Relations of TGF-beta1 with HIF-1 alpha, GLUT-1 and longer survival of colorectal cancer patients.


AIMS AND METHODS:During colorectal carcinogenesis, transforming growth factor beta 1 (TGF-beta1) undergoes a functional change from suppression of cancer cell proliferation to inhibition of T cell mediated anti-cancer immunity. We aimed to evaluate relations among TGF-beta1 and cancer cell survival factors hypoxia inducible factor-1 alpha (HIF-1 alpha) and glucose transporter 1 (GLUT-1) by immunohistochemistry in 108 colorectal cancers. RESULTS:TGF-beta1 was detected in 87% (94/108), HIF-1 alpha in 85% (92/108), and GLUT-1 in 65% (70/108) of colorectal cancers. Not only did TGF-beta1 accumulate in cytoplasm of cancer cells but also there was strong immunoreactivity to TGF-beta1 in adjacent inflammatory cells. GLUT-1 was visualised in a membranous fashion while HIF-1 was expressed in a paranuclear pattern and occasionally in nuclei of malignant cells. Cancer immunoreactivities to TGF-beta1 correlated with HIF-1 alpha (p < 0.001, r = 0.516) and GLUT-1 (p < [corrected] 0.001, r = 0.355) in general and subgroups of different clinicopathological traits. TGF-beta1 expressions of inflammatory infiltrates correlated with longer patient survival (p = 0.05, r = 0.449) and immunoreactivities to HIF-1 alpha of cancer cells (p = 0.008, r = 0.254) particularly in node positive and deeply invading cancers but failed to associate significantly with GLUT-1. CONCLUSIONS:HIF-1 alpha and GLUT-1 could cooperate with TGF-beta1, and TGF-beta1 might mediate cross-talk between the inflammatory environment and tumour with a favourable impact on patient survival.






Sulkowska M,Wincewicz A,Sulkowski S,Koda M,Kanczuga-Koda L




Has Abstract


2009-01-01 00:00:00














  • c-erbB-2 (HER-2/neu) immunohistochemistry in invasive breast cancer: is there concordance between standard sections and tissue microarrays?

    abstract:AIMS:Immunohistochemical detection of the 185-kDa transmembrane glycoprotein product of the proto-oncogene c-erbB-2 (also known as HER-2/neu), located on chromosome 17q21, is a well established method of evaluation in invasive breast cancer. This investigation is currently performed on standard sections cut from the tu...


    pub_type: 杂志文章


    authors: Selvarajan S,Tan SY,Sii LH,Tan PH

    更新日期:2006-08-01 00:00:00

  • Prognostic impact of the cancer stem cell related markers ALDH1 and EZH2 in triple negative and basal-like breast cancers.

    abstract:AIMS:We assessed the expression of ALDH1 and EZH2, cancer stem cell (CSC) related markers, in triple negative and basal-like breast cancers, investigating their association with clinicopathological features and outcome. METHODS:Clinicopathological data were obtained from 140 cases of triple negative breast cancer. A t...


    pub_type: 杂志文章


    authors: De Brot M,Rocha RM,Soares FA,Gobbi H

    更新日期:2012-06-01 00:00:00

  • Functional antithrombin-III variant (41 Pro----Leu) identified by liquid secondary ion mass spectrometry.

    abstract::A genetic variant of antithrombin with impaired heparin cofactor activity was identified in 4 members of a French family. Both the variant and normal antithrombin component were purified by affinity chromatography on heparin Sepharose. Reverse phase peptide mapping revealed a single altered peak when tryptic digests o...


    pub_type: 杂志文章


    authors: Brennan SO,Borg JY,Shaw GJ,Caen J,George PM

    更新日期:1991-01-01 00:00:00

  • LAMP1 expression is associated with malignant behaviours and predicts unfavourable prognosis in laryngeal squamous cell carcinoma.

    abstract::Lysosome-associated membrane protein-1 (LAMP1) has been suggested to play complicated roles in cancer development and metastasis. The aim of this study was to explore the expression of LAMP1 in laryngeal squamous cell carcinoma (LSCC) and investigate the relationship between LAMP1 expression and clinicopathological ch...


    pub_type: 杂志文章


    authors: Lu M,Zhu H,Wang X,Zhang D,Xiong L,Zhu J,Mao Y,Qiang J

    更新日期:2016-12-01 00:00:00

  • Oral malignant gastrointestinal neuroectodermal tumour with junctional component mimicking mucosal melanoma.

