Gene targeting technology and advances in the pathophysiology of inflammation.

abstract：:Neuroendocrine (NE) tumours are uncommon in the gynecological tract. In addition to their histological features, what defines NE carcinoma is the expression of markers such as chromogranin, synaptophysin and neural cell adhesion molecule (CD56) by immunohistochemistry (IHC). Although limited data have demonstrated tha...

journal_title：Pathology

authors： Moritz AW,Schlumbrecht MP,Nadji M,Pinto A

更新日期：2019-06-01 00:00:00

abstract：:Deregulation of the receptors of TNF-related apoptosis inducing ligand (TRAIL) has been reported in various cancers. In an effort to define the role of these receptors we profiled their expression in gallbladder cancer (GBC) and explored their clinical significance. Expression of TRAIL receptors' mRNA in GBC was analy...

journal_title：Pathology

authors： Singh D,Prasad CB,Biswas D,Tewari M,Kar AG,Ansari MA,Singh S,Narayan G

更新日期：2020-04-01 00:00:00

abstract：:The application of glucose point of care testing (PoCT) in hospitals has been a contentious subject for many years. No information is available regarding the extent to which glucose PoCT is used within the Australian hospital system and whether such testing is fit for its intended purpose. The aim of this study was to...

journal_title：Pathology

authors： Sharp L,Farrance I,Greaves RF

更新日期：2016-01-01 00:00:00

abstract：:Recently, both the World Health Organization/International Agency for Research on Cancer (WHO/IARC) and the American Joint Committee on Cancer (AJCC) have classified oropharyngeal squamous cell carcinoma (OPSCC) on the basis of HPV status. For this purpose, the WHO/IARC recommended direct molecular HPV testing. In pra...

journal_title：Pathology

authors： Veyer D,Wack M,Grard O,Bonfils P,Hans S,Bélec L,Badoual C,Péré H

更新日期：2019-06-01 00:00:00

abstract：:Serial bone marrow aspirates were obtained from 16 adults with acute myeloid leukaemia (AML) before and after a single infusion of cytarabine (5.0 mg/kg i.v. over 30 min). Changes in the proliferative activity of the leukaemic myeloblasts were monitored by determination of the labelling index (LI) and the mitotic inde...

journal_title：Pathology

authors： Buchanan JG,Matthews JR,Postlewaight BF,Upsdell M

更新日期：1979-07-01 00:00:00

abstract：:Distinct differences in the extent and progression of the lateral and epicardial boundaries of evolving regional infarcts were demonstrated in isolated rabbit hearts. Ischemia was produced by interrupting (0-240 minutes) flow in the ventral interventricular branch of the left coronary artery, whilst the remainder of t...

journal_title：Pathology

authors： Sage MD,Gavin JB

更新日期：1985-10-01 00:00:00

abstract：INTRODUCTION:Detection of the V600E hotspot mutation in BRAF oncogene is extremely useful for the screening of hereditary non-polyposis colorectal cancer (Lynch's syndrome) and for the prediction of sensitivity to MEK inhibitors. Here we describe a method for detecting this mutation based upon pyrosequencing technology...

journal_title：Pathology

authors： Tan YH,Liu Y,Eu KW,Ang PW,Li WQ,Salto-Tellez M,Iacopetta B,Soong R

更新日期：2008-04-01 00:00:00

abstract：:In various tumor types dentritic cell, infiltration and the presence of tumor-infiltrating lymphocytes have been associated with an improved clinical outcome. In the uterine cervix these immunocompetent cells have been associated with improved prognosis in high stage disease. The current study examines the significanc...

journal_title：Pathology

authors： Bethwaite PB,Holloway LJ,Thornton A,Delahunt B

更新日期：1996-11-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are a non-homogeneous population of plastic-adherent cells which were initially isolated from post-natal bone marrow. They have the capacity to differentiate to multiple mesodermal lineages including bone, cartilage and adipose tissue. In stringent culture conditions, MSCs can also be ...

journal_title：Pathology

authors： Larsen S,Lewis ID

更新日期：2011-10-01 00:00:00

abstract：AIM:Hepcidin, a recently identified peptide, acts as a central regulator of iron metabolism. It is regarded as a factor regulating the uptake of dietary iron and its mobilisation from macrophages and hepatic stores. It is considered as a mediator of anaemia of inflammation. The aim of this study was to assess whether s...

journal_title：Pathology

authors： Jayaranee S,Sthaneshwar P,Sokkalingam S

更新日期：2009-02-01 00:00:00

abstract：:Although most carcinomas of the bladder occur de novo, some vesical lesions progress to malignancy over time. These lesions appear morphologically benign, but often harbour genetic changes that signify their malignant potential. Despite their benign appearance, accurate identification is important given that these pat...

