Abstract:
AIMS:Whereas most caspases play roles in apoptosis and/or inflammation, caspase-14 plays a main role in epithelial differentiation. In cancers, expression of caspase-14 is frequently altered and is associated with some clinicopathological characteristics, suggesting caspase-14 might contribute to the pathogenesis of cancers. As a potential mechanism of caspase-14 alterations in cancers, we explored the possibility that mutation of caspase-14 gene is a characteristic of human cancers. METHODS:We analysed the entire coding region and all splice sites of human caspase-14 gene for the detection of somatic mutations in a series of 345 cancers, including 105 colorectal, 60 gastric, 60 hepatocellular, 60 breast and 60 lung carcinomas, by a single-strand conformation polymorphism (SSCP) assay. RESULTS:Overall, we detected two somatic mutations of caspase-14 gene, which consisted of one missense mutation (S32Y) and one silent mutation (T234T). The caspase-14 mutations were detected in two of 105 colorectal carcinomas (1.9%), but not in other carcinomas. CONCLUSION:These data indicate that caspase-14 gene is rarely mutated in colorectal carcinomas, but not mutated in gastric, lung, breast and hepatocellular carcinomas. The data also suggest that the caspase-14 mutation may not be a direct target of inactivation in tumorigenesis of common carcinomas.
journal_name
Pathologyjournal_title
Pathologyauthors
Yoo NJ,Soung YH,Lee SH,Jeong EG,Lee SHdoi
10.1080/00313020701329815subject
Has Abstractpub_date
2007-06-01 00:00:00pages
330-3issue
3eissn
0031-3025issn
1465-3931pii
779273901journal_volume
39pub_type
杂志文章相关文献
PATHOLOGY文献大全abstract::In order to determine whether routine culturing for Clostridium difficile was warranted or whether culturing a selected group of patients was adequate, we conducted a prospective trial of culturing all stool specimens for C. difficile. A total of 408 specimens from 297 patients was studied. Two hundred and eighteen st...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409068530
更新日期:1984-07-01 00:00:00
abstract::Gene targeting ('knock-out') technology is now widely used in the basic science of all disciplines of pathology and particularly auto-immune and inflammatory disease. Gene targeting is the wilful introduction of precise mutations into the genome of an animal, usually a mouse, affecting the function of a single gene or...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/003130201201111230
更新日期:2002-04-01 00:00:00
abstract:AIMS:Pancreatic endocrine tumours (PET) containing ductules are an uncommon histological variant. Considerable conjecture surrounds the origin and histogenesis of the ductules. Opinions range from the ductules being an inherent part of the tumour, to others who feel they are merely entrapped. A study of 21 cases of thi...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020500444633
更新日期:2006-02-01 00:00:00
abstract::The cell surface markers of 75 cases of non-Hodgkin's lymphoma were studied on cryostat sections using a panel of monoclonal antibodies. Forty-nine cases (65.3%) were found to express a B-cell phenotype, 23 cases (30.7%) a T-cell phenotype, 1 case (1.3%) a histiocytic phenotype and 2 cases (2.7%) no demonstrable surfa...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028609087562
更新日期:1986-10-01 00:00:00
abstract::Lymph node metastasis (LNM) is an important factor for predicting prognosis and selecting appropriate treatment in early gastric cancers (EGCs). We investigated the histopathological and microenvironmental predictors of LNM in EGCs. We retrieved 43 cases of EGC without LNM and 59 cases with LNM. Clinicopathological va...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2017.06.003
更新日期:2017-10-01 00:00:00
abstract::The failure of N. gonorrhoeae to grow on isolation media was found to be due to inhibitory substances present in commercially available horse sera. Subsequent investigations indicated that the inhibitory action of the horse serum may have been due to antibodies to N. gonorrhoeae, H. influenzae, H. parainfluenzae and b...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409068534
更新日期:1984-07-01 00:00:00
abstract::Rheumatoid Arthritis (RA) synovial membranes were examined by single and dual immunohistological techniques with a number of monoclonal antibodies against lymphocyte and macrophage related antigens. CD4 positive T lymphocytes frequently expressed MHC Class II antigens and were found in sublining collections in close a...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029209063615
更新日期:1992-01-01 00:00:00
abstract::The recent upsurge in the association of congenital neurological disorders and infection by the Zika virus (ZIKV) has resulted in increased research focus on the biology of this flavivirus. Studies in animal models indicate that ZIKV can breach the placental barrier and selectively infect and deplete neuroprogenitor c...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2017.07.008
