Iron tablets cause histopathologically distinctive lesions in mucosal biopsies of the stomach and esophagus.

Abstract:

:Iron tablets are widely used in the community. Severe, sometimes lethal, damage to the gastrointestinal tract following overdose is well known, but there is less appreciation of the damage that can be caused by therapeutic dosage. In this histological study of three esophageal lesions and six gastric lesions (including one autopsy case), heavy iron accumulation was demonstrated within ulcer granulation tissue, in connective tissue and blood vessels of the mucosal lamina propria, and within glandular and squamous epithelium. The appearance was distinctive and was similar to that seen following overdosage, although more localized. Five of the patients studied had evidence of delayed esophageal or gastric emptying which could have contributed to the damaging effect of the iron tablets. In most of the patients ulceration appeared to have preceded the commencement of iron therapy, so that the iron probably exacerbated rather than initiated ulceration and stricture formation. Histopathological reporting of iron-induced changes in endoscopic biopsies will alert clinicians to a correctable pathological process.

journal_name

Pathology

journal_title

Pathology

authors

Eckstein RP,Symons P

doi

10.1080/00313029600169763

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

142-5

issue

2

eissn

0031-3025

issn

1465-3931

journal_volume

28

pub_type

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