Abstract:
:Age-specific paediatric reference intervals are used in interpretation of laboratory results. However, interpretation may be problematic when a child just crosses an age bracket and the difference between the original and the subsequent age-specific reference interval is large. Moreover, details about the physiological changes with age may be masked. For the 12 months ending 30 September 2013, results of 16 common clinical biochemistry tests of ambulatory paediatric patients aged 0-19, requested by primary care physicians, were retrospectively collected in a large pathology service, and used to construct smoothed centile charts using a penalised maximum likelihood method. From the developed centile charts, the concentrations of sodium, bicarbonate, creatinine, urate, total protein, and albumin all increased with increasing age of the children. In contrast, the concentrations of potassium, chloride, anion gap, calcium, phosphate and lactate dehydrogenase decreased with increasing age of the children. Changes in the concentrations of urea, alkaline phosphatase, glucose, and total cholesterol varied by age. Generally, the boys and girls shared similar trend patterns until 10-15 years of age, when variations in the age of onset of puberty and development caused the trends of some biochemical measures to differ. The paediatric biochemistry centile charts are intuitive tools to use. They complement age-specific reference intervals in the tracking, interpretation and discussion of laboratory results. They also enhance the understanding of underlying physiological changes in biochemistry in children.
journal_name
Pathologyjournal_title
Pathologyauthors
Loh TP,Antoniou G,Baghurst P,Metz MPdoi
10.1097/PAT.0000000000000118subject
Has Abstractpub_date
2014-06-01 00:00:00pages
336-43issue
4eissn
0031-3025issn
1465-3931journal_volume
46pub_type
杂志文章相关文献
PATHOLOGY文献大全abstract::The estrogen receptor (ER) content of breast carcinoma is generally accepted as valuable in predicting clinical outcome and tumour response to hormonal manipulation. We applied a new immunocytochemical assay for estrogen receptors (Abbott ERICA Monoclonal) to 20 breast tumours, and examined the efficacy of 16 fixation...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809085211
更新日期:1988-10-01 00:00:00
abstract::Noncondylomatous papilloma virus infection of the cervix is much more common than formerly realized. The majority of patients are young, but two cases are reported here in postmenopausal women. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027809063526
更新日期:1978-10-01 00:00:00
abstract::We report a patient with unusual venous and arterial thromboses in association with the common thermolabile methyltetrahydrofolate (MTHFR) variant. The patient responded directly to folate supplementation. To our knowledge, this is the first report describing hyperhomocysteinemia in association with this type of throm...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/003130299105502
更新日期:1999-02-01 00:00:00
abstract:AIMS:Mounting evidence indicates that deregulation of apoptosis is involved in the mechanisms of cancer development. Bax-interacting factor-1 (Bif-1) interacts with both Bax and Bak that are crucial for the intrinsic apoptosis signalling. Functionally, loss of Bif-1 expression has been proven to enhance tumorigenesis. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020802320440
更新日期:2008-10-01 00:00:00
abstract::One hundred and two cases of benign nerve sheath tumors (NSTs) were studied with a combined approach using routine light microscopy (LM), immunohistochemistry (IH) for myelin basic protein (MBP) and S-100 protein as well as transmission electron microscopy (TEM) with the aim of obtaining greater insight into the true ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029009086659
更新日期:1990-10-01 00:00:00
abstract::The estimation of plasma alanine aminotransferase (ALT) has been proposed as a surrogate test to identify potential non-A, non-B hepatitis carriers in blood donor populations. This report describes an ALT screening procedure which uses wells of microtitration trays as reactant vessels. The method utilizes a rate readi...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809059506
更新日期:1988-07-01 00:00:00
abstract::Ethanol in blood was assayed by 2 currently available procedures: a commercial kit enzymatic assay and a gas chromatographic procedure. Both methods were performed with commercially available materials and equipment. Results by the 2 procedures agreed well. For the 192 specimens studied, the correlation coefficient wa...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409059096
更新日期:1984-04-01 00:00:00
