Adrenocortical tumours in children and adults: a study of pathological and proliferation features.

Abstract:

AIMS:To demonstrate the correlation between morphological and proliferation parameters with the biological behaviour of adrenocortical tumours (ACTs) in different age groups. METHODS:Seventy-six cases of ACT were evaluated comparing tumours of children (< or =15 years, n=24) and adults (>15 years, n=52) regarding morphological features and proliferation rates. These parameters were also compared in clinically benign (CB) and clinically malignant (CM) tumours. Tumours were analysed according to Weiss' histological parameters. Proliferation rates were assessed by MIB-1 labelling index and silver binding nucleolar organiser regions (AgNORs) were quantified by image analysis. RESULTS:ACTs in children presented higher proliferative activity than in adults. In adult's ACTs, MIB-1 labelling index (cut-off, 10%) (P=0.037) and the AgNOR pattern (P<0.001) had influence over the disease-free survival (DFS). The AgNOR pattern type I was associated with CB-ACT and the AgNOR pattern type II with CM-ACT. The AgNOR pattern type III was characteristic of children's ACTs and type IV was characteristic of non-neoplasic adrenal glands. CONCLUSION:ACTs in children had a different morphological spectrum and higher proliferative activity than those tumours in adults, which should be always analysed as a separate group. In adults, our findings reinforce that the morphological criteria proposed by Weiss are an efficient way of differentiating CB-ACT from CM-ACT.

journal_name

Pathology

journal_title

Pathology

authors

Sredni ST,Alves VA,Latorre Mdo R,Zerbini MC

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

130-5

issue

2

eissn

0031-3025

issn

1465-3931

pii

1A5TRGU5XAJP811D

journal_volume

35

pub_type

杂志文章
  • Teratoid carcinosarcoma of the paranasal sinuses.

    abstract::Malignant tumours with teratoid or blastomatous features are exceptionally rare in the upper respiratory tract with only 8 documented cases, including the 3 in this report. The tumours occurred in adults aged 27 to 62 yr, and the sites of origin were the ethmoid sinus (4 cases), ethmoid and other paranasal sinuses (2 ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028309085168

    authors: Shanmugaratnam K,Kunaratnam N,Chia KB,Chiang GS,Sinniah R

    更新日期:1983-10-01 00:00:00

  • High reproducibility is attainable in assessing histoprognostic parameters of pT1 colorectal cancer using routine histopathology slides and immunohistochemistry analyses.

    abstract::Assessment of the risk of lymph node invasion and tumour recurrence is critical to determine whether additional surgery is required in patients with endoscopically-removed pT1 colorectal cancer (CRC). A reproducible assessment of this risk of recurrence based on histopathological parameters is crucial for relevant the...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2018.10.007

    authors: Barel F,Auffret A,Cariou M,Kermarrec T,Samaison L,Bourhis A,Badic B,Jézéquel J,Cholet F,Bail JP,Marcorelles P,Nousbaum JB,Robaszkiewicz M,Doucet L,Uguen A

    更新日期:2019-01-01 00:00:00

  • The detection of myoglobin in urine and its application to the diagnosis of myocardial infarction.

    abstract::An indirect haemaglutination method was developed for the immunochemical detection of myoglobin in human urine. Myoglobin was found in the urine of 84% of 44 patients with acute myocardial infarction. In contrast, it was detected in the urine of 2.7% of 147 control subjects and in none of a control group of 15 patient...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313027609101494

    authors: Cloonan JM,Donald TG,Neale C,Wilcken DE

    更新日期:1976-10-01 00:00:00

  • Actin-like contractile protein in carbon tetrachloride-induced cirrhosis in the rat.

    abstract::Cryostat sections of livers from rats treated with carbon tetrachloride (CCl4) for 12 weeks were examined by indirect immunofluorescence for reactivity with human serum containing smooth muscle antibody (SMA). Increased binding of SMA serum to hepatocytes was observed as early as the first week of CCl4 treatment and r...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313027709084807

    authors: Toh BH,Cauchi MN,Muller HK

    更新日期:1977-07-01 00:00:00

  • An immunohistochemical and molecular analysis of papillary proliferation of the endometrium.

    abstract::Papillary proliferations of the endometrium (PPEs) are uncommon lesions that are often associated with endometrial polyps. PPEs occasionally precede or co-exist with atypical endometrial hyperplasia or adenocarcinoma, but their pathogenesis and relationship to endometrial neoplasia is uncertain. In the present study 1...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2017.10.013

    authors: Stewart CJR,Bigby S,Giardina T,Grieu-Iacopetta F,Amanuel B

    更新日期:2018-04-01 00:00:00

  • The indirect estimation of hemoglobin concentration in whole blood.

