Gentamicin nephropathy in a neonate.

Abstract:

:The clinical and autopsy findings in a premature baby who died of acute renal failure after therapy with gentamicin (5 mg/kg/day) and penicillin are presented. The serum gentamicin concentration had reached toxic levels when anuria developed. Numerous periodic acid Schiff (PAS) positive, diastase resistant cytoplasmic inclusion bodies which appeared as myelin figures in cytosegresomes under the electron microscope were identified in the proximal convoluted tubules. The pathological changes induced by gentamicin in the human neonatal kidneys have not been previously reported.

journal_name

Pathology

journal_title

Pathology

authors

Chan KW,Ng WL

doi

10.3109/00313028509105512

subject

Has Abstract

pub_date

1985-07-01 00:00:00

pages

514-5

issue

3

eissn

0031-3025

issn

1465-3931

journal_volume

17

pub_type

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