Abstract:
:A total of 52 of 238 patients (22%) with non-Hodgkin's lymphoma presented with disease in a primary extranodal site. The gastrointestinal tract was the commonest site involved (50%) and diffuse large cell was the commonest histological sub-type of the lymphoma (64%). Survivorship analysis of these patients, treated predominantly with chemotherapy, suggests that long-term survival is associated with: low-grade malignancy--median survival greater than 120 months; localized disease or spread of disease confined to the regional lymph nodes--median survival 65.5 months; and the use of aggressive combination chemotherapy for intermediate grade malignancy when the disease is localized or spread is confined to the regional lymph nodes--median survival greater than 110 months.
journal_name
Pathologyjournal_title
Pathologyauthors
Manoharan A,Smart RC,Pitney WRdoi
10.3109/00313028609087561subject
Has Abstractpub_date
1986-10-01 00:00:00pages
413-7issue
4eissn
0031-3025issn
1465-3931journal_volume
18pub_type
杂志文章相关文献
PATHOLOGY文献大全abstract::The careers and contributions of some of those who have played a major role in the development of knowledge concerning gynaecological pathology are summarised. The emphasis is on workers of prior times beginning with those of the German-speaking school: Carl Ruge, Felix Marchand, Hermann Pfannenstiel, Oskar Frankl, Wa...
journal_title:Pathology
pub_type: 历史文章,杂志文章
doi:10.1080/00313020601153281
更新日期:2007-02-01 00:00:00
abstract:AIM:To determine whether whole of gestation exposure of fetal mouse brain to mobile telephone radiofrequency fields produces a stress response detectable by induction of heat shock proteins (HSPs). METHODS:Using a purpose-designed exposure system at 900 MHz, pregnant mice were given a single, far-field, whole body exp...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020902756261
更新日期:2009-01-01 00:00:00
abstract::We have previously shown that HOMER2 (Homer scaffolding protein 2), a protein coding gene, was highly expressed in low grade (LG) endometrioid adenocarcinoma (EAC) of the uterus. The role of HOMER2 in endometrial cancer (EC) is widely unknown; therefore, the aim of this study was to determine the expression and the pr...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2018.03.004
更新日期:2018-08-01 00:00:00
abstract::Four hundred and ten thyroid nodules, 127 breast lumps and 43 lymph nodes were sampled and analyzed to compare the classical aspiration (ASP) technique with the non aspiration needle jab (NASP) technique. The adequacy of cellularity, significant blood staining and the discomfort felt by the patient were assessed and s...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029500169243
更新日期:1995-10-01 00:00:00
abstract::Sex cord-stromal tumours (SCSTs) consist of a heterogeneous group of neoplasms with diverse clinicopathological features and biological behaviour. They often present as a diagnostic challenge as they have varied and occasionally overlapping histomorphology and some may even mimic non-SCSTs. An accurate diagnosis is im...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2017.10.008
更新日期:2018-02-01 00:00:00
abstract::Birth defects of the brain result from malformation and disruptions. They remain an important cause of childhood morbidity and mortality. Effective treatments are scarce and prevention strategies limited. As aetiological screening is costly and uncertain, genetic counselling remains empirical in most cases. A patholog...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313020701813719
更新日期:2008-02-01 00:00:00
abstract::A total of 1434 strains of Neisseria meningitidis isolated from cases of invasive meningococcal disease (IMD) in Australia between 1994 and 1999 were examined by standard methods for susceptibility to antibiotics used for treatment and prophylaxis. The proportion of isolates fully susceptible to penicillin decreased f...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/pat.33.3.359.361
更新日期:2001-08-01 00:00:00
abstract:AIMS:Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase. Recently, some studies have suggested that SIRT1 could be over-expressed in breast, prostate and colon cancers and up-regulated SIRT1 inactivates p53 by deacetylation. Therefore, we investigated the prevalence and the prognostic impact ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020902884451
更新日期:2009-01-01 00:00:00
