Expression of CARD6, an NF-kappaB activator, in gastric, colorectal and oesophageal cancers.

Abstract:

AIMS:Activation of nuclear factor-kappa B (NF-kappaB) signalling is considered a crucial mechanism in the development of cancers. Caspase-associated recruitment domain 6 (CARD6) is a protein that activates NF-kappaB signalling evoked by RIP1, RIP2, Bcl-10 and MEKK. In this study, we analysed tissue expression of CARD6 protein in oesophageal squamous cell carcinoma (ESCC), gastric adenocarcinomas (GC) and colorectal adenocarcinomas (CRC). METHODS:We analysed the expression of CARD6 protein in 58 ESCC, 100 GC and 103 CRC patients' tissues by immunohistochemistry using a tissue microarray (TMA) approach. RESULTS:We found CARD6 immunostaining in cancer cells of ESCC (41/58; 70.7%), GC (45/100; 45.0%) and CRC (81/103; 78.6%). In the GC, intestinal-type GC (77.8%) showed higher expression of CARD6 than diffuse-type GC (20.0%) and mixed-type GC (50.0%). By contrast, corresponding normal epithelial cells of oesophagus (0%), stomach (8.0%) and colon (5.0%) displayed lower frequencies of CARD6 immunostaining. The CARD6 immunostaining was observed in nucleus/cytoplasm (ESCC) or cytoplasm (GC and CRC). The CARD6 expression was evident from an early TNM stage (stage I). CONCLUSION:The increased expression of CARD6 in ESCC, GC and CRC tissues compared to their corresponding normal cells suggested that neoexpression of CARD6 might be related to activation of NF-kappaB pathway in the cancers and might play a role in the development of most types of gastrointestinal cancers.

journal_name

Pathology

journal_title

Pathology

authors

Kim SS,Ahn CH,Kang MR,Kim YR,Kim HS,Yoo NJ,Lee SH

doi

10.3109/00313020903434421

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

50-3

issue

1

eissn

0031-3025

issn

1465-3931

journal_volume

42

pub_type

杂志文章
  • Bilateral primary seminal vesicle carcinoma.

    abstract::We report a rare case of bilateral primary seminal vesicle carcinoma in a 73 yr old Australian man. To our knowledge this case report is the 48th histologically confirmed case of primary seminal vesicle neoplasia and only the fourth reported case of primary bilateral seminal vesicle carcinoma. Macroscopically the tumo...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029600169883

    authors: Ormsby AH,Haskell R,Ruthven SE,Mylne GE

    更新日期:1996-05-01 00:00:00

  • Autoantibody to aldolase in acute and chronic hepatitis.

    abstract::Sera from 82 patients with acute or chronic hepatitis and 40 chronic carriers of hepatitis B were examined by ELISA and immunoblotting for reactivity with the glycolytic enzyme aldolase. The results of the ELISA tests, expressed as a percentage of a positive control, were compared to those obtained with sera from 39 p...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028709103881

    authors: Brown C,Toh BH,Pedersen JS,Clarke FM,Mackay IR,Gust I

    更新日期:1987-10-01 00:00:00

  • Clonal status of fibrous dysplasia.

    abstract:AIM:The purpose of this study was to elucidate the clonality of fibrous dysplasia based on X-chromosome inactivation mosaicism and polymorphism in female somatic cells at the phosphoglycerate kinase (PGK) and androgen receptor (AR) loci using microdissection technology. MATERIALS AND METHODS:Nine patients with fibrous...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020801911496

    authors: Gong L,Zhang W,Su Q

    更新日期:2008-06-01 00:00:00

  • Nodular fasciitis: an analysis of 250 patients.

    abstract::A clinicopathological analysis was made of data from 250 cases of nodular fasciitis. These benign nodules usually occurred in young and middle-aged adults in the 4th and 5th decades, most often in the forearm (27%) followed by the thigh (17%) and the upper arm (12%), and grew rather rapidly to reach a mean diameter of...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028409059097

    authors: Shimizu S,Hashimoto H,Enjoji M

    更新日期:1984-04-01 00:00:00

  • Teratoid carcinosarcoma of the paranasal sinuses.

    abstract::Malignant tumours with teratoid or blastomatous features are exceptionally rare in the upper respiratory tract with only 8 documented cases, including the 3 in this report. The tumours occurred in adults aged 27 to 62 yr, and the sites of origin were the ethmoid sinus (4 cases), ethmoid and other paranasal sinuses (2 ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028309085168

    authors: Shanmugaratnam K,Kunaratnam N,Chia KB,Chiang GS,Sinniah R

    更新日期:1983-10-01 00:00:00

  • NF-kappaB signalling proteins p50/p105, p52/p100, RelA, and IKKepsilon are over-expressed in oesophageal squamous cell carcinomas.

