Discordant neutrophil alkaline phosphatase activity and cytogenetic response in chronic myeloid leukemia treated with alpha-interferon.

Abstract:

:Decreased neutrophil alkaline phosphatase (NAP) synthesis is a classical feature of Philadelphia (Ph) positive chronic phase chronic myeloid leukemia (CML). Whether this aberration is an integral leukemic property of the cell or results from mediation by other factors is unclear. During alpha-interferon (alpha-IFN) based therapy the relationship between Ph chromosome suppression and NAP synthesis was examined. Four categories of response were observed in 19 patients studied sequentially. Significantly, persistent low NAP activity was observed in one patient in complete cytogenetic remission, while a second group of 7 patients demonstrated normal NAP activity in spite of persistence of the Ph chromosome in 100% of metaphases. In the absence of various clinical influences that can modulate NAP activity in chronic phase CML, the results reinforce the observation that the BCR/ABL fusion gene product is not a key factor influencing NAP activity in CML.

journal_name

Pathology

journal_title

Pathology

authors

Taylor DL,Kerwick AM,Elliott SL,Rodwell RL,Wright SJ,Marlton PV,Veleba AR,Taylor KM

doi

10.3109/00313029309090860

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

363-6

issue

4

eissn

0031-3025

issn

1465-3931

journal_volume

25

pub_type

杂志文章
  • The detection of myoglobin in urine and its application to the diagnosis of myocardial infarction.

    abstract::An indirect haemaglutination method was developed for the immunochemical detection of myoglobin in human urine. Myoglobin was found in the urine of 84% of 44 patients with acute myocardial infarction. In contrast, it was detected in the urine of 2.7% of 147 control subjects and in none of a control group of 15 patient...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313027609101494

    authors: Cloonan JM,Donald TG,Neale C,Wilcken DE

    更新日期:1976-10-01 00:00:00

  • External quality assurance in microbiology. The programme of the Royal College of Pathologists of Australasia.

    abstract::Since 1967 the Royal College of Pathologists of Australasia has been providing an external quality assurance programme in microbiology. The number of participants has risen from 70 to 222, and the samples distributed for investigation have increased in quantity, now totalling 35-40 per annum, and in variety, so that m...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028409068529

    authors: Ackerman VP,Pritchard RC

    更新日期:1984-07-01 00:00:00

  • The mast cell: distribution and maturation in the peritoneal cavity of the adult rat.

    abstract::In the peritoneal cavity of the adult rat mast cells at the four stages of progressive maturation (and corresponding increase of sulphation of granules) are best demonstrated in free peritoneal fluid. Of the 0.1-0.2x10(6) cells in the free fluid, 26% are at stage 1 of maturation (all granules are stained by Alcian blu...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313027509081687

    authors: Yong LC,Watkins S,Wilhelm DL

    更新日期:1975-10-01 00:00:00

  • Apoptosis in the human thymus in sudden and delayed death.

    abstract::We counted apoptotic thymic cortical lymphocytes in semi-thin plastic sections of 266 human autopsy thymuses. The decreased patients included in the study were all aged less than 40 yrs and all died within 72 hrs of the onset of symptoms. Based on published data on animal and human material it was anticipated that ind...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029400169261

    authors: Middleton G,Reid LE,Harmon BV

    更新日期:1994-04-01 00:00:00

  • A rapid method for assessing megathrombocytes: its application to thrombocytotic and acquired thrombocytopenic states.

    abstract::A rapid technique suitable for routine laboratory use for determining the percentage of large platelets in the peripheral blood is described. In 50 haematologically normal subjects, megathrombocytes (platelets with a volume of 16-33 fl) constituted 3.0-16.6% (mean +/- 2 SD) of the platelet count. Of the 10 patients ex...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313027609094424

    authors: Hunt FA

    更新日期:1976-01-01 00:00:00

  • Further evidence of hepatic transdifferentiation in hepatoid adenocarcinomas of the stomach: quantitative analysis of mRNA for albumin and hepatocyte nuclear factor-4alpha.

    abstract:AIMS:To assess the production of a liver-specific protein, albumin, and of a master transcriptional factor, hepatocyte nuclear factor (HNF)-4alpha, in hepatoid adenocarcinoma tissue. METHODS:Standard and quantitative RT-PCR, using five cases of hepatoid and three cases of non-hepatoid gastric adenocarcinoma. RESULTS:...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:

    authors: Yano T,Kishimoto T,Tomaru U,Kawarada Y,Kato H,Yoshiki T,Ishikura H

    更新日期:2003-02-01 00:00:00

  • Squamous cell carcinoma arising in an eccrine hidrocystoma.

