Abstract:
:Human glomerular basement membrane (GBM) emulsified in Freund's complete adjuvant was injected into 16 Holtzman rats. Eleven (69%) of them subsequently developed glomerulonephritis. This disease was characterized by glomerular changes which included focal lobular hypercellularity due to localized hyperplasia of intracapillary (mesangial or endothelial) cells which often obstructed glomerular capillaries. Later, affected lobules showed necrosis of intracapillary cells, and capillary lumina were filled with homogeneous eosinophilic material. An immunoperoxidase technique revealed autologous anti-GBM antibody in all 3 layers of the GBM and in some regions it was present in greater amount in the lamina rara interna and externa than in the lamina densa. Experimental auto-immune glomerulonephritis in the rat is thus characterized morphologically by a focal proliferative glomerulonephritis which proceeds to focal glumerulosclerosis.
journal_name
Pathologyjournal_title
Pathologyauthors
McCausland IP,Herdson PB,Gavin JBdoi
10.3109/00313027609094437subject
Has Abstractpub_date
1976-04-01 00:00:00pages
117-26issue
2eissn
0031-3025issn
1465-3931journal_volume
8pub_type
杂志文章相关文献
PATHOLOGY文献大全abstract::A sequential study has been made of the ultrastructure of local renal graft-versus-host reactions produced in cyclophosphamide-pretreated rats by injection of either allogeneic or xenogeneic (mouse) spleen cells beneath the renal capsule. Early in the reaction, immunoblasts were seen between the outer cortical tubules...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027509081682
更新日期:1975-10-01 00:00:00
abstract::The sections in the following review cover six main neurodegenerative diseases. The first article on Alzheimer's disease (AD) outlines the major evidence available to date that links Aβ-amyloid peptide as a proximal cause of AD. The article also highlights how an initial finding of the protein content of the amyloid p...
journal_title:Pathology
pub_type: 杂志文章,多中心研究,评审
doi:10.1097/PAT.0b013e3283426eee
更新日期:2011-02-01 00:00:00
abstract::Chromosome identification techniques have shown the non-random nature of cytogenetic changes in leukemia. In addition, they have identified structural chromosome abnormalities occurring in specific types of acute leukemia as classified by the FAB criteria. Such cytogenetic sub groups are associated with differing prog...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028209061379
更新日期:1982-07-01 00:00:00
abstract::A method for the preparation of human renal biopsy specimens for scanning electron microscopy (SEM) is described. This involves glomerular isolation by fine needle dissection and the simultaneous processing of 10 or more specimens in a specially designed tissue cassette. The method is simple and reliable with minimal ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028209061381
更新日期:1982-07-01 00:00:00
abstract::The clinical and autopsy findings in a premature baby who died of acute renal failure after therapy with gentamicin (5 mg/kg/day) and penicillin are presented. The serum gentamicin concentration had reached toxic levels when anuria developed. Numerous periodic acid Schiff (PAS) positive, diastase resistant cytoplasmic...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028509105512
更新日期:1985-07-01 00:00:00
abstract::This report describes the diagnostic problem caused by an atypical immunoglobulin-bound creatine kinase isoenzyme in a patient who had a myocardial infarction. In the presence of this atypical isoenzyme, creatine kinase isoenzyme electrophoresis was of no help in determining whether myocardial infarction had occurred....