    abstract::The present conventional methods for determination of Hemoglobin (Hb) concentration in whole blood depend on the direct colorimetric measurement of chemically modified Hb following its release from red cells by lysis. This paper examines an alternative, indirect method which does not require initial red cell lysis, co...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313029109060808

    authors: Kalache GR,Sartor MM,Hughes WG

    更新日期:1991-04-01 00:00:00

  • KRAS, NRAS, BRAF mutations and high counts of poorly differentiated clusters of neoplastic cells in colorectal cancer: observational analysis of 175 cases.

    abstract::A novel grading system based on the counting of poorly differentiated clusters (PDC) of neoplastic cells at the invasive margin and in the tumour stroma was recently introduced among the histological parameters predictive of adverse clinical outcome in colorectal cancer (CRC). The aim of this study was to correlate th...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1097/PAT.0000000000000300

    authors: Barresi V,Bonetti LR,Bettelli S

    更新日期:2015-10-01 00:00:00

  • Reduced CD151 expression is related to advanced tumour stage in urothelial bladder cancer.

    abstract:AIMS:CD151 belongs to the group of tetraspanins and is aberrantly expressed in different tumours and differential expression has been associated with prognosis. The aim of this study was to clarify the relationship of CD151 expression with tumour phenotype and clinical outcome in bladder cancer. METHODS:A bladder canc...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1097/PAT.0b013e32835576ee

    authors: Minner S,De Silva C,Rink M,Dahlem R,Chun F,Fisch M,Höppner W,Wagner W,Bokemeyer C,Terracciano L,Simon R,Sauter G,Wilczak W

    更新日期:2012-08-01 00:00:00

  • Tumour-infiltrating lymphocytes in melanoma prognosis and cancer immunotherapy.

    abstract::The field of systemic cancer therapy for metastatic disease has entered an exciting era with the advent of novel immunomodulatory strategies targeting immune checkpoints. At the heart of these promising efforts are the tumour-infiltrating lymphocytes (TILs). As the reports demonstrating efficacy of modulating TIL effe...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.pathol.2015.12.006

    authors: Lee N,Zakka LR,Mihm MC Jr,Schatton T

    更新日期:2016-02-01 00:00:00

  • Gamna body of the heart.

    abstract::A patient with cerebral strokes had a cardiac tumour excised. Histologically, it was an infarcted myxoma with features of a Gamna body. Findings are compared with other cardiac Gamna bodies reported in the literature. Most probably represent unusual degenerative changes in a myxoma. ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028409084740

    authors: Coard KC,Silver MD

    更新日期:1984-10-01 00:00:00

  • Fever in the returned traveller: the utility of the Platelia Dengue NS1 antigen enzyme immunoassay for the diagnosis of dengue in a non-endemic setting.

    abstract::Investigating fever in the returned traveller can be difficult and costly. Dengue is one of the most frequently reported aetiologies. NS1 is a non-structural dengue virus protein detectable during acute infection. The aim of this report is to describe the utility of the Platelia Dengue NS1 antigen enzyme immunoassay (...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2020.01.438

    authors: Foley DA,Yeoh DK,Karapanagiotidis T,Nhindri T,Catton M

    更新日期:2020-04-01 00:00:00

  • Malignant solitary fibrous tumour of the prostate: four cases emphasising significant histological and immunophenotypical overlap with sarcomatoid carcinoma.

    abstract::Solitary fibrous tumour (SFT) is well-described in the urinary tract, but malignant examples are rare. We studied our experience with high grade malignant SFT of the prostate to address the degree of histological and immunophenotypical overlap with sarcomatoid carcinoma and prostatic stromal sarcoma. Four cases were i...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2020.06.004

    authors: Bakhshwin A,Berry RS,Cox RM,Li R,Reynolds JP,Rubin BP,McKenney JK

    更新日期:2020-10-01 00:00:00

  • Mitral and aortic valve abnormalities in a patient with fibrodysplasia ossificans progressiva.

    abstract::A 36-yr-old female with a 20-yr history of fibrodysplasia ossificans progressiva (FOP) died as the result of ruptured gastric ulcers. The patient had been treated with disodium ethane-l-hydroxy-1, 1-diphosphonate (EHDP). Post mortem there was thickening of the aortic valve cusps and mitral valve leaflets as well as sh...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028309083514

    authors: Jaworski RC,Gibson M

    更新日期:1983-07-01 00:00:00

  • Expression of placental proteins in complete and partial hydatidiform moles.

