Abstract:
:About 10% of gastric carcinomas are associated with Epstein-Barr virus (EBV), which are defined as EBV-associated gastric carcinomas (EBVaGCs). EBVaGCs are usually accompanied by massive lymphocytes infiltration, among which CD8+ T cells are predominant. To date, the apoptosis of the infiltrating CD8+ T cells in EBVaGC has not been investigated. In the present study, we assessed the immunophenotype and apoptosis of tumour infiltrating lymphocytes (TILs) in both EBVaGC and EBV-negative gastric carcinoma (EBVnGC). We found that CD8+CCR7+ T lymphocytes were increased in EBVaGC compared to EBVnGC [60.53 ± 28.41/high power fields (HPF) vs 19.63 ± 15.97/HPF; p < 0.001]. Moreover, the apoptosis index of TILs was lower in EBVaGC than that in EBVnGC (1.34 ± 0.90 vs 5.94 ± 3.77; p < 0.001). Given that the CCL21-CCR7 axis is reported to be potentially involved in apoptosis, we examined the expression of CCL21 in both EBVaGC and EBVnGC. We found that CCL21 expression was higher in EBVaGC than in EBVnGC (p < 0.001). We also showed that the expression of CCL21 by EBVaGC cells protected CD8+CCR7+ T lymphocytes from apoptosis. Furthermore, the up-regulation of Bcl-2 contributed to the inhibition of apoptosis in CD8+CCR7+ T cells. Collectively, these findings suggest that expression of CCL21 by EBVaGC cells protects CD8+CCR7+ T lymphocytes from apoptosis via the mitochondria-mediated pathway. To our best knowledge, this is the first study to investigate the apoptosis of CD8+ T cells in EBVaGC.
journal_name
Pathologyjournal_title
Pathologyauthors
Tang F,Chen JN,Zhang NN,Gong LP,Jiang Y,Feng ZY,Xiao L,Li HG,Du H,Wu B,Shao CKdoi
10.1016/j.pathol.2018.05.004subject
Has Abstractpub_date
2018-10-01 00:00:00pages
613-621issue
6eissn
0031-3025issn
1465-3931pii
S0031-3025(17)30535-4journal_volume
50pub_type
杂志文章相关文献
PATHOLOGY文献大全abstract::Various tumour markers have been evaluated in malignant pleural effusions, but not CD66c. This study evaluated the diagnostic ability of CD66c in lung adenocarcinoma-associated malignant pleural effusions (LA-MPEs) and compared it with other known tumour markers. Forty-seven cases of LA-MPE and 52 cases of benign pleu...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000215
更新日期:2015-02-01 00:00:00
abstract::The current public health emergency surrounding the COVID-19 pandemic, that is the illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in thousands of cases in Australia since 25 January 2020 when the first case was diagnosed. This emerging virus presents particular hazards to ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2020.09.006
更新日期:2020-12-01 00:00:00
abstract::The terminal complement complex has been implicated in the development of glomerular injury in both experimental and, indirectly, in human glomerulonephritis. Recent data suggests that the terminal complement complex in human glomerulonephritis may be in the cytolytically inactive SC5b-9 form which also contains S-pro...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028909061073
更新日期:1989-10-01 00:00:00
abstract::Results are presented of a study comparing cerbB2 (neu or Her2) expression as assessed immunohistochemically in breast neoplasia using a panel of 6 commercially available antibodies. The antibodies were examined utilizing conventional formalin fixed paraffin embedded tissue, and compared with molecular analysis of gen...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029400169611
更新日期:1994-07-01 00:00:00
abstract::There are few studies addressing survival of diffuse peritoneal mesotheliomas (DPM).In this study, survival data were obtained retrospectively from 73 patients treated with intended cytoreductive surgery for DPM, with a mean follow-up of 42 months. Mesotheliomas were classified as well differentiated papillary (WDPM, ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000181
更新日期:2014-12-01 00:00:00
abstract::Atypical teratoid/rhabdoid tumours (AT/RTs) are rare, highly malignant tumours of the central nervous system (CNS) with poor prognosis that usually affect young children. The aim of this study was to assess the clinicopathological features and prognostic factors of AT/RTs. Here, we describe the clinicopathological and...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2016.05.010
更新日期:2016-10-01 00:00:00
abstract::Thirty-one patients aged over 60 yrs and with lupus anticoagulant (LA) were reviewed for their drug intake. Twenty-three (73%) were taking cinchona alkaloids, 10 (32%) quinine for night cramps, 11 (35%) quinidine for cardiac arrhythmia and 2 (6%) were taking both. These frequencies of drugs usage differed significantl...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029500169742
更新日期:1995-04-01 00:00:00
