Abstract:
AIM:To determine whether whole of gestation exposure of fetal mouse brain to mobile telephone radiofrequency fields produces a stress response detectable by induction of heat shock proteins (HSPs). METHODS:Using a purpose-designed exposure system at 900 MHz, pregnant mice were given a single, far-field, whole body exposure at a specific absorption rate of 4 W/kg for 60 min/day from day 1 to day 19 of gestation. Control mice were sham-exposed or freely mobile in a cage to control for any stress caused by restraint in the exposure module. Immediately prior to parturition on day 19, fetal brains were collected, fixed in 4% paraformaldehyde and paraffin-embedded. Three coronal sections encompassing a wide range of anatomical regions were cut from each brain and any stress response detected by immunostaining for HSP25, 32 and 70. RESULTS:There was no induction of HSP32 or 70 in any brains, while HSP25 expression was limited to two brainstem nuclei and occurred consistently in exposed and non-exposed brains. CONCLUSION:Whole of gestation exposure of fetal mouse brains to mobile phone radiofrequency fields did not produce any stress response using HSPs as an immunohistochemical marker.
journal_name
Pathologyjournal_title
Pathologyauthors
Finnie JW,Chidlow G,Blumbergs PC,Manavis J,Cai Zdoi
10.1080/00313020902756261subject
Has Abstractpub_date
2009-01-01 00:00:00pages
276-9issue
3eissn
0031-3025issn
1465-3931pii
S0031-3025(16)32024-4journal_volume
41pub_type
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