Relations of TGF-beta1 with HIF-1 alpha, GLUT-1 and longer survival of colorectal cancer patients.


AIMS AND METHODS:During colorectal carcinogenesis, transforming growth factor beta 1 (TGF-beta1) undergoes a functional change from suppression of cancer cell proliferation to inhibition of T cell mediated anti-cancer immunity. We aimed to evaluate relations among TGF-beta1 and cancer cell survival factors hypoxia inducible factor-1 alpha (HIF-1 alpha) and glucose transporter 1 (GLUT-1) by immunohistochemistry in 108 colorectal cancers. RESULTS:TGF-beta1 was detected in 87% (94/108), HIF-1 alpha in 85% (92/108), and GLUT-1 in 65% (70/108) of colorectal cancers. Not only did TGF-beta1 accumulate in cytoplasm of cancer cells but also there was strong immunoreactivity to TGF-beta1 in adjacent inflammatory cells. GLUT-1 was visualised in a membranous fashion while HIF-1 was expressed in a paranuclear pattern and occasionally in nuclei of malignant cells. Cancer immunoreactivities to TGF-beta1 correlated with HIF-1 alpha (p < 0.001, r = 0.516) and GLUT-1 (p < [corrected] 0.001, r = 0.355) in general and subgroups of different clinicopathological traits. TGF-beta1 expressions of inflammatory infiltrates correlated with longer patient survival (p = 0.05, r = 0.449) and immunoreactivities to HIF-1 alpha of cancer cells (p = 0.008, r = 0.254) particularly in node positive and deeply invading cancers but failed to associate significantly with GLUT-1. CONCLUSIONS:HIF-1 alpha and GLUT-1 could cooperate with TGF-beta1, and TGF-beta1 might mediate cross-talk between the inflammatory environment and tumour with a favourable impact on patient survival.






Sulkowska M,Wincewicz A,Sulkowski S,Koda M,Kanczuga-Koda L




Has Abstract


2009-01-01 00:00:00














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    abstract::Recent updated models of the coagulation mechanism suggest that factor VII/thromboplastin complex is the main initiator or trigger of coagulation. Factor VII activation of factor IX is likely to be an important activation pathway. Inhibition of factor VII by tissue factor pathway inhibitor may have a regulatory role i...


    pub_type: 杂志文章


    authors: Wei DC,Wong RW,Robertson EP

    更新日期:1997-05-01 00:00:00

  • The effect of 50 grams of glucose orally on a number of biochemical variables.

    abstract::The values of a number of biochemical variables have been studied before and after a 50-gram load of glucose orally. Reductions which were statistically significant were found for sodium, potassium, urea, total protein, albumin, calcium, phosphorus, urate, bilirubin, alkaline phosphatase, but not for bicarbonate, crea...


    pub_type: 杂志文章


    authors: Masarei JR

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  • von Willebrand's disease characterized by increased ristocetin sensitivity and the presence of all von Willebrand factor multimers in plasma: a new subtype.

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    pub_type: 杂志文章


    authors: Wylie B,Gibson J,Uhr E,Kronenberg H

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  • BRAFV600E mutation analysis by immunohistochemistry in patients with thoracic metastases from colorectal cancer.

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    更新日期:2014-06-01 00:00:00

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    authors: Dax EM,Arnott A

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    authors: Christenson RH,Phillips D

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    authors: Pillay K,Chetty R

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    authors: Cloonan MJ,Bishop GA,Wilton-Smith PD,Carter IW,Allan RM,Wilcken DE

    更新日期:1979-10-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Wang W,Lin P

    更新日期:2020-01-01 00:00:00

  • CD146 protein in prostate cancer: revisited with two different antibodies.

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    authors: Fritzsche FR,Wassermann K,Rabien A,Schicktanz H,Dankof A,Loening SA,Dietel M,Jung K,Kristiansen G

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    authors: Bethwaite PB,Holloway LJ,Thornton A,Delahunt B

    更新日期:1996-11-01 00:00:00

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    pub_type: 杂志文章


    authors: McClure J,Smith PS,Sorby-Adams G,Hopwood J

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    authors: Radhi JM,Loewy J

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    authors: Nagel H,Brinck U,Lüthje D,Füzesi L

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    authors: Sims FH

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  • Acute tonsillitis in children: microbial pathogens in relation to age.

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    authors: Douglas RM,Miles H,Hansman D,Fadejevs A,Moore B,Bollen MD

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    pub_type: 杂志文章,评审


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