abstract::The cell surface markers of 75 cases of non-Hodgkin's lymphoma were studied on cryostat sections using a panel of monoclonal antibodies. Forty-nine cases (65.3%) were found to express a B-cell phenotype, 23 cases (30.7%) a T-cell phenotype, 1 case (1.3%) a histiocytic phenotype and 2 cases (2.7%) no demonstrable surfa...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028609087562
更新日期:1986-10-01 00:00:00
abstract::Associations between histologically defined proliferative, but benign, epithelial disorders of the breast and risk factors for breast carcinoma were examined in 568 patients whose breast biopsies were submitted consecutively to the laboratory. Some disorders were associated with multiparity. Blunt duct adenosis was as...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029109063590
更新日期:1991-10-01 00:00:00
abstract::Penile metastases from prostate cancer are rare and are usually a manifestation of wide-spread cancer dissemination. Isolated urethral metastases form a small fraction of these cases, have a longer survival rate and may represent spread by implantation following instrumentation. We report a case of prostatic carcinoma...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029800169306
更新日期:1998-05-01 00:00:00
abstract::We present the clinical and postmortem findings in seven adults (four females and three males), who died with dissection of the coronary arteries. The median age was 56 years. Five of the coronary artery dissections (CADs) were spontaneous and two followed trauma: one a motor vehicle accident, the other occurred durin...
journal_title:Pathology
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
abstract::Ethanol in blood was assayed by 2 currently available procedures: a commercial kit enzymatic assay and a gas chromatographic procedure. Both methods were performed with commercially available materials and equipment. Results by the 2 procedures agreed well. For the 192 specimens studied, the correlation coefficient wa...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409059096
更新日期:1984-04-01 00:00:00
abstract::Ulex europaeus agglutinin-1 (UEA-1) binds specifically to alpha-L-fucose, the terminal sugar of blood group substances H2 and Ley the expression of which is confined mainly to the proximal colon. The aim of the study was to determine whether there is neo-expression of alpha-L-fucose in the normal appearing mucosa of t...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029309084782
更新日期:1993-04-01 00:00:00
abstract::A 5-year-old Chinese boy had dull pain in his right knee for about one year. An intraosseous osteolytic lesion in the metaphysis of the right lower femur was curetted. The diagnosis of desmoplastic fibroma, possibly the first in a Hong Kong Chinese, was based on the clinical, radiological and histological findings. Ab...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028709077135
更新日期:1987-04-01 00:00:00
abstract::Proliferation of isolated hepatocytes in long-term splenic implants was assessed by flash labelling with a 1 pulse of tritiated thymidine (3H TdR). Cell kinetics showed that the basal labelling index was 0.9% which was greater than normal non-regenerating liver. Twenty four hours following partial hepatectomy the labe...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028709065131
更新日期:1987-01-01 00:00:00
abstract::Prenatal diagnoses of the genetic disorders alpha, beta thalassemia, HbS, Hb Lepore, hemophilia and cystic fibrosis were sought in 88 cases. Six unsuccessful attempts at diagnosis resulted from DNA polymorphisms which were only 50% informative (four cases) and prenatal diagnoses which had been undertaken before it was...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029009063558
更新日期:1990-07-01 00:00:00
abstract::A sequential study has been made of the ultrastructure of local renal graft-versus-host reactions produced in cyclophosphamide-pretreated rats by injection of either allogeneic or xenogeneic (mouse) spleen cells beneath the renal capsule. Early in the reaction, immunoblasts were seen between the outer cortical tubules...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027509081682
更新日期:1975-10-01 00:00:00
abstract:AIMS:Only a small number of mesenchymal tumours have been previously evaluated for hTERT expression. We hypothesised that hTERT expression would be frequently present in sarcomas, but not in benign tumours. METHODS:Sections from 143 bone/soft tissue tumours were immunostained for hTERT (44F12, 1:20; Novocastra) using ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020903121614
更新日期:2009-01-01 00:00:00
abstract::Review of problematic melanocytic consultation cases has enabled identification of the most common variants of benign melanocytic proliferations which can be confused with melanoma. Apart from Spitz naevus, the most common in this group of lesions are pigmented spindle cell naevus and atypical dermal nodule. Potential...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313020412331283842
