Abstract:
AIMS:Activation of nuclear factor-kappa B (NF-kappaB) signalling is considered a crucial mechanism in the development of cancers. Caspase-associated recruitment domain 6 (CARD6) is a protein that activates NF-kappaB signalling evoked by RIP1, RIP2, Bcl-10 and MEKK. In this study, we analysed tissue expression of CARD6 protein in oesophageal squamous cell carcinoma (ESCC), gastric adenocarcinomas (GC) and colorectal adenocarcinomas (CRC). METHODS:We analysed the expression of CARD6 protein in 58 ESCC, 100 GC and 103 CRC patients' tissues by immunohistochemistry using a tissue microarray (TMA) approach. RESULTS:We found CARD6 immunostaining in cancer cells of ESCC (41/58; 70.7%), GC (45/100; 45.0%) and CRC (81/103; 78.6%). In the GC, intestinal-type GC (77.8%) showed higher expression of CARD6 than diffuse-type GC (20.0%) and mixed-type GC (50.0%). By contrast, corresponding normal epithelial cells of oesophagus (0%), stomach (8.0%) and colon (5.0%) displayed lower frequencies of CARD6 immunostaining. The CARD6 immunostaining was observed in nucleus/cytoplasm (ESCC) or cytoplasm (GC and CRC). The CARD6 expression was evident from an early TNM stage (stage I). CONCLUSION:The increased expression of CARD6 in ESCC, GC and CRC tissues compared to their corresponding normal cells suggested that neoexpression of CARD6 might be related to activation of NF-kappaB pathway in the cancers and might play a role in the development of most types of gastrointestinal cancers.
journal_name
Pathologyjournal_title
Pathologyauthors
Kim SS,Ahn CH,Kang MR,Kim YR,Kim HS,Yoo NJ,Lee SHdoi
10.3109/00313020903434421subject
Has Abstractpub_date
2010-01-01 00:00:00pages
50-3issue
1eissn
0031-3025issn
1465-3931journal_volume
42pub_type
杂志文章相关文献
PATHOLOGY文献大全abstract::We report a rare case of bilateral primary seminal vesicle carcinoma in a 73 yr old Australian man. To our knowledge this case report is the 48th histologically confirmed case of primary seminal vesicle neoplasia and only the fourth reported case of primary bilateral seminal vesicle carcinoma. Macroscopically the tumo...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029600169883
更新日期:1996-05-01 00:00:00
abstract::Sera from 82 patients with acute or chronic hepatitis and 40 chronic carriers of hepatitis B were examined by ELISA and immunoblotting for reactivity with the glycolytic enzyme aldolase. The results of the ELISA tests, expressed as a percentage of a positive control, were compared to those obtained with sera from 39 p...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028709103881
更新日期:1987-10-01 00:00:00
abstract:AIM:The purpose of this study was to elucidate the clonality of fibrous dysplasia based on X-chromosome inactivation mosaicism and polymorphism in female somatic cells at the phosphoglycerate kinase (PGK) and androgen receptor (AR) loci using microdissection technology. MATERIALS AND METHODS:Nine patients with fibrous...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020801911496
更新日期:2008-06-01 00:00:00
abstract::A clinicopathological analysis was made of data from 250 cases of nodular fasciitis. These benign nodules usually occurred in young and middle-aged adults in the 4th and 5th decades, most often in the forearm (27%) followed by the thigh (17%) and the upper arm (12%), and grew rather rapidly to reach a mean diameter of...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409059097
更新日期:1984-04-01 00:00:00
abstract::Malignant tumours with teratoid or blastomatous features are exceptionally rare in the upper respiratory tract with only 8 documented cases, including the 3 in this report. The tumours occurred in adults aged 27 to 62 yr, and the sites of origin were the ethmoid sinus (4 cases), ethmoid and other paranasal sinuses (2 ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028309085168
更新日期:1983-10-01 00:00:00
abstract:AIMS:Nuclear factor-kappa B (NF-kappaB) activation has been recognised as an important mechanism in the development of cancers. However, expression status of NF-kappaB-related proteins in oesophageal squamous cell carcinoma (ESCC) tissues is largely unknown. In this study, we analysed expressions of NF-kappaB members (...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313020903257756
更新日期:2009-01-01 00:00:00
abstract::With the use of 2 independent techniques, circulating monomeric and oligomeric IgM were detected in the majority of 29 patients with chronic lymphocytic leukemia (CLL). In contrast it was detected only in trace quantities in a minority of healthy subjects. In the CLL group no significant correlation was observed betwe...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029309068902
更新日期:1993-01-01 00:00:00
