Abstract:
AIMS:Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase. Recently, some studies have suggested that SIRT1 could be over-expressed in breast, prostate and colon cancers and up-regulated SIRT1 inactivates p53 by deacetylation. Therefore, we investigated the prevalence and the prognostic impact of SIRT1 and p53 expression in ovarian epithelial tumours. METHODS:Immunohistochemical expression of SIRT1 and p53 were evaluated using tissue microarray in 40 cases of benign epithelial tumours, 36 cases of borderline tumours, and 90 cases of malignant tumours. RESULTS:Expression of SIRT1 was significantly increased in malignant epithelial tumours compared to benign and borderline epithelial tumours (p < 0.001). In particular, a high proportion of serous carcinoma expressed SIRT1 (86%, 55/64 cases). Despite the frequent expression of SIRT1 in malignant ovarian epithelial tumours, serous carcinomas of high FIGO stage showed less frequent SIRT1 expression compared to that of low stage serous carcinomas (p = 0.029). Moreover, increased expression of SIRT1 in serous carcinoma correlated with increased overall survival by univariate (p = 0.014) and multivariate analyses. CONCLUSIONS:Over-expression of SIRT1 may play an important role in the early stage of ovarian carcinogenesis.
journal_name
Pathologyjournal_title
Pathologyauthors
Jang KY,Kim KS,Hwang SH,Kwon KS,Kim KR,Park HS,Park BH,Chung MJ,Kang MJ,Lee DG,Moon WSdoi
10.1080/00313020902884451subject
Has Abstractpub_date
2009-01-01 00:00:00pages
366-71issue
4eissn
0031-3025issn
1465-3931pii
S0031-3025(16)31998-5journal_volume
41pub_type
杂志文章相关文献
PATHOLOGY文献大全abstract:AIMS:INI1 expression and its correlation with MGMT gene promoter methylation status and follow-up was investigated in 77 surgically removed glioblastomas then treated with radiotherapy (RT) or RT plus temozolomide (TMZ). METHODS:INI1 was determined by immunohistochemistry and MGMT by methylation-specific PCR. RESULTS...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e328340bb26
更新日期:2011-01-01 00:00:00
abstract::Ulex europaeus agglutinin-1 (UEA-1) binds specifically to alpha-L-fucose, the terminal sugar of blood group substances H2 and Ley the expression of which is confined mainly to the proximal colon. The aim of the study was to determine whether there is neo-expression of alpha-L-fucose in the normal appearing mucosa of t...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029309084782
更新日期:1993-04-01 00:00:00
abstract:AIMS:Malakoplakia is a characteristic inflammatory condition which is usually seen in the urogenital tract. Gastrointestinal malakoplakia is seen in association with a variety of conditions such as ulcerative colitis, diverticular disease, adenomatous polyps and carcinoma. The purpose of this paper is to report four ad...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/003130202760120481
更新日期:2002-08-01 00:00:00
abstract:AIMS:BRAF mutation has been shown in a large meta-analysis to be an independent prognostic marker for papillary thyroid carcinoma (PTC) with poorer survival and higher recurrence rates. METHODS:We studied prevalence of BRAF mutation in 77 patients with PTC from an Australian cohort using competitive polymerase chain r...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000008
更新日期:2013-12-01 00:00:00
abstract::Investigating fever in the returned traveller can be difficult and costly. Dengue is one of the most frequently reported aetiologies. NS1 is a non-structural dengue virus protein detectable during acute infection. The aim of this report is to describe the utility of the Platelia Dengue NS1 antigen enzyme immunoassay (...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2020.01.438
更新日期:2020-04-01 00:00:00
abstract::A clinicopathological analysis was made of data from 250 cases of nodular fasciitis. These benign nodules usually occurred in young and middle-aged adults in the 4th and 5th decades, most often in the forearm (27%) followed by the thigh (17%) and the upper arm (12%), and grew rather rapidly to reach a mean diameter of...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409059097
更新日期:1984-04-01 00:00:00
abstract::The aim of the present study is to describe the histological and mutational characteristics of a series of both large and small bowel adenocarcinomas in patients with Crohn's disease from a tertiary referral centre of inflammatory bowel disease. Bowel adenocarcinoma was diagnosed in 11 (1.7%) of 660 consecutive patien...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000123
更新日期:2014-08-01 00:00:00
