Abstract:
:Granulomatous (lobular) mastitis is a rare inflammatory breast disease affecting parous reproductive-aged women. Once considered idiopathic, there is growing evidence of an association with corynebacteria infection, especially in the setting of a distinct histological pattern termed cystic neutrophilic granulomatous mastitis (CNGM). We describe 15 cases with histological features either confirming (n = 12) or suggesting (n = 3) CNGM, and concurrent microbiological evidence of Corynebacterium species. The organism was detected by culture or 16S rRNA gene sequencing of specimens obtained at surgery or fine needle aspiration. In seven cases, Gram-positive organisms were seen within vacuolated spaces. Speciation was performed in nine cases, with Corynebacterium kroppenstedtii subsequently identified. These cases provide further evidence in support of this association and in doing so highlight the importance of recognising these histological clues as well as the limitations of Gram stain and microbiological culture in detecting this previously under-recognised disease process.
journal_name
Pathologyjournal_title
Pathologyauthors
Johnstone KJ,Robson J,Cherian SG,Wan Sai Cheong J,Kerr K,Bligh JFdoi
10.1016/j.pathol.2017.01.006subject
Has Abstractpub_date
2017-06-01 00:00:00pages
405-412issue
4eissn
0031-3025issn
1465-3931pii
S0031-3025(16)40500-3journal_volume
49pub_type
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