Abstract:
:In this review, we focus on B-cell lymphoproliferative disorders (LPDs) and lymphomas associated with Epstein-Barr virus (EBV). In some of these diseases-such as EBV-positive diffuse large B-cell lymphoma (DLBCL), not otherwise specified-virus detection is required for the diagnosis, while in others its detection is not necessary for diagnosis. EBV infection has three main latency patterns (types III, II, and I). Different latency patterns are found in different LPD types and are related to the host immune system status. For each of the LPDs/lymphomas, we discuss the clinical presentation, epidemiology, pathology, immunophenotype, and genetic or molecular basis. We provide data for a better understanding of the relationships among the discussed diseases and other information that can be useful in differential diagnosis. Not included in this review are classic Hodgkin lymphoma and some specific variants of DLBCL, as these entities are discussed in separate reviews in this issue.
journal_name
Pathologyjournal_title
Pathologyauthors
Marques-Piubelli ML,Salas YI,Pachas C,Becker-Hecker R,Vega F,Miranda RNdoi
10.1016/j.pathol.2019.09.006subject
Has Abstractpub_date
2020-01-01 00:00:00pages
40-52issue
1eissn
0031-3025issn
1465-3931pii
S0031-3025(19)30396-4journal_volume
52pub_type
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