Relations of TGF-beta1 with HIF-1 alpha, GLUT-1 and longer survival of colorectal cancer patients.

abstract：AIMS:INI1 expression and its correlation with MGMT gene promoter methylation status and follow-up was investigated in 77 surgically removed glioblastomas then treated with radiotherapy (RT) or RT plus temozolomide (TMZ). METHODS:INI1 was determined by immunohistochemistry and MGMT by methylation-specific PCR. RESULTS...

journal_title：Pathology

authors： Zunarelli E,Bigiani N,Sartori G,Migaldi M,Sgambato A,Maiorana A

更新日期：2011-01-01 00:00:00

abstract：AIMS:Nuclear factor-kappa B (NF-kappaB) activation has been recognised as an important mechanism in the development of cancers. However, expression status of NF-kappaB-related proteins in oesophageal squamous cell carcinoma (ESCC) tissues is largely unknown. In this study, we analysed expressions of NF-kappaB members (...

journal_title：Pathology

authors： Kang MR,Kim MS,Kim SS,Ahn CH,Yoo NJ,Lee SH

更新日期：2009-01-01 00:00:00

abstract：:Semen analysis is the most important laboratory investigation for men when assessing the infertile couple. Advances in in vitro fertilisation (IVF) techniques, particularly intracytoplasmic sperm injection (ICSI) involving the direct injection of a single spermatozoon into an egg, have not diminished the role of semen...

journal_title：Pathology

authors： McLachlan RI,Baker HW,Clarke GN,Harrison KL,Matson PL,Holden CA,de Kretser DM,Andrology Australia Australian Centre of Excellence in Male Reproductive Health.,Fertility Society of Australia Scientists in Reproductive Technology Subcommit

更新日期：2003-02-01 00:00:00

abstract：:Apoptosis in the myocardium is complex and often difficult to recognise. Myocyte apoptosis is scattered across the myocardial wall and is restricted to individual cells. In the present study, we describe the amount of apoptosis in 50 endomyocardial biopsies taken from 50 patients with dilated cardiomyopathy, in 14 hea...

journal_title：Pathology

authors： Kavantzas NG,Lazaris AC,Agapitos EV,Nanas J,Davaris PS

更新日期：2000-08-01 00:00:00

abstract：AIM:Gasdermin-like (GSDML) is a novel member of the cancer associated gasdermin-domain containing (GSDMDC) protein family. The GSDMDC family has been linked to cancer development and progression, and this is the first study analysing the expression and intracellular localisation of GSDML. METHODS:GSDML gene transcript...

journal_title：Pathology

authors： Carl-McGrath S,Schneider-Stock R,Ebert M,Röcken C

更新日期：2008-01-01 00:00:00

abstract：AIMS:Predicting the clinical behaviour of gastrointestinal stromal tumours (GISTs) is difficult and criteria delineating benign from malignant cases are not firmly established. The aims of this study were to define the clinicopathological and molecular features of 66 GISTs, and to determine whether any specific paramet...

journal_title：Pathology

authors： Koay MH,Goh YW,Iacopetta B,Grieu F,Segal A,Sterrett GF,Platten M,Spagnolo DV

更新日期：2005-02-01 00:00:00

abstract：:The dense fine speckled (DFS) pattern is an antinuclear antibody (ANA) pattern that has recently become of interest. This particular pattern has not been associated with systemic autoimmune rheumatic disorders (SARD) but has been associated with other inflammatory conditions such as interstitial nephritis, autoimmune ...

journal_title：Pathology

authors： Broadfoot A,Sivertsen T,Baumgart K

更新日期：2016-04-01 00:00:00

abstract：AIM:Lignocaine, a topical anaesthetic agent, is generally used in variable concentrations usually between 2% and 4% on the vocal cords prior to flexible bronchoscopy and bronchoalveolar lavage (BAL) procedures. The aim of this study was to investigate whether 2% or 1% lignocaine significantly inhibits the growth of org...

journal_title：Pathology

authors： Chandan SS,Faoagali J,Wainwright CE

更新日期：2005-08-01 00:00:00

abstract：:Changes in the contracture and stiffness of ventricular walls during ischemia and their effect on vascular reperfusion were studied in isolated rat hearts. Global ischemia was induced by stopping the flow of oxygenated perfusate for 60 min. Contracture pressures generated against water-filled left ventricular balloons...

journal_title：Pathology

authors： Humphrey SM,Gavin JB

更新日期：1985-07-01 00:00:00

abstract：AIMS:To correlate the immunostaining for INI1 protein and mutations in INI1 gene in possible rhabdoid tumours (RT) and atypical teratoid/rhabdoid tumours (AT/RT) seen at the Royal Children's Hospital in the last 10 years, and to study the clinicopathological features of those patients with negative nuclear staining. M...