    abstract:AIMS:Nuclear factor-kappa B (NF-kappaB) activation has been recognised as an important mechanism in the development of cancers. However, expression status of NF-kappaB-related proteins in oesophageal squamous cell carcinoma (ESCC) tissues is largely unknown. In this study, we analysed expressions of NF-kappaB members (...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313020903257756

    authors: Kang MR,Kim MS,Kim SS,Ahn CH,Yoo NJ,Lee SH

    更新日期:2009-01-01 00:00:00

  • Low molecular weight IgM in the sera of patients with chronic lymphocytic leukemia.

    abstract::With the use of 2 independent techniques, circulating monomeric and oligomeric IgM were detected in the majority of 29 patients with chronic lymphocytic leukemia (CLL). In contrast it was detected only in trace quantities in a minority of healthy subjects. In the CLL group no significant correlation was observed betwe...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313029309068902

    authors: Xu HJ,Roberts-Thomson PJ

    更新日期:1993-01-01 00:00:00

  • Susceptibility of Campylobacter jejuni to twenty-three antimicrobial agents.

    abstract::Twenty-three antimicrobial agents, including 4 new broadspectrum beta-lactam antibiotics were tested against 50 clinical isolates of Campylobacter jejuni. The activity of metabolites of metronidazole and tinidazole was also tested. Minimum inhibitory concentrations (MIC) were determined by agar dilution. beta-lactamas...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028309061403

    authors: Shanker S,Sorrell TC

    更新日期:1983-01-01 00:00:00

  • An experimental study on the effects of ethanol and folic acid deficiency, alone or in combination, on pregnant Swiss mice.

    abstract:INTRODUCTION:Ethanol is teratogenic, interferes with folic acid and is extensively used by young women. Our objective was to determine the effects of ethanol and/or folate deficiency on mouse fetuses. METHOD:In Experiment 1, pregnant mice receiving a commercial diet were divided into three groups: control (C), low eth...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020701449290

    authors: Gutierrez CM,Ribeiro CN,de Lima GA,Yanaguita MY,Peres LC

    更新日期:2007-10-01 00:00:00

  • Premalignant lesions of the urinary bladder.

    abstract::Although most carcinomas of the bladder occur de novo, some vesical lesions progress to malignancy over time. These lesions appear morphologically benign, but often harbour genetic changes that signify their malignant potential. Despite their benign appearance, accurate identification is important given that these pat...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1097/PAT.0b013e32835f6169

    authors: Samaratunga H,Martignoni G,Egevad L,Delahunt B

    更新日期:2013-04-01 00:00:00

  • Comparison of infliximab drug measurement across three commercially available ELISA kits.

    abstract::The monitoring of infliximab drug levels aids in the management of several autoimmune diseases, notably inflammatory bowel disease. Several commercial kits are now available and approved by the Therapeutic Goods Administration (TGA) for the measurement of infliximab levels, but there have been limited verification or ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2016.07.001

    authors: Lee MW,Connor S,Ng W,Toong CM

    更新日期:2016-10-01 00:00:00

  • External quality assurance in microbiology. The programme of the Royal College of Pathologists of Australasia.

    abstract::Since 1967 the Royal College of Pathologists of Australasia has been providing an external quality assurance programme in microbiology. The number of participants has risen from 70 to 222, and the samples distributed for investigation have increased in quantity, now totalling 35-40 per annum, and in variety, so that m...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028409068529

    authors: Ackerman VP,Pritchard RC

    更新日期:1984-07-01 00:00:00

  • How sensitive and specific is urinalysis 'dipstick' testing for detection of hyperglycaemia and ketosis? An audit of findings from coronial autopsies.

    abstract:AIMS:Biochemical analysis of glucose and ketones in the vitreous humour obtained at post-mortem examination is representative of the levels in the blood prior to death. Elevated levels can be indicative of conditions including diabetic ketoacidosis, which can be a cause for unexpected death. A rapid screening test for ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1097/PAT.0b013e3283650b93

    authors: Mitchell R,Thomas SD,Langlois NE

    更新日期:2013-10-01 00:00:00

  • Laboratory biosafety measures involving SARS-CoV-2 and the classification as a Risk Group 3 biological agent.