    abstract::Examination of routinely stained haematoxylin and eosin sections may sometimes prove inadequate in differentiating partial hydatidiform moles (PHM) from complete hydatidiform moles (CHM). While cytogenetic analysis can aid in the distinction, such facilities are not always available. The possibility of using immunohis...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029400169311

    authors: Cheah PL,Looi LM

    更新日期:1994-04-01 00:00:00

  • Ovarian sex cord-stromal tumours: an update in recent molecular advances.

    abstract::Sex cord-stromal tumours (SCSTs) consist of a heterogeneous group of neoplasms with diverse clinicopathological features and biological behaviour. They often present as a diagnostic challenge as they have varied and occasionally overlapping histomorphology and some may even mimic non-SCSTs. An accurate diagnosis is im...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.pathol.2017.10.008

    authors: Lim D,Oliva E

    更新日期:2018-02-01 00:00:00

  • HPV detection and genotyping of head and neck cancer biopsies by molecular testing with regard to the new oropharyngeal squamous cell carcinoma classification based on HPV status.

    abstract::Recently, both the World Health Organization/International Agency for Research on Cancer (WHO/IARC) and the American Joint Committee on Cancer (AJCC) have classified oropharyngeal squamous cell carcinoma (OPSCC) on the basis of HPV status. For this purpose, the WHO/IARC recommended direct molecular HPV testing. In pra...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2019.02.002

    authors: Veyer D,Wack M,Grard O,Bonfils P,Hans S,Bélec L,Badoual C,Péré H

    更新日期:2019-06-01 00:00:00

  • Prognostic histopathological factors in malignant melanoma.

    abstract::An analysis of prognostic factors in 4000 patients with cutaneous malignant melanoma at the Sydney Melanoma Unit and the University of Alabama in Birmingham has demonstrated that the histological features of the primary melanoma become less predictive of survival the more advanced the disease becomes. Thus, whilst 4 f...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028509063766

    authors: Shaw HM,Balch CM,Soong SJ,Milton GW,McCarthy WH

    更新日期:1985-04-01 00:00:00

  • Stereotactic biopsy of 100 intracerebral lesions at Sir Charles Gairdner Hospital.

    abstract::The pathological findings in a retrospective review of 100 consecutive intracranial stereotactic biopsies are presented. Definite diagnosis could be established in the majority (89) of cases and included 85 neoplasms (69 primary cerebral tumors, 10 non-Hodgkin's lymphomas and 6 metastases) and 4 non-neoplastic process...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029400169092

    authors: Robbins PD,Yu LL,Lee M,Stokes BA,Thomas GW,Watson P,Wong G

    更新日期:1994-10-01 00:00:00

  • Surrogate testing for non-A, non-B hepatitis in Queensland, Australia: an ALT microtitre tray method for screening blood donors.

    abstract::The estimation of plasma alanine aminotransferase (ALT) has been proposed as a surrogate test to identify potential non-A, non-B hepatitis carriers in blood donor populations. This report describes an ALT screening procedure which uses wells of microtitration trays as reactant vessels. The method utilizes a rate readi...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028809059506

    authors: Hyland CA,Douglas R,Mazzocchi R,Young IF

    更新日期:1988-07-01 00:00:00

  • Precursors and pathogenesis of ovarian carcinoma.

    abstract::The ultimate goal of defining cancer specific precursors is to facilitate early detection and intervention before the development of invasive malignancy. Unlike other malignancies involving the female genital tract such as cervical or endometrial carcinomas, precursor lesions of ovarian carcinomas have not been well c...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1097/PAT.0b013e32835f2264

    authors: Lim D,Oliva E

    更新日期:2013-04-01 00:00:00

  • An ovarian tumour specific mucin antigen--immunohistological and biochemical studies.

    abstract::A new mucin antigen was detected in a mucinous cystadenoma of human ovary. An antiserum produced in rabbits against the crude cyst fluid, following appropriate absorptions, showed immunoreactivity exclusively with tumour epithelium, particularly endocervical type epithelium. The antigen responsible for the immunoreact...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028309085164

    authors: Ma J,Handley CJ,de Boer WG

    更新日期:1983-10-01 00:00:00

  • Decreased expression of Bax-interacting factor-1 (Bif-1) in invasive urinary bladder and gallbladder cancers.

