Expression and prognostic value of NSD1 and SETD2 in pancreatic ductal adenocarcinoma and its precursor lesions.

abstract：AIMS:To correlate the immunostaining for INI1 protein and mutations in INI1 gene in possible rhabdoid tumours (RT) and atypical teratoid/rhabdoid tumours (AT/RT) seen at the Royal Children's Hospital in the last 10 years, and to study the clinicopathological features of those patients with negative nuclear staining. M...

journal_title：Pathology

authors： Wu X,Dagar V,Algar E,Muscat A,Bandopadhayay P,Ashley D,Wo Chow C

更新日期：2008-12-01 00:00:00

abstract：:The terminal complement complex has been implicated in the development of glomerular injury in both experimental and, indirectly, in human glomerulonephritis. Recent data suggests that the terminal complement complex in human glomerulonephritis may be in the cytolytically inactive SC5b-9 form which also contains S-pro...

journal_title：Pathology

authors： Murphy BF,Davies DJ,Morrow W,d'Apice AJ

更新日期：1989-10-01 00:00:00

abstract：:Tonsil swabs were collected from 248 children (1 through 10 yr) who presented with acute tonsillitis. A beta-hemolytic streptococcus was grown from 129 (53%) of 244 cases and as the sole pathogen from 83 (47%) of 178 cases. Beta-Hemolytic streptococci were especially common over the age of 6 yr (68% of children) relat...

journal_title：Pathology

authors： Douglas RM,Miles H,Hansman D,Fadejevs A,Moore B,Bollen MD

更新日期：1984-01-01 00:00:00

abstract：:In order to determine whether routine culturing for Clostridium difficile was warranted or whether culturing a selected group of patients was adequate, we conducted a prospective trial of culturing all stool specimens for C. difficile. A total of 408 specimens from 297 patients was studied. Two hundred and eighteen st...

journal_title：Pathology

authors： Bowman RA,Riley TV

更新日期：1984-07-01 00:00:00

abstract：:Malignant tumours with teratoid or blastomatous features are exceptionally rare in the upper respiratory tract with only 8 documented cases, including the 3 in this report. The tumours occurred in adults aged 27 to 62 yr, and the sites of origin were the ethmoid sinus (4 cases), ethmoid and other paranasal sinuses (2 ...

journal_title：Pathology

authors： Shanmugaratnam K,Kunaratnam N,Chia KB,Chiang GS,Sinniah R

更新日期：1983-10-01 00:00:00

abstract：AIMS:The aim of the study was to evaluate the role of Serpin B3/B4 in advanced idiopathic pulmonary fibrosis (IPF) patients, mainly focusing on epithelial proliferation. METHODS:Lungs from 48 IPF patients (including cases with cancer or high-grade epithelial dysplasia) were studied and compared with other diffuse pare...

journal_title：Pathology

authors： Calabrese F,Lunardi F,Balestro E,Marulli G,Perissinotto E,Loy M,Nannini N,Valente M,Saetta M,Agostini C,Rea F

更新日期：2012-04-01 00:00:00

abstract：:The objective of this study was to establish a population based reference range for a commercial immunoblot assay detecting myositis specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs), and to assess the diagnostic performance of this reference range against the manufacturer's recommended rang...

journal_title：Pathology

authors： Bundell C,Rojana-Udomsart A,Mastaglia F,Hollingsworth P,McLean-Tooke A

更新日期：2016-06-01 00:00:00

abstract：:An enzyme-immunoassay has been developed for rapid isotyping of murine monoclonal antibodies. This assay has several advantages over the commonly used typing methods. It does not require the presence of specific antigen. Typing plates can be prepared in advance and stored frozen. Unequivocal results can be obtained in...

journal_title：Pathology

authors： Gardner ID

更新日期：1985-01-01 00:00:00

abstract：:A study of 103 fetal adrenals obtained from stillborn fetuses and those dying in the neonatal period was performed to assess the significance of definitive cortex cystic change, compact cell change and lipid patterns, and their relationship to other pathological processes. The findings confirm that these changes are m...

journal_title：Pathology

authors： Delprado WJ,Baird PJ

更新日期：1984-07-01 00:00:00

abstract：:A method for the preparation of human renal biopsy specimens for scanning electron microscopy (SEM) is described. This involves glomerular isolation by fine needle dissection and the simultaneous processing of 10 or more specimens in a specially designed tissue cassette. The method is simple and reliable with minimal ...

