The detection of Chlamydia pneumoniae in atherosclerotic plaques of Australian subjects.

Abstract:

AIM:To determine whether the common respiratory pathogen, Chlamydia pneumoniae, was associated with atherosclerotic plaques in Australian subjects. METHODS:A total of 29 coronary atherosclerotic lesions and 18 normal coronary arterial samples were tested for the presence of C. pneumoniae by PCR and immunofluorescence methods. RESULTS:Chlamydia pneumoniae was detected in 15 of the atheromatous lesions as well as in three of the normal tissues; the immunofluorescence assay was more sensitive (P=0.028) than PCR (P=0.26). CONCLUSIONS:These findings contradict previous Australian studies which did not detect C. pneumoniae in atherosclerotic plaques, thereby discounting the speculation that its absence was likely due to geographical variation. The detection of the bacterium in some of the normal tissues suggests that C. pneumoniae infection might be an initial trigger of atherosclerotic development.

journal_name

Pathology

journal_title

Pathology

authors

Cochrane M,Kalle WH,Roffey P,Moriarty HT

doi

10.1080/00313020220131363

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

270-4

issue

3

eissn

0031-3025

issn

1465-3931

journal_volume

34

pub_type

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