abstract::Although most carcinomas of the bladder occur de novo, some vesical lesions progress to malignancy over time. These lesions appear morphologically benign, but often harbour genetic changes that signify their malignant potential. Despite their benign appearance, accurate identification is important given that these pat...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1097/PAT.0b013e32835f6169
更新日期:2013-04-01 00:00:00
abstract::A male iniencephalic foetus of about 25 weeks gestation is described. The baby was born to a 22-year-old mother, who presented with abdominal pain of 1 day duration. An ultrasound scan at that time showed multiple foetal anomalies and the pregnancy was terminated. A stillborn baby was delivered. At autopsy, characteri...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:
更新日期:2001-02-01 00:00:00
abstract::Patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) often exhibit clonal chromosomal abnormalities. Using a probe for the centromeric region of chromosome 8, fluorescence in situ hybridization (FISH) on interphase cells was used to detect trisomy 8 in an AML patient whose leukemia was characte...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029700169115
更新日期:1997-08-01 00:00:00
abstract::A patient with cerebral strokes had a cardiac tumour excised. Histologically, it was an infarcted myxoma with features of a Gamna body. Findings are compared with other cardiac Gamna bodies reported in the literature. Most probably represent unusual degenerative changes in a myxoma. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409084740
更新日期:1984-10-01 00:00:00
abstract::The estimation of plasma alanine aminotransferase (ALT) has been proposed as a surrogate test to identify potential non-A, non-B hepatitis carriers in blood donor populations. This report describes an ALT screening procedure which uses wells of microtitration trays as reactant vessels. The method utilizes a rate readi...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809059506
更新日期:1988-07-01 00:00:00
abstract::The aims of this study were to assess the value of specimen radiographs of stereotactic core biopsy, the usefulness of measuring size of calcifications on tissue sections, whether demonstration of calcifications in tissue sections alters the pathological diagnosis when specimen radiograph demonstrates calcifications, ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020120083160
更新日期:2001-11-01 00:00:00
abstract:AIMS:Biochemical analysis of glucose and ketones in the vitreous humour obtained at post-mortem examination is representative of the levels in the blood prior to death. Elevated levels can be indicative of conditions including diabetic ketoacidosis, which can be a cause for unexpected death. A rapid screening test for ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e3283650b93
更新日期:2013-10-01 00:00:00
abstract::A fatal case of multiple sulfatase deficiency in a 10-year-old girl is reported. In this rare disease, which is inherited as an autosomal recessive, features of metachromatic leukodystrophy and of mucopolysaccharidoses occur together. The white matter suffers progressive destruction with sulfatides accumulating in mac...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809059509
更新日期:1988-07-01 00:00:00
abstract::An enzyme-immunoassay has been developed for the detection of myoglobin in human serum and urine which is specific, accurate, precise, and has a sensitivity of 3 ng/ml. When compared with radioimmunoassay, the enzyme-immunoassay gives markedly similar results. Sera from normal adults had a myoglobin concentration in t...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027909059049
更新日期:1979-10-01 00:00:00
abstract:AIM:The purpose of this study was to elucidate the clonality of fibrous dysplasia based on X-chromosome inactivation mosaicism and polymorphism in female somatic cells at the phosphoglycerate kinase (PGK) and androgen receptor (AR) loci using microdissection technology. MATERIALS AND METHODS:Nine patients with fibrous...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020801911496
更新日期:2008-06-01 00:00:00
abstract::The clinical course and biopsy findings of twenty-one patients with IgA nephropathy, followed up for a mean period of 37.4 mth (range 24-54 mth) after diagnosis, were reviewed retrospectively to determine whether the clinical presentations, the laboratory findings or histopathologic changes have prognostic implication...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028609090824
更新日期:1986-01-01 00:00:00
abstract::A calcified nodule on the liver of a 62-year-old man from North Carolina, USA, contained a degenerated nymph of Linguatula serrata. The nodule was incidentally discovered at laparotomy for malignant lymphoma and cholelithiasis. The cuticle was all that remained of the parasite, but sclerotized openings and large spine...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809066635
