Abstract:
:In 2004, the diagnosis of established human immunodeficiency virus (HIV) infection can be made with close to 100% assurity. The extraordinarily engineered performances of HIV-screening assays are unprecedented. The well-established confirmatory tests performed by well-versed laboratories using criteria that are well understood in order to interpret the results of these tests give highly accurate outcomes of diagnostic testing strategies. Furthermore, the ability to monitor the progress of the infection and the viral pathogenesis is possible through the use of tests that quantify viral load or the peripheral CD4+ T-cells and other lymphocyte sub-type levels. Newer laboratory testing mechanisms, such as assessment of reverse transcriptase activity and sophisticated cell staining and flow cytometric analyses, have been used to map disease processes and progress on a research level and may be used in future to fine-tune therapy and to follow disease progression in even greater detail. Regulation of all HIV tests is of the highest level in Australia. In-house tests will be expected to conform to the levels specified for commercially produced tests.
journal_name
Pathologyjournal_title
Pathologyauthors
Dax EM,Arnott Adoi
10.1080/00313020400010922subject
Has Abstractpub_date
2004-12-01 00:00:00pages
551-60issue
6eissn
0031-3025issn
1465-3931journal_volume
36pub_type
杂志文章,评审相关文献
PATHOLOGY文献大全abstract::An epidemiological study of childhood cancer in New Zealand identified 409 children aged 0 to 14 years with malignant neoplasms newly diagnosed between 1990 and 1993 inclusive. The original microscopic material on which the diagnoses were based was reviewed in 398 cases and the neoplasms were allocated into the 12 maj...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/003130299105232
更新日期:1999-05-01 00:00:00
abstract::A 5-year-old Chinese boy had dull pain in his right knee for about one year. An intraosseous osteolytic lesion in the metaphysis of the right lower femur was curetted. The diagnosis of desmoplastic fibroma, possibly the first in a Hong Kong Chinese, was based on the clinical, radiological and histological findings. Ab...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028709077135
更新日期:1987-04-01 00:00:00
abstract::We present the clinical and postmortem findings in seven adults (four females and three males), who died with dissection of the coronary arteries. The median age was 56 years. Five of the coronary artery dissections (CADs) were spontaneous and two followed trauma: one a motor vehicle accident, the other occurred durin...
journal_title:Pathology
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
abstract::The mitogenic and chemotactic potency of platelet-derived growth factor (PDGF) has linked this polypeptide to the pathogenesis of several disease states including atherosclerosis and neoplasia. We have reviewed the recent literature on aspects relating to the structure, distribution and biology of PDGF and its high-af...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.3109/00313029209068882
更新日期:1992-10-01 00:00:00
abstract::A novel grading system based on the counting of poorly differentiated clusters (PDC) of neoplastic cells at the invasive margin and in the tumour stroma was recently introduced among the histological parameters predictive of adverse clinical outcome in colorectal cancer (CRC). The aim of this study was to correlate th...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000300
更新日期:2015-10-01 00:00:00
abstract::We counted apoptotic thymic cortical lymphocytes in semi-thin plastic sections of 266 human autopsy thymuses. The decreased patients included in the study were all aged less than 40 yrs and all died within 72 hrs of the onset of symptoms. Based on published data on animal and human material it was anticipated that ind...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029400169261
更新日期:1994-04-01 00:00:00