    abstract::The current public health emergency surrounding the COVID-19 pandemic, that is the illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in thousands of cases in Australia since 25 January 2020 when the first case was diagnosed. This emerging virus presents particular hazards to ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2020.09.006

    authors: Kaufer AM,Theis T,Lau KA,Gray JL,Rawlinson WD

    更新日期:2020-12-01 00:00:00

  • Immunohistochemistry for human telomerase reverse transcriptase catalytic subunit (hTERT): a study of 143 benign and malignant soft tissue and bone tumours.

    abstract:AIMS:Only a small number of mesenchymal tumours have been previously evaluated for hTERT expression. We hypothesised that hTERT expression would be frequently present in sarcomas, but not in benign tumours. METHODS:Sections from 143 bone/soft tissue tumours were immunostained for hTERT (44F12, 1:20; Novocastra) using ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020903121614

    authors: Patel RM,Folpe AL

    更新日期:2009-01-01 00:00:00

  • Eccrine syringofibroadenoma: a report of 2 cases.

    abstract::Eccrine syringofibroadenoma is a rare benign tumor of the skin arising from the acrosyringeal portion of the eccrine duct. The tumor was first described by Mascaro in 1963, and since then only 8 case reports in 6 publications have been documented. This lesion is likely to be misdiagnosed both clinically and histologic...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313029109063580

    authors: Billson VR,Dyall-Smith DJ

    更新日期:1991-07-01 00:00:00

  • Automated differential leucocyte counters: an evaluation of the Hemalog D and A comparison with the Hematrak. II. Evaluation of performance on routine blood samples from hospital patients.

    abstract::The performance of the Hemalog D on routine blood samples from patients was assessed over a 6 wk period, 500 samples being studied in detail. The performance of the Hematrak was assessed on 85 routine blood samples. It was found that in our hospital population at least 58% of blood samples counted by the Hemalog D wou...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028009060058

    authors: Bain BJ,Scott D,Scott TJ

    更新日期:1980-01-01 00:00:00

  • c-erbB-2 (HER-2/neu) immunohistochemistry in invasive breast cancer: is there concordance between standard sections and tissue microarrays?

    abstract:AIMS:Immunohistochemical detection of the 185-kDa transmembrane glycoprotein product of the proto-oncogene c-erbB-2 (also known as HER-2/neu), located on chromosome 17q21, is a well established method of evaluation in invasive breast cancer. This investigation is currently performed on standard sections cut from the tu...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020600820872

    authors: Selvarajan S,Tan SY,Sii LH,Tan PH

    更新日期:2006-08-01 00:00:00

  • Multiplex mutation screening by mass spectrometry in gastrointestinal stromal tumours.

    abstract:AIMS:Clinical decision making and optimal clinical trial design based on cancer genetic information will be increasingly informed by the mutational status of multiple genes. METHODS:We performed mutation screening on 22 fresh frozen gastrointestinal stromal tumours (GISTs) using a multiplexed oncogene screening panel ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1097/PAT.0b013e3283559c45

    authors: Kang G,Lee J,Jang KT,Beadling C,Corless CL,Heinrich MC,Park JO,Kang WK,Park CK,Kim KM

    更新日期:2012-08-01 00:00:00

  • Enterocolitis due to Yersinia enterocolitica in South Australia.

    abstract::From August 1976 to July 1977, all faecal specimens (3298) sent to the Enteric Department of the Institute of Medical and Veterinary Science, Adelaide were selectively cultured for Yersinia enterocolitica. Yersinia enterocolitica was isolated from three patients with diarrhoea, one of whom acquired her infection overs...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313027909063540

    authors: Steele TW,McDermott SN

    更新日期:1979-01-01 00:00:00

  • Diffuse mesothelioma of the peritoneum: correlation between histological and clinical parameters and survival in 73 patients.

    abstract::There are few studies addressing survival of diffuse peritoneal mesotheliomas (DPM).In this study, survival data were obtained retrospectively from 73 patients treated with intended cytoreductive surgery for DPM, with a mean follow-up of 42 months. Mesotheliomas were classified as well differentiated papillary (WDPM, ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1097/PAT.0000000000000181

    authors: Liu S,Staats P,Lee M,Alexander HR,Burke AP

    更新日期:2014-12-01 00:00:00

  • Xanthogranulomatous cholecystitis and cholecystoduodenal fistula formation associated with total parenteral nutrition in a six year old child.