    abstract:AIMS:Mounting evidence indicates that deregulation of apoptosis is involved in the mechanisms of cancer development. Bax-interacting factor-1 (Bif-1) interacts with both Bax and Bak that are crucial for the intrinsic apoptosis signalling. Functionally, loss of Bif-1 expression has been proven to enhance tumorigenesis. ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020802320440

    authors: Kim SY,Oh YL,Kim KM,Jeong EG,Kim MS,Yoo NJ,Lee SH

    更新日期:2008-10-01 00:00:00

  • An enzyme immunoassay for rapid isotyping of monoclonal antibodies.

    abstract::An enzyme-immunoassay has been developed for rapid isotyping of murine monoclonal antibodies. This assay has several advantages over the commonly used typing methods. It does not require the presence of specific antigen. Typing plates can be prepared in advance and stored frozen. Unequivocal results can be obtained in...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028509063727

    authors: Gardner ID

    更新日期:1985-01-01 00:00:00

  • Cardiac pathology and adult aboriginal mortality: a coronial study of sudden and external cause deaths in the top end of the Northern Territory in 1990.

    abstract::A retrospective review of coronial records was performed for 179 adult decedents who came to coronial autopsy in 1990 and who had been living in the Top End of the Northern Territory at the time of death. The directly standardized rate of autopsy-examined sudden death was 7.4 times higher for Aboriginal people than fo...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029600169503

    authors: Weeramanthri TS,Powers JR,Collier JW

    更新日期:1996-01-01 00:00:00

  • Gram negative anaerobe susceptibility testing in clinical isolates using Sensititre and Etest methods.

    abstract::Gram negative anaerobic organisms are important pathogens in a range of clinical infections, and susceptibility testing is not commonly performed in the microbiology laboratory. We performed anaerobic susceptibility testing on 70 clinically relevant Gram negative anaerobes isolated from routine cultures in a busy diag...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2017.10.020

    authors: Hughes C,Ashhurst-Smith C,Ferguson JK

    更新日期:2018-06-01 00:00:00

  • Primary extranodal non-Hodgkin's lymphoma.

    abstract::A total of 52 of 238 patients (22%) with non-Hodgkin's lymphoma presented with disease in a primary extranodal site. The gastrointestinal tract was the commonest site involved (50%) and diffuse large cell was the commonest histological sub-type of the lymphoma (64%). Survivorship analysis of these patients, treated pr...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028609087561

    authors: Manoharan A,Smart RC,Pitney WR

    更新日期:1986-10-01 00:00:00

  • Diffuse mesothelioma of the peritoneum: correlation between histological and clinical parameters and survival in 73 patients.

    abstract::There are few studies addressing survival of diffuse peritoneal mesotheliomas (DPM).In this study, survival data were obtained retrospectively from 73 patients treated with intended cytoreductive surgery for DPM, with a mean follow-up of 42 months. Mesotheliomas were classified as well differentiated papillary (WDPM, ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1097/PAT.0000000000000181

    authors: Liu S,Staats P,Lee M,Alexander HR,Burke AP

    更新日期:2014-12-01 00:00:00

  • TERT promoter methylation and protein expression as predictive biomarkers for recurrence risk in patients with serous borderline ovarian tumours.

    abstract::Epithelial ovarian neoplasms can be divided into three distinct clinicopathological groups: benign, malignant and borderline tumours. Borderline tumours are less aggressive than epithelial carcinomas, with an indolent clinical course and delayed recurrence. However, a subset of these cases can progress to malignancy a...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2020.07.010

    authors: Losi L,Botticelli L,Garagnani L,Fabbiani L,Panini R,Gallo G,Sabbatini R,Maiorana A,Benhattar J

    更新日期:2021-02-01 00:00:00

  • Bilateral primary seminal vesicle carcinoma.

    abstract::We report a rare case of bilateral primary seminal vesicle carcinoma in a 73 yr old Australian man. To our knowledge this case report is the 48th histologically confirmed case of primary seminal vesicle neoplasia and only the fourth reported case of primary bilateral seminal vesicle carcinoma. Macroscopically the tumo...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029600169883

    authors: Ormsby AH,Haskell R,Ruthven SE,Mylne GE

    更新日期:1996-05-01 00:00:00

  • Seroimmunology of AIDS retrovirus infection. I. Use of immunofluorescence assay to confirm sera with ELISA reactivity.

    abstract::One thousand sera shown to be reactive by one of two commercial enzyme linked immunosorbent assays (ELISA) for antibodies to the AIDS virus were referred to the NSW State Reference Laboratory for confirmatory assays. Each serum was retested by two commercial ELISA systems (Abbott and ENI), the ENI exclusionary H9 ELIS...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028609087565

    authors: Imrie AA,Kehrer S,Smith GW,Penny R,Cooper DA

    更新日期:1986-10-01 00:00:00