    abstract::Malignant gastrointestinal neuroectodermal tumour (GNET) is a recently characterised rare and aggressive tumour that typically arises in association with the small intestine of adults. We present a novel case of this entity and expand the spectrum of its reported morphological features. The patient was a 5-year-old fe...


    pub_type: 杂志文章


    authors: Allanson BM,Weber MA,Jackett LA,Chan C,Lau L,Ziegler DS,Warby M,Mayoh C,Cowley MJ,Tucker KM,Long GV,Maher A,Anazodo A,Scolyer RA

    更新日期:2018-10-01 00:00:00

  • Low molecular weight IgM in the sera of patients with chronic lymphocytic leukemia.

    abstract::With the use of 2 independent techniques, circulating monomeric and oligomeric IgM were detected in the majority of 29 patients with chronic lymphocytic leukemia (CLL). In contrast it was detected only in trace quantities in a minority of healthy subjects. In the CLL group no significant correlation was observed betwe...


    pub_type: 杂志文章


    authors: Xu HJ,Roberts-Thomson PJ

    更新日期:1993-01-01 00:00:00

  • Cell culture studies on human nerve sheath tumors.

    abstract::The main controversy about nerve sheath tumors (NSTs) has been their histogenesis. A Schwann cell origin has been proposed by many investigators for both schwannomas and neurofibromas. However Erlandson and Woodruff observed that while schwannomas appeared to be composed predominantly of Schwann cells, neurofibromas c...


    pub_type: 杂志文章


    authors: Kharbanda K,Dinda AK,Sarkar C,Karak AK,Mathur M,Roy S

    更新日期:1994-01-01 00:00:00

  • Comparison of thromboplastins using the ISI and INR system.

    abstract::Twelve thromboplastins were tested against a secondary reference thromboplastin (human brain CRM BCR No. 147) or a tertiary house standard (human brain thromboplastin) with plasmas from normal healthy individuals and patients on oral anticoagulant therapy. The relationship between the prothrombin ratios of the thrombo...


    pub_type: 杂志文章


    authors: Moriarty HT,Lam-Po-Tang PR,Anastas N

    更新日期:1990-04-01 00:00:00

  • B cell chronic lymphocytic leukaemia cells have reduced capacity to upregulate expression of MHC class I in response to interferon-gamma.

    abstract:AIMS:An important consideration in the design of a tumour vaccine is the ability of tumour-specific cytotoxic T lymphocytes (CTL) to recognise unmanipulated tumour cells in vivo. To determine whether B-CLL might use an escape strategy, the current studies compared B-CLL and normal B cell MHC class I expression. METHOD...


    pub_type: 杂志文章


    authors: Juffs H,Fowler N,Saal R,Grimmett K,Beasley S,O'Sullivan B,Frazer I,Gill D,Thomas R

    更新日期:2004-02-01 00:00:00

  • Intravascular large cell lymphoma: diagnosis on renal biopsy.

    abstract::The case is reported of a woman aged 60 yrs who presented with systemic symptoms and who was found to have proteinuria of 3.5 g per day. A renal biopsy revealed numerous neoplastic cells filling many of the glomerular capillary lumina. Immunoperoxidase stains revealed that the phenotype of the malignant cells was LCA+...


    pub_type: 杂志文章


    authors: Axelsen RA,Laird PP,Horn M

    更新日期:1991-07-01 00:00:00

  • A rapid method for assessing megathrombocytes: its application to thrombocytotic and acquired thrombocytopenic states.

    abstract::A rapid technique suitable for routine laboratory use for determining the percentage of large platelets in the peripheral blood is described. In 50 haematologically normal subjects, megathrombocytes (platelets with a volume of 16-33 fl) constituted 3.0-16.6% (mean +/- 2 SD) of the platelet count. Of the 10 patients ex...


    pub_type: 杂志文章


    authors: Hunt FA

    更新日期:1976-01-01 00:00:00

  • Review of 253 cases of significant pathology in 7,910 cholecystectomies in Hong Kong.

    abstract::A retrospective study of gallbladders submitted as surgical specimens over a period of fifteen years (1972-1986) was performed in the Department of Pathology, Queen Mary Hospital, Hong Kong. Seven thousand nine hundred and ten gallbladders were examined. A total of 253 more unusual and significant pathological lesions...


    pub_type: 杂志文章


    authors: Chan KW

    更新日期:1988-01-01 00:00:00

  • Ultrastructure of human melanosis coli with reference to its pathogenesis.

    abstract::Colonic mucosal biopsies from patients with melanosis coli were examined by electron microscopy. They showed apoptosis of colonic surface epithelial cells and phagocytosis of resulting apoptotic bodies by intraepithelial macrophages. The latter migrated to the lamina propria where intracellular degradation of the apop...