更新日期:2004-10-01 00:00:00
abstract::As autopsy rates in general hospitals decline, interest in the perinatal autopsy continues to rise, reflecting the emergence of a vigorous specialty growing in parallel with fetal medicine, prenatal diagnosis and clinical genetics. Perinatal autopsies are best carried out in tertiary centres which provide these servic...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.3109/00313029209063622
更新日期:1992-04-01 00:00:00
abstract::A variant of gelatinous transformation of marrow was described in leukemic patients post-chemotherapy. This lesion was found in 8 out of 1833 post-chemotherapy bone marrows from 429 patients with leukemia. Histologically, this variant form was identical to the classical gelatinous transformation except for the absence...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029309066592
更新日期:1993-07-01 00:00:00
abstract:AIMS:We have identified in malignant melanoma an angio-tumoural complex in which tumour cells occupy a pericytic location along the endothelium of microvessels without evidence of intravasation. This pericytic angiotropism of melanoma cells, without any sign of intravasation, suggests that melanoma cells may migrate al...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020412331282708
更新日期:2004-10-01 00:00:00
abstract::The clinical and laboratory features of a patient with a recently recognized new variant of von Willebrand's disease are presented. The importance of this variant is that it is associated with a clinically significant bleeding diathesis but with a normal skin bleeding time, PTTK, factor VIIIc and platelet aggregation ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809085199
更新日期:1988-01-01 00:00:00
abstract::Assessment of the risk of lymph node invasion and tumour recurrence is critical to determine whether additional surgery is required in patients with endoscopically-removed pT1 colorectal cancer (CRC). A reproducible assessment of this risk of recurrence based on histopathological parameters is crucial for relevant the...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2018.10.007
更新日期:2019-01-01 00:00:00
abstract:AIMS:The roles of tumour suppressor genes: adenomatous polyposis coli (APC) and E-cadherin (CDH1) were investigated in clear cell renal cell carcinoma. METHODS:Forty-five human clear cell renal cell carcinomas were tested for APC gene instability by polymerase chain reaction/loss of heterozygosity using the restrictio...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020410001671984
更新日期:2004-04-01 00:00:00
abstract:AIMS:Malakoplakia is a characteristic inflammatory condition which is usually seen in the urogenital tract. Gastrointestinal malakoplakia is seen in association with a variety of conditions such as ulcerative colitis, diverticular disease, adenomatous polyps and carcinoma. The purpose of this paper is to report four ad...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/003130202760120481
更新日期:2002-08-01 00:00:00
abstract:AIMS:Immunohistochemical detection of the 185-kDa transmembrane glycoprotein product of the proto-oncogene c-erbB-2 (also known as HER-2/neu), located on chromosome 17q21, is a well established method of evaluation in invasive breast cancer. This investigation is currently performed on standard sections cut from the tu...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020600820872
更新日期:2006-08-01 00:00:00
abstract::The distinction between partial hydatidiform mole (PHM) and trisomy gestation is not always straightforward histologically and it is unclear which morphological features, alone or in combination, provide the greatest diagnostic accuracy. We performed a comparative review of 89 products of conception (POC) specimens in...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2016.06.006
更新日期:2016-10-01 00:00:00
abstract:AIM:Both hypoxia inducible factor 1 (HIF-1) and basic fibroblast growth factor (bFGF) play important roles in tumour angiogenesis. This study was designed to clarify the cooperative effect of these two mediators in induction of vascular endothelial cell growth factor (VEGF) release from breast cancer and probe possible...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020701444549
更新日期:2007-08-01 00:00:00
abstract::HLA-B27 is a risk marker for ankylosing spondylitis and other associated seronegative spondyloarthropathies. We compared three methods of HLA-B*27 typing in a New South Wales (NSW) population: flow cytometry, rs4349859 single nucleotide polymorphism (SNP) detection assay, and allele-specific real-time polymerase chain...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2019.09.013
更新日期:2020-02-01 00:00:00