Prostatic stromal proliferations: a review.

Abstract:

:Prostatic stromal proliferations account for the majority of benign tumour-like lesions in the prostate. The most common is nodular hyperplasia, seen in a majority of elderly men. Diagnostic difficulty is encountered with some variants, including stromal hyperplasia with atypia, characterised by degenerative changes of myofibroblasts. In contrast with benign stromal tumours, malignant stromal tumours of the prostate are rare, accounting for less than 0.1% of all prostatic malignancies. The most common are rhabdomyosarcoma (paediatric) and leiomyosarcoma (adults); others include phyllodes tumour and stromal sarcoma. Some authors lump malignant tumours with poor outcome (e.g., phyllodes tumour and stromal sarcoma) with benign stromal tumours (e.g., stromal hyperplasia with atypia, leiomyoma), considering them collectively to be of uncertain malignant potential, but this approach is discouraged. This review presents a contemporary approach to classification and diagnosis of prostatic stromal tumours.

journal_name

Pathology

journal_title

Pathology

authors

Bostwick DG,Egevad L

doi

10.1016/j.pathol.2020.09.017

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

12-25

issue

1

eissn

0031-3025

issn

1465-3931

pii

S0031-3025(20)30952-1

journal_volume

53

pub_type

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