    pub_type: 杂志文章


    authors: Walker NI,Smith MM,Smithers BM

    更新日期:1993-04-01 00:00:00

  • An improved procedure for accurate assays of factor VIII.

    abstract::An improved one-stage method for accurate assays of factor VIII combines highly reproducible end points with elimination of temporal drift and of subjective factors involved in graphic analysis. Activated deficient plasma substrate (ADPS) is used as a single reagent for parallel tests. The assays can be performed manu...


    pub_type: 杂志文章


    authors: Margolis J

    更新日期:1979-04-01 00:00:00

  • Detection of minimal residual disease in an AML patient with trisomy 8 using interphase fish.

    abstract::Patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) often exhibit clonal chromosomal abnormalities. Using a probe for the centromeric region of chromosome 8, fluorescence in situ hybridization (FISH) on interphase cells was used to detect trisomy 8 in an AML patient whose leukemia was characte...


    pub_type: 杂志文章


    authors: White DL,Hutchins CJ,Turczynowicz S,Suttle J,Haylock DN,Hughes TP,Juttner CA,To LB

    更新日期:1997-08-01 00:00:00

  • An improved screening method for 3-methoxy-4-hydroxy mandelic acid excretion in urine.

    abstract::A screening method is described for urinary 3-methoxy-4-hydroxy mandelic acid using an initial ion exchange procedure, vanillin formation and extraction into toluene. The technique, is simple, rapid and specific, with a reference value up to 35 mumol (7.0 mg)/day established on 92 normal human subjects. Over 200 patie...


    pub_type: 杂志文章


    authors: Rumble BA,Dick M

    更新日期:1978-01-01 00:00:00

  • Squamous cell carcinoma arising in an eccrine hidrocystoma.

    abstract::This report describes the case of a 63 yr old male with an enlarging lesion on the left cheek. Excision biopsy showed a squamous cell carcinoma arising from an eccrine hidrocystoma. The eccrine hidrocystoma showed foci of squamous metaplasia and the sequence of squamous metaplasia complicated by squamous carcinoma is ...


    pub_type: 杂志文章


    authors: Theocharous C,Jaworski RC

    更新日期:1993-04-01 00:00:00

  • Rare (new) entities of the breast and medullary carcinoma.

    abstract::Rare tumours are a heterogeneous group of conditions that encompass benign to malignant lesions both of stromal and epithelial origin. Here some of these tumours are described, in which the authors have most familiarity. An outline of medullary carcinoma is also presented. ...


    pub_type: 杂志文章


    authors: Foschini MP,Eusebi V

    更新日期:2009-01-01 00:00:00

  • Mesocolonic lymphangioma: a case report with immunoperoxidase and electron microscopic studies.

    abstract::A 14 yr old girl presented with a large cystic mass in the transverse mesocolon which was completely excised. Cystic lymphangioma was diagnosed, based on the specific histologic, immunoperoxidase and ultrastructural findings. ...


    pub_type: 杂志文章


    authors: Yuen ST,Ng IO,Ho J,Ma L

    更新日期:1992-07-01 00:00:00

  • Implications of p53 protein expression in clear cell sarcoma of the kidney.

    abstract::Eight histologically-confirmed cases of clear cell sarcoma of the kidney (CCSK) were studied for possible mutations in the p53 tumor suppressor gene by the immunohistochemical demonstration of mutant p53 proteins using a monoclonal (DO7: Dako) and a polyclonal (AB565: Chemicon) antibody to p53 protein. All cases exhib...


    pub_type: 杂志文章


    authors: Cheah PL,Looi LM

    更新日期:1996-08-01 00:00:00

  • Erythroblastosis fetalis--the discovery and partial elimination of rhesus incompatibility--the origins of exchange transfusion in Australia.

    abstract::The first 2 exchange transfusions in Australia for Rhesus-induced erythroblastosis (hemolytic disease of the newborn) were conducted in the 9 mth period from December 1945 to August 1946. These pioneering endeavours in medical research were undertaken by 3 transfusionists who were, or had been, directors of the Red Cr...


    pub_type: 历史文章,杂志文章


    authors: Pearn JH

    更新日期:1994-04-01 00:00:00

  • An enzyme immunoassay for rapid isotyping of monoclonal antibodies.

    abstract::An enzyme-immunoassay has been developed for rapid isotyping of murine monoclonal antibodies. This assay has several advantages over the commonly used typing methods. It does not require the presence of specific antigen. Typing plates can be prepared in advance and stored frozen. Unequivocal results can be obtained in...