abstract::Results are presented of a study comparing cerbB2 (neu or Her2) expression as assessed immunohistochemically in breast neoplasia using a panel of 6 commercially available antibodies. The antibodies were examined utilizing conventional formalin fixed paraffin embedded tissue, and compared with molecular analysis of gen...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029400169611
更新日期:1994-07-01 00:00:00
abstract::Sera from 82 patients with acute or chronic hepatitis and 40 chronic carriers of hepatitis B were examined by ELISA and immunoblotting for reactivity with the glycolytic enzyme aldolase. The results of the ELISA tests, expressed as a percentage of a positive control, were compared to those obtained with sera from 39 p...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028709103881
更新日期:1987-10-01 00:00:00
abstract::The mitogenic and chemotactic potency of platelet-derived growth factor (PDGF) has linked this polypeptide to the pathogenesis of several disease states including atherosclerosis and neoplasia. We have reviewed the recent literature on aspects relating to the structure, distribution and biology of PDGF and its high-af...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.3109/00313029209068882
更新日期:1992-10-01 00:00:00
abstract::Decreased neutrophil alkaline phosphatase (NAP) synthesis is a classical feature of Philadelphia (Ph) positive chronic phase chronic myeloid leukemia (CML). Whether this aberration is an integral leukemic property of the cell or results from mediation by other factors is unclear. During alpha-interferon (alpha-IFN) ba...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029309090860
更新日期:1993-10-01 00:00:00
abstract::A novel grading system based on the counting of poorly differentiated clusters (PDC) of neoplastic cells at the invasive margin and in the tumour stroma was recently introduced among the histological parameters predictive of adverse clinical outcome in colorectal cancer (CRC). The aim of this study was to correlate th...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000300
更新日期:2015-10-01 00:00:00
abstract::Multiplex immunofluorescence (mIF) allows simultaneous antibody-based detection and quantification of the expression of up to six markers, plus a nuclear counterstain, on a single tissue section. Recent studies have shown the potential for mIF to advance our understanding of complex disease processes, including cancer...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2017.11.087
更新日期:2018-04-01 00:00:00
abstract::The alkaline phosphatase from neutrophils of pregnant women and normal males has been extracted, subjected to various inhibitory procedures and to electrophoresis. It is demonstrated that the iso-enzyme obtained from each group is indistinguishable from the skeletal iso-enzyme, in contrast to the serum iso-enzyme of p...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027709085233
更新日期:1977-01-01 00:00:00
abstract:AIMS:To examine the impact of microwave (MW) tissue processing on turnaround times (TATs) in a routine diagnostic laboratory. METHODS:A retrospective review of TATs for tissue processing (specimen receipt to completion of H&E-stained section) and pathologists' report generation (receipt of stained section to validatio...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020410001721564
更新日期:2004-08-01 00:00:00
abstract::An epidemiological study of childhood cancer in New Zealand identified 409 children aged 0 to 14 years with malignant neoplasms newly diagnosed between 1990 and 1993 inclusive. The original microscopic material on which the diagnoses were based was reviewed in 398 cases and the neoplasms were allocated into the 12 maj...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/003130299105232
更新日期:1999-05-01 00:00:00
abstract:AIMS:There are many variants of papillary carcinoma, and some of these variants have been reported to show biological behaviours differing from that of conventional papillary carcinoma. In this study, we present our experience regarding the prevalence and prognoses of these variants of papillary carcinoma. METHODS:H&E...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020802320630
更新日期:2008-10-01 00:00:00
abstract::A total of 1434 strains of Neisseria meningitidis isolated from cases of invasive meningococcal disease (IMD) in Australia between 1994 and 1999 were examined by standard methods for susceptibility to antibiotics used for treatment and prophylaxis. The proportion of isolates fully susceptible to penicillin decreased f...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/pat.33.3.359.361
更新日期:2001-08-01 00:00:00
abstract:AIM:Lignocaine, a topical anaesthetic agent, is generally used in variable concentrations usually between 2% and 4% on the vocal cords prior to flexible bronchoscopy and bronchoalveolar lavage (BAL) procedures. The aim of this study was to investigate whether 2% or 1% lignocaine significantly inhibits the growth of org...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020500168752
