日期:2014-10-01 00:00:00

  • Utility of B-type natriuretic peptides and cardiac troponins for population screening regarding cardiac abnormalities.

    abstract:AIMS:The increasing importance of cardiac disease has generated an interest in improved screening strategies regarding preclinical cardiac abnormalities and employing measurement of circulating biomarkers. This review focuses on the utility of the B-type natriuretic peptides (NP) and the cardiac troponins (cTns) for th...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1097/PAT.0b013e32834e786e

    authors: Eggers KM,Venge P

    更新日期:2012-02-01 00:00:00

  • Cystic neutrophilic granulomatous mastitis associated with Corynebacterium including Corynebacterium kroppenstedtii.

    abstract::Granulomatous (lobular) mastitis is a rare inflammatory breast disease affecting parous reproductive-aged women. Once considered idiopathic, there is growing evidence of an association with corynebacteria infection, especially in the setting of a distinct histological pattern termed cystic neutrophilic granulomatous m...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2017.01.006

    authors: Johnstone KJ,Robson J,Cherian SG,Wan Sai Cheong J,Kerr K,Bligh JF

    更新日期:2017-06-01 00:00:00

  • Adrenocortical tumours in children and adults: a study of pathological and proliferation features.

    abstract:AIMS:To demonstrate the correlation between morphological and proliferation parameters with the biological behaviour of adrenocortical tumours (ACTs) in different age groups. METHODS:Seventy-six cases of ACT were evaluated comparing tumours of children (< or =15 years, n=24) and adults (>15 years, n=52) regarding morp...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:

    authors: Sredni ST,Alves VA,Latorre Mdo R,Zerbini MC

    更新日期:2003-04-01 00:00:00

  • Intracytoplasmic barium salts in pleural fluid.

    abstract::Cytological examination of the pleural effusion fluid obtained from a 66-yr-old Chinese lady showed numerous intra- and extracytoplasmic colourless refractile non-birefringent crystals. X-ray analysis of the crystals identified barium salts. On further inquiry, it was learnt that the fluid obtained had been placed in ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313029309090870

    authors: Chan AC,Collins RJ,Cheung TK

    更新日期:1993-10-01 00:00:00

  • Overexpression of HOMER2 predicts better outcome in low-grade endometrioid endometrial adenocarcinoma.

    abstract::We have previously shown that HOMER2 (Homer scaffolding protein 2), a protein coding gene, was highly expressed in low grade (LG) endometrioid adenocarcinoma (EAC) of the uterus. The role of HOMER2 in endometrial cancer (EC) is widely unknown; therefore, the aim of this study was to determine the expression and the pr...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2018.03.004

    authors: Mhawech-Fauceglia P,Walia S,Yessaian A,Machida H,Matsuo K,Lawrenson K

    更新日期:2018-08-01 00:00:00

  • LAMP1 expression is associated with malignant behaviours and predicts unfavourable prognosis in laryngeal squamous cell carcinoma.

    abstract::Lysosome-associated membrane protein-1 (LAMP1) has been suggested to play complicated roles in cancer development and metastasis. The aim of this study was to explore the expression of LAMP1 in laryngeal squamous cell carcinoma (LSCC) and investigate the relationship between LAMP1 expression and clinicopathological ch...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2016.08.001

    authors: Lu M,Zhu H,Wang X,Zhang D,Xiong L,Zhu J,Mao Y,Qiang J

    更新日期:2016-12-01 00:00:00

  • Laboratory biosafety measures involving SARS-CoV-2 and the classification as a Risk Group 3 biological agent.

    abstract::The current public health emergency surrounding the COVID-19 pandemic, that is the illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in thousands of cases in Australia since 25 January 2020 when the first case was diagnosed. This emerging virus presents particular hazards to ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2020.09.006

    authors: Kaufer AM,Theis T,Lau KA,Gray JL,Rawlinson WD

    更新日期:2020-12-01 00:00:00

  • 'Why don't they ever call?' Expectations of clinicians and pathologists regarding the communication of critical diagnoses in dermatopathology.

    abstract::Certain diagnoses in dermatopathology have significant implications for patient management and on occasion appropriate clinical care may be facilitated by a phone call from the reporting dermatopathologist to the referring doctor. Whether this is appropriate depends on a number of factors. The concept of 'critical dia...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2017.10.015

    authors: Korbl JD,Wood BA,Harvey NT

    更新日期:2018-04-01 00:00:00

  • Seven patients with respiratory infections due to Corynebacterium pseudodiphtheriticum.