journal_title：Pathology

authors： Wu X,Dagar V,Algar E,Muscat A,Bandopadhayay P,Ashley D,Wo Chow C

更新日期：2008-12-01 00:00:00

abstract：:In various tumor types dentritic cell, infiltration and the presence of tumor-infiltrating lymphocytes have been associated with an improved clinical outcome. In the uterine cervix these immunocompetent cells have been associated with improved prognosis in high stage disease. The current study examines the significanc...

journal_title：Pathology

authors： Bethwaite PB,Holloway LJ,Thornton A,Delahunt B

更新日期：1996-11-01 00:00:00

abstract：:A 40 year old Chinese woman presented with anasarca and later developed features of POEMS syndrome. These are peripheral neuropathy (P), organomegaly (O), endocrine dysfunction (E), monoclonal gammopathy (M), and skin changes (S) which are usually associated with plasma cell dyscrasia. In our patient, monoclonal gammo...

journal_title：Pathology

authors： Leung NW,Lam CW,Pang JC

更新日期：1991-04-01 00:00:00

abstract：:Solitary fibrous tumour (SFT) is well-described in the urinary tract, but malignant examples are rare. We studied our experience with high grade malignant SFT of the prostate to address the degree of histological and immunophenotypical overlap with sarcomatoid carcinoma and prostatic stromal sarcoma. Four cases were i...

journal_title：Pathology

authors： Bakhshwin A,Berry RS,Cox RM,Li R,Reynolds JP,Rubin BP,McKenney JK

更新日期：2020-10-01 00:00:00

abstract：:The use of purified intrinsic factor in vitamin B12 radioassays has greatly reduced the misdiagnosis of pernicious anaemia in recent years, but anomalies still occur. Observations made on current vitamin B12 radioassays suggest that many methods fail to convert all serum cobalamins to cyanocobalamin and thus are not t...

journal_title：Pathology

authors： Brown RD,Robin H,Kronenberg H

更新日期：1982-01-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is often associated with a poor prognosis and options for the treatment of this disease are few. To date, the important role of the immune microenvironment in modifying the disease natural history is well established. The programmed cell death pathway (PD-1/PD-L1) limits the T lymp...

journal_title：Pathology

authors： Rrapaj E,Giacometti L,Spina P,Salvo M,Baselli GA,Veggiani C,Rena O,Trisolini E,Boldorini RL

更新日期：2020-11-30 00:00:00

abstract：AIMS:Activation of β-catenin has been identified as a possible mechanism for the development of nephroblastomas. In our study we investigated whether this activation occurs already in precursor lesions of nephroblastomas, called nephrogenic rests (NRs). Inactivation of the adenomatous polyposis coli (APC) protein is an...

journal_title：Pathology

authors： Grill C,Sunitsch S,Hatz M,Hauser-Kronberger C,Leuschner I,Hoefler G,Guertl B

更新日期：2011-12-01 00:00:00

abstract：AIMS:Twenty-six cases of granulomatous mastitis were examined to determine the common histological and clinical features and the possible association with micro-organisms. METHODS:A retrospective review of the clinical and histological features of these cases was undertaken, including granuloma, inflammatory cell infi...

journal_title：Pathology

authors： Tse GM,Poon CS,Ramachandram K,Ma TK,Pang LM,Law BK,Chu WC,Tang AP,Cheung HS

更新日期：2004-06-01 00:00:00

abstract：AIMS:Biochemical analysis of glucose and ketones in the vitreous humour obtained at post-mortem examination is representative of the levels in the blood prior to death. Elevated levels can be indicative of conditions including diabetic ketoacidosis, which can be a cause for unexpected death. A rapid screening test for ...

journal_title：Pathology

authors： Mitchell R,Thomas SD,Langlois NE

更新日期：2013-10-01 00:00:00

abstract：:Epithelial ovarian neoplasms can be divided into three distinct clinicopathological groups: benign, malignant and borderline tumours. Borderline tumours are less aggressive than epithelial carcinomas, with an indolent clinical course and delayed recurrence. However, a subset of these cases can progress to malignancy a...

journal_title：Pathology

authors： Losi L,Botticelli L,Garagnani L,Fabbiani L,Panini R,Gallo G,Sabbatini R,Maiorana A,Benhattar J

更新日期：2021-02-01 00:00:00

abstract：:Gene targeting ('knock-out') technology is now widely used in the basic science of all disciplines of pathology and particularly auto-immune and inflammatory disease. Gene targeting is the wilful introduction of precise mutations into the genome of an animal, usually a mouse, affecting the function of a single gene or...