更新日期:2005-08-01 00:00:00
abstract::A 5-year-old Chinese boy had dull pain in his right knee for about one year. An intraosseous osteolytic lesion in the metaphysis of the right lower femur was curetted. The diagnosis of desmoplastic fibroma, possibly the first in a Hong Kong Chinese, was based on the clinical, radiological and histological findings. Ab...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028709077135
更新日期:1987-04-01 00:00:00
abstract::A case of chronic endometritis with unusual histological features due to the presence of abundant foam cells and lipid material is described. The presence of foam cells, abundant intra- and extracellular lipid together with other inflammatory cells in the absence of endometrial hyperplasia or carcinoma warrants the di...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027809063496
更新日期:1978-04-01 00:00:00
abstract::In the 20 years that cardiac troponin testing has been available in clinical laboratories, the biomarker has revolutionised testing of patients with acute coronary syndromes. Cardiac troponin I and T testing has become the cornerstone for diagnosis of myocardial infarction and is useful for risk assessment and managem...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1097/PAT.0b013e328343762d
更新日期:2011-04-01 00:00:00
abstract:AIMS:Only a small number of mesenchymal tumours have been previously evaluated for hTERT expression. We hypothesised that hTERT expression would be frequently present in sarcomas, but not in benign tumours. METHODS:Sections from 143 bone/soft tissue tumours were immunostained for hTERT (44F12, 1:20; Novocastra) using ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020903121614
更新日期:2009-01-01 00:00:00
abstract::In 14 stock rabbits experimental aneurysms (saccular, fusiform or berry) were produced on the common carotid artery or the aorta by microvascular surgery using a modification of the venous pouch technique. The animals were given a cholesterol-rich diet at varying times postoperatively to determine the susceptibility o...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028109086647
更新日期:1981-10-01 00:00:00
abstract::Birth defects of the brain result from malformation and disruptions. They remain an important cause of childhood morbidity and mortality. Effective treatments are scarce and prevention strategies limited. As aetiological screening is costly and uncertain, genetic counselling remains empirical in most cases. A patholog...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313020701813719
更新日期:2008-02-01 00:00:00
abstract::A 36-yr-old female with a 20-yr history of fibrodysplasia ossificans progressiva (FOP) died as the result of ruptured gastric ulcers. The patient had been treated with disodium ethane-l-hydroxy-1, 1-diphosphonate (EHDP). Post mortem there was thickening of the aortic valve cusps and mitral valve leaflets as well as sh...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028309083514
更新日期:1983-07-01 00:00:00
abstract::A calcified nodule on the liver of a 62-year-old man from North Carolina, USA, contained a degenerated nymph of Linguatula serrata. The nodule was incidentally discovered at laparotomy for malignant lymphoma and cholelithiasis. The cuticle was all that remained of the parasite, but sclerotized openings and large spine...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809066635
更新日期:1988-04-01 00:00:00
abstract::Cryostat sections of livers from rats treated with carbon tetrachloride (CCl4) for 12 weeks were examined by indirect immunofluorescence for reactivity with human serum containing smooth muscle antibody (SMA). Increased binding of SMA serum to hepatocytes was observed as early as the first week of CCl4 treatment and r...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027709084807
更新日期:1977-07-01 00:00:00
abstract::Weanling rats were given a low Ca (0.003%)/high P (0.64%) diet with and without vitamin D for periods up to 6 weeks. An ultrastructural examination of selected areas of the proximal tibial metaphysis was carried out to study osteoclasts and their relation to calcified and uncalcified bone tissue. Osteoclasts were seen...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027909059045
更新日期:1979-10-01 00:00:00
abstract::Exfoliative, abrasive and aspiration cytology were increasingly relied upon for tissue diagnosis of tumours. The established histological stains for the differentiation of mucin and non-mucin-secreting tumours are not ideal for alcohol-fixed cytology smears and a more reliable cytological technique for the preservatio...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028309083509
更新日期:1983-07-01 00:00:00