    abstract::Seven cases of lower respiratory tract infection due to Corynebacterium pseudodiphtheriticum are described. Lower respiratory tract infections with C. pseudodiphtheriticum in immunocompetent patients are usually associated with pre-existing chronic pulmonary disease, and are sometimes associated with endotracheal intu...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029400169721

    authors: Freeman JD,Smith HJ,Haines HG,Hellyar AG

    更新日期:1994-07-01 00:00:00

  • Histological correlation of mammographically detected microcalcifications in stereotactic core biopsies.

    abstract::The aims of this study were to assess the value of specimen radiographs of stereotactic core biopsy, the usefulness of measuring size of calcifications on tissue sections, whether demonstration of calcifications in tissue sections alters the pathological diagnosis when specimen radiograph demonstrates calcifications, ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020120083160

    authors: Dahlstrom JE,Jain S

    更新日期:2001-11-01 00:00:00

  • Gliomatosis cerebri--report of a case.

    abstract::An unusual case of gliomatosis cerebri in a 37 yr-old man is reported. He presented with a variable clinical picture. Mental changes, brain stem signs, cerebellar signs and rise in intracranial pressure were the constant findings. The postmortem findings are described and the available literature is reviewed. ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028509063740

    authors: Balakrishnan V,Hornabrook RW,Alexander WS

    更新日期:1985-01-01 00:00:00

  • Cell culture studies on human nerve sheath tumors.

    abstract::The main controversy about nerve sheath tumors (NSTs) has been their histogenesis. A Schwann cell origin has been proposed by many investigators for both schwannomas and neurofibromas. However Erlandson and Woodruff observed that while schwannomas appeared to be composed predominantly of Schwann cells, neurofibromas c...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029400169051

    authors: Kharbanda K,Dinda AK,Sarkar C,Karak AK,Mathur M,Roy S

    更新日期:1994-01-01 00:00:00

  • Interobserver variations in histopathological assessment of gastric pathology.

    abstract:AIM:Considering the fact that histology and its grading systems are accepted gold standards in diagnosis of diverse clinical disorders, assessing the accuracy and reliability of this method of diagnosis is of utmost importance. Thus, this study was performed to measure the agreement values between four independent hist...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020903041044

    authors: Talebkhan Y,Mohammadi M,Rakhshani N,Abdirad A,Fayaz Moughadam K,Fereidooni F

    更新日期:2009-01-01 00:00:00

  • Serum prohepcidin concentrations in rheumatoid arthritis.

    abstract:AIM:Hepcidin, a recently identified peptide, acts as a central regulator of iron metabolism. It is regarded as a factor regulating the uptake of dietary iron and its mobilisation from macrophages and hepatic stores. It is considered as a mediator of anaemia of inflammation. The aim of this study was to assess whether s...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020802436840

    authors: Jayaranee S,Sthaneshwar P,Sokkalingam S

    更新日期:2009-02-01 00:00:00

  • Cerebral gliosarcoma, pulmonary adenoid-cystic carcinoma, and pulmonary metastatic gliosarcoma: report of an untreated case.

    abstract::An elderly woman had a cerebral gliosarcoma with a single pulmonary metastasis, together with a separate pulmonary adenoid-cystic carcinoma. Spontaneous extraneural metastases of primary intracranial neoplasms are exceedingly unusual; so far, only 8 proven cases are recorded in the English language medical literature....

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028409059108

    authors: Ojeda VJ,Sterrett GF

    更新日期:1984-04-01 00:00:00

  • Teratoid carcinosarcoma of the paranasal sinuses.

    abstract::Malignant tumours with teratoid or blastomatous features are exceptionally rare in the upper respiratory tract with only 8 documented cases, including the 3 in this report. The tumours occurred in adults aged 27 to 62 yr, and the sites of origin were the ethmoid sinus (4 cases), ethmoid and other paranasal sinuses (2 ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028309085168

    authors: Shanmugaratnam K,Kunaratnam N,Chia KB,Chiang GS,Sinniah R

    更新日期:1983-10-01 00:00:00

  • B cell chronic lymphocytic leukaemia cells have reduced capacity to upregulate expression of MHC class I in response to interferon-gamma.

    abstract:AIMS:An important consideration in the design of a tumour vaccine is the ability of tumour-specific cytotoxic T lymphocytes (CTL) to recognise unmanipulated tumour cells in vivo. To determine whether B-CLL might use an escape strategy, the current studies compared B-CLL and normal B cell MHC class I expression. METHOD...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020310001644499

    authors: Juffs H,Fowler N,Saal R,Grimmett K,Beasley S,O'Sullivan B,Frazer I,Gill D,Thomas R

    更新日期:2004-02-01 00:00:00

  • Expression of neuroendocrine markers in non-neuroendocrine endometrial carcinomas.