journal_title：Pathology

authors： Riminton DS

更新日期：2002-04-01 00:00:00

abstract：AIMS:Immunohistochemical detection of the 185-kDa transmembrane glycoprotein product of the proto-oncogene c-erbB-2 (also known as HER-2/neu), located on chromosome 17q21, is a well established method of evaluation in invasive breast cancer. This investigation is currently performed on standard sections cut from the tu...

journal_title：Pathology

authors： Selvarajan S,Tan SY,Sii LH,Tan PH

更新日期：2006-08-01 00:00:00

abstract：:A male iniencephalic foetus of about 25 weeks gestation is described. The baby was born to a 22-year-old mother, who presented with abdominal pain of 1 day duration. An ultrasound scan at that time showed multiple foetal anomalies and the pregnancy was terminated. A stillborn baby was delivered. At autopsy, characteri...

journal_title：Pathology

authors： Loo CK,Freeman B,Stanford D

更新日期：2001-02-01 00:00:00

abstract：:The main controversy about nerve sheath tumors (NSTs) has been their histogenesis. A Schwann cell origin has been proposed by many investigators for both schwannomas and neurofibromas. However Erlandson and Woodruff observed that while schwannomas appeared to be composed predominantly of Schwann cells, neurofibromas c...

journal_title：Pathology

authors： Kharbanda K,Dinda AK,Sarkar C,Karak AK,Mathur M,Roy S

更新日期：1994-01-01 00:00:00

abstract：:The frequency of simultaneous infection with Neisseria gonorrhoeae and Chlamydia trachomatis in men and women in Eastern Sydney was examined prospectively over a 21 month period in patients from whom appropriate specimens were obtained. In men gonococcal disease (113 cases) and chlamydial infections (124 cases) occurr...

journal_title：Pathology

authors： Tapsall JW,Kinchington M

更新日期：1996-01-01 00:00:00

abstract：:A histopathological examination was made of 60 stapes obtained during surgery for clinical otosclerosis. The findings, correlated with the clinical history and macroscopic appearances of the stapes, led to the following observations. The histological extent of the focus of otosclerosis agrees well with the macroscopic...

journal_title：Pathology

authors： Iyer PV,Gristwood RE

更新日期：1984-01-01 00:00:00

abstract：:A case is described of a mediastinal soft tissue sarcoma, in a 76-year-old man, characterized microscopically by the intimate combined features of liposarcoma and leiomyosarcoma. The lipomatous component consisted of well differentiated liposarcoma with myxoid areas. The smooth muscle component was characterized by fa...

journal_title：Pathology

authors： Gómez-Román JJ,Val-Bernal JF

更新日期：1997-11-01 00:00:00

abstract：AIMS:To assess the production of a liver-specific protein, albumin, and of a master transcriptional factor, hepatocyte nuclear factor (HNF)-4alpha, in hepatoid adenocarcinoma tissue. METHODS:Standard and quantitative RT-PCR, using five cases of hepatoid and three cases of non-hepatoid gastric adenocarcinoma. RESULTS:...

journal_title：Pathology

authors： Yano T,Kishimoto T,Tomaru U,Kawarada Y,Kato H,Yoshiki T,Ishikura H

更新日期：2003-02-01 00:00:00

abstract：:Tissue from the epiphyseal plate of a patient with Morquio type A syndrome (mucopolysaccharidosis type IVA) was studied by undecalcified histological and electron microscopical techniques. Cartilage cells in the plate were vacuolated to a variable degree. The orderly proliferating structure of the epiphyseal plate was...

journal_title：Pathology

authors： McClure J,Smith PS,Sorby-Adams G,Hopwood J

更新日期：1986-04-01 00:00:00

abstract：:Forty four ventilated premature infants from three Neonatal Intensive Care Units around Melbourne were evaluated prospectively for evidence of Ureaplasma urealyticum and Chlamydia trachomatis infection in the respiratory tract. No C. trachomatis was found and this probably reflects the low prevalence of genital carria...

journal_title：Pathology

authors： Garland SM,Bowman ED

更新日期：1996-08-01 00:00:00

abstract：:Lymphomatous involvement of skin usually manifests as plaques, maculopapules, papulonodules, tumorous masses or ulcerated eruptions. We report an unusual case in which the cutaneous relapse of nasal T-cell lymphoma clinically mimicked erythema multiforme by the abrupt onset of lesions and the presence of targetoid and...

journal_title：Pathology

authors： Chan JK,Sin VC,Ng CS,Lau WH

更新日期：1989-07-01 00:00:00