    abstract::A unique complication of florid xanthogranulomatous cholecystitis with cholecystoduodenal fistula formation is described in a 6 yr old male. The patient, who had a short gut syndrome, had been maintained on lifelong total parenteral nutrition (TPN) following extensive neonatal ischemic bowel necrosis secondary to gast...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313029009086671

    authors: Byard RW,Thorner PS,Cutz E,Filler RM,Durie P

    更新日期:1990-10-01 00:00:00

  • LAMP1 expression is associated with malignant behaviours and predicts unfavourable prognosis in laryngeal squamous cell carcinoma.

    abstract::Lysosome-associated membrane protein-1 (LAMP1) has been suggested to play complicated roles in cancer development and metastasis. The aim of this study was to explore the expression of LAMP1 in laryngeal squamous cell carcinoma (LSCC) and investigate the relationship between LAMP1 expression and clinicopathological ch...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2016.08.001

    authors: Lu M,Zhu H,Wang X,Zhang D,Xiong L,Zhu J,Mao Y,Qiang J

    更新日期:2016-12-01 00:00:00

  • Histological assessment of apoptotic cell death in cardiomyopathies.

    abstract::Apoptosis in the myocardium is complex and often difficult to recognise. Myocyte apoptosis is scattered across the myocardial wall and is restricted to individual cells. In the present study, we describe the amount of apoptosis in 50 endomyocardial biopsies taken from 50 patients with dilated cardiomyopathy, in 14 hea...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:

    authors: Kavantzas NG,Lazaris AC,Agapitos EV,Nanas J,Davaris PS

    更新日期:2000-08-01 00:00:00

  • Multiple hepatic abscesses due to Yersinia enterocolitica.

    abstract::We report a case of multiple hepatic abscesses due to Yersinia enterocolitica in a 58 yr old male. This case is typical of the other 39 cases reported in the literature in that the patient had alcoholism, malnutrition, iron overload and a subsequently diagnosed malignancy. Ultrasound showed multiple hypoechoic areas i...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1080/00313029500169353

    authors: Strungs I,Farrell DJ,Matar LD,Dekker L,Franz RJ

    更新日期:1995-10-01 00:00:00

  • Prostatic stromal proliferations: a review.

    abstract::Prostatic stromal proliferations account for the majority of benign tumour-like lesions in the prostate. The most common is nodular hyperplasia, seen in a majority of elderly men. Diagnostic difficulty is encountered with some variants, including stromal hyperplasia with atypia, characterised by degenerative changes o...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.pathol.2020.09.017

    authors: Bostwick DG,Egevad L

    更新日期:2021-01-01 00:00:00

  • Broadsheet number 56: Mechanisms of fetal loss.

    abstract::The most significant task of the pathologist examining a fetal death is, if possible, the provision of an explanation for the event, which will allow the clinical attendants to counsel the family in an informed and relevant manner. In some cases, no adequate explanation will be possible, though many conditions will be...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1080/003130200104330

    authors: Smith NM

    更新日期:2000-05-01 00:00:00

  • A biometrical view on normal values of CD4 and CD8 lymphocyte counts in peripheral blood.

    abstract::Statistical methods have been used to determine an optimal approach to the definition of the reference range for CD4 ("helper") and CD8 ("suppressor/cytotoxic") T cell numbers and the CD4/CD8 ratio in the peripheral blood. A graphical presentation of the absolute values for CD4 and CD8 for 85 healthy blood donors show...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028809085219

    authors: Zachar V,Mikulecky M,Mayer V,Mackay I,Frazer I

    更新日期:1988-10-01 00:00:00

  • CD146 protein in prostate cancer: revisited with two different antibodies.

    abstract:AIMS:CD146 is a potentially metastasis promoting cell adhesion molecule and its expression has been described in various solid tumours. We aimed to evaluate the expression of CD146 in prostate cancer by immunohistochemistry in a clinically characterised study cohort to evaluate its prognostic properties. METHODS:We ev...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020802197996

    authors: Fritzsche FR,Wassermann K,Rabien A,Schicktanz H,Dankof A,Loening SA,Dietel M,Jung K,Kristiansen G

    更新日期:2008-08-01 00:00:00

  • Benign bone tumours in Western Australia, 1972-1996.

    abstract:AIMS:To review the benign bone tumours accessioned by the Bone Tumour Registry (BTR) of Western Australia (WA) during the years 1972-1996 and to determine the incidence of the more common types. METHODS:Information was extracted from the Registry database using 58 selected fields. RESULTS:During the 25 year period, 8...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020701684334

    authors: Blackwell JB,Curnow MN

    更新日期:2007-12-01 00:00:00