Abstract:
:Lymphadenopathy associated with hemorrhage as a presenting feature of primary (AL) amyloidosis has not previously been described. We report two such cases one of whom had an acquired factor X and IX deficiency. The clinical presentations were characterized by sudden spontaneous enlargement of lymph nodes followed by partial regression. In both cases significant delay in diagnosis, and hence treatment, occurred due to the mode of presentation. One patient died with rapidly progressive disease but the other has had an excellent response to therapy with high-dose melphalan (HDM, 200 mg/m2) and peripheral blood stem cell rescue. AL amyloid should be considered in all patients presenting with hemorrhagic lymphadenopathy.
journal_name
Pathologyjournal_title
Pathologyauthors
Hanley JP,MacLean FR,Evans JL,Colls BM,Robinson BA,Patton WN,Heaton DCdoi
10.1080/003130200104510subject
Has Abstractpub_date
2000-02-01 00:00:00pages
21-3issue
1eissn
0031-3025issn
1465-3931journal_volume
32pub_type
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