更新日期:2017-12-01 00:00:00
abstract::This retrospective study evaluated 15,377 sets of BacT/Alert blood cultures to determine incubation time for blood cultures. Ninety-six per cent (1476) of total isolates signalled positive within five days and 56 isolates turned positive in five to seven days. Of the 56 organisms recovered between five and seven days,...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029800169176
更新日期:1998-05-01 00:00:00
abstract:AIMS:Hep Par 1 has been described as a specific marker of hepatocellular differentiation and its immunohistochemical use has been suggested as a helpful tool for hepatocellular carcinoma (HCC) diagnosis. Most metastatic liver tumours come from the gastrointestinal tract and usually can be distinguished from HCC only th...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/0031302021000009333
更新日期:2002-10-01 00:00:00
abstract:AIM:The purpose of this study was to elucidate the clonality of fibrous dysplasia based on X-chromosome inactivation mosaicism and polymorphism in female somatic cells at the phosphoglycerate kinase (PGK) and androgen receptor (AR) loci using microdissection technology. MATERIALS AND METHODS:Nine patients with fibrous...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020801911496
更新日期:2008-06-01 00:00:00
abstract:AIMS:To correlate the immunostaining for INI1 protein and mutations in INI1 gene in possible rhabdoid tumours (RT) and atypical teratoid/rhabdoid tumours (AT/RT) seen at the Royal Children's Hospital in the last 10 years, and to study the clinicopathological features of those patients with negative nuclear staining. M...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020802436451
更新日期:2008-12-01 00:00:00
abstract::The lupus anticoagulant (LA) phenomenon created world-wide interest recently. Various tests have been devised to identify LA in plasma, but none of these methods have been universally accepted. In this study 16 cases labelled LA positive by a prior kaolin clotting time (KCT) test were reassessed by four other methods,...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029009063794
更新日期:1990-04-01 00:00:00
abstract::Distinction between melanocytic naevi and melanoma occasionally poses a diagnostic challenge in ambiguous cases showing overlapping histological features. Melanomas are characterised by the presence of multiple genomic copy number variants (CNVs), while this is not a feature of naevi. We assessed the feasibility and u...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2016.11.008
更新日期:2017-04-01 00:00:00
abstract::A novel grading system based on the counting of poorly differentiated clusters (PDC) of neoplastic cells at the invasive margin and in the tumour stroma was recently introduced among the histological parameters predictive of adverse clinical outcome in colorectal cancer (CRC). The aim of this study was to correlate th...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000300
更新日期:2015-10-01 00:00:00
abstract::Appropriate investigation of a patient with suspected von Willebrand's disease (VWD) involves a clinical assessment of the patient followed by laboratory testing. A variety of laboratory assays may be performed, not necessarily restricted to an assessment of von Willebrand factor (VWF). Due to the limitations of each ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029700169365
更新日期:1997-11-01 00:00:00
abstract:AIMS:This study was undertaken to investigate the genetic factors underlying the development of multifocality and phenotypic diversity in multifocal papillary thyroid carcinoma (mPTC). METHODS:Loss of heterozygosity (LOH) and BRAF(V600E) mutation status were analysed in a total of 55 individual tumour foci from 18 cas...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313025.2010.508780
更新日期:2010-01-01 00:00:00
abstract::Post-transplant lymphoproliferative disorders (PTLD) are a consequence of the immunosuppressive therapy following organ transplant. We describe a patient who developed PTLD seven years after liver transplant and while receiving cyclosporine and prednisone. Magnetic resonance imaging demonstrated a paraspinal mass exte...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029800169636
更新日期:1998-11-01 00:00:00
abstract::The clinical course and biopsy findings of twenty-one patients with IgA nephropathy, followed up for a mean period of 37.4 mth (range 24-54 mth) after diagnosis, were reviewed retrospectively to determine whether the clinical presentations, the laboratory findings or histopathologic changes have prognostic implication...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028609090824
更新日期:1986-01-01 00:00:00
abstract::Apoptosis in the myocardium is complex and often difficult to recognise. Myocyte apoptosis is scattered across the myocardial wall and is restricted to individual cells. In the present study, we describe the amount of apoptosis in 50 endomyocardial biopsies taken from 50 patients with dilated cardiomyopathy, in 14 hea...