journal_title：Pathology

authors： Samaratunga H,Martignoni G,Egevad L,Delahunt B

更新日期：2013-04-01 00:00:00

abstract：:The 2005 International Society of Urological Pathology (ISUP) modified Gleason grading system was further amended in 2014 with the establishment of grade groupings (ISUP grading). This study examined the predictive value of ISUP grading, comparing results with recognised prognostic parameters.Of 3700 men undergoing ra...

journal_title：Pathology

authors： Samaratunga H,Delahunt B,Gianduzzo T,Coughlin G,Duffy D,LeFevre I,Johannsen S,Egevad L,Yaxley J

更新日期：2015-10-01 00:00:00

abstract：AIMS:CD146 is a potentially metastasis promoting cell adhesion molecule and its expression has been described in various solid tumours. We aimed to evaluate the expression of CD146 in prostate cancer by immunohistochemistry in a clinically characterised study cohort to evaluate its prognostic properties. METHODS:We ev...

journal_title：Pathology

authors： Fritzsche FR,Wassermann K,Rabien A,Schicktanz H,Dankof A,Loening SA,Dietel M,Jung K,Kristiansen G

更新日期：2008-08-01 00:00:00

abstract：:The in vitro activity of cefepime was compared to that of a range of other broad-spectrum agents, using a gradient diffusion MIC method, against 995 recent clinical isolates of Enterobacteriaceae, Pseudomonas aeruginosa, other nonfermentative gram-negative bacilli, staphylococci (except oxacillin-resistant Staphylococ...

journal_title：Pathology

authors： Bell JM,Turnidge JD,Cefepime Study Group.

更新日期：2001-02-01 00:00:00

abstract：:Certain diagnoses in dermatopathology have significant implications for patient management and on occasion appropriate clinical care may be facilitated by a phone call from the reporting dermatopathologist to the referring doctor. Whether this is appropriate depends on a number of factors. The concept of 'critical dia...

journal_title：Pathology

authors： Korbl JD,Wood BA,Harvey NT

更新日期：2018-04-01 00:00:00

abstract：:A sequential study has been made of the ultrastructure of local renal graft-versus-host reactions produced in cyclophosphamide-pretreated rats by injection of either allogeneic or xenogeneic (mouse) spleen cells beneath the renal capsule. Early in the reaction, immunoblasts were seen between the outer cortical tubules...

journal_title：Pathology

authors： Davies DJ,Conway MS

更新日期：1975-10-01 00:00:00

abstract：:The aim of this study was to subcategorise large cell carcinoma (LCC) with null immunophenotype according to the World Health Organization (WHO) Classification of 2015 into the existing groups of adenocarcinoma and squamous cell carcinoma by further molecular genetic analysis. Lineage-specific molecular alterations of...

journal_title：Pathology

authors： Harms A,Endris V,Winter H,Kriegsmann M,Stenzinger A,Schirmacher P,Warth A,Kazdal D

更新日期：2018-08-01 00:00:00

abstract：:An elderly woman had a cerebral gliosarcoma with a single pulmonary metastasis, together with a separate pulmonary adenoid-cystic carcinoma. Spontaneous extraneural metastases of primary intracranial neoplasms are exceedingly unusual; so far, only 8 proven cases are recorded in the English language medical literature....

journal_title：Pathology

authors： Ojeda VJ,Sterrett GF

更新日期：1984-04-01 00:00:00

abstract：AIMS:An important consideration in the design of a tumour vaccine is the ability of tumour-specific cytotoxic T lymphocytes (CTL) to recognise unmanipulated tumour cells in vivo. To determine whether B-CLL might use an escape strategy, the current studies compared B-CLL and normal B cell MHC class I expression. METHOD...

journal_title：Pathology

authors： Juffs H,Fowler N,Saal R,Grimmett K,Beasley S,O'Sullivan B,Frazer I,Gill D,Thomas R

更新日期：2004-02-01 00:00:00

abstract：:A total of 1434 strains of Neisseria meningitidis isolated from cases of invasive meningococcal disease (IMD) in Australia between 1994 and 1999 were examined by standard methods for susceptibility to antibiotics used for treatment and prophylaxis. The proportion of isolates fully susceptible to penicillin decreased f...