journal_title：Pathology

authors： Ng W,So KF,So PC,Ngai HK

更新日期：1982-07-01 00:00:00

abstract：:The Hippo pathway is a tumour-suppressive pathway and its inactivation is known to be associated with progression and metastasis of various cancers. LATS1/2 (large tumour suppressor homolog 1 and 2), YAP1 (Yes-associated protein 1), and TEAD4 (TEA domain-containing sequence-specific transcription factors 4) are core c...

journal_title：Pathology

authors： Kim E,Ahn B,Oh H,Lee YJ,Lee JH,Lee Y,Kim CH,Chae YS,Kim JY

更新日期：2019-04-01 00:00:00

abstract：:We report a case of a 25-year-old man who presented with a large rectal bleed and positive Meckel's scan followed by surgical excision of a Meckel's diverticulum. The diverticulum was lined by gastric body type mucosa showing evidence of active chronic gastritis associated with the presence of Helicobacter pylori orga...

journal_title：Pathology

authors： Hill P,Rode J

更新日期：1998-02-01 00:00:00

abstract：:A patient with cerebral strokes had a cardiac tumour excised. Histologically, it was an infarcted myxoma with features of a Gamna body. Findings are compared with other cardiac Gamna bodies reported in the literature. Most probably represent unusual degenerative changes in a myxoma. ...

journal_title：Pathology

authors： Coard KC,Silver MD

更新日期：1984-10-01 00:00:00

abstract：:We counted apoptotic thymic cortical lymphocytes in semi-thin plastic sections of 266 human autopsy thymuses. The decreased patients included in the study were all aged less than 40 yrs and all died within 72 hrs of the onset of symptoms. Based on published data on animal and human material it was anticipated that ind...

journal_title：Pathology

authors： Middleton G,Reid LE,Harmon BV

更新日期：1994-04-01 00:00:00

abstract：:Eccrine syringofibroadenoma is a rare benign tumor of the skin arising from the acrosyringeal portion of the eccrine duct. The tumor was first described by Mascaro in 1963, and since then only 8 case reports in 6 publications have been documented. This lesion is likely to be misdiagnosed both clinically and histologic...

journal_title：Pathology

authors： Billson VR,Dyall-Smith DJ

更新日期：1991-07-01 00:00:00

abstract：:The lupus anticoagulant (LA) phenomenon created world-wide interest recently. Various tests have been devised to identify LA in plasma, but none of these methods have been universally accepted. In this study 16 cases labelled LA positive by a prior kaolin clotting time (KCT) test were reassessed by four other methods,...

journal_title：Pathology

authors： Stark RA,Gordon S

更新日期：1990-04-01 00:00:00

abstract：:Soft tissue tumours represent a heterogeneous group of mesenchymal lesions and their classification continues to evolve as a result of incorporating advances in cytogenetic and molecular techniques. In the last decade, traditional diagnostic approaches were supplemented with a significant number of reliable molecular ...

journal_title：Pathology

authors： Antonescu CR,Dal Cin P

更新日期：2014-02-01 00:00:00

abstract：AIMS:CD151 belongs to the group of tetraspanins and is aberrantly expressed in different tumours and differential expression has been associated with prognosis. The aim of this study was to clarify the relationship of CD151 expression with tumour phenotype and clinical outcome in bladder cancer. METHODS:A bladder canc...

journal_title：Pathology

authors： Minner S,De Silva C,Rink M,Dahlem R,Chun F,Fisch M,Höppner W,Wagner W,Bokemeyer C,Terracciano L,Simon R,Sauter G,Wilczak W

更新日期：2012-08-01 00:00:00

abstract：:Granulomatous (lobular) mastitis is a rare inflammatory breast disease affecting parous reproductive-aged women. Once considered idiopathic, there is growing evidence of an association with corynebacteria infection, especially in the setting of a distinct histological pattern termed cystic neutrophilic granulomatous m...

journal_title：Pathology

authors： Johnstone KJ,Robson J,Cherian SG,Wan Sai Cheong J,Kerr K,Bligh JF

更新日期：2017-06-01 00:00:00

abstract：:Paracetamol in serum was assayed by a new enzymatic method, and the results compared with a high performance liquid chromatographic method. Results by the two procedures agreed well (t = 0.05). The correlation coefficient was 0.999, and the slope and intercept by Deming analysis were 0.975 and 0.003 mmol/l respectivel...