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029009061424
更新日期:1990-01-01 00:00:00
abstract::Review of problematic melanocytic consultation cases has enabled identification of the most common variants of benign melanocytic proliferations which can be confused with melanoma. Apart from Spitz naevus, the most common in this group of lesions are pigmented spindle cell naevus and atypical dermal nodule. Potential...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313020412331283842
更新日期:2004-10-01 00:00:00
abstract::Phospholipid preparations from the nematode Ascaris suum or cysts of Echinococcus granulosus (hydatid cysts) induced an eosinophilia when injected into the peritoneal cavity of rats. Peritoneal eosinophilia persisted throughout 21 days of daily injections of Ascaris lipid and was accompanied by blood eosinophilia, mas...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027709085252
更新日期:1977-04-01 00:00:00
abstract:AIMS:The roles of tumour suppressor genes: adenomatous polyposis coli (APC) and E-cadherin (CDH1) were investigated in clear cell renal cell carcinoma. METHODS:Forty-five human clear cell renal cell carcinomas were tested for APC gene instability by polymerase chain reaction/loss of heterozygosity using the restrictio...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020410001671984
更新日期:2004-04-01 00:00:00
abstract::The monitoring of infliximab drug levels aids in the management of several autoimmune diseases, notably inflammatory bowel disease. Several commercial kits are now available and approved by the Therapeutic Goods Administration (TGA) for the measurement of infliximab levels, but there have been limited verification or ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2016.07.001
更新日期:2016-10-01 00:00:00
abstract::We report a rare case of bilateral primary seminal vesicle carcinoma in a 73 yr old Australian man. To our knowledge this case report is the 48th histologically confirmed case of primary seminal vesicle neoplasia and only the fourth reported case of primary bilateral seminal vesicle carcinoma. Macroscopically the tumo...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029600169883
更新日期:1996-05-01 00:00:00
abstract:AIMS:Mounting evidence indicates that deregulation of apoptosis is involved in the mechanisms of cancer development. Bax-interacting factor-1 (Bif-1) interacts with both Bax and Bak that are crucial for the intrinsic apoptosis signalling. Functionally, loss of Bif-1 expression has been proven to enhance tumorigenesis. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020802320440
更新日期:2008-10-01 00:00:00
abstract::The early and late effects of wound healing on tumour development at a distant site were evaluated morphologically in an experimental model of colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH). Random bred male Wistar rats were given subcutaneous injections of DMH (20 mg/kg) or saline, once a week, for eight...
journal_title:Pathology
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
abstract::The results of semi-solid cultures of fresh biopsy material from 86 primary human melanomas are reported. Detailed histological assessments by Professor McGovern were available for 80 of the 86 melanomas, and these were compared with the growth characteristics of each specimen. Significant correlations were found betw...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028509063780
更新日期:1985-04-01 00:00:00
abstract::The objective of this study was to establish a population based reference range for a commercial immunoblot assay detecting myositis specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs), and to assess the diagnostic performance of this reference range against the manufacturer's recommended rang...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2016.03.012
更新日期:2016-06-01 00:00:00
abstract:AIMS:Activation of nuclear factor-kappa B (NF-kappaB) signalling is considered a crucial mechanism in the development of cancers. Caspase-associated recruitment domain 6 (CARD6) is a protein that activates NF-kappaB signalling evoked by RIP1, RIP2, Bcl-10 and MEKK. In this study, we analysed tissue expression of CARD6 ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313020903434421
更新日期:2010-01-01 00:00:00
abstract:AIMS:Matrix metalloproteinases (MMPs) have various functions that play roles in carcinoma development. In this study, we investigated the expression of two representative MMPs, MMP-7 and MMP-11, in papillary thyroid carcinomas. METHODS:We immunohistochemically investigated the expression of these MMPs in 196 cases of ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020600922496
更新日期:2006-10-01 00:00:00
abstract::The Hippo pathway is a tumour-suppressive pathway and its inactivation is known to be associated with progression and metastasis of various cancers. LATS1/2 (large tumour suppressor homolog 1 and 2), YAP1 (Yes-associated protein 1), and TEAD4 (TEA domain-containing sequence-specific transcription factors 4) are core c...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2019.01.001