    abstract::Neuroendocrine (NE) tumours are uncommon in the gynecological tract. In addition to their histological features, what defines NE carcinoma is the expression of markers such as chromogranin, synaptophysin and neural cell adhesion molecule (CD56) by immunohistochemistry (IHC). Although limited data have demonstrated tha...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2019.02.003

    authors: Moritz AW,Schlumbrecht MP,Nadji M,Pinto A

    更新日期:2019-06-01 00:00:00

  • Digital papillary adenocarcinoma: a tumour that should be considered in the differential diagnosis of neoplasms involving the digits.

    abstract:BACKGROUND:Digital papillary adenocarcinoma (DPA) is a rare malignant adnexal tumour that occurs almost exclusively in a digital location. Only two case series have been reported previously. AIMS:To document the clinical and histopathological findings in a series of patients with DPA. RESULTS:Of the 8 patients identi...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1097/PAT.0b013e32835af778

    authors: Scolyer RA,Karim RZ,Thompson JF,Stretch JR,McCarthy SW,Murali R

    更新日期:2013-01-01 00:00:00

  • Breast carcinoma in a fibroadenoma: diagnosis by fine needle aspiration cytology.

    abstract::We describe a case of ductal carcinoma in situ (DCIS) occurring in a fibroadenoma diagnosed by fine needle aspiration (FNA) cytology. The cytological features comprised a small population of pleomorphic cells admixed with a dominant population of bland epithelial cells showing features consistent with those of a fibro...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029800169736

    authors: Psarianos T,Kench JG,Ung OA,Bilous AM

    更新日期:1998-11-01 00:00:00

  • Ulex europaeus agglutinin-1 binding in hereditary bowel cancer.

    abstract::Ulex europaeus agglutinin-1 (UEA-1) binds specifically to alpha-L-fucose, the terminal sugar of blood group substances H2 and Ley the expression of which is confined mainly to the proximal colon. The aim of the study was to determine whether there is neo-expression of alpha-L-fucose in the normal appearing mucosa of t...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313029309084782

    authors: Jass JR,Allison LJ,Stewart SM,Lane MR

    更新日期:1993-04-01 00:00:00

  • Laboratory assays for von Willebrand factor: relative contribution to the diagnosis of von Willebrand's disease.

    abstract::Appropriate investigation of a patient with suspected von Willebrand's disease (VWD) involves a clinical assessment of the patient followed by laboratory testing. A variety of laboratory assays may be performed, not necessarily restricted to an assessment of von Willebrand factor (VWF). Due to the limitations of each ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029700169365

    authors: Favaloro EJ,Koutts J

    更新日期:1997-11-01 00:00:00

  • Multiple hepatic abscesses due to Yersinia enterocolitica.

    abstract::We report a case of multiple hepatic abscesses due to Yersinia enterocolitica in a 58 yr old male. This case is typical of the other 39 cases reported in the literature in that the patient had alcoholism, malnutrition, iron overload and a subsequently diagnosed malignancy. Ultrasound showed multiple hypoechoic areas i...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1080/00313029500169353

    authors: Strungs I,Farrell DJ,Matar LD,Dekker L,Franz RJ

    更新日期:1995-10-01 00:00:00

  • Benign nerve sheath tumors: a light microscopic, electron microscopic and immunohistochemical study of 102 cases.

    abstract::One hundred and two cases of benign nerve sheath tumors (NSTs) were studied with a combined approach using routine light microscopy (LM), immunohistochemistry (IH) for myelin basic protein (MBP) and S-100 protein as well as transmission electron microscopy (TEM) with the aim of obtaining greater insight into the true ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313029009086659

    authors: Sharma S,Sarkar C,Mathur M,Dinda AK,Roy S

    更新日期:1990-10-01 00:00:00

  • Prognostic values of KAI1 and survivin expression in an infiltrating ductal carcinoma of the breast.

    abstract:AIMS:To investigate KAI1 and survivin expression in infiltrating ductal carcinomas, and to evaluate the relationship between clinicopathological factors and KAI1 and survivin expression levels in breast cancers. METHODS AND RESULTS:KAI and survivin expression levels were measured in 62 patients, using immunohistochemi...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020500058144

    authors: Son BH,Choi JS,Lee JH

    更新日期:2005-04-01 00:00:00

  • Malakoplakia in association with colorectal carcinoma: a series of four cases.

    abstract:AIMS:Malakoplakia is a characteristic inflammatory condition which is usually seen in the urogenital tract. Gastrointestinal malakoplakia is seen in association with a variety of conditions such as ulcerative colitis, diverticular disease, adenomatous polyps and carcinoma. The purpose of this paper is to report four ad...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1080/003130202760120481

    authors: Pillay K,Chetty R

    更新日期:2002-08-01 00:00:00