Infiltration by immunocompetent cells in early stage invasive carcinoma of the uterine cervix: a prognostic study.

abstract：:The distinction between partial hydatidiform mole (PHM) and trisomy gestation is not always straightforward histologically and it is unclear which morphological features, alone or in combination, provide the greatest diagnostic accuracy. We performed a comparative review of 89 products of conception (POC) specimens in...

journal_title：Pathology

authors： Wilson Y,Bharat C,Crook ML,Kee AR,Peverall J,Ruba S,Stewart CJ

更新日期：2016-10-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is often associated with a poor prognosis and options for the treatment of this disease are few. To date, the important role of the immune microenvironment in modifying the disease natural history is well established. The programmed cell death pathway (PD-1/PD-L1) limits the T lymp...

journal_title：Pathology

authors： Rrapaj E,Giacometti L,Spina P,Salvo M,Baselli GA,Veggiani C,Rena O,Trisolini E,Boldorini RL

更新日期：2020-11-30 00:00:00

abstract：:Tumour infiltrating lymphocytes in primary melanoma have been found to correlate with patient outcomes. A subpopulation of tumour infiltrating lymphocytes expresses the transcription factor forkhead box protein 3 (FOXP3). These are known as FOXP3+ T-regulatory cells (Tregs) and are thought to play an immune suppressiv...

journal_title：Pathology

authors： Leslie C,Bowyer SE,White A,Grieu-Iacopetta F,Trevenen M,Iacopetta B,Amanuel B,Millward M

更新日期：2015-10-01 00:00:00

abstract：:Rare tumours are a heterogeneous group of conditions that encompass benign to malignant lesions both of stromal and epithelial origin. Here some of these tumours are described, in which the authors have most familiarity. An outline of medullary carcinoma is also presented. ...

journal_title：Pathology

authors： Foschini MP,Eusebi V

更新日期：2009-01-01 00:00:00

abstract：:This review will focus on the molecular biology of lymphoproliferative disorders with emphasis on lymphomas. The spectrum of known recurrent gene rearrangements found in lymphomas will be outlined and their relevance to diagnosis and subclassification of disease will be discussed. Finally, a survey of the current tren...

journal_title：Pathology

authors： Catalano A,Iland H

更新日期：2005-12-01 00:00:00

abstract：:The most common of all activating BRAF mutations (T1799A) leads to a substitution of valine (V) to glutamic acid (E) at the position 600 of the amino acid sequence. The major goal of this study was to compare detection of the BRAF V600E mutation by DNA sequencing with immunohistochemistry (IHC) using the anti-BRAF V60...

journal_title：Pathology

authors： Dvorak K,Aggeler B,Palting J,McKelvie P,Ruszkiewicz A,Waring P

更新日期：2014-10-01 00:00:00

abstract：:Semen analysis is the most important laboratory investigation for men when assessing the infertile couple. Advances in in vitro fertilisation (IVF) techniques, particularly intracytoplasmic sperm injection (ICSI) involving the direct injection of a single spermatozoon into an egg, have not diminished the role of semen...

journal_title：Pathology

authors： McLachlan RI,Baker HW,Clarke GN,Harrison KL,Matson PL,Holden CA,de Kretser DM,Andrology Australia Australian Centre of Excellence in Male Reproductive Health.,Fertility Society of Australia Scientists in Reproductive Technology Subcommit

更新日期：2003-02-01 00:00:00

abstract：:A genetic variant of antithrombin with impaired heparin cofactor activity was identified in 4 members of a French family. Both the variant and normal antithrombin component were purified by affinity chromatography on heparin Sepharose. Reverse phase peptide mapping revealed a single altered peak when tryptic digests o...

journal_title：Pathology

authors： Brennan SO,Borg JY,Shaw GJ,Caen J,George PM

更新日期：1991-01-01 00:00:00

abstract：:Measurement of extracellular hemoglobin is useful for assessing the relative success of different blood storage strategies. The test is now also included in routine quality assurance procedures. With the recent trend towards transfusion of concentrated red cells resuspended in "additive" solutions, a safe and efficien...

journal_title：Pathology

authors： Raftos JE,Stewart IM,Lovric VA

更新日期：1986-01-01 00:00:00

abstract：AIMS:The roles of tumour suppressor genes: adenomatous polyposis coli (APC) and E-cadherin (CDH1) were investigated in clear cell renal cell carcinoma. METHODS:Forty-five human clear cell renal cell carcinomas were tested for APC gene instability by polymerase chain reaction/loss of heterozygosity using the restrictio...

