Detection of false-negative Papanicolaou smears by rapid rescreening in a large routine cervical cytology laboratory.

abstract：:In 50 necropsies on leukaemic children, the major cause of death was infection. In patients dying during therapy for induction or reinduction of remission, the most frequent infection was a distinctive neutropenic enterocolitis or typhlitis. This was seen in 46% of the whole series and was a major factor in the death ...

journal_title：Pathology

authors： Moir DH,Bale PM

更新日期：1976-07-01 00:00:00

abstract：:Isolation of the new pandemic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for diagnostic and research purposes including assessment of novel therapeutics. Several primary and continuous cell lines are currently used, and new organoid and engineered cell lines are being developed for...

journal_title：Pathology

authors： Stelzer-Braid S,Walker GJ,Aggarwal A,Isaacs SR,Yeang M,Naing Z,Ospina Stella A,Turville SG,Rawlinson WD

更新日期：2020-12-01 00:00:00

abstract：AIM:To determine whether the common respiratory pathogen, Chlamydia pneumoniae, was associated with atherosclerotic plaques in Australian subjects. METHODS:A total of 29 coronary atherosclerotic lesions and 18 normal coronary arterial samples were tested for the presence of C. pneumoniae by PCR and immunofluorescence ...

journal_title：Pathology

authors： Cochrane M,Kalle WH,Roffey P,Moriarty HT

更新日期：2002-06-01 00:00:00

abstract：:The aim of this study was to establish the diagnostic utility of p53 immunohistochemistry in Barrett's esophagus. Three pathologists reviewed endoscopic biopsy specimens and one surgical specimen derived from 102 subjects in a prospective follow-up series. Dysplasia was graded as negative, indefinite, low grade and hi...

journal_title：Pathology

authors： Khan S,Do KA,Kuhnert P,Pillay SP,Papadimos D,Conrad R,Jass JR

更新日期：1998-05-01 00:00:00

abstract：:Lymphadenopathy associated with hemorrhage as a presenting feature of primary (AL) amyloidosis has not previously been described. We report two such cases one of whom had an acquired factor X and IX deficiency. The clinical presentations were characterized by sudden spontaneous enlargement of lymph nodes followed by p...

journal_title：Pathology

authors： Hanley JP,MacLean FR,Evans JL,Colls BM,Robinson BA,Patton WN,Heaton DC

更新日期：2000-02-01 00:00:00

abstract：:A fatal case of multiple sulfatase deficiency in a 10-year-old girl is reported. In this rare disease, which is inherited as an autosomal recessive, features of metachromatic leukodystrophy and of mucopolysaccharidoses occur together. The white matter suffers progressive destruction with sulfatides accumulating in mac...

journal_title：Pathology

authors： Kepes JJ,Berry A 3rd,Zacharias DL

更新日期：1988-07-01 00:00:00

abstract：:We have devised a simple, sensitive quantitative method for the determination of serum methemalbumin. The method uses a modified Allen correction to correct the alpha band of methemalbumin at 623 nm for background turbidity. The technique is robust and is more sensitive than Schumm's test. ...

journal_title：Pathology

authors： Cowley DM,Powell VR

更新日期：1986-07-01 00:00:00

abstract：:Sera from 82 patients with acute or chronic hepatitis and 40 chronic carriers of hepatitis B were examined by ELISA and immunoblotting for reactivity with the glycolytic enzyme aldolase. The results of the ELISA tests, expressed as a percentage of a positive control, were compared to those obtained with sera from 39 p...

journal_title：Pathology

authors： Brown C,Toh BH,Pedersen JS,Clarke FM,Mackay IR,Gust I

更新日期：1987-10-01 00:00:00

abstract：:Eccrine syringofibroadenoma is a rare benign tumor of the skin arising from the acrosyringeal portion of the eccrine duct. The tumor was first described by Mascaro in 1963, and since then only 8 case reports in 6 publications have been documented. This lesion is likely to be misdiagnosed both clinically and histologic...

journal_title：Pathology

authors： Billson VR,Dyall-Smith DJ

更新日期：1991-07-01 00:00:00

abstract：:Co-operation by outside centres has made it possible to offer bone marrow chromosome analysis to patients living up to 1800 kilometres from the central cytogenetics laboratory. Diagnostic karyotypes have been obtained in 9 of 10 bone marrow specimens which were partially processed before being transported to the city ...

