Abstract：
:Phospholipid preparations from the nematode Ascaris suum or cysts of Echinococcus granulosus (hydatid cysts) induced an eosinophilia when injected into the peritoneal cavity of rats. Peritoneal eosinophilia persisted throughout 21 days of daily injections of Ascaris lipid and was accompanied by blood eosinophilia, mast cell granule lysis and mast cell hyperplasia. The active material consisted of lecithin and lecithin plasmalogen, and in aqueous suspension had a membrane-like appearance. Electron microscopy revealed that the phospholipid was ingested by all types of cells in the peritoneal cavity, including mast cells, and was rapidly broken down by eosinophils. Phagocytosis was found to be complement dependent. The lipid combined with properdin in human serum and stimulated complement breakdown via the alternative complement pathway.
journal_name
Pathologyjournal_title
Pathologyauthors
Archer GT,Robson JE,Thompson ARdoi
10.3109/00313027709085252subject
Has Abstractpub_date
1977-04-01 00:00:00pages
137-53issue
2eissn
0031-3025issn
1465-3931journal_volume
9pub_type
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