journal_title：Pathology

authors： Tapsall JW,Shultz T,Limnios E,Munro R,Mercer J,Porritt R,Griffith J,Hogg G,Lum G,Lawrence A,Hansman D,Collignon P,Southwell P,Ott K,Gardam M,Richardson CJ,Bates J,Murphy D,Smith H,National Neisseria Network of Austr

更新日期：2001-08-01 00:00:00

abstract：:Trichostrongylus infection, an uncommonly reported zoonosis in Australia, is common in parts of the world where there is close human contact with herbivorous animals. We report 5 cases diagnosed in our laboratory since 1992. Over this period the laboratory has conducted over 46,000 parasitological examinations on fece...

journal_title：Pathology

authors： Boreham RE,McCowan MJ,Ryan AE,Allworth AM,Robson JM

更新日期：1995-04-01 00:00:00

abstract：:Use of cellular products for therapeutic purposes has predominantly been unregulated in Australia until recently. Transplant of haemopoietic progenitor cells (HPC) for bone marrow regeneration is now a routine treatment for many disorders with an established mechanism of facility accreditation. However, other cellular...

journal_title：Pathology

authors： Trickett AE,Wall DM

更新日期：2011-10-01 00:00:00

abstract：:A rapid technique suitable for routine laboratory use for determining the percentage of large platelets in the peripheral blood is described. In 50 haematologically normal subjects, megathrombocytes (platelets with a volume of 16-33 fl) constituted 3.0-16.6% (mean +/- 2 SD) of the platelet count. Of the 10 patients ex...

journal_title：Pathology

authors： Hunt FA

更新日期：1976-01-01 00:00:00

abstract：:A retrospective review of coronial records was performed for 179 adult decedents who came to coronial autopsy in 1990 and who had been living in the Top End of the Northern Territory at the time of death. The directly standardized rate of autopsy-examined sudden death was 7.4 times higher for Aboriginal people than fo...

journal_title：Pathology

authors： Weeramanthri TS,Powers JR,Collier JW

更新日期：1996-01-01 00:00:00

abstract：:A case of chronic endometritis with unusual histological features due to the presence of abundant foam cells and lipid material is described. The presence of foam cells, abundant intra- and extracellular lipid together with other inflammatory cells in the absence of endometrial hyperplasia or carcinoma warrants the di...

journal_title：Pathology

authors： Barua R,Kirkland JA,Petrucco OM

更新日期：1978-04-01 00:00:00

abstract：:As autopsy rates in general hospitals decline, interest in the perinatal autopsy continues to rise, reflecting the emergence of a vigorous specialty growing in parallel with fetal medicine, prenatal diagnosis and clinical genetics. Perinatal autopsies are best carried out in tertiary centres which provide these servic...

journal_title：Pathology

authors： Chambers HM

更新日期：1992-04-01 00:00:00

abstract：:Epigenetic regulation is emerging as a critical mechanism for pancreatic ductal adenocarcinoma (PDA) development. Histone methylation is an important regulatory mechanism, altering chromatin structure and promoter accessibility and causing aberrant gene expression. NSD1 and SETD2 genes encoding two histone H3K36 methy...

journal_title：Pathology

authors： Ettel M,Zhao L,Schechter S,Shi J

更新日期：2019-06-01 00:00:00

abstract：AIMS:p73, a homologue of p53, is known as a negative regulator of tumour progression. However, delta Np73, an isoform of p73 lacking the NH2-terminal transactivation domain plays an oncogenic role by interfering with the activity of p53 and TA (full-length transactivating isoforms) p73. In this study, we investigated t...

journal_title：Pathology

authors： Ito Y,Uramoto H,Funa K,Yoshida H,Jikuzono T,Asahi S,Higashiyama T,Tomoda C,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi A

更新日期：2006-06-01 00:00:00

abstract：:The use of purified intrinsic factor in vitamin B12 radioassays has greatly reduced the misdiagnosis of pernicious anaemia in recent years, but anomalies still occur. Observations made on current vitamin B12 radioassays suggest that many methods fail to convert all serum cobalamins to cyanocobalamin and thus are not t...

journal_title：Pathology

authors： Brown RD,Robin H,Kronenberg H

更新日期：1982-01-01 00:00:00

abstract：:Statistical methods have been used to determine an optimal approach to the definition of the reference range for CD4 ("helper") and CD8 ("suppressor/cytotoxic") T cell numbers and the CD4/CD8 ratio in the peripheral blood. A graphical presentation of the absolute values for CD4 and CD8 for 85 healthy blood donors show...

journal_title：Pathology

authors： Zachar V,Mikulecky M,Mayer V,Mackay I,Frazer I

更新日期：1988-10-01 00:00:00