journal_title：Pathology

authors： Bell JA

更新日期：1978-07-01 00:00:00

abstract：:Tumour infiltrating lymphocytes in primary melanoma have been found to correlate with patient outcomes. A subpopulation of tumour infiltrating lymphocytes expresses the transcription factor forkhead box protein 3 (FOXP3). These are known as FOXP3+ T-regulatory cells (Tregs) and are thought to play an immune suppressiv...

journal_title：Pathology

authors： Leslie C,Bowyer SE,White A,Grieu-Iacopetta F,Trevenen M,Iacopetta B,Amanuel B,Millward M

更新日期：2015-10-01 00:00:00

abstract：:We report a case of a 25-year-old man who presented with a large rectal bleed and positive Meckel's scan followed by surgical excision of a Meckel's diverticulum. The diverticulum was lined by gastric body type mucosa showing evidence of active chronic gastritis associated with the presence of Helicobacter pylori orga...

journal_title：Pathology

authors： Hill P,Rode J

更新日期：1998-02-01 00:00:00

abstract：:Multiplex immunofluorescence (mIF) allows simultaneous antibody-based detection and quantification of the expression of up to six markers, plus a nuclear counterstain, on a single tissue section. Recent studies have shown the potential for mIF to advance our understanding of complex disease processes, including cancer...

journal_title：Pathology

authors： Lim JCT,Yeong JPS,Lim CJ,Ong CCH,Wong SC,Chew VSP,Ahmed SS,Tan PH,Iqbal J

更新日期：2018-04-01 00:00:00

abstract：AIMS:Mounting evidence indicates that deregulation of apoptosis is involved in the mechanisms of cancer development. Bax-interacting factor-1 (Bif-1) interacts with both Bax and Bak that are crucial for the intrinsic apoptosis signalling. Functionally, loss of Bif-1 expression has been proven to enhance tumorigenesis. ...

journal_title：Pathology

authors： Kim SY,Oh YL,Kim KM,Jeong EG,Kim MS,Yoo NJ,Lee SH

更新日期：2008-10-01 00:00:00

abstract：AIMS:Matrix metalloproteinases (MMPs) have various functions that play roles in carcinoma development. In this study, we investigated the expression of two representative MMPs, MMP-7 and MMP-11, in papillary thyroid carcinomas. METHODS:We immunohistochemically investigated the expression of these MMPs in 196 cases of ...

journal_title：Pathology

authors： Ito Y,Yoshida H,Kakudo K,Nakamura Y,Kuma K,Miyauchi A

更新日期：2006-10-01 00:00:00

abstract：:Noncondylomatous papilloma virus infection of the cervix is much more common than formerly realized. The majority of patients are young, but two cases are reported here in postmenopausal women. ...

journal_title：Pathology

authors： Laverty CR,Booth N,Hills E,Cossart Y,Wills EJ

更新日期：1978-10-01 00:00:00

abstract：:The pathological findings in a retrospective review of 100 consecutive intracranial stereotactic biopsies are presented. Definite diagnosis could be established in the majority (89) of cases and included 85 neoplasms (69 primary cerebral tumors, 10 non-Hodgkin's lymphomas and 6 metastases) and 4 non-neoplastic process...

journal_title：Pathology

authors： Robbins PD,Yu LL,Lee M,Stokes BA,Thomas GW,Watson P,Wong G

更新日期：1994-10-01 00:00:00

abstract：:The ultimate goal of defining cancer specific precursors is to facilitate early detection and intervention before the development of invasive malignancy. Unlike other malignancies involving the female genital tract such as cervical or endometrial carcinomas, precursor lesions of ovarian carcinomas have not been well c...

journal_title：Pathology

authors： Lim D,Oliva E

更新日期：2013-04-01 00:00:00

abstract：:The estimation of plasma alanine aminotransferase (ALT) has been proposed as a surrogate test to identify potential non-A, non-B hepatitis carriers in blood donor populations. This report describes an ALT screening procedure which uses wells of microtitration trays as reactant vessels. The method utilizes a rate readi...

journal_title：Pathology

authors： Hyland CA,Douglas R,Mazzocchi R,Young IF

更新日期：1988-07-01 00:00:00

abstract：:A novel grading system based on the counting of poorly differentiated clusters (PDC) of neoplastic cells at the invasive margin and in the tumour stroma was recently introduced among the histological parameters predictive of adverse clinical outcome in colorectal cancer (CRC). The aim of this study was to correlate th...