    abstract::This report describes the case of a 63 yr old male with an enlarging lesion on the left cheek. Excision biopsy showed a squamous cell carcinoma arising from an eccrine hidrocystoma. The eccrine hidrocystoma showed foci of squamous metaplasia and the sequence of squamous metaplasia complicated by squamous carcinoma is ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313029309084796

    authors: Theocharous C,Jaworski RC

    更新日期:1993-04-01 00:00:00

  • Virus isolation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for diagnostic and research purposes.

    abstract::Isolation of the new pandemic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for diagnostic and research purposes including assessment of novel therapeutics. Several primary and continuous cell lines are currently used, and new organoid and engineered cell lines are being developed for...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.pathol.2020.09.012

    authors: Stelzer-Braid S,Walker GJ,Aggarwal A,Isaacs SR,Yeang M,Naing Z,Ospina Stella A,Turville SG,Rawlinson WD

    更新日期:2020-12-01 00:00:00

  • Benign nerve sheath tumors: a light microscopic, electron microscopic and immunohistochemical study of 102 cases.

    abstract::One hundred and two cases of benign nerve sheath tumors (NSTs) were studied with a combined approach using routine light microscopy (LM), immunohistochemistry (IH) for myelin basic protein (MBP) and S-100 protein as well as transmission electron microscopy (TEM) with the aim of obtaining greater insight into the true ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313029009086659

    authors: Sharma S,Sarkar C,Mathur M,Dinda AK,Roy S

    更新日期:1990-10-01 00:00:00

  • Cardiac pathology and adult aboriginal mortality: a coronial study of sudden and external cause deaths in the top end of the Northern Territory in 1990.

    abstract::A retrospective review of coronial records was performed for 179 adult decedents who came to coronial autopsy in 1990 and who had been living in the Top End of the Northern Territory at the time of death. The directly standardized rate of autopsy-examined sudden death was 7.4 times higher for Aboriginal people than fo...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029600169503

    authors: Weeramanthri TS,Powers JR,Collier JW

    更新日期:1996-01-01 00:00:00

  • Effect on organism recovery rate from BacT/Alert blood cultures with reduced incubation period.

    abstract::This retrospective study evaluated 15,377 sets of BacT/Alert blood cultures to determine incubation time for blood cultures. Ninety-six per cent (1476) of total isolates signalled positive within five days and 56 isolates turned positive in five to seven days. Of the 56 organisms recovered between five and seven days,...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029800169176

    authors: Mukerjee C,Heron LG,Varettas K

    更新日期:1998-05-01 00:00:00

  • Seroimmunology of AIDS retrovirus infection. I. Use of immunofluorescence assay to confirm sera with ELISA reactivity.

    abstract::One thousand sera shown to be reactive by one of two commercial enzyme linked immunosorbent assays (ELISA) for antibodies to the AIDS virus were referred to the NSW State Reference Laboratory for confirmatory assays. Each serum was retested by two commercial ELISA systems (Abbott and ENI), the ENI exclusionary H9 ELIS...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028609087565

    authors: Imrie AA,Kehrer S,Smith GW,Penny R,Cooper DA

    更新日期:1986-10-01 00:00:00

  • Bilateral primary seminal vesicle carcinoma.

    abstract::We report a rare case of bilateral primary seminal vesicle carcinoma in a 73 yr old Australian man. To our knowledge this case report is the 48th histologically confirmed case of primary seminal vesicle neoplasia and only the fourth reported case of primary bilateral seminal vesicle carcinoma. Macroscopically the tumo...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029600169883

    authors: Ormsby AH,Haskell R,Ruthven SE,Mylne GE

    更新日期:1996-05-01 00:00:00

  • The prognostic significance of the 2014 International Society of Urological Pathology (ISUP) grading system for prostate cancer.

    abstract::The 2005 International Society of Urological Pathology (ISUP) modified Gleason grading system was further amended in 2014 with the establishment of grade groupings (ISUP grading). This study examined the predictive value of ISUP grading, comparing results with recognised prognostic parameters.Of 3700 men undergoing ra...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1097/PAT.0000000000000315

    authors: Samaratunga H,Delahunt B,Gianduzzo T,Coughlin G,Duffy D,LeFevre I,Johannsen S,Egevad L,Yaxley J

