Abstract:
:A rapid technique suitable for routine laboratory use for determining the percentage of large platelets in the peripheral blood is described. In 50 haematologically normal subjects, megathrombocytes (platelets with a volume of 16-33 fl) constituted 3.0-16.6% (mean +/- 2 SD) of the platelet count. Of the 10 patients examined with immune thrombocytopenic purpura, an increased percentage of megathrombocytes (mean 26.6%) was found in all with severe thrombocytopenia, and in 6 of 8 (mean 19.8%) with moderate thrombocytopenia; the percentages were not influenced by prior splenectomy. Six of 12 patients with severe hypomegakaryocytic thrombocytopenia had an increased percentage of large platelets (mean 15.9%), as did one of 21 patients (mean 9.9%) with moderate thrombocytopenia of simimlar aetiology. When patients with nearly identical platelet counts were compared, the mean percentage of megathrombocytes was greater in immune than in hypomegakaryocytic thrombocytopenia for both severe (t=3.17, P less than 0.01) and moderate (t=4.5, P less than 0.001) thrombocytopenia. An increased percentage of large platelets (mean 21.9%) was found in 6 to 8 patients with disseminated intravascular coagulation, in 7 of 20 (mean 15.8%) with chronic myeloproliferative disorders and in one of 15 (mean 8.8%) with reactive thrombocytosis. Determination of the percentage of megathrombocytes by this technique assists in differentiating immune thrombocytopenia from hypomegakaryocytic thrombocytopenia, in diagnosing mild disseminated intravascular coagulation, and in determining whether thrombocytosis is reactive or a consequence of a myeloproliferative disorders.
journal_name
Pathologyjournal_title
Pathologyauthors
Hunt FAdoi
10.3109/00313027609094424subject
Has Abstractpub_date
1976-01-01 00:00:00pages
47-55issue
1eissn
0031-3025issn
1465-3931journal_volume
8pub_type
杂志文章相关文献
PATHOLOGY文献大全abstract::Lymph node metastasis (LNM) is an important factor for predicting prognosis and selecting appropriate treatment in early gastric cancers (EGCs). We investigated the histopathological and microenvironmental predictors of LNM in EGCs. We retrieved 43 cases of EGC without LNM and 59 cases with LNM. Clinicopathological va...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2017.06.003
更新日期:2017-10-01 00:00:00
abstract::With the use of 2 independent techniques, circulating monomeric and oligomeric IgM were detected in the majority of 29 patients with chronic lymphocytic leukemia (CLL). In contrast it was detected only in trace quantities in a minority of healthy subjects. In the CLL group no significant correlation was observed betwe...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029309068902
更新日期:1993-01-01 00:00:00
abstract::Epithelial ovarian neoplasms can be divided into three distinct clinicopathological groups: benign, malignant and borderline tumours. Borderline tumours are less aggressive than epithelial carcinomas, with an indolent clinical course and delayed recurrence. However, a subset of these cases can progress to malignancy a...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2020.07.010
更新日期:2021-02-01 00:00:00
abstract::A 59 yr old male presented with abdominal pain and jaundice. CT scan showed a tumor in the pancreas with secondaries in the liver, peri-pancreatic lymph nodes, vertebral bone marrow and subcutaneous tissue of the neck together with a cervical lymph node. The patient died after 2 wks and autopsy revealed complete repla...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.3109/00313029309066580
更新日期:1993-07-01 00:00:00
abstract::The morphology of livers of Wistar rats treated with beta-carotene (BC), vitamin A (VA, retinol acetate) or corn oil (CO, controls) and submitted to the resistant hepatocyte model of carcinogenesis was studied. Preneoplastic lesions (PNL) were smaller and less numerous in the BC group. The latter group also presented ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029800169416
更新日期:1998-08-01 00:00:00
abstract:AIMS:Hep Par 1 has been described as a specific marker of hepatocellular differentiation and its immunohistochemical use has been suggested as a helpful tool for hepatocellular carcinoma (HCC) diagnosis. Most metastatic liver tumours come from the gastrointestinal tract and usually can be distinguished from HCC only th...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/0031302021000009333
更新日期:2002-10-01 00:00:00
abstract:AIM:To determine whether whole of gestation exposure of fetal mouse brain to mobile telephone radiofrequency fields produces a stress response detectable by induction of heat shock proteins (HSPs). METHODS:Using a purpose-designed exposure system at 900 MHz, pregnant mice were given a single, far-field, whole body exp...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020902756261