abstract::Twenty-three antimicrobial agents, including 4 new broadspectrum beta-lactam antibiotics were tested against 50 clinical isolates of Campylobacter jejuni. The activity of metabolites of metronidazole and tinidazole was also tested. Minimum inhibitory concentrations (MIC) were determined by agar dilution. beta-lactamas...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028309061403
更新日期:1983-01-01 00:00:00
abstract:INTRODUCTION:Ethanol is teratogenic, interferes with folic acid and is extensively used by young women. Our objective was to determine the effects of ethanol and/or folate deficiency on mouse fetuses. METHOD:In Experiment 1, pregnant mice receiving a commercial diet were divided into three groups: control (C), low eth...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020701449290
更新日期:2007-10-01 00:00:00
abstract::Although most carcinomas of the bladder occur de novo, some vesical lesions progress to malignancy over time. These lesions appear morphologically benign, but often harbour genetic changes that signify their malignant potential. Despite their benign appearance, accurate identification is important given that these pat...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1097/PAT.0b013e32835f6169
更新日期:2013-04-01 00:00:00
abstract::The monitoring of infliximab drug levels aids in the management of several autoimmune diseases, notably inflammatory bowel disease. Several commercial kits are now available and approved by the Therapeutic Goods Administration (TGA) for the measurement of infliximab levels, but there have been limited verification or ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2016.07.001
更新日期:2016-10-01 00:00:00
abstract::Since 1967 the Royal College of Pathologists of Australasia has been providing an external quality assurance programme in microbiology. The number of participants has risen from 70 to 222, and the samples distributed for investigation have increased in quantity, now totalling 35-40 per annum, and in variety, so that m...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409068529
更新日期:1984-07-01 00:00:00
abstract:AIMS:Biochemical analysis of glucose and ketones in the vitreous humour obtained at post-mortem examination is representative of the levels in the blood prior to death. Elevated levels can be indicative of conditions including diabetic ketoacidosis, which can be a cause for unexpected death. A rapid screening test for ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e3283650b93
更新日期:2013-10-01 00:00:00
abstract::The current public health emergency surrounding the COVID-19 pandemic, that is the illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in thousands of cases in Australia since 25 January 2020 when the first case was diagnosed. This emerging virus presents particular hazards to ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2020.09.006
更新日期:2020-12-01 00:00:00
abstract:AIMS:Only a small number of mesenchymal tumours have been previously evaluated for hTERT expression. We hypothesised that hTERT expression would be frequently present in sarcomas, but not in benign tumours. METHODS:Sections from 143 bone/soft tissue tumours were immunostained for hTERT (44F12, 1:20; Novocastra) using ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020903121614
更新日期:2009-01-01 00:00:00
abstract::Eccrine syringofibroadenoma is a rare benign tumor of the skin arising from the acrosyringeal portion of the eccrine duct. The tumor was first described by Mascaro in 1963, and since then only 8 case reports in 6 publications have been documented. This lesion is likely to be misdiagnosed both clinically and histologic...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029109063580
更新日期:1991-07-01 00:00:00
abstract::The performance of the Hemalog D on routine blood samples from patients was assessed over a 6 wk period, 500 samples being studied in detail. The performance of the Hematrak was assessed on 85 routine blood samples. It was found that in our hospital population at least 58% of blood samples counted by the Hemalog D wou...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028009060058
更新日期:1980-01-01 00:00:00
abstract:AIMS:Immunohistochemical detection of the 185-kDa transmembrane glycoprotein product of the proto-oncogene c-erbB-2 (also known as HER-2/neu), located on chromosome 17q21, is a well established method of evaluation in invasive breast cancer. This investigation is currently performed on standard sections cut from the tu...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020600820872
更新日期:2006-08-01 00:00:00
abstract:AIMS:Clinical decision making and optimal clinical trial design based on cancer genetic information will be increasingly informed by the mutational status of multiple genes. METHODS:We performed mutation screening on 22 fresh frozen gastrointestinal stromal tumours (GISTs) using a multiplexed oncogene screening panel ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e3283559c45
