Abstract:
:Colonic mucosal biopsies from patients with melanosis coli were examined by electron microscopy. They showed apoptosis of colonic surface epithelial cells and phagocytosis of resulting apoptotic bodies by intraepithelial macrophages. The latter migrated to the lamina propria where intracellular degradation of the apoptotic bodies resulted in formation of lipofuscin, characteristic of this condition. The results showed the pathogenesis of human melanosis coli was identical to that determined in an animal model of this disease.
journal_name
Pathologyjournal_title
Pathologyauthors
Walker NI,Smith MM,Smithers BMdoi
10.3109/00313029309084783subject
Has Abstractpub_date
1993-04-01 00:00:00pages
120-3issue
2eissn
0031-3025issn
1465-3931journal_volume
25pub_type
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