abstract::The field of systemic cancer therapy for metastatic disease has entered an exciting era with the advent of novel immunomodulatory strategies targeting immune checkpoints. At the heart of these promising efforts are the tumour-infiltrating lymphocytes (TILs). As the reports demonstrating efficacy of modulating TIL effe...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2015.12.006
更新日期:2016-02-01 00:00:00
abstract::AxI, Dtk and Mer are recently described receptors that constitute a new receptor tyrosine kinase subfamily. They bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) that is structurally related to the anticoagulation factor protein S. Studies suggest a role for these receptors in developmental pr...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313029700169744
更新日期:1997-05-01 00:00:00
abstract:AIMS:We aimed to evaluate the effects of caffeic acid phenethyl ester (CAPE) on lithium (Li)-induced lung toxicity. METHODS:Twenty-two adult male Wistar albino rats weighing between 280 and 300 g were used. The rats were randomly divided into three groups: control, Li and Li+CAPE groups. Li and CAPE were co-administer...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020500464904
更新日期:2006-02-01 00:00:00
abstract::Since its first description in the early part of the twentieth century, struma ovarii has elicited considerable interest because of its many unique features; however, at present a number of aspects remain enigmatic. Although the typical presentation is that of a pelvic mass, unusual clinical manifestations such as hyp...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313020601123979
更新日期:2007-02-01 00:00:00
abstract::Isolation of the new pandemic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for diagnostic and research purposes including assessment of novel therapeutics. Several primary and continuous cell lines are currently used, and new organoid and engineered cell lines are being developed for...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2020.09.012
更新日期:2020-12-01 00:00:00
abstract::The cell surface markers of 75 cases of non-Hodgkin's lymphoma were studied on cryostat sections using a panel of monoclonal antibodies. Forty-nine cases (65.3%) were found to express a B-cell phenotype, 23 cases (30.7%) a T-cell phenotype, 1 case (1.3%) a histiocytic phenotype and 2 cases (2.7%) no demonstrable surfa...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028609087562
更新日期:1986-10-01 00:00:00
abstract::Distinct differences in the extent and progression of the lateral and epicardial boundaries of evolving regional infarcts were demonstrated in isolated rabbit hearts. Ischemia was produced by interrupting (0-240 minutes) flow in the ventral interventricular branch of the left coronary artery, whilst the remainder of t...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028509084763
更新日期:1985-10-01 00:00:00
abstract::Rheumatoid Arthritis (RA) synovial membranes were examined by single and dual immunohistological techniques with a number of monoclonal antibodies against lymphocyte and macrophage related antigens. CD4 positive T lymphocytes frequently expressed MHC Class II antigens and were found in sublining collections in close a...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029209063615
更新日期:1992-01-01 00:00:00
abstract::Sclerosing adenosis (SA) of the breast if a disease associated with an increase relative risk of malignancy. The exact incidence and factors influencing malignant transformation in association with SA are not well established. Two counts of the AgNOR silver staining technique have been correlated with ploidy and proli...
journal_title:Pathology
pub_type: 临床试验,杂志文章
doi:10.1080/00313029700169015
更新日期:1997-08-01 00:00:00
abstract::Apoptosis in the myocardium is complex and often difficult to recognise. Myocyte apoptosis is scattered across the myocardial wall and is restricted to individual cells. In the present study, we describe the amount of apoptosis in 50 endomyocardial biopsies taken from 50 patients with dilated cardiomyopathy, in 14 hea...