journal_title:Pathology
pub_type: 杂志文章
doi:
更新日期:2000-08-01 00:00:00
abstract::An analysis of prognostic factors in 4000 patients with cutaneous malignant melanoma at the Sydney Melanoma Unit and the University of Alabama in Birmingham has demonstrated that the histological features of the primary melanoma become less predictive of survival the more advanced the disease becomes. Thus, whilst 4 f...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028509063766
更新日期:1985-04-01 00:00:00
abstract::HLA-B27 is a risk marker for ankylosing spondylitis and other associated seronegative spondyloarthropathies. We compared three methods of HLA-B*27 typing in a New South Wales (NSW) population: flow cytometry, rs4349859 single nucleotide polymorphism (SNP) detection assay, and allele-specific real-time polymerase chain...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2019.09.013
更新日期:2020-02-01 00:00:00
abstract::Results are presented of a study comparing cerbB2 (neu or Her2) expression as assessed immunohistochemically in breast neoplasia using a panel of 6 commercially available antibodies. The antibodies were examined utilizing conventional formalin fixed paraffin embedded tissue, and compared with molecular analysis of gen...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029400169611
更新日期:1994-07-01 00:00:00
abstract::A rare case of extraskeletal osteosarcoma of the scalp in a 56-year-old woman is described. At presentation she was found to have an 8-cm diameter, tender, firm, exophytic scalp tumor. MRI scan confirmed absence of underlying skeletal origin and showed extension along the subcutaneous plane. The tumor was excised and ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/003130200104457
更新日期:2000-05-01 00:00:00
abstract::Although most carcinomas of the bladder occur de novo, some vesical lesions progress to malignancy over time. These lesions appear morphologically benign, but often harbour genetic changes that signify their malignant potential. Despite their benign appearance, accurate identification is important given that these pat...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1097/PAT.0b013e32835f6169
更新日期:2013-04-01 00:00:00
abstract:AIMS:The increasing importance of cardiac disease has generated an interest in improved screening strategies regarding preclinical cardiac abnormalities and employing measurement of circulating biomarkers. This review focuses on the utility of the B-type natriuretic peptides (NP) and the cardiac troponins (cTns) for th...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1097/PAT.0b013e32834e786e
更新日期:2012-02-01 00:00:00
abstract::Exfoliative, abrasive and aspiration cytology were increasingly relied upon for tissue diagnosis of tumours. The established histological stains for the differentiation of mucin and non-mucin-secreting tumours are not ideal for alcohol-fixed cytology smears and a more reliable cytological technique for the preservatio...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028309083509
更新日期:1983-07-01 00:00:00
abstract:AIM:To determine whether the common respiratory pathogen, Chlamydia pneumoniae, was associated with atherosclerotic plaques in Australian subjects. METHODS:A total of 29 coronary atherosclerotic lesions and 18 normal coronary arterial samples were tested for the presence of C. pneumoniae by PCR and immunofluorescence ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020220131363
更新日期:2002-06-01 00:00:00
abstract::The present conventional methods for determination of Hemoglobin (Hb) concentration in whole blood depend on the direct colorimetric measurement of chemically modified Hb following its release from red cells by lysis. This paper examines an alternative, indirect method which does not require initial red cell lysis, co...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029109060808
更新日期:1991-04-01 00:00:00
abstract::Tumor cell-platelet interactions have been shown to be involved in the process of metastasis. This study characterizes the aggregation of washed platelets induced by the human uterine carcinosarcoma Colo 526. Ultrastructural studies revealed a two-stage process in which the earliest events were the adhesion and degran...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029700169844
更新日期:1997-05-01 00:00:00