    更新日期:2015-10-01 00:00:00

  • Erythroblastosis fetalis--the discovery and partial elimination of rhesus incompatibility--the origins of exchange transfusion in Australia.

    abstract::The first 2 exchange transfusions in Australia for Rhesus-induced erythroblastosis (hemolytic disease of the newborn) were conducted in the 9 mth period from December 1945 to August 1946. These pioneering endeavours in medical research were undertaken by 3 transfusionists who were, or had been, directors of the Red Cr...

    journal_title:Pathology

    pub_type: 历史文章,杂志文章

    doi:10.1080/00313029400169431

    authors: Pearn JH

    更新日期:1994-04-01 00:00:00

  • Human papillomavirus update with a particular focus on cervical disease.

    abstract::Human papillomavirus (HPV) is a common viral infection of squamous epithelial tissues, but its importance has only recently been recognised by the medical community. HPVs are now realised to consist of many genotypes and are associated with a diverse spectrum of clinical manifestations. Within the genital tract, some ...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1080/00313020212469

    authors: Garland SM

    更新日期:2002-06-01 00:00:00

  • The preparation of glomeruli from renal biopsy specimens for scanning electron microscopy.

    abstract::A method for the preparation of human renal biopsy specimens for scanning electron microscopy (SEM) is described. This involves glomerular isolation by fine needle dissection and the simultaneous processing of 10 or more specimens in a specially designed tissue cassette. The method is simple and reliable with minimal ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028209061381

    authors: Ng W,So KF,So PC,Ngai HK

    更新日期:1982-07-01 00:00:00

  • Childhood cancer in New Zealand 1990 to 1993.

    abstract::An epidemiological study of childhood cancer in New Zealand identified 409 children aged 0 to 14 years with malignant neoplasms newly diagnosed between 1990 and 1993 inclusive. The original microscopic material on which the diagnoses were based was reviewed in 398 cases and the neoplasms were allocated into the 12 maj...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/003130299105232

    authors: Becroft DM,Dockerty JD,Berkeley BB,Chan YF,Lewis ME,Skeen JE,Synek BJ,Teague LR

    更新日期:1999-05-01 00:00:00

  • Histological assessment of apoptotic cell death in cardiomyopathies.

    abstract::Apoptosis in the myocardium is complex and often difficult to recognise. Myocyte apoptosis is scattered across the myocardial wall and is restricted to individual cells. In the present study, we describe the amount of apoptosis in 50 endomyocardial biopsies taken from 50 patients with dilated cardiomyopathy, in 14 hea...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:

    authors: Kavantzas NG,Lazaris AC,Agapitos EV,Nanas J,Davaris PS

    更新日期:2000-08-01 00:00:00

  • Atypical teratoid/rhabdoid tumours: clinicopathological characteristics, prognostic factors and outcomes of 22 children from 2010 to 2015 in China.

    abstract::Atypical teratoid/rhabdoid tumours (AT/RTs) are rare, highly malignant tumours of the central nervous system (CNS) with poor prognosis that usually affect young children. The aim of this study was to assess the clinicopathological features and prognostic factors of AT/RTs. Here, we describe the clinicopathological and...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2016.05.010

    authors: Wang RF,Guan WB,Yan Y,Jiang B,Ma J,Jiang MW,Wang LF

    更新日期:2016-10-01 00:00:00

  • Multiplex mutation screening by mass spectrometry in gastrointestinal stromal tumours.

    abstract:AIMS:Clinical decision making and optimal clinical trial design based on cancer genetic information will be increasingly informed by the mutational status of multiple genes. METHODS:We performed mutation screening on 22 fresh frozen gastrointestinal stromal tumours (GISTs) using a multiplexed oncogene screening panel ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1097/PAT.0b013e3283559c45

    authors: Kang G,Lee J,Jang KT,Beadling C,Corless CL,Heinrich MC,Park JO,Kang WK,Park CK,Kim KM

    更新日期:2012-08-01 00:00:00

  • Pancreatic endocrine tumour with ductules: further observations of an unusual histological subtype.

    abstract:AIMS:Pancreatic endocrine tumours (PET) containing ductules are an uncommon histological variant. Considerable conjecture surrounds the origin and histogenesis of the ductules. Opinions range from the ductules being an inherent part of the tumour, to others who feel they are merely entrapped. A study of 21 cases of thi...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020500444633

    authors: Chetty R,Serra S,Asa SL,Volkan Adsay N

    更新日期:2006-02-01 00:00:00

  • Plexiform leiomyoma of the uterus in a patient with breast carcinoma: case report and review of the literature.