abstract::Recent updated models of the coagulation mechanism suggest that factor VII/thromboplastin complex is the main initiator or trigger of coagulation. Factor VII activation of factor IX is likely to be an important activation pathway. Inhibition of factor VII by tissue factor pathway inhibitor may have a regulatory role i...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029700169954
更新日期:1997-05-01 00:00:00
abstract:AIM:Clostridium difficile is the major pathogen associated with nosocomial diarrhoea. We evaluated the performances of a commercially available toxin A enzyme immunoassay (EIA; Clearview C. difficile Toxin A Test), culture and tissue culture cytotoxin assay in the diagnosis of C. difficile-associated diarrhoea. METHOD...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/0031302031000123236
更新日期:2003-06-01 00:00:00
abstract::An improved one-stage method for accurate assays of factor VIII combines highly reproducible end points with elimination of temporal drift and of subjective factors involved in graphic analysis. Activated deficient plasma substrate (ADPS) is used as a single reagent for parallel tests. The assays can be performed manu...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027909061940
更新日期:1979-04-01 00:00:00
abstract::This review will focus on the molecular biology of lymphoproliferative disorders with emphasis on lymphomas. The spectrum of known recurrent gene rearrangements found in lymphomas will be outlined and their relevance to diagnosis and subclassification of disease will be discussed. Finally, a survey of the current tren...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313020500376553
更新日期:2005-12-01 00:00:00
abstract::Colonic mucosal biopsies from patients with melanosis coli were examined by electron microscopy. They showed apoptosis of colonic surface epithelial cells and phagocytosis of resulting apoptotic bodies by intraepithelial macrophages. The latter migrated to the lamina propria where intracellular degradation of the apop...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029309084783
更新日期:1993-04-01 00:00:00
abstract::Mesenchymal stromal cells (MSCs) are a non-homogeneous population of plastic-adherent cells which were initially isolated from post-natal bone marrow. They have the capacity to differentiate to multiple mesodermal lineages including bone, cartilage and adipose tissue. In stringent culture conditions, MSCs can also be ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e32834ab72d
更新日期:2011-10-01 00:00:00
abstract:AIMS:Biochemical analysis of glucose and ketones in the vitreous humour obtained at post-mortem examination is representative of the levels in the blood prior to death. Elevated levels can be indicative of conditions including diabetic ketoacidosis, which can be a cause for unexpected death. A rapid screening test for ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e3283650b93
更新日期:2013-10-01 00:00:00
abstract:AIM:Considering the fact that histology and its grading systems are accepted gold standards in diagnosis of diverse clinical disorders, assessing the accuracy and reliability of this method of diagnosis is of utmost importance. Thus, this study was performed to measure the agreement values between four independent hist...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020903041044
更新日期:2009-01-01 00:00:00
abstract::In situ stages of malignancy have been characterised in various neoplasms. Mesothelioma in situ (MIS) has been a controversial diagnosis, lacking clear diagnostic criteria and understanding as to whether it is truly a premalignant lesion in the progression of malignant mesothelioma (MM). Originally understood as a con...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2020.06.010
更新日期:2020-10-01 00:00:00
abstract::A unique complication of florid xanthogranulomatous cholecystitis with cholecystoduodenal fistula formation is described in a 6 yr old male. The patient, who had a short gut syndrome, had been maintained on lifelong total parenteral nutrition (TPN) following extensive neonatal ischemic bowel necrosis secondary to gast...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029009086671
更新日期:1990-10-01 00:00:00
abstract::Recent controversies both in Australia and overseas have focused public attention on autopsy practice. It has become apparent that there is an increasing expectation amongst the public for more detailed information concerning autopsy procedures and, in particular, tissue retention. This article attempts to review the ...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313020120105660
更新日期:2002-02-01 00:00:00