更新日期:2009-01-01 00:00:00
abstract:AIM:We investigated the role of renal sympathetic innervation in the deterioration of renal haemodynamic and excretory functions during the early post-ischaemic phase of renal ischaemia/reperfusion injury. METHODS:Anaesthetised male Sprague-Dawley rats were subjected to unilateral renal ischaemia by clamping the left ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313021003631304
更新日期:2010-04-01 00:00:00
abstract::We describe a 44-year-old female with a known history of a solitary osteochondroma of the scapula followed on X-ray for five years. She then presented with a rapidly growing lump. Imaging studies confirmed the presence of an aggressive looking lesion. Excision was performed and pathology showed a dedifferentiated chon...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/003130299104873
更新日期:1999-11-01 00:00:00
abstract:AIMS:The increasing importance of cardiac disease has generated an interest in improved screening strategies regarding preclinical cardiac abnormalities and employing measurement of circulating biomarkers. This review focuses on the utility of the B-type natriuretic peptides (NP) and the cardiac troponins (cTns) for th...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1097/PAT.0b013e32834e786e
更新日期:2012-02-01 00:00:00
abstract::Three cases of nodular lymphomas with cytoplasmic inclusions were studied histologically, histochemically and immunocytochemically, and ultrastructurally. One case had Russell body-like inclusions, another had needle-like inclusions not previously reported, while the last showed cells with cytoplasmic vacuoles. Two of...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.3109/00313028209092121
更新日期:1982-10-01 00:00:00
abstract:AIMS:We have identified in malignant melanoma an angio-tumoural complex in which tumour cells occupy a pericytic location along the endothelium of microvessels without evidence of intravasation. This pericytic angiotropism of melanoma cells, without any sign of intravasation, suggests that melanoma cells may migrate al...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020412331282708
更新日期:2004-10-01 00:00:00
abstract::Recent controversies both in Australia and overseas have focused public attention on autopsy practice. It has become apparent that there is an increasing expectation amongst the public for more detailed information concerning autopsy procedures and, in particular, tissue retention. This article attempts to review the ...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313020120105660
更新日期:2002-02-01 00:00:00
abstract::The case is reported of a woman aged 60 yrs who presented with systemic symptoms and who was found to have proteinuria of 3.5 g per day. A renal biopsy revealed numerous neoplastic cells filling many of the glomerular capillary lumina. Immunoperoxidase stains revealed that the phenotype of the malignant cells was LCA+...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029109063574
更新日期:1991-07-01 00:00:00
abstract::Granulomatous (lobular) mastitis is a rare inflammatory breast disease affecting parous reproductive-aged women. Once considered idiopathic, there is growing evidence of an association with corynebacteria infection, especially in the setting of a distinct histological pattern termed cystic neutrophilic granulomatous m...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2017.01.006
更新日期:2017-06-01 00:00:00
abstract:AIMS:To investigate KAI1 and survivin expression in infiltrating ductal carcinomas, and to evaluate the relationship between clinicopathological factors and KAI1 and survivin expression levels in breast cancers. METHODS AND RESULTS:KAI and survivin expression levels were measured in 62 patients, using immunohistochemi...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020500058144
更新日期:2005-04-01 00:00:00
abstract::Contamination of cell cultures for virus isolation has been increasingly encountered. By reviewing and changing the antimicrobials incorporated in cell culture media, we aim to control this problem. Contaminated cell culture fluids were inoculated for bacterial and fungal isolation, identification and antibacterial su...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029600169374
更新日期:1996-11-01 00:00:00
abstract::A calcified nodule on the liver of a 62-year-old man from North Carolina, USA, contained a degenerated nymph of Linguatula serrata. The nodule was incidentally discovered at laparotomy for malignant lymphoma and cholelithiasis. The cuticle was all that remained of the parasite, but sclerotized openings and large spine...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809066635
更新日期:1988-04-01 00:00:00
