Abstract:
:Ulex europaeus agglutinin-1 (UEA-1) binds specifically to alpha-L-fucose, the terminal sugar of blood group substances H2 and Ley the expression of which is confined mainly to the proximal colon. The aim of the study was to determine whether there is neo-expression of alpha-L-fucose in the normal appearing mucosa of the distal bowel in subjects with or at risk of hereditary bowel cancer. UEA-1 binding was investigated by means of a direct lectin-peroxidase technique in tissues derived from patients with familial adenomatous polyposis (9) and affected (16) or at risk of (14) hereditary non-polyposis colorectal cancer. Control tissues were obtained from normal subjects and patients with sporadic bowel cancer and no family history of the condition. There was increased expression of alpha-L-fucose in some adenomas (mosaic pattern), in most carcinomas (diffuse), in hyperplastic polyps (crypt base), but not in normal appearing mucosa or transitional mucosa (adjacent to carcinoma) in any of the groups of patients examined. In view of the negative findings for normal-appearing mucosa, the suggestion that there is a pre-neoplastic field change in subjects at risk of hereditary bowel cancer may be unfounded.
journal_name
Pathologyjournal_title
Pathologyauthors
Jass JR,Allison LJ,Stewart SM,Lane MRdoi
10.3109/00313029309084782subject
Has Abstractpub_date
1993-04-01 00:00:00pages
114-9issue
2eissn
0031-3025issn
1465-3931journal_volume
25pub_type
杂志文章相关文献
PATHOLOGY文献大全abstract::Prenatal diagnoses of the genetic disorders alpha, beta thalassemia, HbS, Hb Lepore, hemophilia and cystic fibrosis were sought in 88 cases. Six unsuccessful attempts at diagnosis resulted from DNA polymorphisms which were only 50% informative (four cases) and prenatal diagnoses which had been undertaken before it was...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029009063558
更新日期:1990-07-01 00:00:00
abstract::Rapid rescreening was established in our laboratory in 1995, following the publication of several studies indicating improved sensitivity for the detection of abnormalities in cervical smears. During the study period, 285,841 negative smears (representing 89.09% of the total workload) were rapidly rescreened. A total ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/003130299104765
更新日期:1999-11-01 00:00:00
abstract::Post-transplant lymphoproliferative disorders (PTLD) are a consequence of the immunosuppressive therapy following organ transplant. We describe a patient who developed PTLD seven years after liver transplant and while receiving cyclosporine and prednisone. Magnetic resonance imaging demonstrated a paraspinal mass exte...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029800169636
更新日期:1998-11-01 00:00:00
abstract::With the use of 2 independent techniques, circulating monomeric and oligomeric IgM were detected in the majority of 29 patients with chronic lymphocytic leukemia (CLL). In contrast it was detected only in trace quantities in a minority of healthy subjects. In the CLL group no significant correlation was observed betwe...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029309068902
更新日期:1993-01-01 00:00:00
abstract::Mycoplasma-like organisms (MLO) are non-cultivated intracellular cell wall deficient pathogenic bacteria with a distinctive ultrastructural appearance. Diagnosis of MLO disease rests on finding the organisms in parasitized cells using a transmission electron microscope. MLO are a well studied cause of transmissible ch...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029400169192
更新日期:1994-10-01 00:00:00
abstract::A clinicopathological analysis was made of data from 250 cases of nodular fasciitis. These benign nodules usually occurred in young and middle-aged adults in the 4th and 5th decades, most often in the forearm (27%) followed by the thigh (17%) and the upper arm (12%), and grew rather rapidly to reach a mean diameter of...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409059097
更新日期:1984-04-01 00:00:00
abstract::Cytological examination of the pleural effusion fluid obtained from a 66-yr-old Chinese lady showed numerous intra- and extracytoplasmic colourless refractile non-birefringent crystals. X-ray analysis of the crystals identified barium salts. On further inquiry, it was learnt that the fluid obtained had been placed in ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029309090870
更新日期:1993-10-01 00:00:00
abstract::An enzyme-immunoassay has been developed for rapid isotyping of murine monoclonal antibodies. This assay has several advantages over the commonly used typing methods. It does not require the presence of specific antigen. Typing plates can be prepared in advance and stored frozen. Unequivocal results can be obtained in...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028509063727
更新日期:1985-01-01 00:00:00
abstract:AIMS:To demonstrate the correlation between morphological and proliferation parameters with the biological behaviour of adrenocortical tumours (ACTs) in different age groups. METHODS:Seventy-six cases of ACT were evaluated comparing tumours of children (< or =15 years, n=24) and adults (>15 years, n=52) regarding morp...