journal_title:Pathology
pub_type: 杂志文章
doi:
更新日期:2000-08-01 00:00:00
abstract::A unique complication of florid xanthogranulomatous cholecystitis with cholecystoduodenal fistula formation is described in a 6 yr old male. The patient, who had a short gut syndrome, had been maintained on lifelong total parenteral nutrition (TPN) following extensive neonatal ischemic bowel necrosis secondary to gast...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029009086671
更新日期:1990-10-01 00:00:00
abstract::Measurement of extracellular hemoglobin is useful for assessing the relative success of different blood storage strategies. The test is now also included in routine quality assurance procedures. With the recent trend towards transfusion of concentrated red cells resuspended in "additive" solutions, a safe and efficien...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028609090838
更新日期:1986-01-01 00:00:00
abstract:AIM:We investigated the role of renal sympathetic innervation in the deterioration of renal haemodynamic and excretory functions during the early post-ischaemic phase of renal ischaemia/reperfusion injury. METHODS:Anaesthetised male Sprague-Dawley rats were subjected to unilateral renal ischaemia by clamping the left ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313021003631304
更新日期:2010-04-01 00:00:00
abstract::Age-specific paediatric reference intervals are used in interpretation of laboratory results. However, interpretation may be problematic when a child just crosses an age bracket and the difference between the original and the subsequent age-specific reference interval is large. Moreover, details about the physiologica...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000118
更新日期:2014-06-01 00:00:00
abstract:AIMS:In hereditary colorectal cancer (CRC) disorders such as familial adenomatous polyposis and hereditary non-polyposis colon cancer, the identification of germline mutations greatly assists in the clinical management of families. In addition, study of somatic mutations in the cancers themselves (both hereditary and s...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/0031302021000035965-1
更新日期:2002-12-01 00:00:00
abstract::The clinical course and biopsy findings of twenty-one patients with IgA nephropathy, followed up for a mean period of 37.4 mth (range 24-54 mth) after diagnosis, were reviewed retrospectively to determine whether the clinical presentations, the laboratory findings or histopathologic changes have prognostic implication...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028609090824
更新日期:1986-01-01 00:00:00
abstract::Paracetamol in serum was assayed by a new enzymatic method, and the results compared with a high performance liquid chromatographic method. Results by the two procedures agreed well (t = 0.05). The correlation coefficient was 0.999, and the slope and intercept by Deming analysis were 0.975 and 0.003 mmol/l respectivel...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028709065142
更新日期:1987-01-01 00:00:00
abstract:AIMS:Mounting evidence indicates that deregulation of apoptosis is involved in the mechanisms of cancer development. Bax-interacting factor-1 (Bif-1) interacts with both Bax and Bak that are crucial for the intrinsic apoptosis signalling. Functionally, loss of Bif-1 expression has been proven to enhance tumorigenesis. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020802320440
更新日期:2008-10-01 00:00:00
abstract:AIMS:It is currently accepted that primary ovarian tumours rarely, if ever, give rise to mucinous ascites/pseudomyxoma peritonei (PMP) which most commonly results from the intra-abdominal spread of an appendiceal mucinous neoplasm. However, primary ovarian mucinous tumours of appendiceal type arising within mature cyst...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020601024078
更新日期:2006-12-01 00:00:00
abstract:AIMS:The increasing importance of cardiac disease has generated an interest in improved screening strategies regarding preclinical cardiac abnormalities and employing measurement of circulating biomarkers. This review focuses on the utility of the B-type natriuretic peptides (NP) and the cardiac troponins (cTns) for th...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1097/PAT.0b013e32834e786e
更新日期:2012-02-01 00:00:00
abstract:AIM:Gasdermin-like (GSDML) is a novel member of the cancer associated gasdermin-domain containing (GSDMDC) protein family. The GSDMDC family has been linked to cancer development and progression, and this is the first study analysing the expression and intracellular localisation of GSDML. METHODS:GSDML gene transcript...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020701716250
更新日期:2008-01-01 00:00:00
abstract::One hundred and two cases of benign nerve sheath tumors (NSTs) were studied with a combined approach using routine light microscopy (LM), immunohistochemistry (IH) for myelin basic protein (MBP) and S-100 protein as well as transmission electron microscopy (TEM) with the aim of obtaining greater insight into the true ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029009086659
更新日期:1990-10-01 00:00:00
abstract:AIMS:Immunohistochemical detection of the 185-kDa transmembrane glycoprotein product of the proto-oncogene c-erbB-2 (also known as HER-2/neu), located on chromosome 17q21, is a well established method of evaluation in invasive breast cancer. This investigation is currently performed on standard sections cut from the tu...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020600820872
更新日期:2006-08-01 00:00:00
abstract::The most significant task of the pathologist examining a fetal death is, if possible, the provision of an explanation for the event, which will allow the clinical attendants to counsel the family in an informed and relevant manner. In some cases, no adequate explanation will be possible, though many conditions will be...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/003130200104330
更新日期:2000-05-01 00:00:00