Abstract:
:Glomeruli from 48 cases of glomerulonephritis (Gn) were isolated and studied by means of the scanning electron microscope (SEM). Overall glomerular loss due to processing was 2.4%. SEM of these isolated glomeruli showed good preservation of glomerular structure. Changes of the podocyte cell body and its foot processes were noted and correlated with light microscopic morphology. Individual podocyte necrosis, variable foot process fusion and cell body swelling were seen in IgA nephropathy. Podocyte degeneration with separation from the glomerular basement membrane was evident in idiopathic minimal change Gn while idiopathic membranous Gn was characterized by globular swelling of the podocyte cell bodies. In focal sclerosing Gn, large spherical bodies arising from swollen podocyte cell bodies were frequently encountered. Innumerable microvilli and small spherical bodies characterized membranoproliferative Gn. Variable podocyte cell body swelling, microvilli and small spherical bodies were seen in cases of lupus nephritis. Taken alone, none of the SEM changes were diagnostic. However, when the type of the change, the severity and the combination of the changes were considered as a whole, they were indicative of what light microscopy might reveal and helpful in differentiating between idiopathic minimal change Gn and focal sclerosing Gn.
journal_name
Pathologyjournal_title
Pathologyauthors
Ng WL,Chan KW,Ma Ldoi
10.3109/00313028309084701subject
Has Abstractpub_date
1983-04-01 00:00:00pages
139-46issue
2eissn
0031-3025issn
1465-3931journal_volume
15pub_type
杂志文章相关文献
PATHOLOGY文献大全abstract::The application of glucose point of care testing (PoCT) in hospitals has been a contentious subject for many years. No information is available regarding the extent to which glucose PoCT is used within the Australian hospital system and whether such testing is fit for its intended purpose. The aim of this study was to...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2015.11.014
更新日期:2016-01-01 00:00:00
abstract::HLA-B27 is a risk marker for ankylosing spondylitis and other associated seronegative spondyloarthropathies. We compared three methods of HLA-B*27 typing in a New South Wales (NSW) population: flow cytometry, rs4349859 single nucleotide polymorphism (SNP) detection assay, and allele-specific real-time polymerase chain...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2019.09.013
更新日期:2020-02-01 00:00:00
abstract::We present the clinicopathological features of eight cases of large cell undifferentiated bladder carcinoma not otherwise specified (LCUBC). LCUBC was characterised by sheets of large polygonal or round cells with moderate to abundant cytoplasm and distinct cell borders. The LCUBC component varied from 90 to 100% of t...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313021003767363
更新日期:2010-06-01 00:00:00
abstract::Associations between histologically defined proliferative, but benign, epithelial disorders of the breast and risk factors for breast carcinoma were examined in 568 patients whose breast biopsies were submitted consecutively to the laboratory. Some disorders were associated with multiparity. Blunt duct adenosis was as...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029109063590
更新日期:1991-10-01 00:00:00
abstract:AIMS:Activation of β-catenin has been identified as a possible mechanism for the development of nephroblastomas. In our study we investigated whether this activation occurs already in precursor lesions of nephroblastomas, called nephrogenic rests (NRs). Inactivation of the adenomatous polyposis coli (APC) protein is an...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e32834bf65c
更新日期:2011-12-01 00:00:00
abstract::Plexiform leiomyomas of the uterus are incidental findings in hysterectomy specimens. Histogenetically, these rare tumors are classified as a variant of epithelioid leiomyomas. Most of the plexiform leiomyomas reported range in size from microscopically small lesions to less than 1 cm in largest diameter, and they mac...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/003130299105197
更新日期:1999-08-01 00:00:00
abstract::The case is reported of a woman aged 60 yrs who presented with systemic symptoms and who was found to have proteinuria of 3.5 g per day. A renal biopsy revealed numerous neoplastic cells filling many of the glomerular capillary lumina. Immunoperoxidase stains revealed that the phenotype of the malignant cells was LCA+...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029109063574
更新日期:1991-07-01 00:00:00