abstract:AIM:Hepcidin, a recently identified peptide, acts as a central regulator of iron metabolism. It is regarded as a factor regulating the uptake of dietary iron and its mobilisation from macrophages and hepatic stores. It is considered as a mediator of anaemia of inflammation. The aim of this study was to assess whether s...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020802436840
更新日期:2009-02-01 00:00:00
abstract::Hypercalcemia is a common biochemical abnormality. It is usually possible to make a presumptive diagnosis of its cause by relatively simple means. In a large majority of cases this involves differentiating between primary hyperparathyroidism and malignancy-associated hypercalcemia. Clinical evaluation and parathyroid ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028609059468
更新日期:1986-04-01 00:00:00
abstract::The most common of all activating BRAF mutations (T1799A) leads to a substitution of valine (V) to glutamic acid (E) at the position 600 of the amino acid sequence. The major goal of this study was to compare detection of the BRAF V600E mutation by DNA sequencing with immunohistochemistry (IHC) using the anti-BRAF V60...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000119
更新日期:2014-10-01 00:00:00
abstract::The frequency of simultaneous infection with Neisseria gonorrhoeae and Chlamydia trachomatis in men and women in Eastern Sydney was examined prospectively over a 21 month period in patients from whom appropriate specimens were obtained. In men gonococcal disease (113 cases) and chlamydial infections (124 cases) occurr...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029600169603
更新日期:1996-01-01 00:00:00
abstract::Rheumatoid Arthritis (RA) synovial membranes were examined by single and dual immunohistological techniques with a number of monoclonal antibodies against lymphocyte and macrophage related antigens. CD4 positive T lymphocytes frequently expressed MHC Class II antigens and were found in sublining collections in close a...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029209063615
更新日期:1992-01-01 00:00:00
abstract::Lymph node metastasis (LNM) is an important factor for predicting prognosis and selecting appropriate treatment in early gastric cancers (EGCs). We investigated the histopathological and microenvironmental predictors of LNM in EGCs. We retrieved 43 cases of EGC without LNM and 59 cases with LNM. Clinicopathological va...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2017.06.003
更新日期:2017-10-01 00:00:00
abstract:AIMS:Activation of nuclear factor-kappa B (NF-kappaB) signalling is considered a crucial mechanism in the development of cancers. Caspase-associated recruitment domain 6 (CARD6) is a protein that activates NF-kappaB signalling evoked by RIP1, RIP2, Bcl-10 and MEKK. In this study, we analysed tissue expression of CARD6 ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313020903434421
更新日期:2010-01-01 00:00:00
abstract::Ulex europaeus agglutinin-1 (UEA-1) binds specifically to alpha-L-fucose, the terminal sugar of blood group substances H2 and Ley the expression of which is confined mainly to the proximal colon. The aim of the study was to determine whether there is neo-expression of alpha-L-fucose in the normal appearing mucosa of t...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029309084782
更新日期:1993-04-01 00:00:00
abstract::Partial regression is common in cutaneous melanoma; however, complete regression manifesting as tumoural melanosis is rare, conceptually challenging and under-reported. In this study we report on clinical, histological and molecular findings in four cases of completely regressed cutaneous melanoma with nodal or brain ...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2019.01.008
更新日期:2019-06-01 00:00:00
abstract::The results of semi-solid cultures of fresh biopsy material from 86 primary human melanomas are reported. Detailed histological assessments by Professor McGovern were available for 80 of the 86 melanomas, and these were compared with the growth characteristics of each specimen. Significant correlations were found betw...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028509063780
更新日期:1985-04-01 00:00:00
abstract::The use of purified intrinsic factor in vitamin B12 radioassays has greatly reduced the misdiagnosis of pernicious anaemia in recent years, but anomalies still occur. Observations made on current vitamin B12 radioassays suggest that many methods fail to convert all serum cobalamins to cyanocobalamin and thus are not t...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028209069040
更新日期:1982-01-01 00:00:00