Abstract：
:The intimal thickness of the coronary arteries of humans less than 20 years of age was compared with that 9 other species. It was found that humans were unique amongst the species studied in showing substantial intimal thickening at an early age. The intimal thickening was associated with defects of the internal elastic lamina (IEL), which in humans were not repaired, but which in other species were associated with an effective reduplication of the IEL. This reformed IEL appeared in other species to form a significant obstruction to the diffusion of macromolecules from the lumen into the arterial wall, but did not do so in humans. Preliminary observations also indicated that the endothelial cells were closely associated with a well-formed elastin membrane in other species, and formed a continuous inner lining for the arterial wall. In human coronary arteries with substantial intimal thickening, the endothelium was incomplete, with many bare areas.
journal_name
Pathologyjournal_title
Pathologyauthors
Sims FHdoi
10.3109/00313028909059547subject
Has Abstractpub_date
1989-04-01 00:00:00pages
115-24issue
2eissn
0031-3025issn
1465-3931journal_volume
21pub_type
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