    abstract::Plexiform leiomyomas of the uterus are incidental findings in hysterectomy specimens. Histogenetically, these rare tumors are classified as a variant of epithelioid leiomyomas. Most of the plexiform leiomyomas reported range in size from microscopically small lesions to less than 1 cm in largest diameter, and they mac...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1080/003130299105197

    authors: Nagel H,Brinck U,Lüthje D,Füzesi L

    更新日期:1999-08-01 00:00:00

  • HPV detection and genotyping of head and neck cancer biopsies by molecular testing with regard to the new oropharyngeal squamous cell carcinoma classification based on HPV status.

    abstract::Recently, both the World Health Organization/International Agency for Research on Cancer (WHO/IARC) and the American Joint Committee on Cancer (AJCC) have classified oropharyngeal squamous cell carcinoma (OPSCC) on the basis of HPV status. For this purpose, the WHO/IARC recommended direct molecular HPV testing. In pra...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2019.02.002

    authors: Veyer D,Wack M,Grard O,Bonfils P,Hans S,Bélec L,Badoual C,Péré H

    更新日期:2019-06-01 00:00:00

  • An immunohistochemical and molecular analysis of papillary proliferation of the endometrium.

    abstract::Papillary proliferations of the endometrium (PPEs) are uncommon lesions that are often associated with endometrial polyps. PPEs occasionally precede or co-exist with atypical endometrial hyperplasia or adenocarcinoma, but their pathogenesis and relationship to endometrial neoplasia is uncertain. In the present study 1...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2017.10.013

    authors: Stewart CJR,Bigby S,Giardina T,Grieu-Iacopetta F,Amanuel B

    更新日期:2018-04-01 00:00:00

  • Cutaneous tumoural melanosis: a presentation of complete regression of cutaneous melanoma.

    abstract::Partial regression is common in cutaneous melanoma; however, complete regression manifesting as tumoural melanosis is rare, conceptually challenging and under-reported. In this study we report on clinical, histological and molecular findings in four cases of completely regressed cutaneous melanoma with nodal or brain ...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.pathol.2019.01.008

    authors: Ching D,Amini E,Harvey NT,Wood BA,Mesbah Ardakani N

    更新日期:2019-06-01 00:00:00

  • Ovarian sex cord-stromal tumours: an update in recent molecular advances.

    abstract::Sex cord-stromal tumours (SCSTs) consist of a heterogeneous group of neoplasms with diverse clinicopathological features and biological behaviour. They often present as a diagnostic challenge as they have varied and occasionally overlapping histomorphology and some may even mimic non-SCSTs. An accurate diagnosis is im...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.pathol.2017.10.008

    authors: Lim D,Oliva E

    更新日期:2018-02-01 00:00:00

  • Seven patients with respiratory infections due to Corynebacterium pseudodiphtheriticum.

    abstract::Seven cases of lower respiratory tract infection due to Corynebacterium pseudodiphtheriticum are described. Lower respiratory tract infections with C. pseudodiphtheriticum in immunocompetent patients are usually associated with pre-existing chronic pulmonary disease, and are sometimes associated with endotracheal intu...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029400169721

    authors: Freeman JD,Smith HJ,Haines HG,Hellyar AG

    更新日期:1994-07-01 00:00:00

  • Serum prohepcidin concentrations in rheumatoid arthritis.

    abstract:AIM:Hepcidin, a recently identified peptide, acts as a central regulator of iron metabolism. It is regarded as a factor regulating the uptake of dietary iron and its mobilisation from macrophages and hepatic stores. It is considered as a mediator of anaemia of inflammation. The aim of this study was to assess whether s...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020802436840

    authors: Jayaranee S,Sthaneshwar P,Sokkalingam S

    更新日期:2009-02-01 00:00:00

  • Diagnostic problem caused by an atypical creatine kinase isoenzyme in a patient with myocardial infarction.

    abstract::This report describes the diagnostic problem caused by an atypical immunoglobulin-bound creatine kinase isoenzyme in a patient who had a myocardial infarction. In the presence of this atypical isoenzyme, creatine kinase isoenzyme electrophoresis was of no help in determining whether myocardial infarction had occurred....

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313029009061424

    authors: Campbell BG,Jones BW,Burnet J

    更新日期:1990-01-01 00:00:00