更新日期:2012-08-01 00:00:00
abstract::From August 1976 to July 1977, all faecal specimens (3298) sent to the Enteric Department of the Institute of Medical and Veterinary Science, Adelaide were selectively cultured for Yersinia enterocolitica. Yersinia enterocolitica was isolated from three patients with diarrhoea, one of whom acquired her infection overs...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027909063540
更新日期:1979-01-01 00:00:00
abstract::There are few studies addressing survival of diffuse peritoneal mesotheliomas (DPM).In this study, survival data were obtained retrospectively from 73 patients treated with intended cytoreductive surgery for DPM, with a mean follow-up of 42 months. Mesotheliomas were classified as well differentiated papillary (WDPM, ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000181
更新日期:2014-12-01 00:00:00
abstract::A unique complication of florid xanthogranulomatous cholecystitis with cholecystoduodenal fistula formation is described in a 6 yr old male. The patient, who had a short gut syndrome, had been maintained on lifelong total parenteral nutrition (TPN) following extensive neonatal ischemic bowel necrosis secondary to gast...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029009086671
更新日期:1990-10-01 00:00:00
abstract::Lysosome-associated membrane protein-1 (LAMP1) has been suggested to play complicated roles in cancer development and metastasis. The aim of this study was to explore the expression of LAMP1 in laryngeal squamous cell carcinoma (LSCC) and investigate the relationship between LAMP1 expression and clinicopathological ch...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2016.08.001
更新日期:2016-12-01 00:00:00
abstract::Apoptosis in the myocardium is complex and often difficult to recognise. Myocyte apoptosis is scattered across the myocardial wall and is restricted to individual cells. In the present study, we describe the amount of apoptosis in 50 endomyocardial biopsies taken from 50 patients with dilated cardiomyopathy, in 14 hea...
journal_title:Pathology
pub_type: 杂志文章
doi:
更新日期:2000-08-01 00:00:00
abstract::We report a case of multiple hepatic abscesses due to Yersinia enterocolitica in a 58 yr old male. This case is typical of the other 39 cases reported in the literature in that the patient had alcoholism, malnutrition, iron overload and a subsequently diagnosed malignancy. Ultrasound showed multiple hypoechoic areas i...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313029500169353
更新日期:1995-10-01 00:00:00
abstract::Prostatic stromal proliferations account for the majority of benign tumour-like lesions in the prostate. The most common is nodular hyperplasia, seen in a majority of elderly men. Diagnostic difficulty is encountered with some variants, including stromal hyperplasia with atypia, characterised by degenerative changes o...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2020.09.017
更新日期:2021-01-01 00:00:00
abstract::The most significant task of the pathologist examining a fetal death is, if possible, the provision of an explanation for the event, which will allow the clinical attendants to counsel the family in an informed and relevant manner. In some cases, no adequate explanation will be possible, though many conditions will be...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/003130200104330
更新日期:2000-05-01 00:00:00
abstract::Statistical methods have been used to determine an optimal approach to the definition of the reference range for CD4 ("helper") and CD8 ("suppressor/cytotoxic") T cell numbers and the CD4/CD8 ratio in the peripheral blood. A graphical presentation of the absolute values for CD4 and CD8 for 85 healthy blood donors show...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809085219
更新日期:1988-10-01 00:00:00
abstract:AIMS:CD146 is a potentially metastasis promoting cell adhesion molecule and its expression has been described in various solid tumours. We aimed to evaluate the expression of CD146 in prostate cancer by immunohistochemistry in a clinically characterised study cohort to evaluate its prognostic properties. METHODS:We ev...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020802197996
更新日期:2008-08-01 00:00:00
abstract:AIMS:To review the benign bone tumours accessioned by the Bone Tumour Registry (BTR) of Western Australia (WA) during the years 1972-1996 and to determine the incidence of the more common types. METHODS:Information was extracted from the Registry database using 58 selected fields. RESULTS:During the 25 year period, 8...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020701684334
更新日期:2007-12-01 00:00:00