journal_title：Pathology

authors： Barresi V,Bonetti LR,Bettelli S

更新日期：2015-10-01 00:00:00

abstract：:The morphology of livers of Wistar rats treated with beta-carotene (BC), vitamin A (VA, retinol acetate) or corn oil (CO, controls) and submitted to the resistant hepatocyte model of carcinogenesis was studied. Preneoplastic lesions (PNL) were smaller and less numerous in the BC group. The latter group also presented ...

journal_title：Pathology

authors： Dagli ML,Guerra JL,Sinhorini IL,Wu TS,Rizzi MB,Penteado MV,Moreno FS

更新日期：1998-08-01 00:00:00

abstract：AIMS:p73, a homologue of p53, is known as a negative regulator of tumour progression. However, delta Np73, an isoform of p73 lacking the NH2-terminal transactivation domain plays an oncogenic role by interfering with the activity of p53 and TA (full-length transactivating isoforms) p73. In this study, we investigated t...

journal_title：Pathology

authors： Ito Y,Uramoto H,Funa K,Yoshida H,Jikuzono T,Asahi S,Higashiyama T,Tomoda C,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi A

更新日期：2006-06-01 00:00:00

abstract：:The clinical and autopsy findings in a premature baby who died of acute renal failure after therapy with gentamicin (5 mg/kg/day) and penicillin are presented. The serum gentamicin concentration had reached toxic levels when anuria developed. Numerous periodic acid Schiff (PAS) positive, diastase resistant cytoplasmic...

journal_title：Pathology

authors： Chan KW,Ng WL

更新日期：1985-07-01 00:00:00

abstract：:Perhexiline maleate is a potent anti-anginal drug which may cause alcoholic-type hepatitis and cirrhosis. We report a case of a patient who developed cirrhosis on a relatively low dose within 16 mth. ...

journal_title：Pathology

authors： Pieterse AS,Rowland R,Dunn D

更新日期：1983-04-01 00:00:00

abstract：:Gene targeting ('knock-out') technology is now widely used in the basic science of all disciplines of pathology and particularly auto-immune and inflammatory disease. Gene targeting is the wilful introduction of precise mutations into the genome of an animal, usually a mouse, affecting the function of a single gene or...

journal_title：Pathology

authors： Riminton DS

更新日期：2002-04-01 00:00:00

abstract：:We counted apoptotic thymic cortical lymphocytes in semi-thin plastic sections of 266 human autopsy thymuses. The decreased patients included in the study were all aged less than 40 yrs and all died within 72 hrs of the onset of symptoms. Based on published data on animal and human material it was anticipated that ind...

journal_title：Pathology

authors： Middleton G,Reid LE,Harmon BV

更新日期：1994-04-01 00:00:00

abstract：:BAP1 (BRCA1-Associated Protein 1) was initially identified as a protein that binds to BRCA1. BAP1 is a tumour suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin-proteasome system and the DNA damage response pathway. Germline mutat...

journal_title：Pathology

authors： Murali R,Wiesner T,Scolyer RA

更新日期：2013-02-01 00:00:00

abstract：:Endomyocardial biopsy (EMB) is a highly-specialised procedure that is associated with some controversy as to its diagnostic role due to its inconsistency in diagnosing a wide variety of cardiac diseases. Given the advances and sophistication in echocardiography and cardiac magnetic resonance imaging (MRI), the vast ma...

journal_title：Pathology

authors： Khan T,Selvakumar D,Trivedi S,Rao K,Harapoz M,Thiagalingam A,Denniss AR,Varikatt W

更新日期：2017-12-01 00:00:00

abstract：:Review of problematic melanocytic consultation cases has enabled identification of the most common variants of benign melanocytic proliferations which can be confused with melanoma. Apart from Spitz naevus, the most common in this group of lesions are pigmented spindle cell naevus and atypical dermal nodule. Potential...

journal_title：Pathology

authors： Cook MG

更新日期：2004-10-01 00:00:00

abstract：:A review of the morphological and metabolic interactions between hepatocytes, the various sinusoidal cells and sinusoidal blood is presented. This field of investigation is rapidly expanding, with widespread implications in the regulation of physiological processes and diseases in the liver and other organs. Although ...

journal_title：Pathology

authors： Fraser R,Day WA,Fernando NS

更新日期：1986-01-01 00:00:00