    pub_type: 杂志文章


    authors: Gardner ID

    更新日期:1985-01-01 00:00:00

  • CD146 protein in prostate cancer: revisited with two different antibodies.

    abstract:AIMS:CD146 is a potentially metastasis promoting cell adhesion molecule and its expression has been described in various solid tumours. We aimed to evaluate the expression of CD146 in prostate cancer by immunohistochemistry in a clinically characterised study cohort to evaluate its prognostic properties. METHODS:We ev...


    pub_type: 杂志文章


    authors: Fritzsche FR,Wassermann K,Rabien A,Schicktanz H,Dankof A,Loening SA,Dietel M,Jung K,Kristiansen G

    更新日期:2008-08-01 00:00:00

  • Recurrent pyogenic cholangitis: a necropsy study.

    abstract::Forty-six necropsy cases of recurrent pyogenic cholangitis (RPC) among Chinese in Hong Kong were reviewed. Intrahepatic biliary pigment stones or bile sludge were present in all cases and liver abscesses were common (80%). Histologically the early lesion was marked by acute inflammation in portal tracts with frequent ...


    pub_type: 杂志文章


    authors: Chou ST,Chan CW

    更新日期:1980-07-01 00:00:00

  • Discordant neutrophil alkaline phosphatase activity and cytogenetic response in chronic myeloid leukemia treated with alpha-interferon.

    abstract::Decreased neutrophil alkaline phosphatase (NAP) synthesis is a classical feature of Philadelphia (Ph) positive chronic phase chronic myeloid leukemia (CML). Whether this aberration is an integral leukemic property of the cell or results from mediation by other factors is unclear. During alpha-interferon (alpha-IFN) ba...


    pub_type: 杂志文章


    authors: Taylor DL,Kerwick AM,Elliott SL,Rodwell RL,Wright SJ,Marlton PV,Veleba AR,Taylor KM

    更新日期:1993-10-01 00:00:00

  • Granulomatous mastitis: a clinicopathological review of 26 cases.

    abstract:AIMS:Twenty-six cases of granulomatous mastitis were examined to determine the common histological and clinical features and the possible association with micro-organisms. METHODS:A retrospective review of the clinical and histological features of these cases was undertaken, including granuloma, inflammatory cell infi...


    pub_type: 杂志文章,评审


    authors: Tse GM,Poon CS,Ramachandram K,Ma TK,Pang LM,Law BK,Chu WC,Tang AP,Cheung HS

    更新日期:2004-06-01 00:00:00

  • Experimental autoimmune glomerulonephritis in the rat. II. A histopathological and fine structural study.

    abstract::Human glomerular basement membrane (GBM) emulsified in Freund's complete adjuvant was injected into 16 Holtzman rats. Eleven (69%) of them subsequently developed glomerulonephritis. This disease was characterized by glomerular changes which included focal lobular hypercellularity due to localized hyperplasia of intrac...


    pub_type: 杂志文章


    authors: McCausland IP,Herdson PB,Gavin JB

    更新日期:1976-04-01 00:00:00

  • Ovarian sex cord-stromal tumours: an update in recent molecular advances.

    abstract::Sex cord-stromal tumours (SCSTs) consist of a heterogeneous group of neoplasms with diverse clinicopathological features and biological behaviour. They often present as a diagnostic challenge as they have varied and occasionally overlapping histomorphology and some may even mimic non-SCSTs. An accurate diagnosis is im...


    pub_type: 杂志文章,评审


    authors: Lim D,Oliva E

    更新日期:2018-02-01 00:00:00

  • TROP-2 immunohistochemistry: a highly accurate method in the differential diagnosis of papillary thyroid carcinoma.

    abstract::We aimed to evaluate the diagnostic utility of the novel immunohistochemical marker TROP-2 on thyroid specimens (226 tumours and 207 controls). Whole slide immunohistochemistry was performed and scored by automated digital image analysis. Non-neoplastic thyroid, follicular adenomas, follicular carcinomas, and medullar...


    pub_type: 杂志文章


    authors: Bychkov A,Sampatanukul P,Shuangshoti S,Keelawat S

    更新日期:2016-08-01 00:00:00

  • The enigma of struma ovarii.

    abstract::Since its first description in the early part of the twentieth century, struma ovarii has elicited considerable interest because of its many unique features; however, at present a number of aspects remain enigmatic. Although the typical presentation is that of a pelvic mass, unusual clinical manifestations such as hyp...


    pub_type: 杂志文章,评审


    authors: Roth LM,Talerman A

    更新日期:2007-02-01 00:00:00