abstract:AIM:Gasdermin-like (GSDML) is a novel member of the cancer associated gasdermin-domain containing (GSDMDC) protein family. The GSDMDC family has been linked to cancer development and progression, and this is the first study analysing the expression and intracellular localisation of GSDML. METHODS:GSDML gene transcript...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020701716250
更新日期:2008-01-01 00:00:00
abstract::Rare tumours are a heterogeneous group of conditions that encompass benign to malignant lesions both of stromal and epithelial origin. Here some of these tumours are described, in which the authors have most familiarity. An outline of medullary carcinoma is also presented. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020802563528
更新日期:2009-01-01 00:00:00
abstract::Rheumatoid Arthritis (RA) synovial membranes were examined by single and dual immunohistological techniques with a number of monoclonal antibodies against lymphocyte and macrophage related antigens. CD4 positive T lymphocytes frequently expressed MHC Class II antigens and were found in sublining collections in close a...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029209063615
更新日期:1992-01-01 00:00:00
abstract::A diptheria immunoglobulin has been prepared from selected blood donations to the Australian Red Cross Transfusion Services. A dose of 250 I.U. has been demonstrated to raise the titre of diptheria antitoxin in non-immune subjects to protective levels within 24 h, and these levels remain protective for at least 5 wk. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027909059015
更新日期:1979-07-01 00:00:00
abstract::Deregulation of the receptors of TNF-related apoptosis inducing ligand (TRAIL) has been reported in various cancers. In an effort to define the role of these receptors we profiled their expression in gallbladder cancer (GBC) and explored their clinical significance. Expression of TRAIL receptors' mRNA in GBC was analy...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2019.12.001
更新日期:2020-04-01 00:00:00
abstract::Lymphoplasmacytic lymphoma (LPL) represents a distinct type of mature B-cell lymphoma with a substantial subset of cases being associated with Waldenström macroglobulinaemia (WM), defined as primarily bone marrow involvement and the presence of an IgM monoclonal paraprotein. MYD88 L265P mutation, although not specific...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2019.09.009
更新日期:2020-01-01 00:00:00
abstract::AxI, Dtk and Mer are recently described receptors that constitute a new receptor tyrosine kinase subfamily. They bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) that is structurally related to the anticoagulation factor protein S. Studies suggest a role for these receptors in developmental pr...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313029700169744
更新日期:1997-05-01 00:00:00
abstract::This review will focus on the molecular biology of lymphoproliferative disorders with emphasis on lymphomas. The spectrum of known recurrent gene rearrangements found in lymphomas will be outlined and their relevance to diagnosis and subclassification of disease will be discussed. Finally, a survey of the current tren...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313020500376553
更新日期:2005-12-01 00:00:00
abstract::Forty-six necropsy cases of recurrent pyogenic cholangitis (RPC) among Chinese in Hong Kong were reviewed. Intrahepatic biliary pigment stones or bile sludge were present in all cases and liver abscesses were common (80%). Histologically the early lesion was marked by acute inflammation in portal tracts with frequent ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028009077105
更新日期:1980-07-01 00:00:00
abstract::A male iniencephalic foetus of about 25 weeks gestation is described. The baby was born to a 22-year-old mother, who presented with abdominal pain of 1 day duration. An ultrasound scan at that time showed multiple foetal anomalies and the pregnancy was terminated. A stillborn baby was delivered. At autopsy, characteri...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:
更新日期:2001-02-01 00:00:00
abstract::The main controversy about nerve sheath tumors (NSTs) has been their histogenesis. A Schwann cell origin has been proposed by many investigators for both schwannomas and neurofibromas. However Erlandson and Woodruff observed that while schwannomas appeared to be composed predominantly of Schwann cells, neurofibromas c...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029400169051
更新日期:1994-01-01 00:00:00
abstract::A 60 year old white male presented with atypical chest pain and exercise-induced myalgia. Physical examination revealed slight proximal limb muscle weakness and wasting. Serum creatine phosphokinase levels were persistently elevated and electromyography showed changes consistent with a mild myopathy. Light microscopic...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029109061442
更新日期:1991-01-01 00:00:00