Hemorrhagic lymphadenopathy as a presenting feature of primary al amyloidosis.

Abstract:

:Lymphadenopathy associated with hemorrhage as a presenting feature of primary (AL) amyloidosis has not previously been described. We report two such cases one of whom had an acquired factor X and IX deficiency. The clinical presentations were characterized by sudden spontaneous enlargement of lymph nodes followed by partial regression. In both cases significant delay in diagnosis, and hence treatment, occurred due to the mode of presentation. One patient died with rapidly progressive disease but the other has had an excellent response to therapy with high-dose melphalan (HDM, 200 mg/m2) and peripheral blood stem cell rescue. AL amyloid should be considered in all patients presenting with hemorrhagic lymphadenopathy.

journal_name

Pathology

journal_title

Pathology

authors

Hanley JP,MacLean FR,Evans JL,Colls BM,Robinson BA,Patton WN,Heaton DC

doi

10.1080/003130200104510

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

21-3

issue

1

eissn

0031-3025

issn

1465-3931

journal_volume

32

pub_type

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