Abstract:
:A genetic variant of antithrombin with impaired heparin cofactor activity was identified in 4 members of a French family. Both the variant and normal antithrombin component were purified by affinity chromatography on heparin Sepharose. Reverse phase peptide mapping revealed a single altered peak when tryptic digests of both antithrombins were compared. After further purification of the aberrant peptide, amino acid analysis indicated a substitution of 41 Leu----Pro (antithrombin Basel). This result was confirmed by liquid secondary ion mass spectrometry which gave a measured mass of 816.4655 Da for the new peptide compared to a calculated mass of 800.3579 Da for the normal peptide and 816.4579 for the Leu----Pro substitution.
journal_name
Pathologyjournal_title
Pathologyauthors
Brennan SO,Borg JY,Shaw GJ,Caen J,George PMdoi
10.3109/00313029109061429subject
Has Abstractpub_date
1991-01-01 00:00:00pages
1-4issue
1eissn
0031-3025issn
1465-3931journal_volume
23pub_type
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