更新日期:2019-04-01 00:00:00
abstract::An enzyme-immunoassay has been developed for the detection of myoglobin in human serum and urine which is specific, accurate, precise, and has a sensitivity of 3 ng/ml. When compared with radioimmunoassay, the enzyme-immunoassay gives markedly similar results. Sera from normal adults had a myoglobin concentration in t...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027909059049
更新日期:1979-10-01 00:00:00
abstract::The aim of this study was to subcategorise large cell carcinoma (LCC) with null immunophenotype according to the World Health Organization (WHO) Classification of 2015 into the existing groups of adenocarcinoma and squamous cell carcinoma by further molecular genetic analysis. Lineage-specific molecular alterations of...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2018.03.005
更新日期:2018-08-01 00:00:00
abstract::Three cases of nodular lymphomas with cytoplasmic inclusions were studied histologically, histochemically and immunocytochemically, and ultrastructurally. One case had Russell body-like inclusions, another had needle-like inclusions not previously reported, while the last showed cells with cytoplasmic vacuoles. Two of...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.3109/00313028209092121
更新日期:1982-10-01 00:00:00
abstract:BACKGROUND:Digital papillary adenocarcinoma (DPA) is a rare malignant adnexal tumour that occurs almost exclusively in a digital location. Only two case series have been reported previously. AIMS:To document the clinical and histopathological findings in a series of patients with DPA. RESULTS:Of the 8 patients identi...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e32835af778
更新日期:2013-01-01 00:00:00
abstract:AIMS:Twenty-six cases of granulomatous mastitis were examined to determine the common histological and clinical features and the possible association with micro-organisms. METHODS:A retrospective review of the clinical and histological features of these cases was undertaken, including granuloma, inflammatory cell infi...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313020410001692602
更新日期:2004-06-01 00:00:00
abstract::Since 1967 the Royal College of Pathologists of Australasia has been providing an external quality assurance programme in microbiology. The number of participants has risen from 70 to 222, and the samples distributed for investigation have increased in quantity, now totalling 35-40 per annum, and in variety, so that m...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409068529
更新日期:1984-07-01 00:00:00
abstract::A fatal case of multiple sulfatase deficiency in a 10-year-old girl is reported. In this rare disease, which is inherited as an autosomal recessive, features of metachromatic leukodystrophy and of mucopolysaccharidoses occur together. The white matter suffers progressive destruction with sulfatides accumulating in mac...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809059509
更新日期:1988-07-01 00:00:00
abstract::Sex cord-stromal tumours (SCSTs) consist of a heterogeneous group of neoplasms with diverse clinicopathological features and biological behaviour. They often present as a diagnostic challenge as they have varied and occasionally overlapping histomorphology and some may even mimic non-SCSTs. An accurate diagnosis is im...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2017.10.008
更新日期:2018-02-01 00:00:00
abstract::The lupus anticoagulant (LA) phenomenon created world-wide interest recently. Various tests have been devised to identify LA in plasma, but none of these methods have been universally accepted. In this study 16 cases labelled LA positive by a prior kaolin clotting time (KCT) test were reassessed by four other methods,...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029009063794
更新日期:1990-04-01 00:00:00
abstract::A variant of gelatinous transformation of marrow was described in leukemic patients post-chemotherapy. This lesion was found in 8 out of 1833 post-chemotherapy bone marrows from 429 patients with leukemia. Histologically, this variant form was identical to the classical gelatinous transformation except for the absence...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029309066592
更新日期:1993-07-01 00:00:00
abstract::Hodgkin lymphoma (HL) is composed of two distinct pathological entities, nodular lymphocyte predominant HL and classic HL, the latter with four subtypes. In contrast with most other human lymphomas, in which the neoplastic cells are a major population of the tumour constituents, the neoplastic 'Hodgkin (H) and Reed-St...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2019.09.005
更新日期:2020-01-01 00:00:00
abstract::Granulomatous (lobular) mastitis is a rare inflammatory breast disease affecting parous reproductive-aged women. Once considered idiopathic, there is growing evidence of an association with corynebacteria infection, especially in the setting of a distinct histological pattern termed cystic neutrophilic granulomatous m...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2017.01.006
更新日期:2017-06-01 00:00:00