abstract::While localised prostate cancer can be cured by local treatment, 'high-risk' prostate cancer often progresses to castration resistant disease and remains incurable with a dismal prognosis. In recent years, technical advances and development of novel methodologies have largely contributed to a better understanding of u...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2020.10.003
更新日期:2021-01-01 00:00:00
abstract:AIMS:To correlate the immunostaining for INI1 protein and mutations in INI1 gene in possible rhabdoid tumours (RT) and atypical teratoid/rhabdoid tumours (AT/RT) seen at the Royal Children's Hospital in the last 10 years, and to study the clinicopathological features of those patients with negative nuclear staining. M...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020802436451
更新日期:2008-12-01 00:00:00
abstract::A unique complication of florid xanthogranulomatous cholecystitis with cholecystoduodenal fistula formation is described in a 6 yr old male. The patient, who had a short gut syndrome, had been maintained on lifelong total parenteral nutrition (TPN) following extensive neonatal ischemic bowel necrosis secondary to gast...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029009086671
更新日期:1990-10-01 00:00:00
abstract::Isolation of the new pandemic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for diagnostic and research purposes including assessment of novel therapeutics. Several primary and continuous cell lines are currently used, and new organoid and engineered cell lines are being developed for...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2020.09.012
更新日期:2020-12-01 00:00:00
abstract::A case of solitary cervical intramedullary schwannoma with an extramedullary extension is reported. This case demonstrates the difficulty of radiologic diagnosis of these tumours and the necessity for pre-treatment biopsy. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809059511
更新日期:1988-07-01 00:00:00
abstract::Post-transplant lymphoproliferative disorders (PTLD) are a consequence of the immunosuppressive therapy following organ transplant. We describe a patient who developed PTLD seven years after liver transplant and while receiving cyclosporine and prednisone. Magnetic resonance imaging demonstrated a paraspinal mass exte...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029800169636
更新日期:1998-11-01 00:00:00
abstract::Patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) often exhibit clonal chromosomal abnormalities. Using a probe for the centromeric region of chromosome 8, fluorescence in situ hybridization (FISH) on interphase cells was used to detect trisomy 8 in an AML patient whose leukemia was characte...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029700169115
更新日期:1997-08-01 00:00:00
abstract::The cell surface markers of 75 cases of non-Hodgkin's lymphoma were studied on cryostat sections using a panel of monoclonal antibodies. Forty-nine cases (65.3%) were found to express a B-cell phenotype, 23 cases (30.7%) a T-cell phenotype, 1 case (1.3%) a histiocytic phenotype and 2 cases (2.7%) no demonstrable surfa...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028609087562
更新日期:1986-10-01 00:00:00
abstract:AIMS:Pancreatic endocrine tumours (PET) containing ductules are an uncommon histological variant. Considerable conjecture surrounds the origin and histogenesis of the ductules. Opinions range from the ductules being an inherent part of the tumour, to others who feel they are merely entrapped. A study of 21 cases of thi...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020500444633
更新日期:2006-02-01 00:00:00
abstract::Rare tumours are a heterogeneous group of conditions that encompass benign to malignant lesions both of stromal and epithelial origin. Here some of these tumours are described, in which the authors have most familiarity. An outline of medullary carcinoma is also presented. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020802563528
更新日期:2009-01-01 00:00:00
abstract::A novel grading system based on the counting of poorly differentiated clusters (PDC) of neoplastic cells at the invasive margin and in the tumour stroma was recently introduced among the histological parameters predictive of adverse clinical outcome in colorectal cancer (CRC). The aim of this study was to correlate th...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000300
更新日期:2015-10-01 00:00:00
abstract:AIM:Gasdermin-like (GSDML) is a novel member of the cancer associated gasdermin-domain containing (GSDMDC) protein family. The GSDMDC family has been linked to cancer development and progression, and this is the first study analysing the expression and intracellular localisation of GSDML. METHODS:GSDML gene transcript...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020701716250
