Abstract:
:This review will focus on the molecular biology of lymphoproliferative disorders with emphasis on lymphomas. The spectrum of known recurrent gene rearrangements found in lymphomas will be outlined and their relevance to diagnosis and subclassification of disease will be discussed. Finally, a survey of the current trends in gene expression profiling of lymphomas by microarray technology will be presented with reference to implications for diagnosis, classification, prognosis and treatment.
journal_name
Pathologyjournal_title
Pathologyauthors
Catalano A,Iland Hdoi
10.1080/00313020500376553subject
Has Abstractpub_date
2005-12-01 00:00:00pages
508-22issue
6eissn
0031-3025issn
1465-3931pii
HX2GPG386102P705journal_volume
37pub_type
杂志文章,评审相关文献
PATHOLOGY文献大全abstract:AIMS:p73, a homologue of p53, is known as a negative regulator of tumour progression. However, delta Np73, an isoform of p73 lacking the NH2-terminal transactivation domain plays an oncogenic role by interfering with the activity of p53 and TA (full-length transactivating isoforms) p73. In this study, we investigated t...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020600696298
更新日期:2006-06-01 00:00:00
abstract::In 14 stock rabbits experimental aneurysms (saccular, fusiform or berry) were produced on the common carotid artery or the aorta by microvascular surgery using a modification of the venous pouch technique. The animals were given a cholesterol-rich diet at varying times postoperatively to determine the susceptibility o...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028109086647
更新日期:1981-10-01 00:00:00
abstract::Malignant tumours with teratoid or blastomatous features are exceptionally rare in the upper respiratory tract with only 8 documented cases, including the 3 in this report. The tumours occurred in adults aged 27 to 62 yr, and the sites of origin were the ethmoid sinus (4 cases), ethmoid and other paranasal sinuses (2 ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028309085168
更新日期:1983-10-01 00:00:00
abstract:AIMS:Predicting the clinical behaviour of gastrointestinal stromal tumours (GISTs) is difficult and criteria delineating benign from malignant cases are not firmly established. The aims of this study were to define the clinicopathological and molecular features of 66 GISTs, and to determine whether any specific paramet...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020400023628
更新日期:2005-02-01 00:00:00
abstract:AIMS:Malakoplakia is a characteristic inflammatory condition which is usually seen in the urogenital tract. Gastrointestinal malakoplakia is seen in association with a variety of conditions such as ulcerative colitis, diverticular disease, adenomatous polyps and carcinoma. The purpose of this paper is to report four ad...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/003130202760120481
更新日期:2002-08-01 00:00:00
abstract::Rare tumours are a heterogeneous group of conditions that encompass benign to malignant lesions both of stromal and epithelial origin. Here some of these tumours are described, in which the authors have most familiarity. An outline of medullary carcinoma is also presented. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020802563528
更新日期:2009-01-01 00:00:00
abstract::Lymphadenopathy associated with hemorrhage as a presenting feature of primary (AL) amyloidosis has not previously been described. We report two such cases one of whom had an acquired factor X and IX deficiency. The clinical presentations were characterized by sudden spontaneous enlargement of lymph nodes followed by p...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/003130200104510
更新日期:2000-02-01 00:00:00
abstract::Epigenetic regulation is emerging as a critical mechanism for pancreatic ductal adenocarcinoma (PDA) development. Histone methylation is an important regulatory mechanism, altering chromatin structure and promoter accessibility and causing aberrant gene expression. NSD1 and SETD2 genes encoding two histone H3K36 methy...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2019.02.005
更新日期:2019-06-01 00:00:00
abstract::We evaluated an immunoradiometric assay for serum TSH (IRMA-TSH) and compared it with established indices of thyroid function in 208 patients with either frank thyroid disease, conditions of abnormal thyroxine protein binding, or conditions which are known to produce discordant thyroid results, viz. pregnancy or estro...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028709066554
更新日期:1987-07-01 00:00:00
abstract::Penile metastases from prostate cancer are rare and are usually a manifestation of wide-spread cancer dissemination. Isolated urethral metastases form a small fraction of these cases, have a longer survival rate and may represent spread by implantation following instrumentation. We report a case of prostatic carcinoma...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029800169306
更新日期:1998-05-01 00:00:00
abstract::In the management of rheumatic diseases, peptic ulceration associated with anti-inflammatory drug therapy is a major problem and seriously limits the usefulness of these agents. In acute experiments with a guinea pig total gastric pouch preparation, gastric damage induced by the prostaglandin synthetase inhibitor indo...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028509105493
更新日期:1985-07-01 00:00:00
abstract::Isolation of the new pandemic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for diagnostic and research purposes including assessment of novel therapeutics. Several primary and continuous cell lines are currently used, and new organoid and engineered cell lines are being developed for...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2020.09.012
更新日期:2020-12-01 00:00:00
abstract::TGF-β induces epithelial-mesenchymal transition (EMT), which is involved in tumour progression. This study aims to identify and characterise novel factors potentially related to TGF-β-mediated tumour aggression in breast cancer. We treated the human mammary epithelial cell line MCF10A with TGF-β and observed TGF-β-dep...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2019.02.001
更新日期:2019-06-01 00:00:00
abstract::Rapid rescreening was established in our laboratory in 1995, following the publication of several studies indicating improved sensitivity for the detection of abnormalities in cervical smears. During the study period, 285,841 negative smears (representing 89.09% of the total workload) were rapidly rescreened. A total ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/003130299104765
更新日期:1999-11-01 00:00:00