journal_title：Pathology

authors： Pećina-SLaus N,Gall-TroSelj K,SLaus M,Radić K,NikuSeva-Martić T,Pavelić K

更新日期：2004-04-01 00:00:00

abstract：:The BRAF(V600E) mutation confers worse prognosis to metastatic colorectal cancer (mCRC) patients. In addition, this mutation has a negative predictive value for response to treatment with monoclonal antibodies against EGFR in patients with KRAS wild-type (wt) mCRC. The utility of immunohistochemistry (IHC) as an alter...

journal_title：Pathology

authors： Ilie MI,Long-Mira E,Hofman V,Mouroux J,Vignaud JM,Gauchotte G,Begueret H,Merlio JP,Emile JF,Hébuterne X,Hofman P

更新日期：2014-06-01 00:00:00

abstract：:Antibodies that bind phospholipid (anti-phospholipid antibodies [APA]) are a focus of major interest to both clinical and laboratory personnel across a variety of disciplines because of the assortment of disorders with which they are reportedly associated. A solid phase assay using cardiolipin as the test phospholipid...

journal_title：Pathology

authors： Favaloro EJ,Silvestrini R,Mohammed A

更新日期：1999-05-01 00:00:00

abstract：:Ebolaviruses, and the other viral causes of haemorrhagic fevers (VHF) have always posed special problems for diagnostic laboratories. These arise from the rarity of human infections, minimal documented experience with test delivery and interpretation, the paucity of established commercial or in-house assays, the lack ...

journal_title：Pathology

authors： Smith DW,Rawlinson WD,Kok J,Dwyer DE,Catton M

更新日期：2015-08-01 00:00:00

abstract：:Cytological examination of the pleural effusion fluid obtained from a 66-yr-old Chinese lady showed numerous intra- and extracytoplasmic colourless refractile non-birefringent crystals. X-ray analysis of the crystals identified barium salts. On further inquiry, it was learnt that the fluid obtained had been placed in ...

journal_title：Pathology

authors： Chan AC,Collins RJ,Cheung TK

更新日期：1993-10-01 00:00:00

abstract：:Multiplex immunofluorescence (mIF) allows simultaneous antibody-based detection and quantification of the expression of up to six markers, plus a nuclear counterstain, on a single tissue section. Recent studies have shown the potential for mIF to advance our understanding of complex disease processes, including cancer...

journal_title：Pathology

authors： Lim JCT,Yeong JPS,Lim CJ,Ong CCH,Wong SC,Chew VSP,Ahmed SS,Tan PH,Iqbal J

更新日期：2018-04-01 00:00:00

abstract：:In 14 stock rabbits experimental aneurysms (saccular, fusiform or berry) were produced on the common carotid artery or the aorta by microvascular surgery using a modification of the venous pouch technique. The animals were given a cholesterol-rich diet at varying times postoperatively to determine the susceptibility o...

journal_title：Pathology

authors： Stehbens WE

更新日期：1981-10-01 00:00:00

abstract：:Rheumatoid Arthritis (RA) synovial membranes were examined by single and dual immunohistological techniques with a number of monoclonal antibodies against lymphocyte and macrophage related antigens. CD4 positive T lymphocytes frequently expressed MHC Class II antigens and were found in sublining collections in close a...

journal_title：Pathology

authors： Smith MD,O'Donnell J,Highton J,Palmer DG,Rozenbilds M,Roberts-Thomson PJ

更新日期：1992-01-01 00:00:00

abstract：:Hypercalcemia is a common biochemical abnormality. It is usually possible to make a presumptive diagnosis of its cause by relatively simple means. In a large majority of cases this involves differentiating between primary hyperparathyroidism and malignancy-associated hypercalcemia. Clinical evaluation and parathyroid ...

journal_title：Pathology

authors： Mason RS

更新日期：1986-04-01 00:00:00

abstract：:Statistical methods have been used to determine an optimal approach to the definition of the reference range for CD4 ("helper") and CD8 ("suppressor/cytotoxic") T cell numbers and the CD4/CD8 ratio in the peripheral blood. A graphical presentation of the absolute values for CD4 and CD8 for 85 healthy blood donors show...

journal_title：Pathology

authors： Zachar V,Mikulecky M,Mayer V,Mackay I,Frazer I

更新日期：1988-10-01 00:00:00

abstract：:Human papillomavirus (HPV) is a common viral infection of squamous epithelial tissues, but its importance has only recently been recognised by the medical community. HPVs are now realised to consist of many genotypes and are associated with a diverse spectrum of clinical manifestations. Within the genital tract, some ...