journal_title：Pathology

authors： Slater S

更新日期：1987-01-01 00:00:00

abstract：:The pathological findings in a retrospective review of 100 consecutive intracranial stereotactic biopsies are presented. Definite diagnosis could be established in the majority (89) of cases and included 85 neoplasms (69 primary cerebral tumors, 10 non-Hodgkin's lymphomas and 6 metastases) and 4 non-neoplastic process...

journal_title：Pathology

authors： Robbins PD,Yu LL,Lee M,Stokes BA,Thomas GW,Watson P,Wong G

更新日期：1994-10-01 00:00:00

abstract：:Patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) often exhibit clonal chromosomal abnormalities. Using a probe for the centromeric region of chromosome 8, fluorescence in situ hybridization (FISH) on interphase cells was used to detect trisomy 8 in an AML patient whose leukemia was characte...

journal_title：Pathology

authors： White DL,Hutchins CJ,Turczynowicz S,Suttle J,Haylock DN,Hughes TP,Juttner CA,To LB

更新日期：1997-08-01 00:00:00

abstract：AIMS:Recent study indicates that the binding of caveolin-1 (CAV1), the essential constituent of caveolae, to endothelial nitric oxide synthase (eNOS) prevents nitric oxide (NO) production in cirrhotic human liver. However, their interplay in hepatocellular carcinoma (HCC) remains undetermined. METHODS:Paraffin-embedde...

journal_title：Pathology

authors： Yang SF,Yang JY,Huang CH,Wang SN,Lu CP,Tsai CJ,Chai CY,Yeh YT

更新日期：2010-01-01 00:00:00

abstract：:Recently developed antibodies against uroplakin II and ΔNp63 (p40) show utility in diagnosing primary bladder urothelial carcinoma, although application in metastatic bladder cancer and patient outcomes has been less well defined. We evaluated these antibodies by immunostain intensity and H-score, in conjunction with ...

journal_title：Pathology

authors： Leivo MZ,Elson PJ,Tacha DE,Delahunt B,Hansel DE

更新日期：2016-10-01 00:00:00

abstract：:We have devised a simple, sensitive quantitative method for the determination of serum methemalbumin. The method uses a modified Allen correction to correct the alpha band of methemalbumin at 623 nm for background turbidity. The technique is robust and is more sensitive than Schumm's test. ...

journal_title：Pathology

authors： Cowley DM,Powell VR

更新日期：1986-07-01 00:00:00

abstract：AIMS:In our previous studies, comparative proteomics demonstrated that lactate dehydrogenase B subunit (LDH-B) is down-regulated in high grade compared to non-high grade urinary bladder urothelial carcinoma (UBUC). However, this finding has not been validated by clinical cohort investigation. Therefore, in the present ...

journal_title：Pathology

authors： Liao AC,Li CF,Shen KH,Chien LH,Huang HY,Wu TF

更新日期：2011-12-01 00:00:00

abstract：:Micropapillary carcinoma of the colon and rectum is associated with an adverse prognosis. This tumour type displays reverse polarity of the tumour cells and is stated to be characterised by an inside-out epithelial membrane antigen (EMA)/MUC1 staining. Nine cases of primary colorectal carcinoma and one omental metasta...

journal_title：Pathology

authors： Cserni G

更新日期：2014-10-01 00:00:00

abstract：:The values of a number of biochemical variables have been studied before and after a 50-gram load of glucose orally. Reductions which were statistically significant were found for sodium, potassium, urea, total protein, albumin, calcium, phosphorus, urate, bilirubin, alkaline phosphatase, but not for bicarbonate, crea...

journal_title：Pathology

authors： Masarei JR

更新日期：1977-01-01 00:00:00

abstract：:Distinction between melanocytic naevi and melanoma occasionally poses a diagnostic challenge in ambiguous cases showing overlapping histological features. Melanomas are characterised by the presence of multiple genomic copy number variants (CNVs), while this is not a feature of naevi. We assessed the feasibility and u...

journal_title：Pathology

authors： Mesbah Ardakani N,Thomas C,Robinson C,Mina K,Harvey NT,Amanuel B,Wood BA

更新日期：2017-04-01 00:00:00

abstract：:As autopsy rates in general hospitals decline, interest in the perinatal autopsy continues to rise, reflecting the emergence of a vigorous specialty growing in parallel with fetal medicine, prenatal diagnosis and clinical genetics. Perinatal autopsies are best carried out in tertiary centres which provide these servic...

journal_title：Pathology

authors： Chambers HM

更新日期：1992-04-01 00:00:00