更新日期:1988-04-01 00:00:00
abstract:AIM:To demonstrate that Flinders Island spotted fever (FISF), a spotted fever group rickettsial infection caused by Rickettsia honei, is found not only on Flinders Island (Bass Strait), Tasmania, but elsewhere in south-east Australia. METHODS:Cases of FISF were identified by rickettsial serology, culture and the detec...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020500099247
更新日期:2005-06-01 00:00:00
abstract::Multiplex immunofluorescence (mIF) allows simultaneous antibody-based detection and quantification of the expression of up to six markers, plus a nuclear counterstain, on a single tissue section. Recent studies have shown the potential for mIF to advance our understanding of complex disease processes, including cancer...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2017.11.087
更新日期:2018-04-01 00:00:00
abstract::Certain diagnoses in dermatopathology have significant implications for patient management and on occasion appropriate clinical care may be facilitated by a phone call from the reporting dermatopathologist to the referring doctor. Whether this is appropriate depends on a number of factors. The concept of 'critical dia...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2017.10.015
更新日期:2018-04-01 00:00:00
abstract::Eight histologically-confirmed cases of clear cell sarcoma of the kidney (CCSK) were studied for possible mutations in the p53 tumor suppressor gene by the immunohistochemical demonstration of mutant p53 proteins using a monoclonal (DO7: Dako) and a polyclonal (AB565: Chemicon) antibody to p53 protein. All cases exhib...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029600169034
更新日期:1996-08-01 00:00:00
abstract::The case is reported of a woman aged 60 yrs who presented with systemic symptoms and who was found to have proteinuria of 3.5 g per day. A renal biopsy revealed numerous neoplastic cells filling many of the glomerular capillary lumina. Immunoperoxidase stains revealed that the phenotype of the malignant cells was LCA+...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029109063574
更新日期:1991-07-01 00:00:00
abstract::A histopathological examination was made of 60 stapes obtained during surgery for clinical otosclerosis. The findings, correlated with the clinical history and macroscopic appearances of the stapes, led to the following observations. The histological extent of the focus of otosclerosis agrees well with the macroscopic...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409067908
更新日期:1984-01-01 00:00:00
abstract::Tonsil swabs were collected from 248 children (1 through 10 yr) who presented with acute tonsillitis. A beta-hemolytic streptococcus was grown from 129 (53%) of 244 cases and as the sole pathogen from 83 (47%) of 178 cases. Beta-Hemolytic streptococci were especially common over the age of 6 yr (68% of children) relat...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409067915
更新日期:1984-01-01 00:00:00
abstract:AIMS:We aimed to evaluate the effects of caffeic acid phenethyl ester (CAPE) on lithium (Li)-induced lung toxicity. METHODS:Twenty-two adult male Wistar albino rats weighing between 280 and 300 g were used. The rats were randomly divided into three groups: control, Li and Li+CAPE groups. Li and CAPE were co-administer...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020500464904
更新日期:2006-02-01 00:00:00
abstract::We counted apoptotic thymic cortical lymphocytes in semi-thin plastic sections of 266 human autopsy thymuses. The decreased patients included in the study were all aged less than 40 yrs and all died within 72 hrs of the onset of symptoms. Based on published data on animal and human material it was anticipated that ind...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029400169261
更新日期:1994-04-01 00:00:00
abstract::Rapid rescreening was established in our laboratory in 1995, following the publication of several studies indicating improved sensitivity for the detection of abnormalities in cervical smears. During the study period, 285,841 negative smears (representing 89.09% of the total workload) were rapidly rescreened. A total ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/003130299104765
更新日期:1999-11-01 00:00:00
abstract::In various tumor types dentritic cell, infiltration and the presence of tumor-infiltrating lymphocytes have been associated with an improved clinical outcome. In the uterine cervix these immunocompetent cells have been associated with improved prognosis in high stage disease. The current study examines the significanc...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029600169274
更新日期:1996-11-01 00:00:00