journal_title:Pathology
pub_type: 杂志文章
doi:
更新日期:2003-04-01 00:00:00
abstract::Exfoliative, abrasive and aspiration cytology were increasingly relied upon for tissue diagnosis of tumours. The established histological stains for the differentiation of mucin and non-mucin-secreting tumours are not ideal for alcohol-fixed cytology smears and a more reliable cytological technique for the preservatio...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028309083509
更新日期:1983-07-01 00:00:00
abstract::Hypercalcemia is a common biochemical abnormality. It is usually possible to make a presumptive diagnosis of its cause by relatively simple means. In a large majority of cases this involves differentiating between primary hyperparathyroidism and malignancy-associated hypercalcemia. Clinical evaluation and parathyroid ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028609059468
更新日期:1986-04-01 00:00:00
abstract:AIMS:We assessed the expression of ALDH1 and EZH2, cancer stem cell (CSC) related markers, in triple negative and basal-like breast cancers, investigating their association with clinicopathological features and outcome. METHODS:Clinicopathological data were obtained from 140 cases of triple negative breast cancer. A t...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e3283534bcb
更新日期:2012-06-01 00:00:00
abstract::Investigating fever in the returned traveller can be difficult and costly. Dengue is one of the most frequently reported aetiologies. NS1 is a non-structural dengue virus protein detectable during acute infection. The aim of this report is to describe the utility of the Platelia Dengue NS1 antigen enzyme immunoassay (...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2020.01.438
更新日期:2020-04-01 00:00:00
abstract:AIMS:Mounting evidence indicates that deregulation of apoptosis is involved in the mechanisms of cancer development. Bax-interacting factor-1 (Bif-1) interacts with both Bax and Bak that are crucial for the intrinsic apoptosis signalling. Functionally, loss of Bif-1 expression has been proven to enhance tumorigenesis. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020802320440
更新日期:2008-10-01 00:00:00
abstract::Eccrine syringofibroadenoma is a rare benign tumor of the skin arising from the acrosyringeal portion of the eccrine duct. The tumor was first described by Mascaro in 1963, and since then only 8 case reports in 6 publications have been documented. This lesion is likely to be misdiagnosed both clinically and histologic...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029109063580
更新日期:1991-07-01 00:00:00
abstract::The aims of this study were to assess the value of specimen radiographs of stereotactic core biopsy, the usefulness of measuring size of calcifications on tissue sections, whether demonstration of calcifications in tissue sections alters the pathological diagnosis when specimen radiograph demonstrates calcifications, ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020120083160
更新日期:2001-11-01 00:00:00
abstract::Semen analysis is the most important laboratory investigation for men when assessing the infertile couple. Advances in in vitro fertilisation (IVF) techniques, particularly intracytoplasmic sperm injection (ICSI) involving the direct injection of a single spermatozoon into an egg, have not diminished the role of semen...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:
更新日期:2003-02-01 00:00:00
abstract::This paper reviews the application of flow cytometric techniques to the analysis and quantitation of mixed red cell populations. Such mixtures may arise in a variety of ways, for example: through transplacental hemorrhage during pregnancy or upon delivery; through iatrogenic procedures such as blood transfusion, bone ...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/003130299104954
更新日期:1999-08-01 00:00:00
abstract::The recent upsurge in the association of congenital neurological disorders and infection by the Zika virus (ZIKV) has resulted in increased research focus on the biology of this flavivirus. Studies in animal models indicate that ZIKV can breach the placental barrier and selectively infect and deplete neuroprogenitor c...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2017.07.008
更新日期:2017-12-01 00:00:00
