Abstract：
AIMS:An important consideration in the design of a tumour vaccine is the ability of tumour-specific cytotoxic T lymphocytes (CTL) to recognise unmanipulated tumour cells in vivo. To determine whether B-CLL might use an escape strategy, the current studies compared B-CLL and normal B cell MHC class I expression. METHODS:Flow cytometry, TAP allele PCR and MHC class I PCR were used. RESULTS:While baseline expression of MHC class I did not differ, upregulation of MHC class I expression by B-CLL cells in response to IFN-gamma was reduced. No deletions or mutations of TAP 1 or 2 genes were detected. B-CLL cells upregulated TAP protein expression in response to IFN-gamma. Responsiveness of B-CLL MHC class I mRNA to IFN-gamma was not impaired. CONCLUSIONS:The data suggest that MHC class I molecules might be less stable at the cell surface in B-CLL than normal B cells, as a result of the described release of beta(2)m and beta(2)m-free class I heavy chains from the membrane. This relative MHC class I expression defect of B-CLL cells may reduce their susceptibility to CTL lysis in response to immunotherapeutic approaches.
journal_name
Pathologyjournal_title
Pathologyauthors
Juffs H,Fowler N,Saal R,Grimmett K,Beasley S,O'Sullivan B,Frazer I,Gill D,Thomas Rdoi
10.1080/00313020310001644499subject
Has Abstractpub_date
2004-02-01 00:00:00pages
69-76issue
1eissn
0031-3025issn
1465-3931pii
15MG3TJ3MG6D6JYUjournal_volume
36pub_type
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