更新日期:2008-01-01 00:00:00
abstract::BAP1 (BRCA1-Associated Protein 1) was initially identified as a protein that binds to BRCA1. BAP1 is a tumour suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin-proteasome system and the DNA damage response pathway. Germline mutat...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1097/PAT.0b013e32835d0efb
更新日期:2013-02-01 00:00:00
abstract:AIMS:This study was undertaken to investigate the genetic factors underlying the development of multifocality and phenotypic diversity in multifocal papillary thyroid carcinoma (mPTC). METHODS:Loss of heterozygosity (LOH) and BRAF(V600E) mutation status were analysed in a total of 55 individual tumour foci from 18 cas...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313025.2010.508780
更新日期:2010-01-01 00:00:00
abstract::The use of purified intrinsic factor in vitamin B12 radioassays has greatly reduced the misdiagnosis of pernicious anaemia in recent years, but anomalies still occur. Observations made on current vitamin B12 radioassays suggest that many methods fail to convert all serum cobalamins to cyanocobalamin and thus are not t...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028209069040
更新日期:1982-01-01 00:00:00
abstract:AIMS:It is currently accepted that primary ovarian tumours rarely, if ever, give rise to mucinous ascites/pseudomyxoma peritonei (PMP) which most commonly results from the intra-abdominal spread of an appendiceal mucinous neoplasm. However, primary ovarian mucinous tumours of appendiceal type arising within mature cyst...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020601024078
更新日期:2006-12-01 00:00:00
abstract::The clinical and laboratory features of a patient with a recently recognized new variant of von Willebrand's disease are presented. The importance of this variant is that it is associated with a clinically significant bleeding diathesis but with a normal skin bleeding time, PTTK, factor VIIIc and platelet aggregation ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809085199
更新日期:1988-01-01 00:00:00
abstract::Use of cellular products for therapeutic purposes has predominantly been unregulated in Australia until recently. Transplant of haemopoietic progenitor cells (HPC) for bone marrow regeneration is now a routine treatment for many disorders with an established mechanism of facility accreditation. However, other cellular...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1097/PAT.0b013e32834b3cfa
更新日期:2011-10-01 00:00:00
abstract::We present the clinical and postmortem findings in seven adults (four females and three males), who died with dissection of the coronary arteries. The median age was 56 years. Five of the coronary artery dissections (CADs) were spontaneous and two followed trauma: one a motor vehicle accident, the other occurred durin...
journal_title:Pathology
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
abstract::Semen analysis is the most important laboratory investigation for men when assessing the infertile couple. Advances in in vitro fertilisation (IVF) techniques, particularly intracytoplasmic sperm injection (ICSI) involving the direct injection of a single spermatozoon into an egg, have not diminished the role of semen...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:
更新日期:2003-02-01 00:00:00
abstract::Although most carcinomas of the bladder occur de novo, some vesical lesions progress to malignancy over time. These lesions appear morphologically benign, but often harbour genetic changes that signify their malignant potential. Despite their benign appearance, accurate identification is important given that these pat...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1097/PAT.0b013e32835f6169
更新日期:2013-04-01 00:00:00
abstract:AIMS:Whereas most caspases play roles in apoptosis and/or inflammation, caspase-14 plays a main role in epithelial differentiation. In cancers, expression of caspase-14 is frequently altered and is associated with some clinicopathological characteristics, suggesting caspase-14 might contribute to the pathogenesis of ca...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020701329815
更新日期:2007-06-01 00:00:00
abstract::IgG4 related disease (IgG4RD) is a recently recognised condition characterised by mass forming lesions associated with storiform fibrosis, obliterative phlebitis, lymphoplasmacytic infiltrate rich in IgG4 positive plasma cells and elevated serum IgG4 levels. Although rare, mammary involvement has been reported as IgG4...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000187
更新日期:2015-01-01 00:00:00