abstract::Colonic mucosal biopsies from patients with melanosis coli were examined by electron microscopy. They showed apoptosis of colonic surface epithelial cells and phagocytosis of resulting apoptotic bodies by intraepithelial macrophages. The latter migrated to the lamina propria where intracellular degradation of the apop...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029309084783
更新日期:1993-04-01 00:00:00
abstract::A "collision" tumor between a serous papillary adenocarcinoma and a steroid cell tumor of the ovary is described. No similar combination has been reported in the literature. The steroid cell component secreted testosterone, resulted in considerable virilization of the patient, and appears to have preceded the carcinom...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029209063624
更新日期:1992-04-01 00:00:00
abstract::Chromosome identification techniques have shown the non-random nature of cytogenetic changes in leukemia. In addition, they have identified structural chromosome abnormalities occurring in specific types of acute leukemia as classified by the FAB criteria. Such cytogenetic sub groups are associated with differing prog...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028209061379
更新日期:1982-07-01 00:00:00
abstract::The main controversy about nerve sheath tumors (NSTs) has been their histogenesis. A Schwann cell origin has been proposed by many investigators for both schwannomas and neurofibromas. However Erlandson and Woodruff observed that while schwannomas appeared to be composed predominantly of Schwann cells, neurofibromas c...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029400169051
更新日期:1994-01-01 00:00:00
abstract::A histopathological examination was made of 60 stapes obtained during surgery for clinical otosclerosis. The findings, correlated with the clinical history and macroscopic appearances of the stapes, led to the following observations. The histological extent of the focus of otosclerosis agrees well with the macroscopic...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409067908
更新日期:1984-01-01 00:00:00
abstract::An improved one-stage method for accurate assays of factor VIII combines highly reproducible end points with elimination of temporal drift and of subjective factors involved in graphic analysis. Activated deficient plasma substrate (ADPS) is used as a single reagent for parallel tests. The assays can be performed manu...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027909061940
更新日期:1979-04-01 00:00:00
abstract::A genetic variant of antithrombin with impaired heparin cofactor activity was identified in 4 members of a French family. Both the variant and normal antithrombin component were purified by affinity chromatography on heparin Sepharose. Reverse phase peptide mapping revealed a single altered peak when tryptic digests o...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029109061429
更新日期:1991-01-01 00:00:00
abstract::Patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) often exhibit clonal chromosomal abnormalities. Using a probe for the centromeric region of chromosome 8, fluorescence in situ hybridization (FISH) on interphase cells was used to detect trisomy 8 in an AML patient whose leukemia was characte...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029700169115
更新日期:1997-08-01 00:00:00
abstract::A 36-yr-old female with a 20-yr history of fibrodysplasia ossificans progressiva (FOP) died as the result of ruptured gastric ulcers. The patient had been treated with disodium ethane-l-hydroxy-1, 1-diphosphonate (EHDP). Post mortem there was thickening of the aortic valve cusps and mitral valve leaflets as well as sh...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028309083514
更新日期:1983-07-01 00:00:00
abstract::The results of semi-solid cultures of fresh biopsy material from 86 primary human melanomas are reported. Detailed histological assessments by Professor McGovern were available for 80 of the 86 melanomas, and these were compared with the growth characteristics of each specimen. Significant correlations were found betw...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028509063780
更新日期:1985-04-01 00:00:00
abstract::IgG4 related disease (IgG4RD) is a recently recognised condition characterised by mass forming lesions associated with storiform fibrosis, obliterative phlebitis, lymphoplasmacytic infiltrate rich in IgG4 positive plasma cells and elevated serum IgG4 levels. Although rare, mammary involvement has been reported as IgG4...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000187
更新日期:2015-01-01 00:00:00