Abstract：
AIMS:p73, a homologue of p53, is known as a negative regulator of tumour progression. However, delta Np73, an isoform of p73 lacking the NH2-terminal transactivation domain plays an oncogenic role by interfering with the activity of p53 and TA (full-length transactivating isoforms) p73. In this study, we investigated the expression of delta Np73 in human thyroid neoplasms originating from follicular cells. METHODS:We immunohistochemically investigated delta Np73 expression in 223 thyroid neoplasms. Delta Np73 expression level was evaluated as the sum of positivity score and intensity score. RESULTS:Normal follicular cells did not express delta Np73, but 27.3% of follicular adenoma, 85.4% of follicular carcinoma, 99.2% of papillary carcinoma, and 95.7% of anaplastic carcinoma were positive for the transcript. Delta Np73 expression level did not differ between widely invasive and minimally invasive follicular carcinomas. In papillary carcinoma, the level was inversely linked to tumour size, extrathyroid extension, and clinically apparent metastasis. Furthermore, in anaplastic carcinoma, delta Np73 expression level was significantly lower than that in papillary carcinoma. CONCLUSIONS:Our findings indicate that delta Np73 plays a role predominantly in the early phase of papillary carcinoma progression.
journal_name
Pathologyjournal_title
Pathologyauthors
Ito Y,Uramoto H,Funa K,Yoshida H,Jikuzono T,Asahi S,Higashiyama T,Tomoda C,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi Adoi
10.1080/00313020600696298subject
Has Abstractpub_date
2006-06-01 00:00:00pages
205-9issue
3eissn
0031-3025issn
1465-3931pii
KR787272021HR225journal_volume
38pub_type
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