journal_title：Pathology

authors： Garland SM

更新日期：2002-06-01 00:00:00

abstract：:Thirty-one patients aged over 60 yrs and with lupus anticoagulant (LA) were reviewed for their drug intake. Twenty-three (73%) were taking cinchona alkaloids, 10 (32%) quinine for night cramps, 11 (35%) quinidine for cardiac arrhythmia and 2 (6%) were taking both. These frequencies of drugs usage differed significantl...

journal_title：Pathology

authors： Bird MR,O'Neill AI,Buchanan RR,Ibrahim KM,Des Parkin J

更新日期：1995-04-01 00:00:00

abstract：:Biochemical confirmation of the identity of Burkholderia pseudomallei in Singapore previously relied on the API 20NE panel of tests. After introducing an alternative proprietary biochemical panel, the Microbact 24E (MedVet, Adelaide, Australia), we noted that the API panel identified some presumptive B. pseudomallei i...

journal_title：Pathology

authors： Inglis TJ,Chiang D,Lee GS,Chor-Kiang L

更新日期：1998-02-01 00:00:00

abstract：:Human glomerular basement membrane (GBM) emulsified in Freund's complete adjuvant was injected into 16 Holtzman rats. Eleven (69%) of them subsequently developed glomerulonephritis. This disease was characterized by glomerular changes which included focal lobular hypercellularity due to localized hyperplasia of intrac...

journal_title：Pathology

authors： McCausland IP,Herdson PB,Gavin JB

更新日期：1976-04-01 00:00:00

abstract：:A rapid technique suitable for routine laboratory use for determining the percentage of large platelets in the peripheral blood is described. In 50 haematologically normal subjects, megathrombocytes (platelets with a volume of 16-33 fl) constituted 3.0-16.6% (mean +/- 2 SD) of the platelet count. Of the 10 patients ex...

journal_title：Pathology

authors： Hunt FA

更新日期：1976-01-01 00:00:00

abstract：:Lymph node metastasis (LNM) is an important factor for predicting prognosis and selecting appropriate treatment in early gastric cancers (EGCs). We investigated the histopathological and microenvironmental predictors of LNM in EGCs. We retrieved 43 cases of EGC without LNM and 59 cases with LNM. Clinicopathological va...

journal_title：Pathology

authors： Kim JY,Kim CH,Lee Y,Lee JH,Chae YS

更新日期：2017-10-01 00:00:00

abstract：:Chromosome identification techniques have shown the non-random nature of cytogenetic changes in leukemia. In addition, they have identified structural chromosome abnormalities occurring in specific types of acute leukemia as classified by the FAB criteria. Such cytogenetic sub groups are associated with differing prog...

journal_title：Pathology

authors： Garson OM

更新日期：1982-07-01 00:00:00

abstract：:Sera from 82 patients with acute or chronic hepatitis and 40 chronic carriers of hepatitis B were examined by ELISA and immunoblotting for reactivity with the glycolytic enzyme aldolase. The results of the ELISA tests, expressed as a percentage of a positive control, were compared to those obtained with sera from 39 p...

journal_title：Pathology

authors： Brown C,Toh BH,Pedersen JS,Clarke FM,Mackay IR,Gust I

更新日期：1987-10-01 00:00:00

abstract：:The aim of this study was to subcategorise large cell carcinoma (LCC) with null immunophenotype according to the World Health Organization (WHO) Classification of 2015 into the existing groups of adenocarcinoma and squamous cell carcinoma by further molecular genetic analysis. Lineage-specific molecular alterations of...

journal_title：Pathology

authors： Harms A,Endris V,Winter H,Kriegsmann M,Stenzinger A,Schirmacher P,Warth A,Kazdal D

更新日期：2018-08-01 00:00:00

abstract：:This paper reviews the application of flow cytometric techniques to the analysis and quantitation of mixed red cell populations. Such mixtures may arise in a variety of ways, for example: through transplacental hemorrhage during pregnancy or upon delivery; through iatrogenic procedures such as blood transfusion, bone ...

journal_title：Pathology

authors： Nelson M

更新日期：1999-08-01 00:00:00

abstract：:The field of systemic cancer therapy for metastatic disease has entered an exciting era with the advent of novel immunomodulatory strategies targeting immune checkpoints. At the heart of these promising efforts are the tumour-infiltrating lymphocytes (TILs). As the reports demonstrating efficacy of modulating TIL effe...

journal_title：Pathology

authors： Lee N,Zakka LR,Mihm MC Jr,Schatton T

更新日期：2016-02-01 00:00:00