abstract::Four hundred and ten thyroid nodules, 127 breast lumps and 43 lymph nodes were sampled and analyzed to compare the classical aspiration (ASP) technique with the non aspiration needle jab (NASP) technique. The adequacy of cellularity, significant blood staining and the discomfort felt by the patient were assessed and s...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029500169243
更新日期:1995-10-01 00:00:00
abstract::The objective of this study was to establish a population based reference range for a commercial immunoblot assay detecting myositis specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs), and to assess the diagnostic performance of this reference range against the manufacturer's recommended rang...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2016.03.012
更新日期:2016-06-01 00:00:00
abstract:AIMS:Clinical decision making and optimal clinical trial design based on cancer genetic information will be increasingly informed by the mutational status of multiple genes. METHODS:We performed mutation screening on 22 fresh frozen gastrointestinal stromal tumours (GISTs) using a multiplexed oncogene screening panel ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e3283559c45
更新日期:2012-08-01 00:00:00
abstract:AIMS:An important consideration in the design of a tumour vaccine is the ability of tumour-specific cytotoxic T lymphocytes (CTL) to recognise unmanipulated tumour cells in vivo. To determine whether B-CLL might use an escape strategy, the current studies compared B-CLL and normal B cell MHC class I expression. METHOD...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020310001644499
更新日期:2004-02-01 00:00:00
abstract::Statistical methods have been used to determine an optimal approach to the definition of the reference range for CD4 ("helper") and CD8 ("suppressor/cytotoxic") T cell numbers and the CD4/CD8 ratio in the peripheral blood. A graphical presentation of the absolute values for CD4 and CD8 for 85 healthy blood donors show...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809085219
更新日期:1988-10-01 00:00:00
abstract::Monoclonal antibodies have been raised against components of glomerular immune deposits in experimental glomerulonephritis and idiopathic human glomerulonephritis. An accelerated model of chronic serum sickness in the rat using cationized human serum albumin was employed to obtain renal tissue with capillary loop and ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809066623
更新日期:1988-04-01 00:00:00
abstract::Although most carcinomas of the bladder occur de novo, some vesical lesions progress to malignancy over time. These lesions appear morphologically benign, but often harbour genetic changes that signify their malignant potential. Despite their benign appearance, accurate identification is important given that these pat...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1097/PAT.0b013e32835f6169
更新日期:2013-04-01 00:00:00
abstract:AIMS:To review the benign bone tumours accessioned by the Bone Tumour Registry (BTR) of Western Australia (WA) during the years 1972-1996 and to determine the incidence of the more common types. METHODS:Information was extracted from the Registry database using 58 selected fields. RESULTS:During the 25 year period, 8...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020701684334
更新日期:2007-12-01 00:00:00
abstract::The estimation of plasma alanine aminotransferase (ALT) has been proposed as a surrogate test to identify potential non-A, non-B hepatitis carriers in blood donor populations. This report describes an ALT screening procedure which uses wells of microtitration trays as reactant vessels. The method utilizes a rate readi...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809059506
更新日期:1988-07-01 00:00:00
abstract::Multiplex immunofluorescence (mIF) allows simultaneous antibody-based detection and quantification of the expression of up to six markers, plus a nuclear counterstain, on a single tissue section. Recent studies have shown the potential for mIF to advance our understanding of complex disease processes, including cancer...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2017.11.087
更新日期:2018-04-01 00:00:00
abstract::In 2004, the diagnosis of established human immunodeficiency virus (HIV) infection can be made with close to 100% assurity. The extraordinarily engineered performances of HIV-screening assays are unprecedented. The well-established confirmatory tests performed by well-versed laboratories using criteria that are well u...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313020400010922
更新日期:2004-12-01 00:00:00
abstract::Tonsil swabs were collected from 248 children (1 through 10 yr) who presented with acute tonsillitis. A beta-hemolytic streptococcus was grown from 129 (53%) of 244 cases and as the sole pathogen from 83 (47%) of 178 cases. Beta-Hemolytic streptococci were especially common over the age of 6 yr (68% of children) relat...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409067915
更新日期:1984-01-01 00:00:00
abstract:AIMS:Whereas most caspases play roles in apoptosis and/or inflammation, caspase-14 plays a main role in epithelial differentiation. In cancers, expression of caspase-14 is frequently altered and is associated with some clinicopathological characteristics, suggesting caspase-14 might contribute to the pathogenesis of ca...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020701329815
更新日期:2007-06-01 00:00:00
abstract:AIMS:To demonstrate the correlation between morphological and proliferation parameters with the biological behaviour of adrenocortical tumours (ACTs) in different age groups. METHODS:Seventy-six cases of ACT were evaluated comparing tumours of children (< or =15 years, n=24) and adults (>15 years, n=52) regarding morp...
journal_title:Pathology
pub_type: 杂志文章
doi:
更新日期:2003-04-01 00:00:00
abstract::Certain diagnoses in dermatopathology have significant implications for patient management and on occasion appropriate clinical care may be facilitated by a phone call from the reporting dermatopathologist to the referring doctor. Whether this is appropriate depends on a number of factors. The concept of 'critical dia...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2017.10.015
更新日期:2018-04-01 00:00:00
abstract::The most common of all activating BRAF mutations (T1799A) leads to a substitution of valine (V) to glutamic acid (E) at the position 600 of the amino acid sequence. The major goal of this study was to compare detection of the BRAF V600E mutation by DNA sequencing with immunohistochemistry (IHC) using the anti-BRAF V60...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000119
更新日期:2014-10-01 00:00:00